JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
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IF 2.369
Yanmin Shen,Wenju Liu,Chen Sun,Paifeng Shi
The solid–liquid phase equilibrium solubility of doxycycline hyclate (DH) in 10 pure organic solvents and cosolvent mixtures DMF (1) + ethanol (2), DMSO (1) + ethanol (2) and acetone (1) + ethanol (2) at a temperature range from 278.15 to 323.15 K was measured and discussed. The results indicated that the experimental mole fraction (x) of DH in 10 neat solvents followed this order: acrylic acid > acetic acid > 1-butanol > 1-pentanol > tetrahydrofuran > isobutyl alcohol > isopropyl alcohol> propanoic acid > acetone > acetonitrile, and temperature affected obviously the solubility especially in acetic acid. Moreover, the experimental mole fraction (x) of DH increased with mass concentration rising of DMF or DMSO in DMF (1) + ethanol (2) or DMSO (1) + ethanol (2), and decreased gradually with mass concentration rising of acetone in acetone (1) + ethanol (2). The experimental solubility in all solvents was correlated better by the modified Apelblat model according to lower values of RAD and RMSD.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2020
·
IF 2.888
Chunhao Guo,Yang Tang,Jinru Wan,Yue Zuo,Yong Wang,Yichang Wang,Xunqiu Wang
The isobaric vapour–liquid equilibrium (VLE) data for the binary system of cyclohexanol + cyclohexylbenzene were determined at (5, 10, 15, 20 and 25) kPa with a dynamic recirculating apparatus and the temperature ranged from 358.10 K to 456.43 K, and the thermodynamic consistency of the experimental data was checked by the Herington area method and Van Ness method. Afterwards, the experimental data was correlated with NRTL, Wilson and UNIQUAC model, and the corresponding interaction of thermodynamic models of the binary system parameters were obtained through the Aspen software. The results indicated that all three models represent the experimental values quite well, while the NRTL model provided a slightly better result than Wilson model and UNIQUAC model. The maximum root mean square deviation of the temperature and vapour phase mole fraction for the NRTL model was less than 0.4 K and 0.004, respectively.
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DESALINATION
·
2020
·
IF 7.098
Weiwei Zhang,Hui-Jing Li,Liwei Chen,Jiani Sun,Xingyi Ma,Yunfei Li,Chao Liu,Xu Han,Boyi Pang,Yan-Chao Wu
An environment-friendly scaling–corrosion inhibitor composed of 10-methylacridinium iodide (MAI) and sodium citrate (SC) was developed, whose scale inhibition performance were studied through weight loss, electrochemical techniques , static tests and surface analysis techniques (SEM, SECM , XPS , XRD). The optimum mass ratio of MAI and SC corrosion inhibition was found to be 1:2, and the optimum mass ratio of scale inhibition was 1:3. The experimental results showed that MAI–SC mixture as mixed-type scaling–corrosion inhibitor with excellent corrosion ( η w = 92.7%) and scale inhibition performance ( η Ca = 98.3%). The electrochemical stability of the inhibitor film was investigated by chronoamperometry (CA). SEM and XRD simulations indicated that the MAI–SC mixture inhibitor can distort and disperse the crystal lattice of calcium carbonate without forming scale, and it plays a dominant role in the inhibition of calcite (110) surface growth. The structure-activity relationship between the molecule structure of the MAI–SC mixture and its scale–corrosion inhibition performance was discussed based on the quantum chemistry calculation.
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JOURNAL OF MOLECULAR LIQUIDS
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2021
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IF 6.165
Lulu Zhang,Zhenning Yan,Yamin Lv,Shuangxia Shen
In the present work, three new pharmaceutical salts based on N -alkyl-pyridinium ([C n Py] + , n = 8, 10, 12) as the cations and acetyl-sulfacetamide ([AceSA] - ) as an anion were synthesized. The thermal stability was measured by synchronous thermal analyzer. The solvation and micellization behaviors in aqueous solution were investigated by experimental density and conductivity data at different temperatures. These data were used to calculate the apparent molar volume at infinite dilution, V 2 , φ 0 , the apparent molar expansibility at infinite dilution, E φ 0 , limiting molar conductivity, Ʌ 0 , critical micelle concentration, cmc , and the relative thermodynamic functions for the micellization of [C n Py][AceSA] in aqueous solution. The effect of the aliphatic chain length of N -alkyl-pyridinium cation and temperature on the estimated properties was examined. The obtained results confirmed that [C n Py] + (n = 8, 10, 12) cations with longer alkyl chain exhibit higher decomposition temperature, large V 2 , φ 0 , low cmc and Ʌ 0 values. The results were discussed in terms of solute–solvent interactions and structural changes of [C n Py][AceSA] in water.
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CNS Neuroscience & Therapeutics
·
2021
·Vol. 27
·期 10
·1157-1172
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IF 5.243
Le Ma,Shiyu Peng,Jinbao Wei,Mengjing Zhao,Khalil Ali Ahmad,Jinghong Chen,Yong-Xiang Wang
Aim This study aimed to investigate the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interleukin (IL)-10 and glucagon-like peptide 1 receptor (GLP-1R) agonist exenatide-induced pain anti-hypersensitivity in neuropathic rats through spinal nerve ligations. Methods Neuropathic pain model was established by spinal nerve ligation of L5/L6 and verified by electrophysiological recording and immunofluorescence staining. Microglial expression of β-endorphin through autocrine IL-10- and exenatide-induced inhibition of glutamatergic transmission were performed by behavioral tests coupled with whole-cell recording of miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) through application of endogenous and exogenous IL-10 and β-endorphin. Results Intrathecal injections of IL-10, exenatide, and the μ-opioid receptor (MOR) agonists β-endorphin and DAMGO inhibited thermal hyperalgesia and mechanical allodynia in neuropathic rats. Whole-cell recordings of bath application of exenatide, IL-10, and β-endorphin showed similarly suppressed enhanced frequency and amplitude of the mEPSCs in the spinal dorsal horn neurons of laminae II, but did not reduce the frequency and amplitude of mIPSCs in neuropathic rats. The inhibitory effects of IL-10 and exenatide on pain hypersensitive behaviors and spinal synaptic plasticity were totally blocked by pretreatment of IL-10 antibody, β-endorphin antiserum, and MOR antagonist CTAP. In addition, the microglial metabolic inhibitor minocycline blocked the inhibitory effects of IL-10 and exenatide but not β-endorphin on spinal synaptic plasticity. Conclusion This suggests that spinal microglial expression of β-endorphin mediates IL-10- and exenatide-induced inhibition of glutamatergic transmission and pain hypersensitivity via presynaptic and postsynaptic MORs in spinal dorsal horn.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
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IF 2.298
Junshuai Chen,Qi Zhou,Taotao Zhan,Maogang He,Ying Zhang
Methyl hexanoate, which was found to be the simplest methyl ester to present a strong cool flame behavior, is expected to be one of the main components of biodiesels. Details of the experimental speeds of sound in methyl hexanoate are scarce up to now. Therefore, the speed of sound in liquid methyl hexanoate was measured by the Brillouin light scattering method in the temperature range of 297.83–588.07 K and at pressures of up to 10 MPa. The relative uncertainty of the speed of sound experimental system is estimated to be less than 0.43%, and when considering the impurity of the sample, the relative uncertainty is 0.47%. The variation of the speed of sound with the temperature and pressure was analyzed. Besides, the correlation for the speed of sound as a function of temperature and pressure is presented based on the experimental data. The absolute average of relative deviation between the experimental data and the calculated results is 0.44%.
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RSC Advances
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2015
·Vol. 5
·期 88
·71749-71755
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IF 3.84
Xueni Li,Longzhen Zheng,Yimin Wang,Nan Zhang,Yan Lou,Ting Xiao,Jiani Liu
This paper reports on an experimental research of a 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) enveloped 10-methylphenothiazine (MPT) catalyst (MPT-HP-β-CD) with high sensitivity and wonderful electrical conductivity for the electrochemical detection of reduced glutathione (GSH) in a neutral environment. We obtained a linear response range from 10−6 mol L−1 to 5.8 × 10−4 mol L−1 for GSH with a low detection limit of 2.87 × 10−7 mol L−1, providing a potentially usefulness in the development of sensors for non-enzyme detection of GSH.
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Polymers
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2015
·Vol. 7
·期 3
·468-483
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IF 3.681
Dongjian Shi,Jinting Hua,Li Zhang,Mingqing Chen
Novel bio-based aliphatic copolyesters, poly(lactic acid-co-10-hydroxy decanoate) (P(LA-co-HDA), PLH), were successfully synthesized from lactic acid (LA) and 10-hydroxycapric acid (HDA) by a thermal polycondensation process, in the presence ofp-toluenesulfonic acid (p-TSA) and SnCl2·2H2O as co-catalyst. The copolymer structure was characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR). The weight average molecular weights (Mw) of PLH, from gel permeation chromatography (GPC) measurements, were controlled from 18,500 to 37,900 by changing the molar ratios of LA and HDA. Thermogravimetric analysis (TGA) results showed that PLH had excellent thermal stability, and the decomposition temperature at the maximum rate was above 280 °C. The glass transition temperature (Tg) and melting temperature (Tm) of PLH decreased continuously with increasing the HDA composition by differential scanning calorimetry (DSC) measurements. PLH showed high ductility, and the breaking elongation increased significantly by the increment of the HDA composition. Moreover, the PLH copolymer could degrade in buffer solution. The cell adhesion results showed that PLH had good biocompatibility with NIH/3T3 cells. The bio-based PLH copolymers have potential applications as thermoplastics, elastomers or impact modifiers in the biomedical, industrial and agricultural fields.Keywords:bio-based copolymer;poly(lactic acid);poly(10-hydroxycapric acid);high performance;mechanical properties
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PeerJ
·
2017
·
IF 2.177
Jihang Dai,Yu Sun,Lianqi Yan,Jingcheng Wang,Xiaolei Li,Jun He
The fibrosis that develops following laminectomy or discectomy often causes serious complications, and the proliferation of fibroblasts is thought to be the major cause of epidural fibrosis. 10-Hydroxycamptothecin (HCPT) has been proven to be efficient in preventing epidural fibrosis, but the exact mechanism is still unclear. NOXA is a significant regulator of cell apoptosis, which has been reported to be beneficial in the treatment of fibrosis. We performed a series of experiments, both in vitro and in vivo , to explore the intrinsic mechanism of HCPT that underlies the induction of apoptosis in fibroblasts, and also to investigate whether HCPT has positive effects on epidural fibrosis following laminectomy in rats. Fibroblasts were cultured in vitro and stimulated by varying concentrations of HCPT (0, 1, 2, 4 µg/ml) for various durations (0, 24, 48, 72 h); the effect of HCPT in inducing the apoptosis of fibroblasts was investigated via Western blots and TUNEL assay. Our results showed that HCPT could induce apoptosis in fibroblasts and up-regulate the expression of NOXA. Following the knockdown of NOXA in fibroblasts, the results of Western blot analysis showed that the level of apoptotic markers, such as cleaved-PARP and Bax, was decreased. The results from the TUNEL assay also showed a decreased rate of apoptosis in NOXA-knocked down fibroblasts. For the in vivo studies, we performed a laminectomy at the L1-L2 levels in rats and applied HCPT of different concentrations (0.2, 0.1, 0.05 mg/ml and saline) locally; the macroscopic histological assessment, hydroxyproline content analysis and histological staining were performed to evaluate the effect of HCPT on reducing epidural fibrosis. The TUNEL assay in epidural tissues showed that HCPT could obviously induce apoptosis in fibroblasts in a dose-dependent manner. Also, immunohistochemical staining showed that the expression of NOXA increased as the concentrations of HCPT increased. Our findings are the first to demonstrate that upregulation of NOXA by HCPT plays a key role in inducing fibroblast apoptosis and in reducing epidural fibrosis. These findings might provide a potential therapeutic target for preventing epidural fibrosis following laminectomy.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2017
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IF 2.536
Huihui Li,Cailing Yang,Xinyue Zhu,Haixia Zhang
A simple ratiometric fluorescent sensor for fructose was presented. It consisted of 10-hydroxybenzo[ h ]quinoline (HBQ) which showed emission at 572 nm and 3-pyridylboronic acid (PDBA) whose complex with HBQ gave emission at 500 nm. The reaction of fructose with PDBA inhibited the complexation of HBQ with PDBA, resulting in the change of dual-emission intensity ratio. The sensor well quantified fructose in the range of 0.015–2.5 mM with detection limit of 0.005 mM. Besides, this sensor exhibited excellent selectivity and was successfully applied to fructose detection in food. This work provides a simple ratiometric sensing platform for sensitive and selective detection of fructose.
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PubMed
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Rui Wang,Pei-Feng Guo,Jing Nie,Xing Hu,Yu-Wei Wu,Shu Zhu,Bo-Ru Chen,Jian Li,Xin-An Zeng,Fei-Yue Xu
In this study, the inhibitory activity and mechanism of three gingerols (6-, 8- and 10-gingerol) on xanthine oxidase (XOD), a key enzyme responsible for the formation of uric acid, were evaluated. The three gingerols reversibly inhibited XOD activity in a mixed manner with IC 50 values of (13.16 ± 0.41), (10.18 ± 0.22) and (6.88 ± 0.11) μM, respectively. 10-gingerol exhibited stronger inhibitory ability, which might contribute to its superior antioxidant properties, higher binding affinity and more significant conformational changes for XOD compared to other gingerols. Fluorescence quenching and molecular docking results indicated that gingerols acted in the vicinity of the flavin adenine dinucleotide in XOD, interacting with the surrounding key amino acid residues through hydrogen bonding and van der Waals forces, thereby preventing substrate entry and the release of catalytic products. Molecular dynamics simulations showed that the addition of gingerol decreased the stability and increased the structural density of XOD. These findings could provide valuable data for the application of gingerols in new XOD inhibitors and hypouricemic functional foods.
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CHEMICAL ENGINEERING JOURNAL
·
2017
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IF 6.216
Yonghao Wang,Biao Chi,Chengliang Xiao,Dagui Chen,Yongjing Wang,Minghua Liu
In this work, a layered nanocomposite with a superior adsorption ability has been designed and prepared for the preconcentration of Eu(III), a chemical analogue of trivalent lanthanides [Ln(III)] and actinides [An(III)] in nuclear waste. This nanocomposite was obtained by fabricating magnesium silicate (MgSi) of the Talc-phase Mg 3 Si 4 O 9 (OH) 10 on graphene oxide (GO) nanosheets, in which the GO matrix can effectively avoid the agglomeration of MgSi. A hierarchical structure of GO@MgSi with interwoven nano-sized MgSi lamellae dispersedly standing on the surface of GO was observed by scanning electron microscope (SEM) and transmission electron microscopy (TEM). Such a hierarchical structure effectively increases the surface area of MgSi, leading to up to date the highest adsorption capacity (344.82 mg·L −1 ) for enriching Eu(III). Powder X-ray diffraction pattern (PXRD) of Mg 3 Si 4 O 9 (OH) 10 shows that the (0 2 0) and (2 0 0) diffraction peaks disappear after the adsorption of Eu(III), indicating structural changes in MgSi lamellae after adsorption. The infrared absorption spectra (IR) and X-ray photoelectron spectroscopy (XPS) measurements confirm the structural transformations in the Si O tetrahedral and Mg OH octahedral sheet in MgSi, suggesting that MgSi lamella rather than GO sheet might play a dominant role during the adsorption process. The superior adsorption behaviors of GO@MgSi indicate that it is a highly promising and efficient candidate for Eu(III) preconcentration in aqueous solution.
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