JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 135
·期 13
·46052
·
IF 1.86
Cong Jia,Xiao Zhang,Yufeng Li,Yanghui Jiang,Min Zhang,Panfang Lu,Hongkun Chen
A novel controlled release fertilizer was developed using interpenetrating polymer network (IPN) as the coating material. The IPN was successfully sprayed on the surface of the urea particles to form IPN-coated fertilizers (IPNCU) for controlled nitrogen release. The IPN was synthesized by bio-based polyamide (PA) from d -glucaric acid and epoxy (EP) through network interpenetrating. The chemical structure and microscopic morphology characteristics of IPN were examined by Fourier transform infrared spectroscopy, 1 H-nuclear magnetic resonance, and scanning electron microscopy. The property of IPN with the different PA/EP mass ratios were investigated and compared with that of EP-coated fertilizers (EPCU). The nutrient release behaviors of IPNCU in water and soil were detected. The results showed that the IPNCU with 5% PA content increased the nitrogen release longevity by 41 days, raised the water contact angle of surface by 23.9°, and then significantly slowed the nitrogen release rate of the IPNCU. The nutrient release mechanism of IPNCU was discussed in detail. This work indicated that the environment-friendly IPN with superior controlled release properties could be especially useful in horticultural and agricultural applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46052.
研究领域:
聚合物科学
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农业化学
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环境科学
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DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Heng Guo,Qilin Wu,Dongni Chen,Minghua Jiang,Bin Chen,Yongjun Lu,Jing Li,Lan Liu,Senhua Chen
Under guidance of 1 H NMR, ten new polypropionate derivatives, decempyrones A–J ( 1 – 10 ) along with two known analogues ( 11 and 12 ), were isolated from the marine-derived fungus Fusarium decemcellulare SYSU-MS6716. The planar structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, and HR-ESIMS). The absolute configuration of the chiral centers in the side chain is a major obstacle for the structure identification of natural polypropionate derivatives. Herein, the J -based configurational analysis (JBCA), chemical degradation, geminal proton rule, and the modified Mosher’s method were adopted to fix their absolute configurations in the side chain. Compounds 3 and 10 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC 50 values 22.4 ± 1.8 and 21.7 ± 1.1 μM. In addition, compounds 3 and 10 displayed MptpA inhibitory activity with an IC 50 value of 19.2 ± 0.9 and 33.1 ± 2.9 µM. Structure-activity relationships of the polypropionate derivatives were discussed.
研究领域:
化学
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药理学
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生物化学
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海洋生物学
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DOI
高影响因子
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2024
·
IF 0.3
Yu-Pei Xia,Yu-Xin Huang
C 40 H 48 Cu 2 N 12 O 12 , monoclinic, P 2 1 / n (no. 14), a = 10.9519(1) Å, b = 17.4351(2) Å, c = 24.4288(3) Å, β = 102.143(1)°, V = 4560.25(9) Å 3 , Z = 4, R gt ( F ) = 0.0647, w R ref ( F 2 ) = 0.1904, T = 120 K.
研究领域:
化学
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材料科学
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晶体学
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DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 7.446
Jinxin Che,Xiaoyang Dai,Jian Gao,Haichao Sheng,Wenhu Zhan,Yang Lu,Dan Li,Zizheng Gao,Zegao Jin,Binhui Chen,Peihua Luo,Bo Yang,Yongzhou Hu,Qiaojun He,Qinjie Weng,Xiaowu Dong
Rash is one of the primary dose-limiting toxicities of Akt (protein kinase B) inhibitors in clinical trials. Here, we demonstrate the inhibition of Akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective Akt inhibitors with an improved cutaneous safety property. According to our previous research, compound 2 is selected for further optimization for overcoming the disadvantages of compound 1, including high Akt2 inhibition and high toxicity against HaCaT keratinocytes. The dihedral angle-based design and molecular dynamics simulation lead to the identification of Hu7691 (B5) that achieves a 24-fold selectivity between Akt1 and Akt2. Hu7691 exhibits low activity in inducing HaCaT apoptosis, promising kinase selectivity, and excellent anticancer cell proliferation potencies. Based on the superior results of safety property, pharmacokinetic profile, and in vivo efficacy, the National Medical Products Administration (NMPA) approved the investigational new drug (IND) application of Hu7691.
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DOI
PubMed
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-12
·
IF 3.8
Yang Bing,Liu Baoliang,Gao Yuanyuan,Wei Junjie,Li Gang,Zhang Hui,Wang Linlin,Hou Zhaosheng
This study developed a kind of PEG-crosslinked O-carboxymethyl chitosan (O-CMC–PEG) with various PEG content for food packaging. The crosslinking agent of isocyanate-terminated PEG was firstly synthesized by a simple condensation reaction between PEG and excess diisocyanate, then the crosslink between O-carboxymethyl chitosan (O-CMC) and crosslinking agent occurred under mild conditions to produce O-CMC–PEG with a crosslinked structure linked by urea bonds. FT-IR and 1 H NMR techniques were utilized to confirm the chemical structures of the crosslinking agent and O-CMC–PEGs. Extensive research was conducted to investigate the impact of the PEG content (or crosslinking degree) on the physicochemical characteristics of the casted O-CMC–PEG films. The results illuminated that crosslinking and components compatibility could improve their tensile features and water vapor barrier performance, while high PEG content played the inverse effects due to the microphase separation between PEG and O-CMC segments. The in vitro degradation rate and water sensitivity primarily depended on the crosslinking degree in comparison with the PEG content. Furthermore, caused by the remaining –NH 2 groups of O-CMC, the films demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus . When the PEG content was 6% (medium crosslinking degree), the prepared O-CMC–PEG −6% film possessed optimal tensile features, high water resistance, appropriate degradation rate, low water vapor transmission rate and fine broad-spectrum antibacterial capacity, manifesting a great potential for application in food packaging to extend the shelf life.
研究领域:
材料科学
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食品科学
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化学
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生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Ming Huang,Changsheng Zhou,Ke-Fang Yang,Ze Li,Guo-Qiao Lai,Pinglu Zhang
An effective (NHC)AgCl catalysis was developed in the hydroborylation of cyclopropenes with B2pin2, delivering a variety of cyclopylboronates in a stereoselective manner, which could be easily transformed for the construction of versatile cyclopropanes. This protocol works effectively under mild reaction conditions in an open-air atmosphere, and it was easy to apply on a gram scale. This novel method in detail was also explored by control experiments, providing a number of key insights. The kinetic process followed by 1H NMR indicated that the reaction was finished in 15 min. Furthermore, the mechanism of silver(I)-catalyzed hydroborylation of cyclopropenes was proposed, with the protonation by methanol as the rate-determining step.
研究领域:
有机化学
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催化
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合成化学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Lingfeng Wang,Ying Qian
In this paper, the heavy-atom-free BODIPY dendrimer TM4-BDP was synthesized for the near-infrared photodynamic therapy, which was composed of the triphenylamine-BODIPY dimer and four 1-(2-morpholinoethyl)-1H-indole-3-ethenyl groups. The TM4-BDP could achieve the near-infrared photodynamic therapy through two different photosensitive pathway, which include the one-photon excitation at 660 nm and two-photon excitation at 1000 nm. In the one-photon excitation pathway, the TM4-BDP could generate singlet oxygen and superoxide radical under 660 nm illumination. In addition, the one-photon PDT experiment in human nasopharyngeal carcinoma (CNE-2) cells also indicated that the TM4-BDP could specific accumulate in lysosomes and shown great cell phototoxicity with the IC50 at 22.1μM. In the two-photon excitation pathway, the two-photon absorption cross section at 1030 nm of TM4-BDP was determined as 383 GM, which make it could generate the reactive oxygen species (ROS) under 1000 nm femtosecond laser excitation. Moreover, the two-photon PDT experiment in zebrafish also indicated the TM4-BDP could be used for the two-photon fluorescence imaging and the two-photon induced ROS generation in biological environment. Besides that, in the ROS generation mechanism aspect, the TM4-BDP employ the novel spin-vibronic coupling intersystem crossing (SV-ISC) process for the mechanism of ROS generation and the femtosecond transient absorption spectra indicated that this novel SV-ISC mechanism was closely related with its’ lifetime of charge transfer state. These above experiments of TM4-BDP demonstrate that the dendrimer design was an effective strategy for constructing heavy-atom-free NIR BODIPY photosensitizers and lay the foundation for the two-photon photodynamic therapy in the future clinical trails.
研究领域:
光动力疗法
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纳米技术
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生物医学工程
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材料科学
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光学
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药物化学
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分子生物学
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细胞生物学
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斑马鱼研究
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DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 4
·1169-1175
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IF 1.1
Qu Yafen,Yu Yanling,Huang Biwu
[2-(3,4-epoxy-cyclohexyl)ethyl]dimethyltert-butylsilane was synthesized, using tert-butyldimethylsilane (TBDMS) and 1,2-epoxy-4-vinylcyclohexane (EVC) as the main raw materials and tris(triphenylphosphine) chlororhodium(I) [RhCl(Ph 3 P) 3 ] as the catalyst. [2-(3,4-epoxy-cyclohexyl)ethyl] dimethyltert-butylsilane is a novel kind of silicon-containing epoxide. The factors affecting the reaction yield, such as catalyst use, reaction time and reaction temperature, were investigated, and the synthesized product was characterized and analyzed by FT-IR and 1 H-NMR. A series of amine-curing resins were prepared with [2-(3,4-epoxy-cyclohexyl)ethyl]dimethyltert-butylsilane, bisphenol A epoxy resin (E-51) and modified amine (593 amine). The mechanical properties of cured splines with the different proportions of amine-curing resins were tested. When the content of 593 amine was 20%, the content of E-51 was 75% and the amount of [2-(3,4-epoxy-cyclohexyl) ethyl] dimethyltert-butylsilane was 5%, the mechanical properties of the cured splines were the best with the tensile strength being 23.3 MPa, the elongation at break being 7.8%, and the Young’s modulus being 421.3 MPa.
研究领域:
高分子化学
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材料科学
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有机合成
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化学工程
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产品关联
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2014
·
IF 0.74
Yunyan Xue,Dandan Ma,Tianzhu Zhang,Siyan Lin,Shengnan Shao,Ning Gu
In this study, a series of comb-like methoxy polyethylene glycol (MPEG) functionalized polyurethanes (PUs) (PU–g–MPEG) were successfully prepared via ‘click’ chemistry and polyaddition reaction. The copper catalyzed Huisgen 1,3-dipolar cycloaddition was firstly carried out between 3,5-bis(hydroxymethyl)-1-propargyloxybenzene (PBM) and methoxy polyethylene glycol azide (MPEG–N3) to obtain MPEGylated diol PBM (MPEG–PBM). Then, the comb-like PUs having MPEG located on the backbones (PU–g–MPEG) were synthesized through the polyaddition of MPEGylated diol PBM and hexamethylene diisocyanate (HDI). Fourier transform infrared (FTIR), 1H NMR spectroscopy, size exclusion chromatography (SEC), and thermo gravimetric analyses (TGA) were used to characterize these synthesized MPEG-functionalized comb-like PUs (PU–g–MPEG). Compared with PU without MPEG grafts, PU–g–MPEG show a better wettability.
研究领域:
高分子化学
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材料科学
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有机合成
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表面化学
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DOI
高影响因子
FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 5
·1713-1725
·
IF 2.2
Tan Lei,Bai Xiuzhi,Yao Rui,Fu Zengjin,Wang Jing,Wang Yicheng,Lin Tingrui,Hao Yan,Yang Hui,Yang Huimin,Sai Huazheng
The biodegradable biomass adsorbent (cellulose- g -PSS) was synthesized in LiCl/ N, N -dimethyl acetamide by the free-radical grafting polymerization reaction between sodium styrene sulfonate (SSS) and cellulose. Systematic optimization was conducted on many reaction parameters, including reaction time, monomer dosage, and reaction temperature. The grafting yield of cellulose- g -PSS was 50.16%. The chemical structures, physical, and chemical characteristics of cellulose- g -PSS were characterized by FTIR, SEM, PZC, 1 H NMR, XRD, TGA and XPS. An assessment was conducted to determine the sorption of Ce (III) on cellulose- g -PSS by changing the contact time, adsorbent dosage, pH, initial Ce (III) concentration, and NaCl concentration. The process of adsorption rapidly reached a state of equilibrium within a time frame of 25 min and was well explained using pseudo-second-order kinetic and Langmuir isotherm model. The maximum adsorption capacity for Ce (III) obtained from the Langmuir isotherm model was 84.80 mg·g −1 . The impact of NaCl concentration on the sorption of Ce (III) and XPS analysis showed that Ce (III) ions were adsorbed onto cellulose- g -PSS through ion-exchange mechanism. As a whole, cellulose- g -PSS exhibited great potential in rare earth wastewater treatment.
研究领域:
环境科学
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化学工程
·
材料科学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Wei Cui,Lingyun Wang,Gang Xiang,Lixia Zhou,Xiaoning An,Derong Cao
Two novel conjugated polymers containing 2,3-di(pyridin-2-yl)quinoxaline (DPQ) unit ( P1 ) and 2,3-di(thiophen-2-yl)quinoxaline (DTQ) unit ( P2 ) were designed and synthesized through Sonogashira coupling reaction. P1 provided high sensitivity and selectivity to silver ions : color change from green to brown red and fluorescent emission quenching, which can be observed by naked eye, even in the presence of interference cations. However, P2 with the similar polymer backbone to P1 showed no absorption and fluorescence changes toward any cations. Therefore, the DPQ units in P1 exhibited a key role for the selective recognition of Ag + , which was further confirmed by the 1 H NMR titration, density functional theory (DFT) calculations and electrochemical studies. These results not only imply that DPQ based conjugated polymer is a promising probe of Ag + ions but also afford a good guidance to design effective polymer sensors in future.
研究领域:
材料科学
·
分析化学
·
高分子化学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xin Liang,Sheng Wang,Jing Zhou,Tengfei Lu,Kaiyu Ruan,Yuqian Xia,Tong Wang
Despite the considerable attention received by switchable solvents in natural product extraction and biorefinery. To tackle this issue, the present study has the following innovative endeavors: (1) Developing an innovative high-speed homogenization assisted extraction method using the DES/SHS/H 2 O system and applying it to the integrated extraction of phenolics, flavonoids, and essential oil from Flos Chrysanthemi Indici . The switching process was characterized using 1 H NMR, the extraction process was optimized employing response surface methodology, the components of extracted essential oils were analyzed by GC–MS, and the cytotoxicity and anti-inflammatory activity of essential oils were determined through MTT and ELISA. Our findings demonstrate that the incorporation of DES can significantly augment the CO 2 switching kinetics of SHS, resulting in a 32.7 % reduction in switching time and a remarkable decrease of 73.7 % residual content within the aqueous phase. The innovative DES/SHS/H 2 O based extraction method exhibited substantial enhancements in phenolics, flavonoids, and essential oil extraction efficiency compared to conventional approaches, yielding extracts with superior chemical profiles and enhanced anti-inflammatory activity. Therefore, the proposed strategy of enhancing the CO 2 switching kinetic properties and extraction ability of SHS by incorporating DES is feasible, providing valuable guidance for the rational design of innovative smart solvent systems. The developed DES/SHS/H 2 O system, exhibiting improved performance, holds significant application and research prospects.
研究领域:
化学工程
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药学
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分析化学
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生物技术
·
天然产物研究
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）