POULTRY SCIENCE
·
2025
·
IF 4.2
Qiyue Zhang,Yue Wang,Yanwei Wang,Jielu Yuan,Yaru Wang,Yongqi Zeng,Haihua Zhang,Hui Yang,Qiugang Ma,Donghui Shi,Shimeng Huang
This study investigates the effects of 3-indoleacrylic acid (IAA), a bacterial metabolite of tryptophan, on LPS-induced liver injury in laying hens. The aim is to explore the potential hepatoprotective mechanisms of IAA, particularly through the modulation of inflammatory and antioxidant pathways. A total of 48, 24-week-old No. 6 Jingfen laying hens were randomly divided into four groups of 12 hens each: the CON group (basal diet), IAA group (basal diet + 150 mg/kg IAA), LPS group (basal diet), and IAA+LPS group (basal diet + 150 mg/kg IAA). The feeding period lasted 8 weeks, and at the end of the 8th week, the laying hens in the LPS and IAA+LPS groups were intraperitoneally injected with 0.5 mg/kg LPS. The four groups were uniformly slaughtered and sampled 12 hours after LPS injection. The expression of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) was significantly alleviated ( P < 0.05), and antioxidant enzymes (T-SOD, CAT, GSH-PX) were significantly elevated ( P < 0.05) in the serum and liver of the IAA+LPS group. Histological analysis revealed reduced hepatocyte necrosis and inflammation in the IAA-treated groups ( P < 0.05). Additionally, the activation of MAPK and Toll-like receptor (TLR) signaling pathways was modulated through transcript analyses, thereby reducing inflammation and oxidative stress. In summary, IAA effectively mitigates liver inflammation and oxidative stress through the regulation of MAPK and TLR signaling pathways, providing a promising strategy for improving liver health in hens. This study represents the first report on the application of IAA in poultry, demonstrating its potential as a novel therapeutic agent for alleviating liver injury.
研究领域:
动物科学
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免疫学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
ACTA DIABETOLOGICA
·
2024
·
IF 3.1
Zhang Ling,Zhao Jing,Peng Zhou,Zhang Zhongxiao,Huang Shan,Dong Xiaohua,Gao Jianfang,Guo Xirong
Background Obesity, defined as excessive or abnormal body fat accumulation, which could significantly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) diseases and seriously affect people’s quality of life. More than 2 billion people are overweight, and the incidence of obesity is increasing rapidly worldwide, it has become a widely concerned public health issue in the world. Diverse evidence show that active metabolites are involved in the pathophysiological processes of obesity. Aims However, whether the downstream catabolite of tryptophan, 3-indole acrylic acid (IA), is involved in obesity remains unclear. Methods We collected the samples of serum from peripheral blood of obesity and health controls, and liquid chromatography–mass spectrometry (LC-MS) was performed to identify the plasma levels of IA. Additionally, we verified the potential benefits of IA on human preadipocytes and HFD- induced zebrafish by cell viability assay, flow cytometry assay, Oil red O staining, total cholesterol (T-CHO), triglyceride (TG) and nonesterified free fatty acids (NEFA) measurements and Nile Red staining. RNA-Seq, functional analysis and western blot revealed the mechanisms underlying the function of IA. Results We found that the content of IA in peripheral blood serum of overweight people was significantly lower than that of normal people. In addition, supplementation with IA in zebrafish larvae induced by a high fat diet (HFD) dramatically reduced HFD induced lipid accumulation. IA had no effect on proliferation and apoptosis of preadipocytes, but significantly inhibited adipogenesis of preadipocytes by down-regulate CEBPα and PPARγ. RNA-Seq and functional analysis revealed that IA regulated the adipogenesis of preadipocytes through stimulate the phosphorylation of STAT1. Conclusions Taken together, IA has been identified as a potent metabolite for the prevention or treatment of obesity. Graphic Abstract
研究领域:
代谢
·
分子生物学
·
营养学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Keyi Sun,Yuxuan Liu,Wenbin Fei,Yian Wang,Huazhang Guo,Kexin Rao,Mengting Deng,Yulei Sui,Ling Wu
Na 4 MnCr(PO 4 ) 3 , a manganese-based NASICON-type phosphate cathode material, is attracted considerable attention due to its high voltage and energy density. However, its practical application is hindered by poor electronic conductivity and inferior sodium ion diffusion kinetics. In this study, trace La 3+ is utilized to optimize the lattice structure of Na 4 MnCr(PO 4 ) 3 due to its unique energy level structure. La 3+ doping significantly enhances the local environment of the Mn-O bond and stabilizes the lattice structure by improving covalency, thereby mitigating Mn dissolution during charge–discharge cycles. Additionally, the large ionic radius of La 3+ promotes the sodium ion transport kinetics by expanding the cell volume and facilitating rapid sodium storage. As a result, the optimal Na 4 MnCr 0.995 La 0.005 (PO 4 ) 3 /C sample demonstrates an impressive initial discharge specific capacity of 124.5 mAh g −1 at 0.1C and superior cycling stability with a capacity retention of 70.2 % after 500 cycles at 5C. Furthermore, density functional theory calculations indicate that La 3+ doping can enhance conductivity and reduce the energy barrier for sodium ion diffusion. This study presents an effective and cost-efficient doping strategy for modifying high-energy density NASICON-type phosphate cathode materials, showing promising potential in the field of sodium ion batteries.
研究领域:
材料科学
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电化学
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能源存储
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无机固体化学
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计算材料学
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 5
·761-765
·
IF 0.875
Sun Weizhi,Yu Shitao,Xian Mo
To investigate the green trinitration method of aromatic compounds, with Lewis acid/ionic liquid as catalyst and HNO 3 /Ac 2 O as nitration reagent, a Lewis acid/ionic liquid/HNO 3 /Ac 2 O system was established. In various combinations of Lewis acids and ionic liquids, Bi(NO 3 ) 3 ·5H 2 O/[HMIM]ClO 4 proved to be a very efficient catalyst for the trinitration of activated aromatic compounds and reusable for 3 times. Reaction conditions for the trinitration were optimized and yields of the trinitro products were from mild to excellent. This sulfuric acid-free system has the advantages of strong trinitration ability, low environment pollution, low toxicity, low cost and high potential for industrial application.
研究领域:
有机化学
·
环境化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Haoyue Ning,Yuemei Zhang,Lixin Lu,Liao Pan
Nanoparticles are used as fillers to improve the properties of biopolymers , and their particle size is an important parameter. This work aims to investigate the effect of particle size of isoreticular metal-organic framework-3 (IRMOF-3) on the mechanical, physical, and release properties of sodium alginate (SA)-based composite active film. In our study, IRMOF-3 with six different particle sizes was synthesized by introducing additives. IRMOF-3 loading with carvacrol (IRMOF-3/CA nanoparticles) was incorporated into the SA matrix to prepare the composite film . The characterization and testing results of films showed that the particle size of nanoparticles affected the physical morphology and chemical structure of the film. Especially smaller nanoparticles uniformly dispersed into the SA matrix more easily, forming a denser and more stable spatial network structure with SA, which could more significantly improve the tensile strength , water vapor barrier, and hydrophobic properties of the film ( P < 0.05). In addition, the CA release rate from the active film could be significantly reduced by about 33.90 % even when the smallest particle size of the IRMOF-3/CA nanoparticles was added. Therefore, when IRMOF-3/CA is used as the nano-filler to develop SA-based active film, its particle size has a potential influence on the properties of the film.
研究领域:
材料科学
·
食品科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Saudi Chemical Society
·
2022
·
IF 4.712
Zeping Wang,Binjie Hu,George Zheng Chen
A hydrophobic ionic liquid (1-octyl-3-methylimidazolium hexafluorophosphate, C 8 mimPF 6 ) with a function of inhibiting corrosion was encapsulated at different concentrations in the copolymer of poly (methyl methacrylate) and poly (butyl acrylate) through miniemulsion polymerization. These latexes were coated on steel samples whose corrosion properties were evaluated by electrochemical techniques. It was found that increasing the C 8 mimPF 6 concentration from 0 wt% to 30 wt%, the corrosion inhibition efficiency was remarkably improved from 41% to 89% based on the charge transfer resistance and from 64% to 87% based on the corrosion current density, respectively. The ionic liquid did not attend the reaction during latex preparation but behaved as corrosion inhibitors on the steel surface. Such an anticorrosion effect could be ascribed to the physical adsorption of the C 8 mim + cation on the reaction sites and the hydrophobicity enhancement resulting from the hydrophobic PF 6 − anion.
研究领域:
材料科学
·
腐蚀与防护
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电化学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 37
·374003
·
IF 3.551
Xitong Liang,Dongfeng Xue
Novel electrode materials with desired specific capacitances are needed for supercapacitors. Rare-earth (RE)-based materials are fascinating in the field of catalysis and energy. Herein, a series of hydroxides including La, Ce, Pr and Nd was synthesized via in situ precipitation. Interestingly, only Ce(OH)3 showed a redox peak in both positive and negative ranges. The other RE hydroxides exhibited a redox peak only in the positive range. Therefore, in order to certify that Ce(OH)3 can be used as a negative electrode, symmetrical supercapacitors consisting of Ce(OH)3 as both positive and negative electrodes were assembled, and showed a voltage window of 1.3 V. Moreover, asymmetrical supercapacitors were successfully fabricated, in which the positive electrode was composed of La(OH)3, Pr(OH)3 or Nd(OH)3. These results may pave the way to novel negative electrode materials.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 17
·3990
·
IF 4.2
Shuang Tian,Yinxu Zhao,Siqi Deng,Liman Hou,Juan Song,Ming Wang,Ming Bu
In the following study, a series of new lupeol-3-carbamate derivatives were synthesized, and the structures of all the newly derived compounds were characterized. The new compounds were screened to determine their anti-proliferative activity against human lung cancer cell line A549, human liver cancer cell line HepG2, and human breast cancer cell line MCF-7. Most of the compounds were found to show better anti-proliferative activity in vitro than lupeol. Among them, obvious anti-proliferation activity (IC50= 5.39~9.43 μM) was exhibited by compound3iagainst all three tumor cell lines. In addition, a salt reaction was performed on compound3k(IC50= 13.98 μM) and it was observed that the anti-proliferative activity and water solubility of compound3k·CH3I(IC50= 3.13 μM), were significantly enhanced subsequent to the salt formation process. The preliminary mechanistic studies demonstrated that apoptosis in HepG2 cells was induced by compound3k·CH3Ithrough the inhibition of the PI3K/AKT/mTOR pathway. In conclusion, a series of new lupeol-3-carbamate derivatives were synthesized via the structural modification of the C-3 site of lupeol, thus laying a theoretical foundation for the design of this new anticancer drug.
研究领域:
药理学
·
肿瘤学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Qingqing Zhou,Yajun Yu,Zuorui Xie,Yingying Zhou,Yanan Li,Ping Li,Jiangning Hu,Qing Gu
Salmonella is a prevalent foodborne pathogen that poses a significant threat to public health. Our previous study identified Lactiplantibacillus plantarum ZJ316, a strain known for its production of indole-3-lactic acid (ILA), which exhibits a broad-spectrum bacteriostatic effect. This study aimed to explore the inhibitory mechanism of ILA against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 ( S . Typhimurium) both in vitro and in vivo , as well as to assess its potential to alleviate colitis induced by S . Typhimurium. In vitro experiments revealed that ILA exerts its ant- Salmonella effect by disrupting the transmembrane proton motive force (PMF) and influencing intracellular ATP synthesis. Subsequent experiments conducted in female C57BL/6 mice demonstrated that oral administration of 45.00 mg/L ILA for 21 d effectively reduced S. Typhimurium infection-induced upregulation of pro-inflammatory cytokines (IL-1β and CXCL15; P < 0.01 and P < 0.05, respectively), while promoting the production of anti-inflammatory cytokines (IL-10 and IL-22; P < 0.001). Compared to the control group, the ILA group had a 4.15% increase in the relative abundance of Firmicutes and a 3.95% decrease in Bacteroidota. Furthermore, ILA also effectively countered the reduction of short-chain fatty acids (SCFAs) such as acetic acid and propionic acid caused by S . Typhimurium. These findings indicate that ILA may possess the capability to suppress pathogens, enhance intestinal microecology, and facilitate the repair of intestinal tissue damage.
研究领域:
微生物学
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免疫学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Electronic Materials
·
2018
·Vol. 5
·期 2
·1800683
·
IF 5.466
Weihuang Wang,Xiaomin Wang,Guilin Chen,Liquan Yao,Xiaojuan Huang,Tao Chen,Changfei Zhu,Shuiyuan Chen,Zhigao Huang,Yi Zhang
Antimony sulfide-selenide Sb 2 (S,Se) 3 as a promising absorber material has drawn extensive attention owing to its rewarding photoelectric properties, low toxicity, and earth abundant components. Here, an available and highly effective method, in situ hydrothermal growth accompanied with postselenization, is successfully applied to fabricate Sb 2 (S,Se) 3 solar cells. The rationale for the preparation of Sb 2 S 3 precursors by the hydrothermal method is discussed, and detailed characterization of Sb 2 (S,Se) 3 films selenized with different temperatures is also carried out. Finally, a solar cell with structure of FTO/CdS/Sb 2 (S,Se) 3 /Spiro-OMeTAD/Au is fabricated, which delivers an encouraging 6.14% efficiency with V oc of 732 mV, J sc of 14.6 mA cm −2 , and fill factor of 60.8%. This work provides valuable references for further development and improvement of Sb 2 (S,Se) 3 solar cells.
研究领域:
材料科学
·
太阳能
·
纳米技术
✓ 已验证
DOI
高影响因子
Crystals
·
2022
·Vol. 12
·期 2
·266
·
IF 2.67
Runqing Liu,Hongping Wu,Hongwei Yu,Zhanggui Hu,Jiyang Wang,Yicheng Wu
A new noncentrosymmetric cadmium indium borate, Cd4InO(BO3)3(CIBO) has been successfully developed via a standard solid-state reaction. Its crystal structure was confirmed by the single crystal X-ray diffraction, which shows that CIBO belongs to the non-centrosymmetric and polar space groupCm. Its structure contains the distorted InO6and CdOn(n = 6, 8) polyhedra, which link together by sharing an edge or corner to build a three dimensions framework with BO3triangles accommodated in tunnels. Benefiting from the approximately parallel configuration of BO3triangles, CIBO exhibited a strong second harmonic generation (SHG) effect (3 × KDP), and moderate birefringence of 0.077@1064 nm. Further optical and thermal characterizations suggest that CIBO possesses a wide transparent window and good thermal stability. Theoretical calculation reveals that the macroscopic SHG coefficients of CIBO results from the synergistic effect of the parallel arrangement of BO3groups andd10Cd2+cation.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR NEUROSCIENCE
·
2025
·Vol. 76
·期 1
·4
·
IF 2.7
Wu Zhixuan,Wang Dianyi,Yao Jing,Zhang Yue,Liu Jiayu
Background Migraine is a complex neurological disorder. While acupuncture is effective in alleviating migraines, its molecular mechanisms remain unclear. This study aims to explore these mechanisms. Methods We used bioinformatics to identify differentially expressed microRNAs (miRNAs) in migraine patients after acupuncture. Subsequently, luciferase reporter assays were utilized to verify the interaction between miRNAs and their regulated target gene mRNAs. RT-qPCR and Western blot analyzed key miRNAs’ regulatory effects on target genes. We also employed Transwell migration assays and a nitroglycerin (NTG)-induced migraine mouse model to systematically evaluate acupuncture’s efficacy and mechanism. Results Bioinformatics analysis revealed a significant upregulation of Hsa-miR-550a-3-5p in the peripheral blood of migraine patients after acupuncture treatment. Hsa-miR-550a-3-5p could directly inhibit the mRNA and protein expression of platelet and endothelial cell adhesion molecule 1 (PECAM1), reducing nitroglycerin-induced human brain microvascular endothelial cells (HBMECs). Following the downregulation of PECAM1 by hsa-miR-550a-3-5p, the transendothelial migration capacity of monocytes-macrophages was significantly reduced, and reducing the secretion of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. Furthermore, it alleviates inflammation by regulating M2 macrophage polarization. In NTG-induced mice, acupuncture relieved migraine-like behaviors, an effect abolished by a miR-550a-3-5p inhibitor. Conclusion This study is the first to reveal that after acupuncture treatment, hsa-miR-550a-3-5p can be upregulated to target and inhibit PECAM1, reducing the transendothelial migration of inflammatory cells and the release of inflammatory cytokines, thereby alleviating migraine symptoms. This discovery provides scientific evidence for the efficacy of acupuncture and offers a new target for developing miRNA-based precision treatment strategies.
✓ 已验证
DOI
PubMed
高影响因子
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