ACS Applied Energy Materials
·
2022
·
IF 6.959
Changfei Zou,Li Yang,Kaili Luo,Lei Liu,Xiyuan Tao,Lingguang Yi,Xianhu Liu,Zhigao Luo,Xianyou Wang
All-solid-state lithium metal batteries (ASSLMBs) with argyrodite-type Li6PS5Cl solid electrolyte (SE) show potential to replace current commercially available lithium-ion batteries by virtue of their potentially high energy density and safety. However, the interface incompatibility between sulfide solid electrolyte and lithium metal leads to an increase in interfacial resistance and the rapid growth of lithium dendrites, which greatly impede its commercial application. To alleviate the above problems, here a cell construction model has been put forward, in which composite polymer electrolytes (CPEs) with high ionic conductivity and good interface compatibility against lithium metal are employed as the interphase between Li6PS5Cl solid electrolyte and lithium metal. CPEs can prevent direct contact between lithium anode and Li6PS5Cl, and a soft CPE layer can solve the problem of high interfacial resistance caused by bad contact between the Li6PS5Cl solid electrolyte and the lithium metal anode. As a result, the symmetric cells Li/CPEs/Li6PS5Cl/CPEs/Li show stable polarization voltage over 140 h at a current density of 0.2 mA at 60 °C. Compared with the rapidly decaying capacity of the LiFePO4/Li6PS5Cl/Li cell, the initial discharge capacity of LiFePO4/Li6PS5Cl/CPEs/Li is 93.74 mAh/g, and after 15 cycles at 0.5 C, the capacity retention rate is still 75.1%. Therefore, the successful design of this cell structure based on the interface modification of Li6PS5Cl solid electrolyte provides good prospects for the commercial application of ASSLMBs.
研究领域:
材料科学
·
电化学
·
能源存储
·
固体离子学
·
电池技术
·
界面工程
✓ 已验证
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 25
·期 1
·402-409
·
IF 3.945
Ran Wang,Fengjin Zhang,Xinghang Pan,Xuming Zheng,Jiadan Xue,Yong Du,Binbin Xie
8-Hydroxy-5-nitroquinoline (NO2-QN-OH) is an antimicrobial, anti-inflammatory and anticancer agent, and has been approved for use in the treatment of diseases. Its photosensitivity, however, cannot be overlooked. The photochemistry of 8-hydroxy-5-nitroquinoline in acetonitrile is investigated using transient absorption and time-resolved resonance Raman spectroscopies. By identifying the short-lived intermediates during the photoreaction, it is clear that the Tn state NO2-QN-OH is generated in 0.8 ps via an ultrafast ISC, followed by the IC in 8.5 ps to produce the T1 state. In neat acetonitrile, the T1 state NO2-QN-OH undergoes intramolecular proton transfer and tautomerizes to form T1 state NO2-QNH-O. To our knowledge, this is the first time that the intramolecular excited state proton transfer of hydroxyl-quinolines in an aprotic polar solvent is observed.
研究领域:
光化学
·
物理化学
·
光谱学
✓ 已验证
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2020
·
IF 4.831
Shiyang Zhou,Gangliang Huang
In this study, a series of novel 7 H -benzo [ c ] [1,3] dioxolo [4, 5- f ] chromen-7-one derivatives were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as inhibitors of tumor. These target compounds have the novel chemical structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong of anti-tumor activity. Such as the target compound 4n to MCF-7 was IC 50 = 0.35 ± 0.01 μM, to A-549 was IC 50 = 0.37 ± 0.01 μM, to Hela was IC 50 = 0.56 ± 0.02 μM, to MDC-803 was IC 50 = 0.53 ± 0.02 μM and COLO-205 was IC 50 = 0.50 ± 0.02 μM in vitro . At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound 4n had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound 4n could be used as a candidate drug for further research and development, in order to be used as early as application in the clinical treatment of tumors.
研究领域:
药物化学
·
肿瘤学
·
有机合成
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Li-Yun Zhang,Jing-Pei Cao,Xue-Yu Ren,Xiao-Bo Feng,Jing-Xian Wang,Zi-Meng He,Tian-Long Liu,Zhen Yang,Xiao-Yan Zhao,Hong-Cun Bai
CeO2 receives extensive researches as an active component due to its providential catalytic center and favorable reducibility. Herein, a series of Ce-modified hierarchical ZSM-5 zeolites (FZ5) were prepared by HF (0.5 mol/L) etching followed by impregnation with different Ce loadings. The role of incorporating extra-framework Ce elements was assessed by catalytic upgrading of the cellulose pyrolysis volatiles to produce light aromatics (LAs). Introducing CeO2 could effectively regulate the acid properties of catalysts with an increase in Lewis acid sites and a decrease in Brönsted acid sites, which could significantly improve the catalytic performance. As a result, the selectivity toward LAs were significantly enhanced and the coke content dramatically decreased. The highest selectivity to LAs and the lowest coke content obtained over 1.0Ce-FZ5 zeolite (loading 1.0 wt % Ce) were 84.0% and 2.42 wt %, respectively. Additionally, the 1.0Ce-FZ5 catalyst exhibited excellent stability, maintaining nearly 90% carbon yield of LAs after the seventh regeneration test. CeO2 modification opened a simple and feasible way for promoting the LAs selectivity and catalyst stability during the reforming of biomass volatiles.
研究领域:
催化化学
·
生物质能源
·
材料化学
·
环境科学
·
能源化工
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Chenxia Yang,Ying Meng,Xintong Wang,Xin Li,Tong Yu,Weiming Liao,Wenjun Xie,Qianchen Jiang,Han Wang,Cheng Shi,Wenxuan Jiao,Xiling Bian,Fang Hu,Xiaowei Wang,Yani Liu,Liangren Zhang,KeWei Wang,Qi Sun
Enhancing α7 nAChR function serves as a therapeutic strategy for cognitive disorders. Here, we report the synthesis and evaluation of 2-arylamino-thiazole-5-carboxylic acid amide derivatives 6–9 that as positive allosteric modulators (PAMs) activate human α7 nAChR current expressed in Xenopus ooctyes. Among the 4-amino derivatives, a representative atypical type I PAM 6p exhibits potent activation of α7 current with an EC50 of 1.3 μM and the maximum activation effect on the current over 48-fold in the presence of acetylcholine (100 μM). The structure–activity relationship (SAR) analysis reveals that the 4-amino group is crucial for the allosteric activation of α7 currents by compound 6p as the substitution of 4-methyl group results in its conversion to compound 7b (EC50 = 2.1 μM; max effect: 58-fold) characterized as a typical type I PAM. Furthermore, both 6p and 7b are able to rescue auditory gating deficits in mouse schizophrenia-like model of acoustic startle prepulse inhibition.
研究领域:
神经科学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Jingyu Liu,Chaoyue Zhang,Daiyu Song,Yihang Guo,Jiyan Leng
Brønsted acidic ionic liquid (BAIL) functionalized dendritic fibrous nanosilica sphere catalysts, [C 3 PrIm][SO 3 CF 3 ]-DFNS (C 3 = PrSO 3 H), are prepared via a hexadecylpyridinium bromide reverse micelle-directed co-condensation of tetraethoxysilane and 3-chloropropyltriethoxysilane in a water-in-oil emulsion system followed by successive chemical modification with imidazole , 1,3-propanesultone and trifluoromethane sulfonic acid , and the particle diameter, fiber thickness and fiber density of the catalysts are well-adjusted by changing the composition of the starting materials. The [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts are successfully applied in transformation of 5-hydroxymethylfurfural (HMF) to ethyl levulinate (EL). Combination of superstrong Brønsted acidity and unique open three-dimensional dendritic fibrous nanostructures , the [C 3 PrIm][SO 3 CF 3 ]-DFNS can transform HMF in ethanol media rapidly and completely; nevertheless, the selectivity to EL remarkably depends on the fiber thickness and fiber density, which affect diffusion and mass transfer of the reactants and products as well as the accessibility to the acid sites. Among the tested [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts, the [C 3 PrIm][SO 3 CF 3 ]-DFNS- 1 with the thinnest fiber sheet and considerably high fiber density exhibits the highest selectivity to EL (93.0%). The [C 3 PrIm][SO 3 CF 3 ]-DFNS catalysts also show good reusability, and they can be reused at least for five times without obvious changes of the reactivity, total selectivity, morphology, textural properties and chemical structure .
研究领域:
催化
·
纳米技术
·
有机化学
·
材料科学
·
绿色化学
✓ 已验证
DOI
高影响因子
ORGANIC ELECTRONICS
·
2019
·
IF 3.495
Tongchao Chu,Xiuping Ju,Xiao Han,Hongmei Du,Yan Zhang,Jinsheng Zhao,Junhong Zhang
Three novel electrochromic copolymers PTPE-1, PTPE-2, and PTPE-3 were synthesized by changing the ratio of donor to acceptor using the Stille coupling polymerization . 5,8,14,17-tetrabromoquinoxaline[2′,3':9,10]phenanthro[4,5-abc] phenazine (monomer b) was first introduced and employed as multi-functionalized unit with bisquinoxaline structure and high planarity, which was used as the acceptor unit. Two electron-rich monomers ProDOT-decyl 2 (monomer a) and thiophene (monomer c) are selected as the co-monomers and donor units. The three polymers were tested by X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), spectro-electrochemistry, kinetics, thermogravimetric analysis (TG), etc. All three polymers have narrow band gaps of lower than 1.85 eV and satisfactory thermal stability. As to electrochromic switching properties, the polymers showed high optical contrast and fast response time both in the visible and near-infrared regions. The optical contrasts are 53.35% at 540 nm and 66.49% at 1325 nm for PTPE-3, and its coloration efficiencies are 163 cm 2 C −1 at 540 nm, 205 cm 2 C −1 at 1325 nm, with fast switch time of less than 1 s. The color changes of three polymers were diversified and distinct, PTPE-1 changes from chestnut color to blue-gray color, PTPE-2 changes from dull red color to wathet color and PTPE-3 changes from deep red color to light blue-gray color. The excellent properties of the polymers might result from their cross-linked structure and consequent formation of the compatible ion transport channel.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 1
·1-9
·
IF 1.434
Li Hanyuan,Wang Wei,Chen Guofei,Liu Yinfeng,Fang Xingzhong
Novel highly soluble phenylethynyl-endcapped oligoimides derived from mixed thioetherdiphthalic anhydride isomers ( m -TDPA) and 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane (DAPI), 4,4′-oxydianiline (4,4’-ODA) with 4-phenylethynylphthalic anhydride (PEPA) as a reactive endcapping agent were synthesized. The calculated molecular weights of all the oligoimides were 2500 g·mol −1 .The effect of the mole ratio of DAPI/4,4’-ODA on solubility and melt viscosity of oligoimides as well as the thermal and mechanical properties of cured polyimide films was investigated. Experimental results indicated that DAPI greatly improved the solubility (>30 wt.%) of the oligoimides in low boiling points solvents when the content of DAPI was more than 10 mol% per total diamine. All the oligoimides exhibited very good processability with minimum melt viscosity lower than 60 Pa·s at about 330 °C. Tough and brown films were obtained after thermally cured at 370 °C for 1 h and dynamic mechanical analysis (DMA) showed that glass transition temperatures of the cured films increased up to 340 °C with the increasing content of DAPI. However, the thermal stability and mechanical properties decreased with the increase of DAPI content. The temperature of 5% weight loss was higher than 470 °C in both air and N 2 atmosphere obtained by thermogravimetric analysis (TGA). And the tensile strengths of the cured films were about 60 MPa.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Food Science & Nutrition
·
2024
·
IF 3.5
Jialing Lin,Chuanhui Zeng,Xueli Li,Qin Tang,Jing Liao,Yan Jiang,Xianchun Zeng
Heterocyclic amines (HAs) are a group of mutagenic and carcinogenic compounds produced from the processing of high-protein foods, which include 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) showing the strongest carcinogenic effect. Camels are able to digest HAs in foods, which provide rich microbial resources for the study. Thus, camel rumen and intestinal microbiota were used to degrade IQ, and the dominant microorganisms and their degradation characteristics were investigated. After three generations of culture with IQ as the sole carbon source, the highest abundance in rumen and intestinal microbes was found in the Proteobacteria phylum. The strains of third generation of the rumen contents were mainly attributed to the genera Brevundimonas and Pseudomonas , and the dominant genera in intestine were Ochrobactrum , Bacillus , and Pseudomonas . Microorganisms were further isolated and purified from the third generation cultures. These 27 strains from the rumen (L1–L27) and 23 strains from the intestine (C1–C23) were obtained. Among them, four strains with the most effective degrading abilities were as follows: L6 (28.55% of IQ degrading rate) and C1 (25.19%) belonged to the genus Ochrobactrum , L15 (23.41%) belonged to the genus Pseudomonas , and C16 (20.89%) were of the genus Bacillus . This study suggested the application of abundant microbial resources from camels' digestive tract to biodegrade foodborne toxins.
研究领域:
微生物学
·
环境科学
·
食品科学
·
毒理学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2024
·Vol. 15
·期 21
·2148-2156
·
IF 4.1
Xiao-Yu Zhang,Hao-Liang Li,Bo Xiang,Xiang-Wei Liu,Shu Zhang,Yi-Xian Wu
A series of imidazolidin-2-iminato vanadium complexes VOCl2[1,3-R2-(CH2N)2CN], Vi1, R = 2,6-Me2C6H3; Vi2, 2,4,6-Me3C6H2; Vi3, R = 2,6-iPr2C6H3; Vi4, R = cyclohexanyl, were synthesized and fully characterized by NMR (1H, 13C and 51V) and elemental analysis. The copolymerizations of ethylene with propylene using the imidazolidin-2-iminato vanadium complexes were conducted in the presence of Et3Al2Cl3. The catalytic activity increased in the order of Vi4 < Vi1 < Vi2 < Vi3, probably due to the different electron donating natures of the imidazolidin-2-iminato ligands. Both high catalytic activity of 2.44 × 106 g copolymer per mol of V per h and incorporation ratio of propylene (up to 32.5 mol%) were afforded by using the Vi3/Et3Al2Cl3 catalytic system in the copolymerization of ethylene with propylene. An ethylene–propylene copolymer with ultra-high molecular weight (Mw = 2660 kg mol−1) could be also synthesized by using the Vi3/Et3Al2Cl3 catalytic system. Importantly, the highly efficient terpolymerizations of ethylene, propylene with 5-ethylidene-2-norbornene (ENB) were also achieved by using this catalytic system, affording ethylene–propylene–ENB terpolymers (EPDMs) with high contents of ENB units up to 9.8 mol% (29.8 wt%) and ultra-high molecular weight (Mw = 1521–2537 kg mol−1). This work offers a unique catalytic system of vanadium complexes for the synthesis of EPDM with both high content of ENB units and ultra-high molecular weight.
研究领域:
聚合物化学
·
材料科学
✓ 已验证
DOI
高影响因子
Chinese Journal of Natural Medicines
·
2017
·
IF 1.667
Qiong YU,Li-Long JIANG,Na LUO,Ya-Xi FAN,Jiang MA,Ping LI,Hui-Jun LI
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4′-tetrahydroxystilbene-2- O-β -D-glucopyranoside (TSG) on the cellular absorption and human liver microsome metabolism of emodin. The obtained results indicated that the absorption of emodin in Caco-2 cells was enhanced and the metabolism of emodin in human liver microsomes was inhibited after TSG treatment. The effects of the transport inhibitors on the cellular emodin accumulation were also examined. Western blot assay suggested that the depressed metabolism of emodin could be attributed to the down-regulation of UDP-glucuronosyltransferases (UGTs) 1A8, 1A10, and 2B7. These findings definitively demonstrated the existence of interaction between TSG and emodin, which provide a basis for a better understanding of the underlying mechanism for PMR-induced liver injury.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Lin Dong,Jordi Morales-Vidal,Lili Mu,Licheng Li,Núria López,Javier Pérez-Ramírez,Zupeng Chen
5-Methylfurfural (MF) is a critical commodity chemical used as food additive and synthetic intermediate. Opening a sustainable route towards highly selective synthesis of MF from 5-hydroxymethylfurfural (HMF) is of great significance, but has demonstrated extremely challenging. Herein, we report an efficient process for the selective production of MF from HMF over an anatase-supported gold catalyst (Au/a-TiO 2 ). During the hydrogenolysis of HMF, the desired C O bond is maintained and MF can be obtained in a high yield of 83.1 %, exhibiting excellent stability both in batch and flow operation. A combination of experimental and theoretical analyses attribute the superior performance of Au/a-TiO 2 to the synergistic effect of limited H access, low adsorption of reactants, and avoiding condensation, driven by the high concentration of oxygen vacancies in the support. This study highlights a novel approach of tailoring the coverage of active species for the selective transformation of renewable compounds into high-value-added chemicals.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）