JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Cheng Tan,Chunyang Kang,Pan Liu,Yajuan Sun,Hui Jin
The neurotoxicological consequences of chronic exposure to polystyrene nanoplastics (PSNPs) at environmentally relevant concentrations remain poorly understood, particularly their impact on hippocampal neurons dysfunction. In this study, a mouse model co-exposed to PSNPs and/or luteolin (LUT) was replicated by intraperitoneal injection to investigate the mechanism and effective treatment of PSNPs induced striatal neurodegeneration. Here, we elucidated that PSNPs exposure induced striatal injury characterized by neuronal disorganization and mitochondrial dysfunction in vivo and in vitro. Notably, PSNPs triggered oxidative dysregulation and iron accumulation by enhancing antioxidant enzyme activity and suppressing lipid peroxidation, leading to ferroptosis and neuroinflammation. Additionally, PSNPs exposure induced a decrease in glycolysis and tricarboxylic acid (TCA) cycle imbalance by disrupting G6PD/glutathione-dependent pathway, leading to an imbalance in cellular energy metabolism. Our findings highlighted the role of the Piezo1/CaN/NFAT1 axis in PSNPs-induced ER Ca 2 + homeostasis imbalance, which was effectively inhibited by LUT. Notably, LUT alleviated the susceptibility to striatal ferroptosis induced by PSNPs via the G6PD/glutathione axis. Collectively, our study provides critical insights into the neurotoxic mechanisms of PSNPs and establishes LUT as a agent against PSNPs-induced neurodegeneration. These findings underscore the urgent need for environmental regulation of nanoplastics and offer potential strategies for combating their health effects.
研究领域:
神经毒理学
·
环境科学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Salah Naji Sufyan,Yusof A. Y. A. Mohammed,Chenglong Mu,Kashan Bashir,Ning Wen,Muhammad Mamoor,Xiuling Jiao,Dairong Chen,Ting Wang
Flexible piezoresistive pressure sensors are crucial for next-generation wearable electronics, yet achieving simultaneous high sensitivity, durability, and mechanical robustness remains a challenge. Herein, we report a high-performance piezoresistive sensor fabricated through the integration of two-dimensional MXene nanosheets with a hierarchically structured modified polyamide 6 nanofiber net (D-PA6 NFN) using scalable vacuum filtration. Benefiting from the synergistic combination of MXene’s excellent electrical properties, web-like architecture, the composite nanofiber tensile strength (52 MPa), and flexibility (40%), the resulting sensor exhibited good sensitivity (0.189 kPa–1), a rapid response/recovery time (14/13 ms), and an ultralow detection limit (4.2 Pa). Moreover, the device maintained stability over 12,000 compression cycles. The sensor precisely captured both subtle physiological signals (pulse waveforms) and large-scale dynamic motions (joint flexion). This work establishes a scalable strategy for engineering durable, high-sensitivity electronic skins, with immediate applications in advanced human-machine interfaces and real-time physiological monitoring.
研究领域:
材料科学
·
纳米技术
·
传感器
·
柔性电子学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Liyuan Zhang,Yiming Li,Feng Liu,Xiaoyu Zhang,Hongyu Chan,Yueyao Liang,Kuanjun Fang
Particulate matter (PM) contamination constituted a significant threat to both human well-being and the worldwide ecological system. However, protective masks achieved high-performance filtration of the PM by tightly stacking fibers, especially for PM 0.1 , which seriously affected the wearing comfort. Herein, a Nylon-6/SiO 2 composite fiber membrane with two-dimension (2D) narrow pore but 3D fluffy structure was designed to harmoniously combine high-performance filtration capabilities with comfort. Based on one-step multi-jet free-surface air-jet spinning and spraying, the introduction of nano-SiO 2 spheres enhanced the surface roughness of the fiber and reduced the pore size of the 2D fiber layer in the membrane structure, improving PM 0.1 particle capture. Additionally, the addition of micro-SiO 2 spheres could construct a fluffy 3D reticular architecture in the membrane, enhancing the flow of air and minimizing gas resistance during the filtration process. Due to the structural design featuring small pores and low packing density, the Nylon-6/SiO 2 -NM membrane exhibited an excellent PM removal rate of 99.99 % and low air resistance of 101 Pa at the flow rate of 32 L/min. At the flow rate of 85 L/min, the filtration efficiency of 99.9 % could be achieved, and the gas resistance was 254 Pa, the performance conformed to the GB 19083-2011. Moreover, the Nylon-6/SiO 2 -NM mask simultaneously possessed superior wearing comfort with air permeability (277.09 mm/s) and moisture permeability (196.50 g·m −2 ·h −1 ) and UV protection (UPF value of 136), as well as good thermal comfort. This research had the potential to introduce a fresh perspective on developing advanced, high-performance, and user-friendly personal protective materials.
研究领域:
材料科学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Xiaoya Weng,Chensheng Lin,Guang Peng,Huixin Fan,Xin Zhao,Kaichuang Chen,Min Luo,Ning Ye
The first tellurium(II) thiourea sulfate semiorganic nonlinear optical (NLO) material, Te(CS(NH2)2)4SO4·2H2O, was successfully obtained using the slow evaporation technique. The structure of this metal-free crystal featured three types of NLO-active units, namely CS(NH2)2, (SO4)2–, and (TeS4)6–, which synergistically contributed to its moderate second harmonic generation response (2.4 × KDP@1064 nm) and large birefringence (0.210@546.1 nm). Remarkably, this is the first example in which the quadrangular (TeS4)6– groups significantly contributed to the SHG effect and birefringence, and the first principles calculations revealed its special mechanism of NLO activity. These findings highlighted the exploration of semiorganic NLO materials and provide new opportunities for the discovery of new NLO crystals.
研究领域:
晶体学
·
材料科学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Ruiqi Huang,Yingfeng Qin,Yanqin Huang,Zengqiong Huang,Gao-Jie Ye
6-mercaptopurine (6-MP) is widely used in the treatment of many diseases, but exhibits some serious side effects due to its toxicity. Therefore, it is important and imperative to effectively control and monitoring concentration of 6-MP. Herein, we designed a smartphone-assisted colorimetric sensing platform for 6-MP detection, based on an excellent β-cyclodextrin modified MnO 2 nanosheets (β-CD@MnO 2 NNS) mediated oxidase-like activity. β-CD@MnO 2 NNS can directly oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) into oxidized TMB with color changes, yielding more than 3-fold higher oxidase-like catalytic activity compared with individual MnO 2 NNS. After adding 6-MP, β-CD@MnO 2 NNS can be reduced to Mn 2+ and lose their oxidase-like properties, resulting in a color and absorbance change for sensitive and selectivity detection of 6-MP. Meanwhile, the smartphone-based color recognition application can intuitively and simply measure the concentration of 6-MP. The limits of detection UV–vis instrument and smartphone were 0.35 μM and 0.86 μM, respectively. This method has also been successfully applied to the detection of real samples. Finally, this study provides a new promising platform for detection of 6-MP and is expected to be used in application of pharmaceutical analysis and biomedicine.
研究领域:
医学诊断
·
药物分析
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cancers
·
2024
·Vol. 16
·期 9
·1614
·
IF 4.5
Tiantian Song,Zheming Yu,Qitao Shen,Yu Xu,Haihong Hu,Junqing Liu,Kui Zeng,Jinxiu Lei,Lushan Yu
Simple SummaryAcute T-lymphoblastic leukemia is a disease with a very low survival rate after relapse, and the search for new therapeutic agents is important for the clinical benefit of patients with acute T-lymphoblastic leukemia. Our study developed YLS010, a small molecule that is more sensitive to acute T-lymphoblastic leukemia cells, based on the structure of the invented small molecule YLS004. This novel small molecule demonstrated good antitumor activity in vivo and in vitro with acceptable toxicity. These findings provide a new avenue for the development of clinical drugs for patients with acute T-lymphoblastic leukemia.Abstract(1) Background: The research group has developed a new small molecule, 6-Isopropyldithio-2′-deoxyguanosine analogs-YLS004, which has been shown to be the most sensitive in acute T-lymphoblastic leukemia cells. Moreover, it was found that the structure of Nelarabine, a drug used to treat acute T-lymphoblastic leukemia, is highly similar to that of YLS004. Consequently, the structure of YLS004 was altered to produce a new small molecule inhibitor for this study, named YLS010. (2) Results: YLS010 has exhibited potent anti-tumor effects by inducing cell apoptosis and ferroptosis. A dose gradient was designed for in vivo experiments based on tentative estimates of the toxicity dose using acute toxicity in mice and long-term toxicity in rats. The study found that YLS010 at a dose of 8 mg/kg prolonged the survival of late-stage acute T-lymphoblastic leukemia mice in the mouse model study. (3) Conclusions: YLS010 has demonstrated specific killing effects against acute T-lymphoblastic leukemia both in vivo and in vitro. Preclinical studies of YLS010 offer a new opportunity for the treatment of patients with acute T-lymphoblastic leukemia in clinical settings.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
血液学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEUROREPORT
·
2020
·
IF 1.394
Liu Zhen,Hao Kai-Min,Wang Hao-Yu,Qi Wen-Xiu
The aim of this study was to investigate the effects of histone deacetyltase (HDAC) 6 on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). Ninety Sprague-Dawley rats were randomly divided into nine groups, consisting of five experimental groups and four control groups. In five experimental groups, Aβ 1–42 was infused intracerebroventricularly and 3 days later, rats in each group were infused intracerebroventricularly with tubastatin A hydrochloride (TSA), the histone deacetyltase 6 (HDAC6)-specific inhibitor (Aβ + TSA group), theophylline, the HDACs agonist (Aβ + theophylline group), PF431396, the PTK2B inhibitor (Aβ + PF group), the combination of PF431396 and theophylline (Aβ + PF + theophylline group) and normal saline (Aβ + normal saline group), respectively. Rats in four control groups took normal saline that was equivalent to the volume of Aβ 1–42 , and 3 days later, TSA group, theophylline group, PF431396 (PF group), or normal saline group was given at a volume of 5 µL for rats in each group. Our results showed that HDAC6 may not only lead to the deterioration of learning and memory abilities but also elevate the levels of Aβo and Tau phosphorylation in Aβ-induced cognitive dysfunction rats via up-regulating PTK2B.
研究领域:
神经科学
·
药理学
·
分子生物学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yang Haoyu,Zhang Xiaoqi,Ma Xintao,Liu Wentao,Liu Hao,Liu Xuying,He Suqin,Huang Miaoming,Xu Wanlin,Zhu Chengshen
Bio-based polyamide elastomers, known for their excellent mechanical properties, represent a promising environmentally friendly material with significant potential. In this study, we synthesized TPA510/6(short for polyamide 510/6 elastomer, the main components of which are 1.5-Pentanediamine, sebacic acid, caprolactam and polyetheramine), a polyamide elastomer with a high bio-based content, outstanding low-temperature resistance, and superior mechanical performance. Additionally, microcellular elastic foams with pore sizes below 10 nm were fabricated by foaming with supercritical carbon dioxide. These TPA510/6 foams demonstrated remarkable tensile strength, compressive strength, low-temperature resistance, and friction resistance. Furthermore, simulations of the thermal insulation properties of the foams under real-world conditions revealed low thermal conductivity, highlighting their excellent insulation performance. As a result, the bio-based polyamide elastomer foams developed in this study show significant promise for applications in areas such as building insulation, sports protection, and thermal camouflage.
研究领域:
材料科学
·
高分子科学
·
热工工程
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Yiming Yao,Yue Meng,Hongwen Sun
Polyfluoroalkyl phosphoric acid diesters (diPAPs) have been widely and increasingly detected in various environmental mediums. The degradation of diPAPs brings perfluoroalkyl carboxylic acids (PFCAs) concerned of adverse health effects. DiPAPs mainly occur in particulate matter in ambient air and their photo-degradation behaviors have not been investigated. In this study, heterogeneous photo-degradation of 6:2 diPAP was studied on four model mineral components in ambient dust. 6:2 diPAP was found to undergo a fast degradation on titanium dioxide (TiO 2 ) particles as well as on artificial mineral dust containing TiO 2 (2.67% in mass) to produce C5–C7 PFCAs and other intermediates. Based on monitored intermediates and further degradation tests on important intermediates, thermodynamic calculation of energy barrier and Gibbs Free Energy was used to explain the observed degradation patterns and accordingly the degradation pathways of diPAPs were proposed. The increase in relative humidity promotes the production of hydroxyl radicals , which enhances the hydrolysis of 6:2 mono- and di-PAPs and the yield of C5 and C7 PFCAs. Oxygen is critical for radical formation, which bypasses the production of fluorotelomer carboxylic acid . Results of this study for the first time demonstrate that diPAP may account for additional PFCA sources in both indoor and outdoor environments and the heterogeneous degradation pathways were different from those of volatile fluorotelomer alcohols.
研究领域:
环境科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Qiuxuan Yang,Qilong Wang,Yingshu Feng,Qiuyu Wei,Congyong Sun,Caleb Kesse Firempong,Michael Adu-Frimpong,Ran Li,Rui Bao,Elmurat Toreniyazov,Hao Ji,Jiangnan Yu,Ximing Xu
The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess diverse pharmacological activities. However, its poor aqueous solubility usually leads to low bioavailability, and further clinical applications will be greatly discounted. The current study aimed to formulate a 6-shogaol-loaded-Self Microemulsifying Drug Delivery System (SMEDDS) to amend low aqueous solubility and bioavailability orally, as well as, potentiate the hyperuricemic activity of the 6-shogaol. SMEDDS was developed with central composite design established on a two system components viz., 18.62% W/W ethyl oleate (oil phase) and ratio of tween 80 (surfactant) to PEG 400 (co-surfactant) (1.73:1, W/W). Based on quadratic model, the navigation of the design space could generate spherically-shaped and homogenous droplets with respective mean particle diameter, polydispersity and of 20.00 ± 0.26 nm and 0.18 ± 0.02. The 6-shogaol-SMEDDS showed significant elevation of cumulative release compared with the free 6-shogaol and more importantly a 571.18% increment in the relative oral bioavailability of the drug. The predominant accumulation of 6-shogaol-SMEDDS in the liver suggested hepatic-targeting potentiality of the drug. Oral administration of 6-shogaol-SMEDDS in hyperuricemic rats also significantly decreased uric acid level and xanthine oxidase activity. Histological studies confirmed formulation groups indeed could provide better protection of kidney than free drug groups. Collectively, these findings indicated that the SMEDDS hold much promise in enhancing the oral delivery and therapeutic efficacy of 6-shogaol.
研究领域:
药剂学
·
代谢病学
·
中药学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Wenwu Yan,Nani Wang,Peimin Zhang,Jiajie Zhang,Shuchao Wu,Yan Zhu
A standard-free and sensitive method was developed for analysis of sucrose acetates in a crude 6- O -acetyl sucrose (S-6-a) product by on-line hydrolysis-high-performance liquid chromatography with pulsed amperometric detection (PAD). Sucrose, three regio-isomers of acetyl sucrose and five regio-isomers of diacetyl sucrose were separated on a C18 column using 3% (v/v) acetonitrile in water as eluent within 25 min. After purification with LC followed by semi-preparative HPLC, their chemical structures were identified by 1D, 2D NMR and LC–MS. Moreover, quantification of those regio-isomers was achieved by on-line alkaline hydrolysis to liberate sucrose using a post-column delivery system, and then detected by PAD for indirect estimation of the sucrose acetate content. Under optimal conditions, the linear ranges were from 0.03 to 150 μmol L −1 for sucrose corresponding to sucrose acetates with coefficient of determination as 0.9997 and detection limit as 0.01 μmol L −1 ( S/N = 3). Good repeatability was obtained (RSD < 3%, n = 6). Furthermore, this method has been successfully applied to the analysis of sucrose and sucrose acetates in a crude S-6-a product during synthesis, purification and structure elucidation studies. The recoveries were from 94.89% to 102.31% for sucrose and sucrose acetates.
研究领域:
分析化学
·
食品科学
·
有机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
·
2025
·
IF 3.7
Qian Zhu,Kangning Wei,Kaihua Pan,Gang Hu,Weihao Zhu,Yanni Huang,Changchang Wang,Qian Li,Mingliang Zhang,Jiguo Qiu,Qing Hong
Isoprocarb (IPC), a widely used carbamate insecticide, causes environmental contamination and poses risks to humans and ecosystems. Rhodococcus sp. D-6, capable of utilizing IPC as the sole growth substrate, was isolated by our lab. Strain D-6 initiates IPC degradation through ester bond hydrolysis by the hydrolase IpcH, yielding 2-isopropylphenol (IPP). In this study, the catabolic pathway of IPP in strain D-6 was elucidated, and the ipp gene cluster responsible for its degradation was predicted by transcriptomic analysis. Key genes, including a novel two-component IPP monooxygenase gene ippA1A2 and a 2-isopropylhydroquinone dioxygenase gene ippB, are responsible for the successive conversion of IPP, resulting in the ring cleavage of IPP. IppA1, a group D flavin-dependent monooxygenase, along with its reductase component IppA2, hydroxylates IPP to 2-isopropylhydroquinone using reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) as cofactors. The optimal molar ratio of IppA1 to IppA2 was 3:1. The apparent Km and kcat values of IppA1 for IPP were 60.52 ± 1.27 µM and 70.07 ± 0.85 s−1, respectively. IppB, an extradiol dioxygenase, catalyzes 2-isopropylhydroquinone ring cleavage to generate 2-isopropyl-4-hydroxymuconic semialdehyde. The apparent Km and kcat values of IppB for 2-isopropylhydroquinone were 29.07 ± 1.54 μM and 147.65 ± 1.92 s−1, respectively. This study provides critical insights into the molecular mechanisms of IPP degradation, contributing to a comprehensive understanding of IPC degradation.
研究领域:
环境微生物学
·
生物降解
·
分子生物学
·
生物化学
·
基因组学
·
农药代谢
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）