RSC Advances
·
2016
·Vol. 6
·期 47
·41108-41113
·
IF 3.289
Hongyan Zhao,Guijie Mao,Huatao Han,Jinyi Song,Yang Liu,Wenyi Chu,Zhizhong Sun
As an outstanding mesh catalyst support, reduced graphene oxide (RGO) has attracted enormous attention in recent years. Cu nanoparticles-RGO (Cu NPs@RGO) as a green catalyst was prepared through a green reduction method by ascorbic acid in N-methyl-2-pyrrolidone. The structure of prepared Cu NPs@RGO was characterized. The catalytic activity of Cu NPs@RGO was estimated. A green and efficient method for synthesizing symmetrical biaryl compounds was developed by Cu NPs@RGO-catalyzed Ullmann homocoupling of aryl halides or arylboronic acids in ionic liquids under microwave (MW) irradiation. The catalytic system could be recycled five times with slight loss of activity. Through this method, nine kinds of biaryls were prepared by homocoupling reaction of the corresponding aryl iodides, aryl bromides, aryl chlorides and aryl boronic acids in moderate to good yields.
研究领域:
材料化学
·
绿色化学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Jiaxing Hou,Guohao Zou,Xinrui Liu,Mingge Li,Pengyu Yang,Xiaobin Zhang,Yan Chen,Qian Zhang,Xiaoping Wu,Tiejun Wang
The one-step hydrothermal reconstruction of bioethanol into higher alcohols represents a pivotal advancement in green chemistry, addressing both environmental sustainability and energy regeneration. Herein, a rational design of Ni@C-CeO2 catalysts via a sol–gel method for efficient aqueous-phase ethanol C–C coupling was reported. Systematic investigation of Ni loading and precursor carbonization temperature revealed their critical roles in modulating catalyst microstructure and performance. The optimized Ni-2@C-CeO2-500 catalyst demonstrated exceptional activity under 190 °C and 12 h, achieving ethanol conversion of 72.0% and C4+ alcohol yield of 55.6%. Advanced characterization techniques unveiled structure-performance relationships: (1) controlled Ni loading ensured optimal nanoparticle dispersion, while excessive loading induced aggregation; (2) carbonization at 500 °C balanced carbon matrix architecture and CeO2 reducibility. XPS analysis revealed that oxygen vacancy concentration critically modulates strong metal–support interactions through Ce3+-induced charge redistribution, facilitating interfacial electron transfer during reaction. Furthermore, the Ni-2@C-CeO2-500 catalyst demonstrated excellent stability with sustained activity retention over five consecutive cycles. This work establishes a renewable and technologically viable alternative to conventional petroleum-derived chemicals widely utilized in the chemical industry, demonstrating significant potential for applications in green and sustainable chemistry.
研究领域:
绿色化学
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催化化学
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材料科学
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Journal of Neuroinflammation
·
2025
·Vol. 22
·期 1
·1-19
·
IF 10.1
Chi Zhexi,Lu Bo,Liu Rongjun,Pan Chen,Meng Bo,Xing Xiuzhong,Yuan Hui,Wu Xuewei,Chen Yushan,Ren Yuxuan,Wu Wenwei,Miao Mengmeng,Chen Junping,Chen Xiaowei
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes. ACY-1215 increased acetylated signal transducer and activator of transcription 3 (Ac-STAT3) and reduced phosphorylated STAT3 (p-STAT3) in the lumbar spinal cord of SNI mice. HDAC6 and p-STAT3 were expressed in spinal dorsal horn neurons, and SNI-enhanced HDAC6/STAT3 interaction was reversed by ACY-1215. Neuronal STAT3 overexpression induced pain hypersensitivity and elevated p-STAT3, tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), effects suppressed by ACY-1215. Cytokine profiling identified CC-chemokine ligand 7 (CCL7) as a key downstream effector of the HDAC6/STAT3 axis, with ACY-1215 attenuating SNI-induced CCL7 upregulation. HDAC6 knockdown in neurons reduced p-STAT3, while HDAC6 or STAT3 knockdown diminished CCL7 production. These findings demonstrate that ACY-1215 mitigates neuropathic pain by modulating STAT3 acetylation/phosphorylation and suppressing HDAC6/STAT3-driven CCL7 and cytokine release. This study underscores the role of the HDAC6/STAT3/CCL7 signaling axis in neuropathic pain and highlights the therapeutic potential of HDAC6 inhibitors for pain management.
研究领域:
神经科学
·
药理学
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DOI
PubMed
高影响因子
CYTOTECHNOLOGY
·
2021
·Vol. 73
·期 5
·715-726
·
IF 2.058
Xu Haiqiao,Lin Shibang,Huang Haizhou
CCL22, which could induce chondrocyte apoptosis, was identified to be overexpressed in damaged cartilage. This study was conducted with the aim of investigating the effects of CCL22 interference on chondrocyte injury. The osteoarthritis model was established by stimulating chondrocytes with LPS. The expressions of CCL22, CCR4, matrix metallopeptidase (MMP) 3, MMP9, MMP13, (a disintegrin and metalloproteinase with thrombospondin-like motifs) ADAMTS-4, collagen II and inflammatory cytokines were measured using quantitative reverse transcription PCR (RT-qPCR) and western blot. Besides, immunoprecipitation (IP) was employed to verify the binding of CCL22 and CCR4. After CCR4 was overexpressed, cell viability was observed using Cell Counting Kit-8 (CCK-8). Additionally, cell apoptosis as well as its related proteins was detected by TUNEL and western blot, respectively. ng What’s more, glycosaminoglycan (GAG) level was detected using GAG kits. CCL22 and CCR4 expression increased noticeably in LPS-stimulated ATDC5 chondrocytes. CCL22 inhibition could suppress the expression of CCR4 in LPS-induced ATDC5 cells. Likewise, CCL22 inhibition could revive the activation of LPS-induced ATDC5 cells by regulating CCR4. In addition, CCL22 knockdown alleviated inflammatory response and cell apoptosis through CCR4. Furthermore, the cartilage degradation of ADTC5 cells could be relieved by CCL22 silence via regulating CCR4. CCL22/CCR4 expression was increased in osteoarthritic cartilage injury and participated in the inflammation and cartilage degradation of chondrocytes.
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PubMed
高影响因子
ADVANCED SYNTHESIS & CATALYSIS
·
2018
·Vol. 360
·期 21
·4191-4196
·
IF 5.123
Yan Zhang,Peiyuan Yao,Yunfeng Cui,Qiaqing Wu,Dunming Zhu
An enzymatic cascade reaction was developed for one-pot enantioselective conversion of aliphatic dialdehydes to chiral vicinal diols using pyruvate decarboxylases (PDCs) and alcohol dehydrogenases (ADHs). The PDCs showed promiscuity in catalysing the cyclization of aliphatic dialdehydes through intramolecular stereoselective carbon-carbon bond formation. Consequently, 1,2-cyclopentanediols in three different stereoisomeric forms and 1,2-cyclohexanediols in two different stereoisomeric forms could be prepared with high conversion and stereoisomeric ratio from the respective initial substrates, glutaraldehyde and adipaldehyde. These cascade reactions represent a promising approach to the biocatalytic synthesis of important chiral vicinal diols.
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ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Yuling Li,Jiahui Bai,Kuofeng Tseng,Xiaoqiang Zhang,Li Zhang,Jing Zhang,Wenjian Sun,Yinlong Guo
Free unsaturated fatty acids (UFA) are key intermediates of lipid metabolism and participate in many metabolic pathways with specific biological functions. Although various fragmentation-based methods for pinpointing C═C locations in UFA were developed, the current mass spectrometry methods are difficult to simultaneously differentiate geometric isomers and positional isomers in trace samples due to low ionization efficiency, low conversion, and low resolution. Herein, an intramolecular ring–chain equilibrium elimination strategy via 4-plex stable isotope labeling dual derivatization-assisted ion mobility-mass spectrometry was developed, thereby one-pot specifically labeling C═C and carboxyl groups among the trace and unstable UFA with high sensitivity, high efficiency, and good substrate generality. It achieved fast separation of both C═C positional and geometric isomers with high resolution, which benefited from eliminating the intramolecular ring–chain equilibrium by suppressing the formation of salt bridges between free carboxyl groups and pyridine cations. 4-plex stable isotope labeling reagents showed similar reactivity, enabling high-throughput quantitative analysis of omics. This method was successfully applied for accurate and rapid identification of the UFA composition in olive oil extract. These results suggest that the developed method provides new insight for rapid characterization of UFA C═C positional and geometric isomers in complex samples to explore disease biomarkers and food quality control indicators.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Ouyang Haibo,Chen Zihao,Li Cuiyan,Shen Tianzhan,Wang Jintao,Chen Qianqian,Gao Ruinan
To address the rapid volatilization and decomposition of SiO 2 at ultra-high temperatures, a silicon-free strategy has been proposed for the design of C/C-(HfZrTi)C composites. These composites were fabricated using a precursor infiltration and pyrolysis method that employed metal chloride and furfuryl alcohol as precursors. The resulting C/C-(HfZrTi)C composites demonstrated exceptional ablation resistance, with a mass ablation rate of −0.567 mg/s and a linear ablation rate of 1.433 μm/s when exposed to a 2.4 MW/m² oxyacetylene flame. This enhanced ablation resistance is attributed to the formation of liquid TiO 2 during the ablation process. The liquid TiO 2 can penetrate oxide scales through capillary action, forming an oxygen diffusion barrier that inhibits the oxidation of the composites. Additionally, it can bond with solid (HfZr)O 2 particles, resulting in the formation of a dense (HfZrTi)O 2 oxide scale that improves resistance to flame scouring. This work provides a new method and strategy for the preparation and design of silicon-free composites for ultra-high temperature applications.
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高影响因子
Catalysis Science & Technology
·
2024
·Vol. 14
·期 6
·1568-1578
·
IF 4.4
Qifeng Chen,Peng Zheng,Haodi Liu,Yuanrong Zhang,Shuaitao Li,Hongpian Guo,Yanfen Fang,Xun Hu,Ran Duan
The combination of photocatalytic dehalogenation of halogenated aromatics and C–C coupling synthesis of valuable organics is an interesting method for the elimination of pollutants and synthesis of valuable chemicals. Herein, we present a green method for the photocatalytic dehalogenation of benzyl bromide and selective coupling synthesis of bibenzyl achieved on the dual active sites of single-atom Cu and surface oxygen vacancies (VOS) generated in situ on ultrathin 2D-TiO2(B) nanosheets. The experimental results show that single-atom Cu sites on ultrathin TiO2(B) nanosheets can improve charge transfer and separation efficiency and stabilize VOS formed in situ; the presence of VOS not only improves light absorption capacity but also favors the adsorption of reactant benzyl bromide molecules. More importantly, the dual sites of single-atom Cu and adjacent VOS form a solid frustrated Lewis pair, favor the adsorption of benzyl bromide molecules, activate the C–Br bond, and boost the C–C coupling synthesis of bibenzyl. This work provides a novel insight into photocatalytic C–C coupling through the synergistic effect of single-atom Cu and VOS on ultrathin nanosheet photocatalysts.
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ACS Catalysis
·
2024
·
IF 11.3
Long Cheng,Rong Wang,Wenzhe Si,Yanxi Deng,Junhua Li,Yue Peng
Cu-based catalysts leveraging Cu+/Cu0 active sites have emerged as pivotal for synthesizing essential hydrocarbons and alcohols in electrochemical CO2 reduction, such as ethylene and ethanol (C2 products). However, the dynamic reduction of Cu+ to Cu0 during electroreduction leads to site instability, resulting in diminished efficiency for CO2 conversion to C2 products. Herein, we introduced Si into CuO by the selective dissolution method, engendering Cu–O–Si units to stabilize the Cu+/Cu0 sites. The catalyst manifested good activity in CO2 electroreduction with an elevated Faradaic efficiency for C2 products reaching 81.9% at −100 mA/cm2. After ten cycles of electrochemical testing, the Cu+/Cu0 sites and performance exhibited no signs of degradation. The Si incorporation significantly improved the hybridization of O 2p and Cu 3d orbitals, thereby reinforcing the Cu–O bonds and stabilizing the Cu+/Cu0 sites, which was critical in promoting C–C coupling via decreasing the energy barriers for *OCCO formation and enhancing C2 product selection. The active Cu+ cations with unsaturated coordination contributed to the reaction stabilization, thereby improving the preservation of Cu2O metastable state.
研究领域:
电化学
·
催化
·
材料科学
·
能源转化
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DOI
高影响因子
Bioengineered
·
2022
·
IF 6.832
Yuanmei Che,Jianglong He,Xiaopeng Li,Daxian Wu,Yi Zhang,Guicai Yuan
microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p’s influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis. In vivo, miR-381-3p expression was abated in HI rats’ ischemic lesions, and miR-381-3p up-regulation could ameliorate inflammation and neuron apoptosis in their brain. C-C chemokine receptor type 2 (CCR2) was identified as the downstream target of miR-381-3p, and miR-381-3p suppressed the CCR2/NF-κB pathway to mitigate microglial activation and neurotoxicity. Therefore, we believed that miR-381-3p overexpression exerts anti-inflammation and anti-apoptosis in ischemic brain injury by targeting CCR2
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PubMed
高影响因子
FUEL
·
2024
·
IF 6.7
Zhuang Li,Zi-Chun Fan,Xiang Bai,Xian-Yong Wei,Yierxiati. Dilixiati,Qian-Qian Kong,Ji Zhao,Yong-Hui Feng,Jun-Long Wang,Xing Fan,Xiao-Yan He,Hai-Xu Zou,Zhi-Min Zong
MY zeolites with mesopores were prepared by hydrothermal method using functionalized SiO 2 (F-SiO 2 ) as a silica source, and hydrophobic bifunctional Ru/MY- O catalysts were obtained by deposition precipitation method and silylation treatment. This work aims at obtaining polycyclic alkane (PCA) based high-density hydrocarbon fuels (HDHFs). We focused on the catalytic hydroconversion (CHC) of 2-phenoxy-1-phenylethanol (PP-ol) and oxydibenzene (ODB), two typical lignin-related model compounds (LRMCs), over Ru/MY- O . The effects of different reaction conditions and catalysts on the product distribution in PP-ol and ODB were investigated. The partial hydrogenation of ODB was found to be a necessary step before achieving C-O ether bond cleavage and C-C bond coupling. The balance of metal/acidic sites is critical for maximizing PCA yields. Changes in the metal/acid ratio had a greater effect on PCA yield in PP-ol than in ODB. Poor stability of cycloalkyl cations and partial hydrogenation of ODB hinder the generation of C-C coupling products. The incorporation of mesopores and hydrophobic treatment were found to weaken the negative effects of C-C bond coupling products and water on the catalyst. The conversion of Ru 3 /MY- O was improved by nearly 10% compared to Ru 3 /Y in the fifth cycle reaction. This work provided a theoretical basis for the generation of HDHFs from lignin.
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