INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2019
·
IF 4.213
Chunlai Feng,Haisheng Zhang,Jiaming Chen,Siqi Wang,Yuanrong Xin,Yang Qu,Qi Zhang,Wei Ji,Fumiyoshi Yamashita,Mengjie Rui,Ximing Xu
Combination therapy is a promising treatment for certain advanced drug-resistant cancers. Although effective inhibition of various tumor cells was reported in vitro , combination treatment requires improvement in vivo due to uncontrolled ratiometric delivery. In this study, a tumor-targeting lipodisk nanoparticle formulation was developed for ratiometric loading and the transportation of two hydrophobic model drugs, doxorubicin (DOX) and paclitaxel (PTX), in one single platform. Furthermore, a slightly acidic pH-sensitive peptide (SAPSP) incorporated into lipodisks effectively enhanced the tumor-targeting and cell internalization. The obtained co-loaded lipodisks were approximately 30 nm with a pH-sensitive property. The ratiometric co-delivery of two drugs via lipodisks was confirmed in both the drug-resistant MCF-7/ADR cell line and its parental MCF-7 cell line in vitro , as well as in a tumor-bearing mouse model in vivo compared with a cocktail solution of free drugs. Co-loaded lipodisks exerted improved cytotoxicity to tumor cells in culture, particularly to drug-resistant tumor cells at synergistic drug ratios. In an in vivo xenograft mouse model, the anti-tumor ability of co-loaded lipodisks was evidenced by the remarkable inhibitory effect on tumor growth of either MCF-7 or MCF-7/ADR tumors, which may be attributed to the increased and ratiometric accumulation of both drugs in the tumor tissues. Therefore, tumor-specific lipodisks were crucial for the combination treatment of DOX and PTX to completely exert a synergistic anti-cancer effect. It is concluded that for co-loaded lipodisks, cytotoxicity data in vitro could be used to predict their inhibitory activity in vivo , potentially enhancing the clinical outcome of synergistic therapy.
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PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2018
·Vol. 32
·期 12
·e4570
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IF 3.581
Xiaobin Dong,Chaoyue Zhao,Qingxin Guan,Wei Li,Xiufang Xu
Industrial production of vinyl chloride through acetylene hydrochlorination is a dominating technique in coal-rich areas, but its development is severely restricted by the use of toxic mercury chloride (HgCl 2 ) catalyst. Inspired by the fact that doped carbon materials active in acetylene hydrochlorination often have good performance in the oxygen reduction reaction, a series of cobalt and nitrogen co-doped porous carbon catalysts prepared by pyrolysis of bimetallic ZIFs based on ZIF-8 and ZIF-67 under N 2 were applied in acetylene hydrochlorination. The catalytic activities of the co-doped catalysts varied with Co addition, and the highest acetylene conversion could be up to 83% with a space velocity of 2.6 ml g −1 min −1 at 220°C when a small amount of cobalt was introduced. Results of several characterizations confirmed the existence of Co–N x in the co-doped carbons, pointing out that this coordination structure makes the catalysts have better ability to adsorb and activate C 2 H 2 . Density functional theory calculation finally proved that C atom adjacent to the N atom in Co–N 4 structure is the primary active site in co-doped catalysts with high activity. We also conclude that the decreased N content caused by Co 2 N decomposition and the coordination structure change of Co–N x should be responsible for the gradually worsening performances of the carbon catalysts with further Co addition. Our study provides a new route for improving the performance of N-doped carbon material in acetylene hydrochlorination and thus enhances its potential for practical application.
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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
·
2015
·
IF 0.606
Haiyan Liu,Yamin Ma,Fengqing Wang,Jiafei Wang,Quanjie Liu
A new poly(1-dodecene-co-trimethylol propane triacrylate-co-ethylene dimethacrylate) [poly(C12-co-TMPTA-co-EDMA)] monolithic column was prepared via in situ free-radical polymerization reaction. Various parameters affecting the polymerization were investigated and optimized. The permeability of the monolithic column was calculated as 2.9098 × 10−14 m2 with methanol as the mobile phase and the surface areas was 73.1 m2/g by the nitrogen adsorption–desorption experiment. The morphologies of the monolith were characterized by scanning electron microscopy (SEM) and the mechanical strength has been studied in detail as well. The prepared monolith was then used as the stationary phase of reversed phase high-performance liquid chromatography (RP-HPLC) to separate small molecule compounds. Column efficiency for chlorobenzene reached 14,340 theoretical plates per meter. The monolith also showed satisfactory reproducibility, based on the retention times of benzene, phenol, chlorobenzene, diphenylamine, and anthracene; the relative standard deviation (RSD) values for run-to-run, column-to-column and batch-to-batch were less than 0.62%, 3.2%, and 5.7%, respectively.
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GREEN CHEMISTRY
·
2017
·Vol. 19
·期 24
·5809-5817
·
IF 9.125
Haidong Yang,Yu Long,Yan Zhu,Ziming Zhao,Ping Ma,Jun Jin,Jiantai Ma
The exploration of highly efficient nonprecious metal-based electrocatalysts for the oxygen evolution reaction (OER) is of great importance for potential applications in sustainable energy conversion. Recently, the layered metal hydroxide (LMH) family is receiving extensive research attention owing to its unique structural properties. However, the gained electrocatalytic performance of LMH-based catalysts for the OER is still far from the state-of-the-art requirements because of its finite number and poor reactivity of exposed active sites. In response, we synthesized crystal lattice distorted ultrathin cobalt hydroxide (denoted as CLD-u-Co(OH)2) nanosheets with a great number of efficient catalytic active sites through the introduction of Ga into ultrathin Co(OH)2, followed by a selective removal of Ga, denoted as the “introduction @ removal” process. As a result, the crystal lattice distortion confined inside CLD-u-Co(OH)2 generates abundant elongated Co–OOH bonds on exposed (10) facets serving as efficient catalytic active sites for the OER. Besides, the optimized amount of “introduction @ removal” of Ga (4 at%) allows for an exquisite balance between distortion engineering and electrical conductivity, synergistically. The as-prepared CLD-u-Co(OH)2 achieves an overpotential of 265 mV at a current density of 10 mA cm−−2, an unexpectedly small Tafel slope of 47 mV dec−−1, and a long-term stability (beyond 20 h) in basic media. It is mainly attributed to abundant catalytic active sites, robust reactivity per site, and good electrical conductivity. Furthermore, the green and sustainable engineering of crystal lattice distortion to improve the intrinsic electrocatalytic activity of CLD-u-Co(OH)2 nanosheets presented in this work may provide a promising strategy to design and synthesize newly highly efficient LMH-based electrocatalysts for the OER.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Tao Zhao,Dazhong Zhong,Qiang Fang,Xin Zhao,Runxin Du,Genyan Hao,Guang Liu,Jinping Li,Qiang Zhao
The rational design of metal-organic frameworks (MOFs) provides potential opportunities for improving energy conversion efficiency. However, developing efficient MOF-based electrocatalysts remains highly challenging. Herein, a strategy involving strain engineering is developed to promote the electrocatalytic performance of MOFs by optimizing electronic configuration and improving the active site. As expected, the optimized CoFe–BDC NO 2 exhibits a low overpotential of 292 mV at 10 mA cm –2 and a small Tafel slope of 31.6 mV dec –1 as oxygen evolution reaction (OER) electrocatalyst. Notably, when CoFe–BDC NO 2 is prepared on Nickel foam (NF), the overpotential is only 345 mV at 1 A cm –2 , which ensures efficient water oxidation properties. Integrating CoFe–BDC NO 2 /NF anode in membrane electrode assembly (MEA) for overall water splitting and CO 2 reduction reaction (CO 2 RR) tests, the results show that the cell voltages of CoFe–BDC NO 2 /NF are 3.14 and 3.09 V at 300 mA cm –2 (25 °C), respectively, indicating that MOFs have various practical application prospects. The research of the structure-performance relationship reveals the lattice oxygen oxidation mechanism (LOM) where the Co-O-Fe bond is formed during the OER process by changing the electronic environment and coordination structure of CoFe–BDC NO 2 , and with high valence Co as active center, which provides a deep understanding of the structure design of MOFs and their structural transformation during OER.
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高影响因子
MATERIALS CHARACTERIZATION
·
2024
·
IF 4.8
Zhaoyang Zheng,Dong Han,Hailong Zhang,Shilin Ma,An Du,Ruina Ma,Yongzhe Fan,Xue Zhao,Xiaoming Cao
The multi-layer composite filler metal (YG18 surface pre-plated with Co layer + Ag–Cu–In–Ti filler metal) was designed in this study. The mechanism of modulation of Co-depleted zone and shear strength of joints by Co plating was elucidated. A more significant Co-rich layer existed around the WC particles, meanwhile, the presence of plastical Ag–Cu–In ternary eutectic between the Ti Co layer and the YG18/TiC layer relieved the joint stress and ensured that no cracks were generated in the Ti Co layer. Under the condition that the width of the Co-depleted zone was smaller (less than 3 μm), the presence of the dispersed Ti 2 Cu particles surrounded by the plastic phases ternary eutectic and Cu [s, s] in the filler layer was superior in terms of preventing crack propagation and absorbing the stress concentration. The best modulation of the filler layer microstructure and the Co-depleted zone was achieved when the pre-plated Co layer was around 2.5 μm. The Co-depleted zone was reduced by 50%, and the shear strength of joints was increased by 49% to 291 MPa. The results of the study provide a new way to design new multilayer composite filler metal.
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高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Wei Wang,Mengrui Li,Liang Liu,Xiaoshuang Zhou,Xiankai Li,Kewei Zhang,Lina Chen,Jun Wei,Long Chen
To meet the practical demands of flexible fiber-shaped supercapacitors (FSSCs) for wearable electronics, it's crucial to develop electrodes with both high energy density and flexibility. In this work, an ultrahigh capacitance (Co,Mn)(Co,Mn) 2 O 4 /Ni(OH) 2 (CMO/Ni(OH) 2 ) fiber electrode is designed. The (Co,Mn)(Co,Mn) 2 O 4 (CMO) nanosheets possessing large specific surface area and enriched active sites, which can be served as nano-substrate for the electrodeposition of Ni(OH) 2 . This special structure facilitates the exposure of more electroactive sites and accelerate rapid electrons transfer, resulting in boosted electrochemical performance. Benefiting from these advantages, the area capacitance of the CMO/Ni(OH) 2 electrode is up to 4787.6 mF cm −2 at 1 mA cm −2 , which is approximately 15 times higher than that of the CMO (311 mF cm −2 ), and 6.7 times higher than that of the Ni(OH) 2 (718 mF cm −2 ). Coupled with activated carbon (AC) electrode, the assembled all-solid-state CMO/Ni(OH) 2 //AC FSSCs demonstrate a high energy density of 89.45 μW h cm −2 at 1505 μW cm −2 , along with great flexibility and stability. Moreover, these devices can be integrated into clothes, and electronic watch, serving as an energy supply. This work offers a novel approach to designing high-performance fiber electrode for wearable flexible energy storage devices.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Bo Liu,Yanping Zheng,Xinwei Yang,Yaping Liu,Dong Yan,Jian Li,Lichao Jia
Achieving both high catalytic performance and low thermal expansion coefficient poses a challenge for the cathode materials in protonic ceramic fuel cells (PCFCs). Most efforts are directed towards reducing the thermal expansion coefficient of Co-based materials, where often accompanies sacrifices in performance. In this article, bits of Co and Ni elements was dopped in BaPrO 3 material to adjust the electronical and proton transport ability. Triple-conducting oxide BaPr 1-x M x O 3-δ (M = Co/Ni, x = 0.1 and 0.2) was prepared as potential cathode for protonic ceramic fuel cells (PCFCs). The crystal structure, conductivity, proton uptake, proton transport, and electrochemical performance of were characterized in detail by experiment and first-principles calculations. BaPrO 3 , BaPr 0.9 Co 0.1 O 3-δ, and BaPr 0.8 Co 0.1 Ni 0.1 O 3-δ (BPCN) material present n-type conductive behavior while BaPr 0.9 Ni 0.1 O 3-δ material present p-type conductive behavior at high temperature. Among them, BPCN material presents the best performance for the highest electron and proton transport ability. The single cell with single BPCN material as cathode showed good performance with a peak power density of 1.42 W cm −2 and polarization resistance of only 0.07 Ω cm 2 at 700 °C, and there was no significant degradation within 100 h. The performance of Pr-based material is comparable to that of most Co and Fe-based materials, which gave a guide for the development of novel cathodes for PCFCs.
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高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Fang Ren,Lin Ma,Chunjie Li,Tong Wu,Jiale Zhang,Lu Pei,Yanling Jin,Zhenfeng Sun,Zhengzheng Guo,Ping Song,Penggang Ren
Metal−organic framework (MOF)-derived magnetic porous carbon not only have excellent magnetic loss, but also can construct various nanostructures through appropriate design to enhance electromagnetic waves (EMWs) absorption. Herein, magnetic porous carbon (Co/Ni@C) derived from rod-shaped Co/Ni-MOFs was selected as magnetic components and MXene was regarded as conductive materials to construct the three-dimensional porous Co/Ni@C/MXene/cellulose-derived carbon foams via a simple solution mixing-regeneration, freeze-drying process and a facile pyrolysis strategy. Due to the electric/magnetic coupling loss and the interfacial polarization loss caused by multi-interface architecture, the synthesized carbon foam achieves an absorption coefficient of 0.54 and a high EMI SE of 70.4 dB, which enhances the electromagnetic shielding performance without damaging the high absorption coefficient. This work provides a basis for the preparation of electromagnetic shielding composite materials with multi-interface structures to achieve efficient EMI SE and superior absorption coefficients.
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高影响因子
Biosensors-Basel
·
2024
·Vol. 14
·期 12
·586
·
IF 4.9
Xiaowei Fan,Guping Zhang,Xiaodi Li,Yao Wang,Yi Wang,Shilei Hao,Defang Liu
In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-C3N4/S2O82−system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant–product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the S2O82−into SO4•−and enhancing the cathodic ECL emission of g-C3N4. Moreover, the signal probe which was synthesized by coupling the 2D CdS@Co/Mo-MOF and graphitic carbon nitride (g-C3N4) achieved the generation of SO4•−in situ and reduced energy loss. The results confirmed that the ECL signal was enhanced 6.2-fold and stabilized by CdS@Co/Mo-MOF. Based on the extremely strong quenching effect of chlorpromazine hydrochloride (CPH) on this system, a “signal-off” type sensor was constructed. The sensor demonstrated excellent sensitivity and linear response to CPH concentrations ranging from 1 pmol L−1to 100 μmol L−1, with a low detection limit of 0.4 pmol L−1(S/N = 3).
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高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Siyi Pan,Pingxiao Wu,Leiye Sun,Meiqing Chen,Bo Li,Tianming Wang,Zhongbo Shang,Jiangmin Fang,Nengwu Zhu,Zhi Dang
Green rust (GR), as a vital intermediate product during the formation of various iron oxides, exists with organic matters and metals contaminants in natural environments. Understanding the effects of these natural factors on the transformation process of GR into iron oxides and the environmental behaviors of heavy metals and organic matters during process are critical for environmental quality management, but the fundamental identification of the interaction mechanisms between them and GR is still challenging. In this study, the transformation mechanisms of Co-bearing green rust (GR-Co) synthesized by co-precipitation, and the redistribution behaviors of Co(II) in an environment containing oxalic acid (OA) and citric acid (CA) were clarified. The findings indicated that OA promoted the Fe(II) dissolution and the transformation of GR-Co to goethite, while CA decreased the Fe(II) dissolution and the proportion of non-extractable Co. Furthermore, in the presence of CA, the transformation products of GR-Co were ferrihydrite, magnetite, lepidocrocite and goethite instead of only lepidocrocite and goethite. Meanwhile, CA prohibited ferrihydrite from transforming into more highly crystalline iron minerals. The finding of this study improves the understanding of the interaction mechanisms between GR-Co and organic matter, and the environmental geochemical behaviors of Co and organic carbon during the transformation processes in nature.
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高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Yilei Sun,Yao Liu,Zeda Meng,Won-Chun Oh
Different concentrations of N-doped modified Zn-based metal-organic frameworks (xN-Zn-MOFs) were prepared by a solvothermal method, as well as the successful synthesis of 0N-Zn-MOFs as well as 1N-Zn-MOFs and 2N-Zn-MOFs catalytic materials. The experimental results suggested that 2N-Zn-MOF displayed the maximum specific surface area and pore size among the three materials. The catalytic material stability and CO 2 reduction reaction (CO 2 RR) activity were investigated by linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronocurrent tests (I-T). The corresponding Faraday efficiency (FE) was calculated in conjunction with product analysis. Among the three catalytic materials, 2N-Zn-MOF had the optimal catalytic reduction performance with a maximum current density of 20 mA-cm −2 ; Its charge transfer resistance was 7.84 Ω. It was stably tested at a potential of −0.45 V (vs. RHE) for 12 h in the IT test, and its reduction products were methane (CH 4 ) and carbon monoxide (CO), with a maximum total Faraday efficiency of 30.64 %.
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