Defence Technology
·
2023
·
IF 5.1
Yujie Yan,Bo Jin,Rufang Peng
Biomass chitosan (CS) was used as a template, graphitic phase carbon nitride (g-C 3 N 4 ) with high nitrogen content and certain catalytic activity was used as a dopant, and nano-transition metal cobalt (Co) was used as a catalytic center point. The carbon aerogel (C (CS)/g-C 3 N 4 /Co) with a three-dimensional network-like structure was prepared by assembling the three materials through experimental operations such as freeze-drying and high-temperature carbonization. It was demonstrated by scanning and transmission characterization that the CS in the carbon aerogel could provide more active sites for the cobalt nanoparticles, and the doping of graphite-phase carbon nitride as a template dispersed the cobalt nanoparticles and changed the conductivity of the CS. To investigate the catalytic effect of carbon aerogel on ammonium perchlorate (AP), it was investigated by differential thermal analyzer and TG thermal analysis. This carbon aerogel was very effective in catalyzing AP, and the 10 wt% content of the catalyst reduced the AP pyrolysis peak from 703.9 to 595.5 K. And to further investigate the synergistic effect of the three materials, further carbon aerogels such as C (CS)/Co, g-C 3 N 4 /Co were prepared and applied to catalyze AP, and the same ratio reduced the AP pyrolysis peak by 98.1 °C and 97.7 °C. This result indicates a synergistic effect of the assembly of the three materials.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2018
·
IF 1.911
Fang Wang,Jian Yuan,Qian Zhang,Siqian Yang,Shaohua Jiang,Chaobo Huang
Poly (lactic-co-glycolic acid) (PLGA) nanoparticles are an ideal paclitaxel (PTX)-carrying system due to its biocompatibility and biodegradability. But it possessed disadvantage of drug burst release. In this research, a layer-by-layer deposition of chitosan (CS) and sodium alginate (ALG) was applied to modify the PLGA nanoparticles. The surface charges and morphology of the PLGA, PLGA/CS and PLGA/CS/ALG particles was measured by capillary electrophoresis and SEM and TEM, respectively. The drug encapsulation and loading efficiency were confirmed by ultraviolet spectrophotometer. The nanoparticles were stable and exhibited controlled drug release performance, with good cytotoxicity to human lung carcinoma cells (HepG 2). Cumulatively, our research suggests that this kind of three-layer nanoparticle with LbL-coated shield has great properties to act as a novel drug-loaded system.
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PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Huanhuan Li,Wenhui Geng,Zhixiong Qi,Waqas Ahmad,Suleiman A. Haruna,Quansheng Chen
In this work, a stimuli-responsive SERS biosensor was fabricated for tetracycline (TTC) by “signal-on” strategy using (EDTA)-driven polyethyleneimine grafted calcium carbonate ( [email protected] 3 ) microcapsule and chitosan-Fe magnetic microbeads ( [email protected] ). Initially, aptamer conjugated magnetic-bead [email protected] @Apt with superparamagnetism and excellent biocompatibility was employed as capture probe, which facilitated the rapid and easy magnetic separation. Subsequently, the PEI cross-linked layer and aptamer network layer were constructed onto the outer layer of CaCO 3 @4-ATP microcapsule to form sensing probes ( [email protected] 3 @ [email protected] ) via the layer-by-layer assembly method. In the presence of TTC, a sandwich SERS-assay was exploited by aptamer recognition induced target-bridged strategy. When the solution of EDTA was added, the core layer of CaCO 3 would be dissolved quickly, destroying the microcapsule to release 4-ATP. The released 4-ATP could be quantitatively monitored by dripping the supernatant onto the [email protected] SERS platform, resulting in a strong Raman “signal-on”. Under the optimal conditions, a good linear relationship was established with a correlation coefficient ( R 2 ) of 0.9938 and a LOD of 0.03 ng/mL. Additionally, the application capacity of the biosensor to detect TTC was also affirmed in food matrixes, and the results were consistent with the standard ELISA method ( P > 0.05). Hence, this SERS biosensor affords extensive application prospects for TTC detection with multiple merits such as high sensitivity, environment friendliness, and high stability.
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PubMed
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International Journal of Polymeric Materials and Polymeric Biomaterials
·
2022
·
IF 3.221
Jia Chen,Shuying Han,Mengjia Huang,Jie Li,Mi Zhou,Jianguo He
For treating tympanic membrane (TM) perforation, a scaffold is helpful for TM repair in myringoplasty. In this work, the green-crosslinked method respectively based on four kinds of polybasic organic acids (maleic acid, tartaric acid, citric acid, and malic acid) has been used to crosslink the composite nanofibrous membranes of chitosan (CS) and poly(vinyl alcohol) (PVA) for preparing the TM scaffold. The crosslinked membranes exhibit nanofibrous morphology, good physical properties, and excellent biocompatibility to promote TM cell proliferation. To summarize, the polybasic organic acids are effective and nontoxic crosslinked agents to prepare composite CS/PVA nanofiber membranes for TM scaffold.
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Water
·
2022
·Vol. 14
·期 17
·2619
·
IF 3.53
Liqiang Tan,Yuxiang Wang,Song Wang,Caijin Wu,Dong Li,Yisheng Chen,Haocheng Wang
Humic substances have a potential role in the fate and transport of toxic metal ions in the environment due to their colloidal characteristics and abundant surface functional groups. Batch techniques (DLS, EPM, FT-IR and fluorescence EEM) were developed to assess the aggregation mechanisms of humic acid (HA) reacting with Cs+or Co2+electrolyte ions in this work. The kinetic experimental results indicated that a much lower Co2+ion concentration (0.03–1.50 mmol/L) induced rapid aggregation of HA compared to that of Cs+(3.0–15 mmol/L), and the divalent Co2+ion was far more effective in enhancing HA aggregation than monovalent Cs+. The aggregation kinetics of HA were also found to be pH-dependent, and a much lower pH condition (pH 5.0) caused more rapid aggregation (the largest hydrodynamic diameter of ~3000 nm) compared to those at pH 7.0 (the largest hydrodynamic diameter of ~2000 nm). Positively charged metal ions in the solution can lower the electrostatic repulsive force between HA molecules through charge neutralization, thus leading to the rapid aggregation of HA aggregates. Furthermore, the carboxylic and phenolic groups on the HA surface were also involved in the aggregation reaction to form inner complexes and accelerate the aggregation process.Keywords:humic acid;aggregation;metal ions;kinetics;spectrum analysis
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Materials Today Communications
·
2022
·
IF 3.662
Jiarui Lu,Ruoman Xu,Yanan Chen,Laiting Chan,Xin Feng,Lichieh Lin,Yichen Yao,Xiaoli Hu,Xiaolei Zhang
Bone possesses the intrinsic capacity for regeneration as part of the repair process in response to injury. However, bone repairing capacity can be affected by many conditions, including genetic disorders. The development of a smart biomaterial to improve bone regeneration for patients with impaired osteogenesis remains a challenge. In this study, a thermosensitive hybrid hydrogel scaffolds, which was based on collagen I (Col-Ⅰ) and chondroitin sulfate (CS) and crosslinked with genipin (Col-Ⅰ/CS hydrogel), was prepared. The Col-I/CS hydrogel was presented with features favoring clinical application, including injectability, mild reaction conditions, rapid cross-linking, and biocompatibility. According to the in vitro assessments, the osteogenic differentiation and biomineralization of pre-osteoblasts and bone marrow mesenchymal stem cells were promoted by the presence of Col-I/CS hydrogel, along with the enhanced molecule/protein expressions of osteogenic markers. To impair osteogenesis in vivo , the conditional knockout of Stat3 in osteoblast precursors (Osx-cre; Stat3 f/f , Stat3 CKO) was generated via the Cre-loxP recombination system using Osterix-Cre (Osx-Cre) transgenic mice. The tibial mono-cortical defect was made on both wild-type and Stat3 CKO mice. Compared with the control, the healing of bone defect was significantly improved by use of the hydrogel, including the increase of the quality and mass of bone in wildtype mice, and the improvement of the bone mass in Stat3 CKO mice. The Col-Ⅰ/CS hydrogel was able to enhance bone regeneration, even under the condition of genetically impaired osteogenesis, showing a promising potential for therapeutic application.
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JOURNAL OF ELECTRONIC MATERIALS
·
2020
·Vol. 49
·期 12
·7044-7053
·
IF 1.774
Yang Yufeng,Luo Jundong,Luo Ningqi,Wei Aixiang,Liu Jun,Zhao Yu,Xiao Zhiming
In this paper, we report the effect of the Cs + fraction x on the structure, morphology and optical properties of mixed organic–inorganic cation Cs x MA 1− x PbI 3 absorption layers prepared using an anti-solvent-assisted one-step solution deposition method in an ambient environment. By changing the ratios of cesium iodide (CsI) to methyl iodide (MAI) in the precursor solution, the Cs + fraction x varies from 0 to 1. The hole-transporting-material (HTM)-free perovskite solar cells (PSCs) based on the Cs x MA 1− x PbI 3 absorption layers were fabricated in ambient air, and their photovoltaic performance was studied. Results indicate that when the Cs + fraction x is less than 0.3, Cs + ions mainly replace a fraction of MA + ions in the MAPbI 3 lattice and do not lead to a change in the crystal structure of the MAPbI 3 . When the Cs + fraction x is between 0.3 and 0.7, one part of Cs + ions incorporated in the MAPbI 3 lattice replaces MA + ions (α-phase), while the other part forms a yellow photovoltaic-inactive δ-CsPbI 3 phase. The Cs x MA 1− x PbI 3 films with x ≥ 0.8 contain much of the photovoltaic-inactive δ-CsPbI 3 phase. The band gap of the Cs x MA 1− x PbI 3 films increases from 1.53 eV to 1.65 eV with the increase of the Cs + fraction x . The PSCs based on the Cs 0.1 MA 0.9 PbI 3 films exhibit remarkable improvement in device efficiency and stability.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Zhijun Guo,Guoliang Zhang,Lei Wang,Ping Li,Chunshan Li
To meet the increasing demand for methyl methacrylate, a series of Fe modified Cs–P/γ-Al2O3 catalysts were developed through the impregnation method and tested for the aldol condensation of methyl propionate with formaldehyde in a fixed-bed reactor. Through various characterization studies, the physicochemical properties of the catalysts were systematically studied, especially the relationship between the number of the acid sites and catalytic activity. The number of medium acid sites was increased effectively by the addition of Fe, and the catalytic selectivity was improved consequently. Moreover, the reaction conditions were also optimized, and the life span of the optimized catalyst was evaluated. The Cs–P–0.1Fe/γ-Al2O3 showed excellent reusability during a 260 h lifetime experiment.
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Materials
·
2020
·Vol. 13
·期 6
·1279
·
IF 3.057
Yanqin Xu,Liyue Xiao,Yating Chang,Yuan Cao,Changguo Chen,Dan Wang
In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.Keywords:mesoporous silica nanoparticles;double response;drug delivery;drug release
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Xin Liu,Jihui Wang,Wenbin Hu
The superparamagnetic Fe 3 O 4 /CS/inhibitor nanocomposite was synthesized by using ionic gel method with Fe 3 O 4 as superparamagnetic core, chitosan as nanocarrier and molybdate (MoO 4 2− ) and benzoate (C 6 H 5 COO − ) working as loaded inhibitors. The morphology, structure and magnetic property of nanocomposite were characterized by transmission electron microscopy , X-ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer . The release behavior of nanocomposite with and without external magnetic field (“no MF” mode and “MF ON” mode) was conducted by UV–vis spectroscopy, and the corrosion inhibition performance of nanocomposite for carbon in 3.5% NaCl solution was investigated by polarization curve and electrochemical impedance spectrum methods. The results show that the obtained Fe 3 O 4 /CS/inhibitors was in a well-defined core-shell structure with MoO 4 2− and C 6 H 5 COO- loaded flake-like chitosan shell stacking closely to Fe 3 O 4 surface. Under no MF mode, the release behavior of nanocomposite was mainly ion exchange and Fickian diffusion mechanism. Under MF ON mode, the swelling of polymer chains and diffusion between magnetic nanoparticles were involved apart from the ion exchange and Fickian diffusion mechanism. With the addition of nanocomposite inhibitors in NaCl solution, the charge transfer resistance and inhibition efficiency of steel increased firstly and then decreased with the prolonging of immersion time. The highest inhibition efficiency of nanocomposite inhibitors in NaCl solution under on MF and MF ON mode was located in 30 min and 90 min respectively. The inhibition of nanocomposite for carbon steel in NaCl solution is resulting from the reduction of aggressive Cl- concentration in the solution due to the ion exchange between Cl- ions in solution and MoO 4 2− and C 6 H 5 COO- ions in the nanocomposite, and the formation of ferric/ferrous molybdate, ferric/ferrous benzoate and basic ferric benzoate inhibition films on steel. This novel as-prepared composite owns superior loading capacity of inhibitors and its preparation process is especially simple relative to other nanocomposites in previous reported works.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 31
·期 2
·1547-1553
·
IF 2.195
Jiang Wenya,Peng Cong,Yuan Yanyu,Yang Shibo,Li Xifeng
In this paper, the indium gallium zinc oxide (IGZO) thin-film transistors (TFTs) with chitosan (CS) gate dielectric are prepared by the conventional photolithography technique on a pilot line. As-prepared devices on 200 × 200 mm substrate is very uniform, and have good performance of high on/off drain current ratio ~ 10 −6 , low subthreshold swing ~ 0.24, low-threshold voltage ~ 0.20 V and high-visible light transmittance > 90%. The glucose oxidase is drop-cased on the CS gate dielectric surfaces to make fully transparent CS-based IGZO TFTs with sensitivity to glucose. It is found that the current noticeably changes with increasing glucose concentrations. Herein, the glucose detection range from 0.5 to 30 mM covers the normal range of human blood glucose concentration. Moreover, the response time for glucose sensing is < 10 s, which is effective in detecting glucose. The results suggest that the CS-based IGZO TFTs can be used to detect glucose and provides a simple process to achieve low-cost- and larger-area fabrication of biosensors.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Fan Wang,Lijuan Zhang,Yeying Wang,Xijian Liu,Sohrab Rohani,Jie Lu
The graphene oxide (GO) functionalized by Fe 3 O 4 @SiO 2 @CS-TETA nanoparticles, Fe 3 O 4 @SiO 2 @CS-TETA-GO, was firstly fabricated in a mild way as a novel adsorbent for the removal of Cu(II) ions and methylene blue (MB) from aqueous solutions. The magnetic composites showed a good dispersity in water and can be conveniently collected for reuse through magnetic separation due to its excellent magnetism. When the Fe 3 O 4 @SiO 2 @CS- TETA-GO was used as an absorbent for the absorption of MB and Cu(II), the adsorption kinetics and isotherms data well fitted the pseudo-second-order model and the Langmuir model, respectively. Under the optimized pH and initial concentration, the maximum adsorption capacity was about 529.1 mg g −1 for MB in 20 min and 324.7 mg g −1 for Cu(II) in 16 min, respectively, exhibiting a better adsorption performance than other GO-based adsorbents reported recently. More importantly, the synthesized adsorbent could be effectively regenerated and repeatedly utilized without significant capacity loss after six times cycles. All the results demonstrated that Fe 3 O 4 @SiO 2 @CS-TETA-GO could be used as an excellent adsorbent for the adsorption of Cu(II) and MB in many fields.
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