Food Chemistry-X
·
2023
·
IF 6.1
Yiwei Tang,He Meng,Wenxiu Wang,Yang Song,Shuo Wang,Zhuanying Li,Xianghong Wang,Xuelian Hu
An innovative core–shell magnetic molecularly imprinted polymers, Fe 3 O 4 @SiO 2 @MIPs, was elaborately tailored for specific separation and enrichment of olaquindox (OLA) and its metabolic marker methyl-3-quinoxaline-2carboxylic acid (MQCA). Herein, benefiting from the combination of functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 ) and MIPs, Fe 3 O 4 @SiO 2 @MIPs not only possessed favorable magnetic properties and stability, avoiding tedious sample pretreatment process, but also demonstrated exceptional selective recognition ability and adsorption capacity, suppressing influence of coexisting interfering substances. Encouraged by prominent merits, Fe 3 O 4 @SiO 2 @MIPs-based magnetic solid phase extraction with HPLC method was developed, realizing simultaneous measurement of OLA and MQCA. Under optimal conditions, excellent linear ranges of 0–100 μg/L with detection limit of 0.175–0.271 μg/L were obtained. The proposed method was finally utilized for determination of OLA and MQCA in fish muscle and milk samples with satisfactory recoveries (80.56–95.26%) and relative standard deviation below 8.1%, furnishing a reliable and sensitive strategy for enrichment and detection residual veterinary drugs in food samples.
研究领域:
分析化学
·
食品安全
·
兽药残留检测
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 28
·17151-17157
·
IF 10.7
Zhenli Sun,Ning Wang,Yiyan Zhang,Xunlong Ji,Zijin Hong,Dan Xie,Wentao Zhang,Wenjing Liu,Jingjing Du
Surface-enhanced Raman scattering (SERS) is a pivotal analytical technique in sensing, yet it grapples with challenges such as reproducibility, substrate stability, and hotspot uniformity. The use of highly effective external field nanocomposites facilitates the dynamic manipulation of “hotspots”—the nanoscale gaps between metal nanoparticles—which is critical for SERS enhancement. The gap between 4-mercaptopyridine-modified (4-MPY) Fe3O4@SiO2@Au nanocomposites (FA) can be precisely reduced by applying an external magnetic field, resulting in up to a 30-fold increase in SERS signal intensity and an 8–39 times increase in the enhancement factor (EF). This approach markedly enhances SERS signal uniformity, demonstrated by the relative standard deviation of the EF dropping from 59.15–9.44% to 28.70–1.14%. By systematically studying the correlations between the SERS EF and the external-magnetic-field strength, hotspot density, and probe molecular density, sensitive magnetic, SERS platforms are established. The optimal hotspots occur in the magnetic field of 80 to 120 mT among the FA-4MPY nanocomposites, as validated by COMSOL finite-element analysis simulations. These findings offer a nuanced understanding of magnetic SERS hotspot tuning, paving the way for precise and improved molecular sensing.
研究领域:
分析化学
·
纳米技术
·
材料科学
·
光谱学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Qiuhua Wu,Yuhong Song,Qianqian Wang,Weihua Liu,Lin Hao,Zhi Wang,Chun Wang
A magnetic o -hydroxyazobenzene (M-HAzo) porous organic polymer was facilely prepared by a green azo coupling reaction in aqueous solution. The prepared M-HAzo was applied as a new adsorbent for the first time to pre-concentrate phthalate esters (PAEs) from plastic bottled juice, followed by their determination with high performance liquid chromatography-ultraviolet detection. The effects of various parameters, i.e., the mass ratio of the Fe 3 O 4 @SiO 2 to HAzo, extraction time, ionic strength, pH of the sample, desorption conditions were optimized. Under the optimized conditions, the M-HAzo based method exhibited good performance in terms of linear range (0.3–50.0 μg L −1 ), detection limit (0.08–0.50 μg L −1 ), accuracy (recovery of 78.0–115.0%) and repeatability (relative standard deviation of 2.9–7.8%). This work provides a sensitive method for analysis of PAEs at trace levels in drinks, which is featured with high sensitivity, simple operation and environmentally-friendly merit and will have a promising potential in analysis of other organic pollutants.
研究领域:
分析化学
·
环境科学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2022
·
IF 3.898
Yiqing Chen,Xin Huang,Suping Ding,Yaoguang Feng,Na Wang,Hongxun Hao
The precise control of active pharmaceutical ingredient (API) crystal nucleation and polymorphism is a key consideration in pharmaceutical manufacturing. In this study, tunable nanoparticles were developed to regulate the nucleation process of coumarin . Magnetic silica nanoparticles with four different functional groups ( NH 2 , COOH, SH, NCO) were prepared and coated on the substrate for inducing the crystallization of coumarin. Confined melt crystallization and microspacing sublimation crystallization methods were used to investigate the regulation mechanism. The results indicated that three metastable forms of coumarin can be obtained as pure components based on the combined influence of crystallization methods and functionalized nanoparticles. Form II could be selectively obtained by microspacing sublimation crystallization on Fe 3 O 4 @SiO 2 SH substrates, and Form IV could be obtained by confined melt crystallization on Fe 3 O 4 @SiO 2 NCO substrates. Form III could be obtained by further heating Form IV crystals to 52 °C on Fe 3 O 4 @SiO 2 NCO substrates. Moreover, the polarized light microscopy results also indicated that the introduction of nanoparticles could also increase the stability of the metastable crystalline forms of coumarin. Finally, the diffusion and surface dynamics during nanoparticle induced crystallization were comparatively investigated and the corresponding polymorphic selectivity mechanism was proposed.
研究领域:
药学
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材料科学
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纳米技术
·
化学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Ying Chen,Qiang Zhang,Jian Shen,Zhiran Liu,Xiaoyu Cui,Li Ma,Yuanyi Zheng,Longchen Wang,Tao Ying
Chemotherapy is the main clinical treatment for ovarian cancer, but still faces challenges of low drug targeting efficiency and insufficient drug permeability. Drug-loaded nanoparticle collectives, which are actuated by magnetic field, could be targeted to a designated location and achieve targeted drug delivery. In this work, we report a strategy that utilizes magnetic mesoporous silica nanoparticles loaded with cis -diaminodichloroplatinum (Fe 3 O 4 @SiO 2 -CDDP) for targeted delivery of chemotherapeutic drugs and enhances penetration into deep tumors. The Fe 3 O 4 @SiO 2 -CDDP collectives actively moved to the target tumor site, and this movement was regulated by a magnetic actuation system. Under the action of a torque-force hybrid magnetic field (TFMF), Fe 3 O 4 @SiO 2 -CDDP could further penetrate into the interior of tumors and achieve pH-responsive drug release in the tumor environment. The feasibility of this strategy was verified in three-dimensional cell spheres in vitro and in a tumor-bearing mouse model in vivo. This magnetically actuated nanoparticle collectives enhanced drug penetration strategy provides a new paradigm for targeted drug delivery and potentiated tumor therapy.
研究领域:
肿瘤学
·
纳米技术
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Yuqi Zhuang,Sinuo Li,Eldon R. Rene,Shuoyu Dong,Weifang Ma
Porous organic polymers (POPs) present superior adsorption performance to steroid endocrine disruptors . However, the effective recovery and high cost have been a big limitation for their large-scale applications. Herein, magnetic azo-linked porous polymers (Fe 3 O 4 @SiO 2 /ALP-p) were designed and prepared in a green synthesis approach using low-price materials from phloroglucinol and pararosaniline via a diazo-coupling reaction under standard temperature and pressure conditions, which embedded with Fe 3 O 4 @SiO 2 nanoparticles to form three-dimensional interlayer network structure with flexible-rigid interweaving. The saturated adsorption capacity to bisphenol-A (BPA) was 485.09 mg/g at 298 K, which increased by 1.4 times compared with ALP-p of relatively smaller mass density. This enhanced adsorption was ascribed to increment from surface adsorption and pore filling with 2.3 times of specific surface area and 2.6 times of pore volume, although the total organic functional groups decreased with Fe 3 O 4 @SiO 2 amendment. Also, the adsorption rate increased by about 1.1 and 1.5-fold due to enhancement in the initial stage of surface adsorption and subsequent stage pore diffusion, respectively. Moreover, this adsorbent could be used in broad pH (3.0–7.0) and salinity adaptability (<0.5 mol/L). The loss of adsorption capacity and magnetic recovery were lower than 1.1% and 0.8% in each operation cycle because of the flexible-rigid interweave . This excellent performance was contributed by synergistic effects from physisorption and chemisorption , such as pore filling, electrostatic attraction, π–π stacking, hydrogen bonding, and hydrophobic interaction. This study offered a cost-effective, high-performing, and ecologically friendly material along with a green preparation method.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2022
·
IF 12.545
Xueqin Huang,Zhubao Zhang,Lingzhi Chen,Yongjian Lin,Runmin Zeng,Jun Xu,Shanze Chen,Jianglin Zhang,Huaihong Cai,Haibo Zhou,Pinghua Sun
Ultra-sensitive detection of pathogenic bacteria is of great significance in the early stage of bacterial infections and treatment. In this work, we report a novel strategy using multifunctional Au nano-bridged nanogap nanoparticles (Au NNPs)-based sandwich nanocomposites , that made of Concanavalin A-conjugated Fe 3 O 4 @SiO 2 NPs (ConA-Fe 3 O 4 @SiO 2 NPs)/bacteria/aptamer-modified Au NNPs (apt-Au NNPs), for bacteria discrimination and quantitative detection by surface-enhanced Raman scattering (SERS) and inductively coupled plasma mass spectrometry (ICP-MS), and subsequently photothermal antibacterial assay. The sandwich nanocomposite consists of ConA-Fe 3 O 4 @SiO 2 NPs to magnetically enrich and photothermal killing bacteria , and dual-signal tags of apt-Au NNPs for both SERS sensing and ICP-MS quantification. This strategy can specifically distinguish different kinds of pathogenic bacteria, and provided a good linear relationship of Staphylococcus aureus ( S. aureus ) in the range from 50 to 10 4 CFU/mL with a detection limit of 11 CFU/mL, as well as realized ultralow amounts of bacterial detection in serum sample with high accuracy. Based on the quantitative detection, high antibacterial efficiency was monitored by ICP-MS. Overall, the established method combines bacteria discrimination, quantitative detection, and photothermal elimination with a simple and rapid process, which provides a novel way for the early diagnosis and treatment of bacterial infection.
研究领域:
纳米技术
·
分析化学
·
生物医学工程
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Fanshan Feng,Wei Xiang,Han Gao,Yanan Jia,Yuansong Zhang,Lingshu Zeng,Jiaxin Chen,Xianzhi Huang,Li Xu
Mulberry twigs are an important source of α-glucosidase inhibitors. To date, research studies on α-glucosidase in mulberry twigs have mainly focused on alkaloids such as 1-deoxynojirimycin (DNJ). Preliminary studies have shown that there may be more active nonalkaloid α-glucosidase inhibitors in mulberry twigs. In this study, we immobilized α-glucosidase on Fe3O4@SiO2 for the first time and rapidly screened four nonalkaloid α-glucosidase inhibitors (kuwanon G, kuwanon C, kuwanon H, and morusin) using ligand fishing technology with ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) from the mulberry twig extract of Jialing 20, the excellent artificial triploid variety of mulberry cultivated extensively in Southwest China. The half maximal inhibitory concentrations (IC50) of kuwanon H and kuwanon G were 2.82 ± 0.68 and 2.83 ± 0.31 μM, respectively, with better inhibition activity than that of DNJ (with an IC50 of 7.04 ± 0.82 μM). Meanwhile, the molecular docking results showed that the action sites of these two isopentenyl flavonoids on α-glucosidase were different from that of DNJ. In brief, this work is beneficial to discovering new α-glucosidase inhibitors from mulberry twigs quickly and accurately and provides a theoretical basis for the mulberry twig extract as a functional food or a natural hypoglycemic drug source, as well as a reference for directional breeding of mulberry, which greatly improves the exploitation and utilization value of mulberry twigs as an agricultural byproduct in the fields of agricultural production, functional food, and natural medicine.
研究领域:
药理学
·
分析化学
·
天然产物
·
农业科学
·
功能食品
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Xu-Hui Sun,Jiang Wu,Ying-Chun Yu,Zheng-Chao Shen,Muhammad Mujahid Ali,Zhen-Xia Du
The disinfection of drinking water is an important treatment process for protecting consumers from potential waterborne infectious and parasitic pathogens. However, the disinfection process may introduce disinfection by-products (DBPs), which are harmful to human health. It is necessary to control the contents of DBPs and their precursors. In this study, we synthesized Fe 3 O 4 @SiO 2 @PDA@NH 2 -MIL-53(Fe) magnetic composites via layer-by-layer self-assembly method. This green and eco-friendly materials were thoroughly characterized and used to adsorb the highly toxic DBPs, 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) and its precursors, bisphenol A and phenol . The maximum adsorption quantity of Fe 3 O 4 @SiO 2 @PDA@NH 2 -MIL-53(Fe) was up to 109.3 mg g -1 for 2,6-DCBQ, 82.4 mg g -1 for bisphenol A, and 64.8 mg g -1 for phenol. The saturation magnetization value of Fe 3 O 4 @SiO 2 @PDA@NH 2 -MIL-53(Fe) was 39 emu g -1 , which could be fast magnetic separated. In addition, the adsorption process was fitted into the pseudo-first-order adsorption model and Freundlich equation, in which π-π interaction, hydrogen bond and pore-filling were the main adsorption mechanisms. After 5 cycles, the adsorption rate of the as-synthesized magnetic composites is still more than 80%. Due to its fast and strong adsorption capability, excellent stability, and easy separation ability from water, Fe 3 O 4 @SiO 2 @PDA@NH 2 -MIL-53(Fe) magnetic composites have the potential to be a promising adsorption material for removing the disinfection by-products in future.
研究领域:
环境科学
·
材料科学
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Yunjia Yang,Man He,Beibei Chen,Bin Hu
A novel adsorbent of magnetic graphene oxide (GO) chemically modified by cysteamine hydrochloride (Fe 3 O 4 @SiO 2 /GO-NH 2 ) through thiol-ene click chemistry reaction was synthesized. The prepared Fe 3 O 4 @SiO 2 /GO-NH 2 exhibit selective adsorption to As(V) with high adsorption capacity (52.66 mg g −1 ). Taking Fe 3 O 4 @SiO 2 /GO-NH 2 as the adsorbents, a new method of magnetic solid phase extraction (MSPE) combined with graphite furnace atomic absorption spectrometry (GFAAS) was developed in determining trace-level inorganic arsenic species (As(III) and As(V)) in environmental water and bottled water samples. Various experimental parameters affecting the MSPE have been optimized. Under the optimal experimental parameters, the limit of detection of the established method for As(V) was 1.02 ng L −1 , the relative standard deviations were 7.9% (intra-day, c = 50 ng L −1 , n = 5) and 4.6% (inter-day, c = 50 ng L −1 , n = 7), respectively, and the enrichment factor of the method was 392. GBW08666 and GBW08667 (certified reference material) were analyzed to confirm the accuracy of the method, and the results were matched well with the certified values. The established MSPE-GFAAS method was successfully applied in analyzing trace/ultratrace As(III) and As(V) in real water samples.
研究领域:
环境化学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 40
·24843-24851
·
IF 3.361
Pengfei Chen,Shun Yao,Dongmei Zheng,Zhiyuan Xu,Jinling Yu,Tingting Liang
Herein, a novel temperature-sensitive magnetic composite (Fe3O4@SiO2@P(NIPAM-co-VI)/Cu2+) with a uniform core–shell–shell structure was successfully prepared via a layer-by-layer method. The resulting magnetic composite revealed good magnetic properties and remarkable affinity to papain with a maximum adsorption capacity of 199.17 mg g−1. The adsorption equilibrium data fitted the pseudo-second-order kinetic and Freundlich models well, and the major thermodynamics parameters indicated that adsorption was an endothermic and spontaneous process. Fe3O4@SiO2@P(NIPAM-co-VI)/Cu2+ could thermally protect papain, which is attributed to the reversible hydrophilic–hydrophobic transition of the composite at temperatures below and above the lower critical solution temperature. More importantly, the magnetic composite could be recycled at least six times without a remarkable loss in its adsorption capacity, and the process of adsorption and elution had no significant effect on the activity and structure of papain. This work could provide a novel separation method for papain without loss of its activity.
研究领域:
材料科学
·
化学工程
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR RECOGNITION
·
2020
·Vol. 33
·期 8
·e2844
·
IF 2.214
Lu Wang,Yanhong Wang,Binbin Zhou,Ming Zhong
A novel type of magnetic molecularly imprinted polymers (MMIP) as the solid-phase extraction sorbent was prepared, which can extract effectively the allocryptopine from the waster of Macleaya cordata (Willd) R . Br . In this study, MMIP was synthesized by using Fe 3 O 4 @SiO 2 , 4-vinyl-pyridine, ethylene glycol dimethacrylate, and allocryptopine, and these ingredients worked as magnetic core, functional monomer, cross-linker, and template, respectively. Concluded by the calculation of Gaussian 09 software, different ratio models of 4-vinyl-pyridine and allocryptopine were simulated, and the optimal ratio was 1:5 and the energy was −2205.34 kJ/mol. Transmission electron microscopy, vibration sample magnetometry, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis were used to determine the morphology and structure of MMIP. Furthermore, the results of adsorption experiments indicated that MMIP had high selectivity, excellent recyclability, and good adsorption performance (9.86 mg/g, 298 K). The adsorption process was consistent with the Langmuir adsorption isotherm ( R 2 > 0.98, 298 K) and pseudo-second-order kinetics model ( R 2 > 0.99, 298 K). After six times adsorption-desorption experiments, the adsorption amount of MMIP only reduced to 8.5%. In the experiments of selective adsorption, MMIP has better adsorption properties for allocryptopine (ALL, C 21 H 23 NO 5 ) than those having the same functional group. The limit of detection (LOD) was 0.4 μg/mL. The relative standard deviation ranged from 0.09% to 0.72%. The recovery of allocryptopine in samples ranged from 93.60% to 106.19%. In addition, the synthesized complex had a certain adsorption effect on allocryptopine separating from the wastewater of Macleaya cordata (Willd) R . Br .
研究领域:
环境科学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）