ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Wenjun Sun,Yuanna Zhang,Zedong Lu,Yanchu Ke,Xuelin Wang,Jing Wu
Organic pollutants are toxic and are present in drinking water. The conventional processes of most water plants can basically meet the discharge standard. However, based on the improvement of the objective of organic pollutants control and the constant change of water characteristics, the results may not be ideal. This study evaluates the effectiveness of different treatments such as microfiltration, nanofiltration, reverse osmosis, activated carbon, and ultraviolet irradiation/H2O2 in terms of the removal of organic pollutants. Among the DOM results, nanofiltration, reverse osmosis, and activated carbon showed optimal performance due to the characteristics of processes and the compound properties. However, the risks of low-molecular-weight organic residue and byproduct formation are still present. Thirty-nine species of synthetic organic compounds (SOC) were qualitatively and semiquantitatively analyzed. Different technologies showed varying removal capabilities for SOC based on their properties and many substances coexisted leading to abnormal removal performances. These residual organics showed the characteristics of lower molecular weight, more hydrophilicity, further unknown impacts, and with risk of DBPs. Based on the above insights, possible methods can be rationally chosen for on-demand decontamination of organics in unconfined aquatic environment and long-time impact on water characteristics and human health also should be considered.
研究领域:
环境科学
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水处理工程
·
公共卫生
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Kudakwashe Meki,Zhuowen Wang,Baojian Jing,Shan Qiu,Fengxia Deng
In the face of challenges presented by rapid urbanization and industrialization, the surge in dye wastewater has emerged as a prominent concern. This study introduces a pioneering novel approach aimed at augmenting the electrocatalytic efficiency of O 2 reduction to H 2 O 2 through the modification of a hybrid catalyst with dimethyl sulfoxide (DMSO) to construct gas diffusion electrodes (GDEs). The hybrid catalyst, consisting of carbon black and DMSO, was meticulously fabricated, and its electrocatalytic activity was thoroughly investigated using various characterization techniques. Within 180 min, the 3 %DM cathode showcased efficient H 2 O 2 generation, reaching 850 μM, and remarkable oxygen utilization, achieving 60.49 %. Intriguingly, the fabricated 3 %DM hybrid catalyst maintained a three-phase interfacial (TPI) due to its super-hydrophilic property. This study elucidates the pivotal role of DMSO in enhancing the performance of hybrid catalysts for O 2 reduction to H 2 O 2 . The insights provide valuable perspectives into the development of efficient and resilient electrochemical systems for sustainable energy conversion and environmental applications.
研究领域:
环境科学
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电化学
·
催化
·
废水处理
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Chan Song,Haibo Liu,Linlin Zhang,Jie Wang,Chenglong Zhao,Qinyuan Xu,Cheng Yao
Nanozymes with high catalytic performance play a vital role in the construction of advanced biosensors for the signal detection and analysis of complicated biological samples. Herein, FeS nanoparticles (NPs) embedded in 2D carbon nanosheets (denoted as [email protected] ) are demonstrated to serve as excellent nanozymes with high catalytic activity . Notably, the introduction of mesoporous carbon substrate could effectively improve the enzymatic peroxidase-like catalytic ability of embedded FeS nanozymes, especially in the fluorescence catalytic system . Based on the high peroxidase-like activity of proposed [email protected] nanozymes, a facile method was then designed for H 2 O 2 assay with detection limit as low as 0.78 μM and 0.86 μM for the colorimetric and fluorescence method , respectively. The oxidation of the colorimetric and fluorescence substrates could be ascribed to the hydroxyl radical (·OH) produced by catalytic reaction of H 2 O 2 with [email protected] nanozymes. Thus, the [email protected] nanozymes-based H 2 O 2 sensing platform was further constructed to evaluate the antioxidant capacity of glutathione (GSH), cysteine (Cys), and gallic acid (GA). Notably, [email protected] nanozymes can keep the functionality in a broad pH range (2.0 ~ 9.0) for catalytic reaction, delivering a great potential in the fabrication of advanced biosensors.
研究领域:
生物化学
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纳米医学
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分析化学
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产品关联
DOI
高影响因子
eFood
·
2024
·Vol. 5
·期 3
·e147
·
IF 4
Biyang Zhu,Liuting Li,Kseniya Hileuskaya,Baojun Xu,Lijun You
Although ultraviolet (UV)/H 2 O 2 treatment could effectively improve the bioactivities of polysaccharides, the relationship between free radical-induced structural changes and the bioactivities of products remains unknown. Therefore, this work investigated the changes in the chemical characteristics and chain conformations of degraded dextrans by the UV/H 2 O 2 system as well as their antioxidant and anti-inflammatory activities. The apparent degradation efficiencies of dextrans under different UV/H 2 O 2 parameters were first investigated. UV/H 2 O 2 treatment effectively destroyed the pyranose rings and glycosidic bonds of dextrans and significantly improved their uronic acid and carboxy contents. Furthermore, conformational studies revealed that besides the rapid decrease in the molecular weight, the compact spherical conformation of dextrans was gradually depolymerized into the flexible random coil conformation. Moreover, the significant antioxidant and anti-inflammatory activities of the degraded dextrans were mainly attributed to their more extended random coil chains, increased quantity of reducing groups, and lower molecular sizes. This study contributes to investigating the structure–activity relationship of polysaccharides prepared by free radicals-mediated degradation.
研究领域:
化学
·
药学
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生物化学
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产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2021
·Vol. 18
·期 4
·e2001007
·
IF 2.408
Yan Zhao,Yu Wang,Min Zhang,Yugang Gao,Zhaowei Yan
Ginsenosides (20 S )-Rg3 and (20 R )-Rg3 are famous rare ginsenosides from red ginseng, and their configurations in C-20 are different. This study aimed to investigate the protective mechanism of ginsenosides (20 S )-Rg3 and (20 R )-Rg3 on H 2 O 2 -induced H9C2 cells and compare their activity. The results showed that the ginsenosides (20 S )-Rg3 and (20 R )-Rg3 could increase the cell activity and the levels of GSH-Px, SOD and CAT, and decrease activities of LDH, MDA and ROS. Further studies showed that ginsenosides (20 S )-Rg3 and (20 R )-Rg3 could prevent oxidative stress injury of H9C2 cells by H 2 O 2 through the Keap-1/Nrf2/HO-1 pathway. But the ML385 counteracts these effects. Interestingly, among these results, ginsenoside (20 R )-Rg3 was superior to (20 S )-Rg3, indicating that ginsenoside (20 R )-Rg3 have a stronger effect of antioxidative stress. This study reflected that ginsenoside (20 R )-Rg3 could be used as a potential Nrf2 activator and a safe effective Chinese herbal monomer in the treatment of cardiovascular disease.
研究领域:
药理学
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心脏病学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Wei Li,Lei Zhang,Kajia Wei,Xu Yin,Hongwei Zhu,Siyuan Cao,Qi Zhang,Weiqing Han,Xiaoyuan Zhang
Appropriate tuning of the nonradical pathway in the heterogeneous Fenton process is important for enhancing its anti-interference ability in wastewater treatment. However, the difficulty in O–H bond cleavage of H 2 O 2 hinders its oxidation routine for nonradical production. Herein, a charge-regulating linkage M–S–Fe (M = Co, Ni, Zn) with S-bridged asymmetric dual-metal centers was established on multiwall carbon nanotubes, i.e., M-FeS 2 /MWCNT, to effectively tune the H 2 O 2 nonradical pathway. The high-charge-positive M centers in M–S–Fe structure significantly reduced the H 2 O 2 oxidation energy barrier by 72%, thereby enhancing the 1 O 2 generation and model pollutant removal efficiency by 1.72 and ~24 times, respectively, compare to the sole-Fe center catalyst. Moreover, the S-bridged asymmetric dual-metal centers catalysts showed excellent complex pollutant adaptability (> 80% organic decontamination in phenolic, antibiotic and dye mixed matrices), ion-resistance and stability. This work offers a new strategy for constructing a charge-asymmetry dual-metallic-center for tunable nonradical pathways in H 2 O 2 activation.
研究领域:
环境科学
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催化
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材料科学
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化学工程
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水处理技术
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Mengyu Zhu,Yang Zhang,Chi Zhang,Lei Chen,Ying Kuang
Oxidative damage of neurons is one of the key pathological markers of Alzheimer’s disease (AD), which eventually leads to neuronal apoptosis and loss. Nuclear factor E2-related factor 2 (Nrf2) is a key regulator of antioxidant response and is considered to be an important therapeutic target for neurodegenerative diseases. In this study, the selenated derivative of antioxidant rutin (Se-Rutin) was synthesized with sodium selenate (Na2SeO3) as raw material by a simple electrostatic-compound in situ selenium reduction method. The effects of Se-Rutin on H2O2 induced oxidative damage in Pheochromocytoma PC12 cells were evaluated by cell viability, apoptosis, reactive oxygen species level and the expression of antioxidant response element (Nrf2). The results showed that H2O2 treatment significantly increased the level of apoptosis and reactive oxygen species, while the level of Nrf2 and HO-1 decreased. However, Se-Rutin significantly reduced H2O2 induced apoptosis and cytotoxicity, and increased the expression of Nrf2 and HO-1, both of which were better than that of pure rutin. Therefore, the activation of Nrf2/HO-1 signaling pathway may be the basis of Se-Rutin’s anti-oxidative damage to AD.
研究领域:
神经科学
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药理学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 7
·3454-3463
·
IF 11.9
Lei Ding,Jinyan Zhao,Zhikang Bao,Shijie Zhang,Huaijie Shi,Jia Liu,Guoliang Wang,Xiaoge Peng,Xing Zhong,Jianguo Wang
H2O2 and O3 production through electrochemical synthesis is a promising approach to replace anthraquinone processes and corona discharge. However, the simultaneous generation of H2O2 and O3 and the use of their synergistic oxidation to degrade organic contaminants remains a challenge. Herein, heterojunction bifunctional ZnO/ZnS@C electrocatalysts were prepared by a one-step pyrolysis method. ZnO/ZnS@C-750 can achieve 90% selectivity for H2O2 and 11% Faraday efficiency for gaseous O3. The primary contributor to such a performance was exploited to accelerate the electron transfer on the heterogeneous interface and generate more reaction sites. H2O2 and O3 can also be simultaneously generated in the electrolyzer and the synergistic effect of H2O2 and O3 can be utilized to completely degrade organic pollutants, such as phenol and tetracycline. This work provided new insights into the design of the 2e− ORR (oxygen reduction reaction) and EOP (electrochemical ozone production) bifunctional electrocatalysts for pollutant degradation.
研究领域:
电化学
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环境科学
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材料科学
·
催化
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Buguang Zhou,Min He,Ping Wang,Haitian Fu,Yuanyuan Yu,Qiang Wang,Xuerong Fan
Silk fibroin (SF) as a bioactive protein can offer growth substrates for hydroxyapatite (HAp) deposition. In the current work, graft copolymerization of acrylic acid (AA) onto fibroin chains was carried out using hydrogen peroxide-horseradish peroxidase (H 2 O 2 -HRP) catalytic system, SF-g-polyacrylic acid (PAA) membranes was prepared subsequently, followed by in situ biomimetic mineralization in the Ca/P solutions, aiming at promoting the deposition of HAp and endowing the fibroin-based biocomposite with enhanced bioactivity. Meanwhile, p -hydroxyphenylacetamide (PHAD) and methyl acrylate (MA), as the model compounds of tyrosine residues in SF and vinyl monomer were used to disclose the mechanism of graft copolymerization. The data from FTIR and SEC chromatograms indicated that vinyl monomer was successfully graft copolymerized with SF during H 2 O 2 -HRP treatment. According to the results of XRD, SEM patterns and EDS-Mapping, mineral phases on the surfaces of SF-g-PAA membranes were detected after different cycles of biomimetic mineralization, and the mechanical property of SF-g-PAA/HAp membrane was noticeably improved. Cell viability and adhesion assays revealed that the composite of SF-g-PAA/HAp exhibited acceptable biocompatibility and outstanding adhesion property. The present work provides a novel method for preparation of the fibroin-based biomaterial for bone tissue engineering.
研究领域:
材料科学
·
生物材料
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组织工程
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2018
·Vol. 19
·期 4
·1135
·
IF 3.687
Maiquan Li,Tao Xu,Fei Zhou,Mengmeng Wang,Huaxin Song,Xing Xiao,Baiyi Lu
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H2O2-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM). Nrf2 siRNA or HO-1 inhibitor zinc protoporphyrin (ZnPP) reduced the neuroprotective effect. PhGs showed potential interaction with the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1). This result may support the hypothesis that PhGs are activators of Nrf2. We demonstrated the potential binding between PhGs and the Keap1-activated Nrf2/ARE pathway, and that PhGs with more glycosides had enhanced effects.Keywords:Keap1;Nrf2;Neuroprotective;PC12 cells;PhGs
研究领域:
神经科学
·
药理学
·
细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Guiyang Yu,Ke Gong,Chuanwang Xing,Lan Hu,Haibin Huang,Lejie Gao,Debao Wang,Xiyou Li
Organic semiconductor under photoexcitation could generate abundant strong-binding Frenkel excitons and inevitably suffer from low dissociation efficiency (<1%) and poor mobility ability, which severely suppresses the efficient utilization of photogenerated charges and corresponding activity. Herein, a dual P-doping strategy is proposed in bay and corner sites implanted polymeric carbon nitride (PCN-D) for visible-driven H 2 O 2 production. The dual P doping breaks localized electron state around original symmetric heptazine units and weakens the binding energy between electrons and holes, increasing dissociation efficiency to reach 11.9% with 20-fold improvement. In addition, the conductivity ability of PCN-D, including formed carrier charge concentration and mobility, achieves 13-fold and 7-fold improvement, which facilitates the charge transfer and separation. The proposed dual doped-P-site strategy, with the blessing of porous structure, provides plentiful active center for effective adsorption and activation of O 2 molecule, further accelerating reaction progress and achieving six-times increase of photocatalytic H 2 O 2 production rate. This work provides in-depth insight into the importance of dual P-doping to optimize kinetic behavior of photogenerated charges and opens an avenue to the multiscale doping-modulation of semiconductor with high efficiency solar energy conversion.
研究领域:
材料科学
·
化学
·
光化学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Bihong Chen,Yuehua Pan,Yuxiang Deng,Yunhao Hou,Haixuan Liang,Nannan Wang,Jun Luo,Kai Chen,Xinpeng Wang
Pyridine heterocyclic covalent organic frameworks (COFs) have attracted widespread attention in the field of photo-driven hydrogen peroxide (H 2 O 2 ) synthesis due to their unique optoelectronic properties and excellent electron affinity. In this study, the microenvironment change of COFs is achieved through the system regulation of pyridine content in its skeleton. Among these COFs, the bipyridine-structured TpDaBp exhibits the best visible-light-driven H 2 O 2 evolution rate of 8156 µmol g −1 h −1 and reveals significant potential for photocatalytic uranium extraction, attributed to its enhanced π–π interactions, improved optoelectronic performance, and enlarged specific surface area. This work not only provided a new strategy for further designing novel pyridine N-heterocyclic-based COFs but also shows its novel advantages of application.
研究领域:
材料科学
·
光催化
·
有机化学
·
能源化学
·
环境修复
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）