Nanoscale
·
2023
·Vol. 15
·期 9
·4457-4468
·
IF 6.7
Chao Cai,Feng Tian,Junping Ma,Zipei Yu,Mo Yang,Changqing Yi
Precision medicine urges the development of theranostics which can efficiently integrate precise diagnosis and effective therapy. In this study, a facile synthesis of Ir/Gd bimetallic oxide nanotheranostics (termed BSA@Gd2O3/IrO2 NPs) with good biocompatibility was demonstrated using a biomineralization method where bovine serum albumin (BSA) served as a versatile template. BSA@Gd2O3/IrO2 NPs exhibited high longitudinal relaxivity (5.2 mM−1 s−1) and X-ray absorption capability (14.5 Hu mM−1), illustrating them to be a good contrast agent for magnetic resonance (MR) and computed tomography (CT) dual-modal imaging. Moreover, BSA@Gd2O3/IrO2 NPs can act as not only a photothermal conversion agent with ultrahigh efficiency (66.7%) as well as a good photosensitizer, but also an effective catalase to decompose endogenous H2O2 to produce O2, thus relieving hypoxia and enhancing the phototherapeutic effect. Both in vitro and in vivo experiments demonstrated the high effectiveness of BSA@Gd2O3/IrO2 NPs in MR/CT dual-modal imaging and photothermal and photodynamic synergistic tumor treatments. This work sheds new light on the development of versatile nanotheranostic systems using mild and robust biomineralization methods.
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高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yu Chen,Xiaodi Hao,Zhentan Lu,Dong Wang
Chronic wounds induced by bacterial infection have seriously affected the health of people in the world. So, it is meaningful to develop a novel strategy with real-time infection monitoring and excellent antibacterial performance for enhancing wound management. Herein, we constructed a composite hydrogel by loading the pH indicator bromothymol blue (BTB) and gold nanocages containing 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (Au NCs@AIPH) into a polyacrylamide-co-poly(acrylic anhydride-modified oxidized sodium alginate) (PAM-co-PAOSA) hydrogel. In vitro and in vivo experimental results demonstrated that the composite hydrogel could effectively detect bacteria and diagnose the infection status of a wound in real time by showing visible color changes. In addition, the composite hydrogel containing Au NCs@AIPH possessed an excellent photothermal effect under near-IR (NIR) laser irradiation. The photothermal effect further activated AIPH to generate toxic free radicals to form combined antibacterial therapy for accelerating wound healing. Moreover, the composite hydrogel showed great biocompatibility. Therefore, the multifunctional hydrogel provided a novel wound management strategy for bacterial infection diagnosis and combined therapy in an infected wound.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Ying Ju,Chunling Yin,Yan Zhang,Xiangru Meng,Liuchuang Zhao,Leqian Hu
Quality evaluation and consistency evaluation of drugs are the keys to ensure the therapeutic effect and safety of drugs. In this study, attenuated total refraction infrared (ATR-IR) spectroscopy and near-infrared (NIR) spectroscopy combined with chemometrics were used for rapid detection and quality evaluation of active components of Shuang-Huang-Lian injection (SHLI), a traditional Chinese medicine preparation commonly used in China. Taking the chromatographic detection results as a reference, the partial least squares (PLS) model based on ATR-IR and NIR data was constructed by removing the bands with serious noise interference and low signal frequency band. The results showed that the PLS model achieved satisfactory results for the prediction of the three active components (chlorogenic acid, baicalin and phillyrin) in SHLI, indicating that the two spectral techniques combined with the PLS regression method could be successfully used for rapid quantitative analysis of the three active ingredients in SHLI. Relatively, the PLS model based on the ATR-IR spectrum has higher R 2 and smaller RMSE than it based on the NIR spectrum. Furthermore, based on the rapid quantitative analysis of the three active ingredients in SHLI, the quality of 140 SHLI samples from seven manufacturers was evaluated by TOPSIS (technique for order preference by similarity to the ideal solution) analysis, and the consistency of different batches of SHLI products from the same manufacturer was evaluated. The results showed that there were differences in the quality of SHLI produced by different manufacturers, and the quality of different batches of SHLI produced by the same manufacturer was not completely consistent. In conclusion, ATR-IR and NIR spectroscopy combined with chemometrics can be used for accurate and rapid quantitative analysis and quality evaluation of SHLI. This study provides a good idea for the rapid quantitative analysis and quality evaluation of drugs or food based on spectroscopic technology and chemometrics.
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INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Zhen Pu,Jianwei Qin,Bingyun Ao,Haopeng Dong,Maobing Shuai,Fang Li
Identifying reaction intermediates in gas-phase investigations will provide understanding for the related catalysts in fundamental aspects including bonding interactions of the reaction species, oxidation states (OSs) of the anchored atoms, and reaction mechanisms. Herein, carbon monoxide (CO) oxidation by praseodymium monoxide (PrO) molecules has been investigated as a model reaction in solid argon using matrix-isolation IR spectroscopy and quantum-chemical calculations. Two reaction intermediates, OPr(η1-CO) and OPr(η2-CO), have been trapped and characterized in argon matrixes. The intermediate OPr(η2-CO) shows an extremely low C–O stretching band at 1624.5 cm–1. Quantum-chemistry studies indicate that the bonding in OPr(η1-CO) is described as “donor–acceptor” interactions conforming to the Dewar–Chatt–Duncanson motif. However, the bonding in OPr(η2-CO) results evidently from a combination of dominant ionic forces and normal Lewis “acid–base” interactions. The electron density of the singly occupied bonding orbital is strongly polarized to the CO fragment in OPr(η2-CO). Electronic structure analysis suggests that the two captured species exhibit Pr(III) OSs. Besides, the pathways of CO oxidation have been discussed.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Ling Liu,Yanbo Li,Man Xu,Cunwen Wang
Two-dimensional Co ultrathin metal–organic framework nanosheets (Co-UMOFNs) were synthesized and blended into poly (ether block amide) (PEBA) to prepare composite mixed matrix membranes on PVDF supports for the pervaporation of phenol aqueous solution. The membranes were characterized by XRD, ATR-IR, TGA, CA and SEM measurements. Effects of the Co-UMOFNs loading, feed temperature and feed concentration on phenol separation performance were investigated. The results showed that Co-UMOFNs have a two-dimensional layered morphology and have good compatibility with the PEBA. A “brick and mortar” architecture morphology was achieved after incorporating Co-UMOFNs into the PEBA membrane. The amorphous PE segments in the PEBA were turned into a crystalline structure, restricting the motion of PE segments. The filling of Co-UMOFNs slightly improved the thermal stability and hydrophobicity as well. With the increase of the Co-UMOFNs loading from 0% to 40%, the phenol separation factor increased from 27 to 45, and the total flux decreased from 1.2 kg m -2 h - 1 to 0.42 kg m -2 h - 1 , when separation of 1000 ppm phenol solution at 70 °C. The interlayer galleries induced by the Co-UMOFNs stacking increased the tortuosity, and the crystalline structure of the Co-UMOFNs-PEBA improved the energy barriers of water penetration. Therefore the water flux was inhibited and the phenol separation factor increased. Depression of water permeation can be another protocol to prepare high-performance organophilic pervaporation membranes.
研究领域:
材料科学
·
化学工程
·
膜技术
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Food and Bioprocess Technology
·
2022
·Vol. 16
·期 3
·667-676
·
IF 5.581
Lin Xiao-Wen,Li Fei-Li,Wang Song,Xie Jun,Pan Qian-Nan,Wang Ping,Xu Chang-Hua
Due to the severe hazard of traces of harmful substances in flour and its massive production, pretreatment-free, rapid, and accurate determination of trace harmful substances was a practical and urgent demand in modern daily life. In this study, multi-molecular infrared (MM-IR), consisting of one-dimensional infrared (1D-IR), synchronous and asynchronous two-trace two-dimensional correlation infrared (2T-2DCOS-IR), as well as their RGB IR-image, was developed and employed to directly identify flour with diverse harmful substances. The present findings indicated that 2T-2DCOS analysis based on asynchronous pictures was better than others at identifying target substances and shedding new light on previous MM-IR-related studies. Systematical comparison of developed MM-IR-AlexNet flour models with conventional machine learning algorithms indicated that asynchronous MM-IR-AlexNet (2T-2DCOS-IR-AlexNet) had the best performance with 99.6% accuracy. Therefore, it was demonstrated that deep learning-based MM-IR could be a robust method for the direct detection of trace harmful substances in power foods.
研究领域:
食品安全
·
光谱学
·
人工智能
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2024
·
IF 4.1
Yahui Zhang,Jing Wang,Yongping Dong
In the present work, the nanosheets of iridium complex (Ir NS) were synthesized by surfactant assisted reprecipitation method. Strong anodic ECL signal of Ir NS was obtained under neutral aqueous condition with electrogenerated hydroxyl radical as coreactant, without the need of additional coreactant. Excellent light absorption ability of gold nanoparticles decorated Cu 2 O cubic nanoparticles (Cu 2 O@Au) could apparently inhibit the ECL intensity of Ir NS. When Cu 2 O@Au was assembled onto the electrode surface by base pair complementarity of DNA, the ECL resonance energy transfer (ECL-RET) system could be fabricated with Ir NS ECL as energy donor and Cu 2 O@Au as energy acceptor. The specific interaction of lincomycin (LIN) with the aptamer could release Cu 2 O@Au from the electrode surface, resulting in the recovery of ECL signal. Based on this, an “off-on” mode ECL sensor was designed to detect LIN. Under the optimal condition, the ECL intensity changed linearly with the logarithm of LIN concentration in the range of 1.0 × 10 −11 –1.0 × 10 −6 mol L −1 with a detection limit of 2.88 × 10 −13 mol L −1 . Importantly, the proposed ECL sensor showed outstanding accuracy and specificity in the detection of LIN, and provided a potential strategy for the determination of antibiotic.
研究领域:
分析化学
·
生物传感器
·
纳米技术
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiaoping Ma,Xiaoman Zhang,Yi He,Lei Huang,Zhuo Chen,Zhihan Xu,Tianyuan Huang,Yu Xin
Reasonably developing and designing bifunctional electrocatalysts with high activity is crucial for continuously obtaining hydrogen fuel during the overall water-splitting process. Earth-abundant spinel nickel cobaltite materials have been investigated as promising oxygen evolution reaction (OER) catalysts in alkaline solution. However, its insufficient performance in the hydrogen evolution reaction (HER) significantly restricts its applicability in integrated water-splitting systems. In this study, a cationic doping and plasma nitriding strategy is employed to synthesize Ir- and N-codoped nickel cobaltite (N-IrNiCoO/CC) as a highly efficient bifunctional electrocatalyst. The incorporation of Ir and N dopants effectively modifies the electronic structure, introduces abundant oxygen vacancies, and enhances the electrical conductivity, thereby substantially improving the catalytic activity. Consequently, the optimized N-IrNiCoO/CC electrode exhibits outstanding bifunctional performance, requiring low overpotentials of 46 mV for HER and 203 mV for OER at a current density of 10 mA cm–2. Assembled in a two-electrode configuration, the N-IrNiCoO/CC||N-IrNiCoO/CC electrolyzer delivers a low cell voltage of 1.46 V at 10 mA cm–2, outperforming commercial Pt/C||Ir/C (1.67 V). Moreover, the electrolyzer retains over 97% of its initial activity after 50 h of operation at 50 mA cm–2, despite a low Ir loading of only 1.36 wt %. These results highlight the strong potential of N-IrNiCoO/CC as a cost-effective and high-performance electrocatalyst for sustainable hydrogen production.
研究领域:
电化学
·
催化
·
纳米材料
·
能量转换
·
氢气生产
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Journal of Physical Chemistry C
·
2016
·
IF 4.509
Changgui Lin,Legang Li,Shixun Dai,Chao Liu,Zhiyong Zhao,Christian Bocker,Christian Rüssel
Nickel ion doped transparent bulk glass-ceramics containing K2SiF6, ZnF2, and KZnF3 nanocrystals were elaborated to show the prospect that this novel group of oxyfluoride glass-ceramics is promising for transition metal ion based photonics. These new oxyfluoride glass-ceramics exhibit a new broadband luminescence of Ni2+ ions in the intriguing near-IR spectral region ranging from 1200 to 2400 nm. Ni2+ ions are incorporated into the precipitated K2SiF6, ZnF2, and KZnF3 crystals, which provide octahedral sites for Ni2+ and make it optically active. Taking into account the microstructure of phase separation observed by replica TEM, a detailed mechanism of phase-separation-assisted nanocrystallization was described for these oxyfluoride glasses. These results allow one to establish a full physical model of the nanocrystallization mechanism. For the precipitation of fluoride crystallites, not only can the nanometric size be explained but also the formation of different crystal phases can be controlled by the initial amorphous phase separation of droplet or interpenetrating structure with a sufficiently elaborated glass design.
研究领域:
材料科学
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光子学
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固态化学
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纳米材料
·
光学材料
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 32
·10828-10833
·
IF 6.4
Dandan Wang,Xinyuan Zhang,Pifu Gong,Zheshuai Lin,Zhanggui Hu,Yicheng Wu
The balance between band gap and second harmonic generation (SHG) response, which are usually inversely related, is the key factor for achieving good performance in a mid-infrared (mid-IR) nonlinear optical (NLO) crystal. Still it remains a challenge to achieve this balance, which strongly hinders the development of mid-IR solid-state lasers. In this work, utilizing an aliovalent substitution strategy of functional units, we successfully realize mid-IR NLO balanced performance in a chiral iodate, Ga(IO3)3, which simultaneously exhibits a strong SHG response (13 × KDP) and a wide optical band gap (3.94 eV). The first-principles calculation is also performed to elucidate its NLO origin. Combining the experimental measurements and theoretical calculations, it is clear that Ga(IO3)3 possesses excellent comprehensive NLO performance including a strong SHG effect, a wide band gap, good thermal stability (450 °C), and a large birefringence, indicating its potential applications as a mid-IR NLO crystal.
研究领域:
材料科学
·
非线性光学
·
无机化学
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固体物理
·
激光技术
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Lin Zhou,Zhanghong Guo,Jingxuan Guo,Haining Cui,Jinxin Ma,Chan Wang,Qijun Song
2, 5-furandicarboxylic acid (FDCA) is an eco-friendly polyester monomer that holds great promise for the production of biodegradable plastics. FDCA can be prepared by the oxidation of 5-hydroxymethylfurfural (HMF), but the transformation was usually achievable only in alkaline conditions, resulting in a millimolar level reaction and complicated product purification. In present work, a series of iridium nanozymes with an average size of 2 nm were synthesized by using tartaric acid (TA) or other structurally similar small molecular ligands as the stabilizing agents. The different ligands significantly affect the Ir 4f binding energy, with TA exhibiting superior electron donation effect to the Ir center, thus facilitates the electron transfer and the enhancement in enzymatic efficiency. In the presence of H 2 O 2 , the TA-Ir nanozymes can directly catalyze the conversion of molar level HMF to FDCA in acidic condition (pH 4), achieving 99.8% HMF conversion and ∼ 90% FDCA yield.
研究领域:
催化化学
·
纳米技术
·
绿色化学
·
材料科学
·
可持续能源
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高影响因子
Advanced Energy and Sustainability Research
·
2023
·Vol. 4
·期 9
·2300023
·
IF 5.8
Shuai Zhang,Mingzi Sun,Leilei Yin,Siyuan Wang,Bolong Huang,Yaping Du,Chun-Hua Yan
The oxygen evolution reaction (OER) is critical for renewable energy conversion and storage devices. However, the rational design of electrocatalysts with suitably high efficiency and stability in strongly acidic electrolytes remains a major challenge. Herein, a solid-phase synthesis strategy is developed for the preparation of Ir-Ln (Ln = La, Ce, Pr, Nd) alloy nanoparticles with uniform particle size on carbon supports as superior acidic OER catalysts. Tailoring by the rare earth (RE) elements, Ir 2 Pr achieves a maximum mass activity of 2.10 A mg −1 Ir at 300 mV overpotential and stability over 200 h at 10 mA cm −2 in 0.5 m H 2 SO 4 , which is 9.5 and 20 times higher to pure Ir nanoparticles. Furthermore, Ir 2 Pr alloy nanoparticles exhibit excellent durability in strongly acidic electrolytes. Theoretical calculations have confirmed that the OER performances are strongly related to the RE elements in the alloy, where the d-band centers show a consistent trend with the overpotential. Moreover, the highest electroactivity of Ir 2 Pr is attributed to the improved electron transfer by 4 f orbitals and the suitable binding strength of intermediates. Herein, a fundamental understanding of the lanthanide–electrochemical performance relationship is provided and will also inspire the rational design of efficient nanoscale RE alloy electrocatalysts.
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