BIOMEDICINE & PHARMACOTHERAPY
·
2023
·
IF 7.5
Jie Cao,Xiaoxuan Du,Hui Zhao,Chenhong Zhu,Chenchen Li,Xin Zhang,Libin Wei,Xue Ke
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CSCs) are thought to be the major cause of failure in cancer therapy due to their considerable resistance to most chemotherapeutic agents, resulting in tumor recurrence and eventually metastasis. Here, we report a treatment strategy for osteosarcoma using hydrogel−microspheres (Gel−Mps) complex mainly composed of collagenase (Col) and PLGA microspheres (Mps) carrying Pioglitazone (Pio) and Doxorubicin (Dox). Col was encapsulated in the thermosensitive gel to preferentially degrade tumor extracellular matrix (ECM), ensuring subsequent drug penetration, while Mps with Pio and Dox were co-delivered to synergistically inhibit tumor growth and metastasis. Our results showed that the Gel−Mps dyad functions as a highly biodegradable, extremely efficient, and low-toxic reservoir for sustained drug release, displaying potent inhibition of tumor proliferation and subsequent lung metastasis. Selective PPARγ agonist Pio reversed drug resistance to Dox by significantly down-regulating the expression of stemness markers and P-glycoprotein (P-gp) in osteosarcoma cells. The [email protected] @Dox/Pio exhibited advanced therapeutic efficacy in vivo , demonstrating its great potential to serve a novel osteosarcoma therapy, which not only inhibits the growth of, but also attenuates the stemness of osteosarcoma. The dual effects reinforce the sensitivity and efficacy of chemotherapy.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 45
·e53110
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IF 3.057
Qihai Wang,Bin Chen,Xiujun Wang,Yifan Wang,Weixin Hu,Ming Duan,Shenwen Fang
Polyacrylamide (PAM) microsphere has been widely used in the field of profile control to reduce water cut in heterogeneous reservoirs. However, its mechanical strength and plugging ability are still needed to be improved. In this paper, a core-shell structure and surface-hydrophobic polyacrylamide M-P(AM-PEP) microsphere was prepared by using acrylamide (AM), block polyether macro monomer (PEP) and modified SiO 2 with double bond on the surface as monomers through dispersion polymerization. After the optimization of synthesis conditions, the results of SEM and TEM confirmed that M-P(AM-PEP) microsphere had the nano-scale spherical shape and the inorganic core/polymer shell structure, while the contact angle test results showed that M-P(AM-PEP) microsphere had the surface-hydrophobicity. Swelling experiments presented that the size of M-P(AM-PEP) microsphere can be increased by 6 times and had obvious self-gathering behavior. The inorganic core and self-gathering behavior are helpful for improving mechanical strength and plugging ability of PAM microsphere, respectively. Profile control and oil recovery improvement experiment showed that injecting 0.1 PV M-P(AM-PEP) microsphere can decrease the water cut and increase the oil recovery of 17.95%. This new microsphere could be an efficient technology for the profile control in the heterogeneous reservoir.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 7
·17994-18013
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IF 5.19
Liu Wei,Zhang Jingwen,Dai Zhao,Luo Ning,Qu Jing,Sun Peiyun,Li Da,Liao Weilong,Wei Junfu,Zhang Huan
Ozone air pollution poses a serious threat to human health and ecological environment. Manganese oxide (MnOx) is a popular material for ozone decomposition with excellent catalytic performance. However, the catalytic activity may be reduced under high-humidity conditions because of oxygen vacancy of MnOx from the water evaporation. In this paper, a new type of MnOx/poly(acrylic acid- co -divinylbenzene) (PAA) catalyst with MnOx supported on hollow PAA was successfully prepared, which greatly improved the ozone decomposition efficiency under high humidity. It was shown that when the acrylic acid (AA) content was more than 50%, the PAA polymer layer was hydrophilic and the ozone decomposition efficiency would keep high activity for both the low- and high-humidity conditions. The best performance of ozone decomposition was identified for the methanol reduction and AA content of 60%, in which the efficiencies reached 94.5% and 85% at 50% and 90% humidity levels, respectively. It is the synergetic effect of the hydrophilic PAA support and hollow structure that retains and improves the decomposition activity, which can absorb the water vapor molecules and increase the ozone retention time. Therefore, the hollow microsphere catalyst prepared in this paper has great potential in solving the problem of ozone air pollution.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Junhui Yi,Haoxian Zeng,Hai Lin,Minghao Li,Runkun Xie,Beifang Chen,Runsi Ding,Zhenghui Liu,Dehao Li,Ning Li
Rational design of Z-scheme heterojunction is known to be a good strategy for promoting photogenerated charge efficient separation. In this paper, a direct Z-scheme Ag 2 O/Bi 2 MoO 6 heterostructured microspheres with good interfacial properties were successfully prepared by hydrothermal synthesis-coprecipitation-calcination decomposition. Various techniques such as Transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and powder X-ray diffraction (PXRD) were used to reveal the structure, morphology, composition, electrochemical and optical properties of the target product. The catalytic activity of the as-prepared composite was evaluated by visible light degradation of Rhodamine B (RhB) and transient photocurrent. As expected, the results showed that 1:5 Ag 2 O/Bi 2 MoO 6 exhibited the optimal catalytic performance. And the visible degradation efficiency is up to 86% in 90 min, which was 2.69 times higher than that of Bi 2 MoO 6 (32%). And 1:5 Ag 2 O/Bi 2 MoO 6 exhibited the highest photocurrent efficiency (0.8 μA/cm 2 ). Meanwhile, the efficiency of 1:5Ag 2 O/Bi 2 MoO 6 keep 90% after four cycles. The enhanced activity can be attributed to the formation of a good interfacial contact between Ag 2 O and Bi 2 MoO 6 . In addition, hole and superoxide were identified as the main active species. Eventually a possible direct Z-scheme mechanism was proposed to explain enhanced performance. This work may provide a new perspective for the rational design of excellent Bi 2 MoO 6 -based Z-scheme heterojunctions for environmental remediation.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Daping Hu,Yuhang Jia,Fuyao Huang,Yuhong Long,Chunjin Ai,Pengcheng Du
Transition metal phosphides (TMPs) are considered excellent candidate electrode materials for supercapacitors (SCs) due to their high theoretical capacity. However, the severe performance degradation of TMPs, originating from poor conductivity and resulting volumetric expansion under electrochemical conditions, hinders the practical and large-scale application in supercapacitor electrodes. Herein, a robust heterostructure of nanoscale nickel phosphide encapsulated in carbon microsphere (Ni 2 P @ CM) is constructed through the carbonization of spherical Ni-MOF, and followed by subsequent low-temperature phosphorylation. The MOF-derived uniform carbon layer on the Ni 2 P surface provides massive electron transport channels and physically restricts the volumetric expansion during electrochemical reactions , facilitating the electrode reaction kinetics and further leading to a good capacitive performance in high capacitance (1622 F/g at 1 A/g), long-term cyclic stability (75.2% capacitance retention after 8000 cycles at 20 A/g), and high rate capability. Furthermore, asymmetric SCs based on Ni 2 P @ CM and AC exhibit a high capacitance of 135.4 F/g at 0.5 A/g, and a remarkable energy density of 47.46 Wh/kg at a power density of 0.397 kW/kg with the excellent cyclic property. These results demonstrate that the methodology is highly promising in the design and construction of Ni 2 P/carbon hybrid electrodes, revealing an attractive candidate electrode material in high-property energy-storage devices.
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ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 44
·2206261
·
IF 19.924
Chao Li,Yawei Du,Hongzhi Lv,Jun Zhang,Pengzhen Zhuang,Wu Yang,Yingze Zhang,Juan Wang,Wenguo Cui,Wei Chen
Artemisinin and its derivatives (artemisinins) are first-line chemotherapeutic agents of lethal malaria, which also showed tremendous value in many other diseases including chronic inflammation. Unfortunately, almost all artemisinins are rapid-acting medicines with an extremely short half-life in vivo, which significantly limits their clinical application for these new adaptation diseases. In this study, a locally injectable long-acting gene/artemisinin co-delivery nano-microplex consisting of a biodegradable hyaluronic acid (HA) microsphere and releasable gene/artemisinin co-delivery nano-lipoplex is developed first, to obtain an improved efficacy for rheumatoid arthritis (RA). Briefly, a cationic multicomponent drug-embedded liposome with pharmacological activity is first reported based on two novel artemisinin derivatives (dAPC and dACC), which possess mimic phospholipids and cationic lipids, respectively. A cationic artemisinin-embedded lipoplex is first reported as a medicative gene carrier here. An in situ injectable TNF-α siRNA/artemisinin co-delivery nano-microplex (MTAsi@MG) is further prepared by immobilization of TNF-α siRNA/lipoplex on porous microfluidic HA microspheres. Using this nano-microplex for intra-articular injection, the sustaining activity of gene therapy and artemisinin efficacy for RA long-term treatment is first realized. Undoubtedly, this intra-articular injectable TNF-α siRNA/artemisinin co-delivery nano-microplex based on dAPC/dACC lipoplex and microfluidic microspheres would be one of the most potent gene/drug co-delivery systems for RA therapy.
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高影响因子
Pharmaceutics
·
2022
·Vol. 14
·期 3
·510
·
IF 6.525
Qianqian Zhang,Jianwei Bao,Tijie Duan,Minxing Hu,Yuting He,Junwei Wang,Rongfeng Hu,Jihui Tang
Lung cancer is the second-most common cancer and has the highest mortality among all cancer types. Nanoparticle (NP) drug delivery systems have been used to improve the therapeutic effectiveness of lung cancer, but rapid clearance and poor targeting limit their clinical utility. Here, we developed a nanomicelle-microsphere composite, in which doxorubicin (DOX) was loaded with spermine (Spm) modified poly (ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) micelles, and then the nanomicelles were noncovalently adsorbed on the surface of poly (lactic-co-glycolic acid) (PLGA) microspheres. The attachment was confirmed by scanning electron microscopy and confocal microscopy. In vitro cell experiments, MTT assays and intracellular uptake assays were used to demonstrate the cytotoxicity and the cellular uptake of micelles in A549 cells. In vivo biodistribution studies were conducted, an orthotopic lung cancer implantation model based on C57BL/6 mice was established, and then real-time fluorescence imaging analysis was used to study the targeted efficacy of the complex. A nanomicelle-microsphere composite was successively constructed. Moreover, Spm-modified micelles significantly enhanced cytotoxicity and displayed more efficient cellular uptake. Notably, an orthotopic lung cancer implantation model based on C57BL/6 mice was also successively established, and in vivo biodistribution studies confirmed that the complex greatly improved the distribution of DOX in the lungs and displayed notable tumor targeting. These results suggested that the nanomicelle-microsphere composite has potential application prospects in the targeted treatment of lung cancer.Keywords:micelles;microsphere;polyamine transport system;targeted drug delivery system;lung cancer
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高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 2
·103
·
IF 5.743
Zhanwei Liang,Tao Peng,Xueshima Jiao,Yang Zhao,Jie Xie,You Jiang,Bo Meng,Xiang Fang,Xiaoping Yu,Xinhua Dai
Neutralizing antibody (NAb) is a family of antibodies with special functions, which afford a degree of protection against infection and/or reduce the risk of clinically severe infection. Receptor binding domain (RBD) in the spike protein of SARS-CoV-2, a portion of the S1 subunit, can stimulate the immune system to produce NAb after infection and vaccination. The detection of NAb against SARS-CoV-2 is a simple and direct approach for evaluating a vaccine’s effectiveness. In this study, a direct, rapid, and point-of-care bicolor lateral flow immunoassay (LFIA) was developed for NAb against SARS-CoV-2 detection without sample pretreatment, and which was based on the principle of NAb-mediated blockage of the interaction between RBD and angiotensin-converting enzyme 2. In the bicolor LFIA, red and blue latex microspheres (LMs) were used to locate the test and control lines, leading to avoidance of erroneous interpretations of one-colored line results. Under the optimal conditions, NAb against SARS-CoV-2 detection carried out using the bicolor LFIA could be completed within 9 min, and the visible limit of detection was about 48 ng/mL. Thirteen serum samples were analyzed, and the results showed that the NAb levels in three positive serum samples were equal to, or higher than, 736 ng/mL. The LM-based bicolor LFIA allows one-step, rapid, convenient, inexpensive, and user-friendly determination of NAb against SARS-CoV-2 in serum.Keywords:neutralizing antibody;latex microspheres;lateral flow immunoassay;SARS-CoV-2;receptor binding domain
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高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jianhong Wei,Zhiqiang Lin,Zuomin Lei,Yadong Xu,Zeyu Zhao,Tao Zhao,Yougen Hu,Hua Miao,Rong Sun
The exploration of lightweight and compressible electromagnetic interference (EMI) shielding materials with outstanding shielding effectiveness (SE) is still a tremendous challenge in the elimination of electromagnetic pollution. Lightweight and highly compressible expandable polymer microsphere/silver nanowire (EPM/AgNW) composites with micron-sized closed pores and an interfacial AgNW conductive network are fabricated via a facile thermal expansion process in an enclosed space. The EPM/AgNW composites with AgNW loading of 0.127 vol % show low density (0.061 g/cm3), high compressibility and compression strength (4.25 MPa at 92.6% of compressive strain), and high EMI SE (over 40 dB, 1 mm) at a wideband of 8–40 GHz. Their EMI SE can be improved to a record 111.5 dB by increasing the AgNW content to 0.340 vol %, which corresponds to the surface-specific SE (SSE/d; SE divided by density and thickness) up to 13433 dB·cm2/g. The EMI shielding mechanism is further discussed using the finite-element analysis software COMSOL Multiphysics, and the application of the EPM/AgNW composites is visually demonstrated via near-field shielding in a practical antenna radiation. The overall properties of light weight, high elasticity, excellent mechanical strength, and outstanding EMI shielding performance suggest that the as-prepared EPM/AgNW composites have a great potential for applications in modern electronics.
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APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Yunye Hu,Chenxia Zhang,Zhengjie Jian,Dong Chen,Yuhong Ma,Wantai Yang
Surface molecularly imprinted polymers (SMIPs) are effective adsorbents for the separation and removal of antibiotics owing to their specific selectivity and high efficiency. Herein, a novel kind of glycidyl methacrylate (GMA)-functionalized poly(maleic anhydride- alt -styrene) (PMS) particles (PMS-GMA) are facilely prepared via self-stabilized precipitation polymerization, which can serve as an ideal support matrix for the scalable preparation of SMIPs. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of norfloxacin (NOR) template and PMS-GMA carrier to obtain NOR-imprinted SMIPs (PMS@MIPs). Due to the presence of NOR-imprinted layer, the resultant PMS@MIPs can effectively and selectively adsorb NOR, featured with high sorption capacity in short equilibrium time (149.3 mg/g in 60 min). The adsorption behavior of NOR by PMS@MIPs fitted better to pseudo-second-order and Freundlich model. More importantly, PMS@MIPs showed high selectivity for NOR over enrofloxacin and levofloxacin with similar chemical structure, and another commonly used antibiotics sulfonamides. Furthermore, PMS@MIPs exhibited excellent reusability, the NOR molecules can be facilely desorbed under acidic condition and the adsorption capacity of the recycled PMS@MIPs only reduced by 6.9% after four adsorption-desorption process, indicating great potential for selective adsorption of NOR.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Shuyue Jia,Dongyan Tang,Yuhong Zhou,Yunchen Du,Jing Peng,Zhaojie Sun,Xu Yang
The usually inconvenient detection and uneasy recycling of polydopamine (PDA) with sphere morphology as an adsorbent restrict its actual applications in wastewater purification. Thus, novel composite fibers were fabricated via the electrospinning technique by integrating polydopamine microspheres (PDA-MPs) with pH/temperature dual-responsive copolymers. The insoluble fraction of the fabricated composite fibers can be maintained to a value above 89% after being immersed in aqueous solutions with different pH values. Also, the regeneration efficiency of the composite fibers can also remain above 80% after undergoing five adsorption–desorption cycles. These results both indicated that the fabricated composite fibers can avoid secondary pollution during the adsorption process effectively. In addition, the presence of abundant N-isopropyl acrylamide (NIPAM) units within the fibers could make it have a relatively higher water swelling ability of 4643%, which could further offer relatively larger inner spaces to accommodate the dye molecules. Meanwhile, by incorporating β-cyclodextrin (β-CD), methacrylic acid (MAA), PDA, and NIPAM components, plentiful active adsorption sites could be supplied to interact with methylene blue (MB) dye. So, the adsorption experiments of the composite fibers showed a maximum adsorption capacity of 1722.1 mg/g at pH 9.0 and a temperature of 55 °C. Furthermore, the pseudo-second-order kinetic model of adsorption suggested that it is a chemisorption process. Moreover, the adsorption experimental data can be better described by Langmuir models, inferring its monolayer adsorption. The adsorption thermodynamic studies revealed that adsorption is a spontaneous and endothermic process. Also, the increase of temperature facilitated the adsorption processes, owing to the increase of adsorbent’s hydrophobicity and molecules’ reactivity. The present work suggested that the combination of smart-responsive polymers and PDA-MPs could form an unprecedented system to be a promising candidate adsorbent for wastewater treatment.
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高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Kunpeng Qian,Qianfan Zhou,Hongmin Wu,Jianhui Fang,Miao Miao,Yuhuan Yang,Shaomei Cao,Liyi Shi,Xin Feng
Well established internal multilayered structures have been demonstrated to contribute greatly towards outstanding shielding effectiveness (SE) in electromagnetic interference (EMI) shielding systems. A specific encapsulation by intercalating carbonized cellulose microspheres into Ti 3 C 2 T x MXene layers (CCM@MXene) is elaborately designed. The CCM@void@MXene composite films with “egg-box” structure are ultimately achieved by annealing treatment with spherical CCM@MXene as “egg” and Ti 3 C 2 T x MXene layers as “box”. The unique structure with interior void space is attributed to internal multiple reflections of incident electromagnetic waves (EMW) and contributes to the enhancement of EMW absorption. Thanks to the electrically conductive network of Ti 3 C 2 T x MXene adhering to cellulose microspheres surface, the egg-box structure composite films exhibit superb electrical conductivity of 1672.0 ± 7.1 S cm −1 and excellent specific EMI shielding efficiency (up to 18637.14 dB cm 2 g −1 ) at an ultrathin thickness (12.1 ± 0.8 μm). This hierarchical porous egg-box structure offers an ideal potential for application in highly efficient EMI shielding systems.
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