JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Tong Feng,Yuanlin Jin,Zhangwen Long,Dacheng Zhou,Xiaqing Jiang,Bitao Liu,Jianbei Qiu
Phosphor conversion light-emitting diode (PC-LED) technology has become a focal point of research for portable near-infrared light sources in recent years. One of the crucial aspects is to develop phosphor materials that can be effectively stimulated by commercial available blue light. Unfortunately, efficient phosphors in the NIR-II that can be excited by commercial blue light are particularly scarce. In this study, Mg 4 Ta 2 O 9 :0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + (MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + ) phosphor was synthesized using the high temperature solid phase method, and its emission spectrum covered the first and second near-infrared windows (700–1200 nm). The internal quantum efficiency (IQE) and external quantum efficiency (EQE) are 88.7 % and 45.6 %, respectively, due to the synergistic effect of energy transfer and Li-ion modification. Additionally, the doping of Yb 3+ ions and Li + ions enhances the thermal stability of luminescence. The thermal stability of MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + and MTO:0.04Cr 3+ ,0.03Yb 3+ is 9.81 % and 14.43 % higher, respectively, than that of MTO:0.04Cr 3+ ,0.03Yb 3+ and MTO:0.04Cr 3+ . To evaluate its potential applications, we developed a prototype PC-LED utilizing MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + phosphor as an emission emitter which demonstrated advantages in biomedical imaging, night vision, and non-destructive testing.
研究领域:
材料科学
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光学工程
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生物医学工程
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SENSORS AND ACTUATORS B-CHEMICAL
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2023
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IF 8.4
Yao Huang,Siyi Huang,Wensheng Liu,Fengyu Tian,Craig A. Grimes,Yi-Ge Zhou,Qingyun Cai
Timely detection of hepatic oxidative stress is effective in preventing the onset and progression of liver disease. However, real-time and dynamic monitoring of oxidative stress in vivo remains challenging. Herein, we report a H 2 O 2 -responsive dual-peak ratiometric NIR-II fluorescent probe (Er@Ag 2 S:Pb), made by combining H 2 O 2 -responsive fluorescent Pb-doped Ag 2 S quantum dots (Ag 2 S:Pb QDs) with a fluorescence-stabilized reference substrate NaYF 4 :Yb/Er @NaYF 4 . By monitoring the change in emitted I 1550 /I 1220 intensities the probe can be used to sense and quantify H 2 O 2 concentrations ranging from 5 to 100 μM with excellent specificity. Experimental studies using mice models have shown that this probe can be used to monitor of hepatic H 2 O 2 -related oxidative stress in real time and non-invasively. Thus, the developed probe provides a powerful ratiometric NIR-II fluorescence imaging tool for timely monitoring of oxidative stress in vivo .
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SENSORS AND ACTUATORS B-CHEMICAL
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2023
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IF 8.4
Huixian Jia,Yujie Liu,Wei Tang,Chenghui Liu,Xinrui Duan
Multiplexed fluorescence imaging is mainly applied to cellular imaging. However, the application of an analogous technique to mammals remains challenging due to the presence of substantial scattering and autofluorescence in biological tissues in the visible (350–700 nm) and near-infrared I region (NIR-I, 700–900 nm). Herein, we report multiplexing excitation and single-channel detection in the near-infrared II region (NIR-II) with two fluorescent probes for dual-color imaging in vivo. The first one, FNIR-1090 was constructed on Pr-1099 derivative by attaching with 1-Ethylpiperazine through the SRN1 displacement reaction. The second one, IR-765 was synthesized by a one-step reaction between the Vilsmeier–Haack reagent with 2-(3,5,5-trimethylcyclohex-2-enylidene) malononitrile (TEMO). It is noteworthy that the absorption spectrum of FNIR-1090 is almost completely separated from that of IR-765, which facilitates dual-color in vivo imaging. The two dyes can be used for high-contrast dual-channel vivo imaging of different tissues. All these prominent performances show the great promise of FNIR-1090 and IR-765 in non-invasive, real-time, and dual-color NIR-II imaging (>900 nm) in vivo.
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ACS Nano
·
2023
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IF 17.1
Weilun Pan,Bodeng Wu,Chengtao Nie,Tingting Luo,Zhenli Song,Jie Lv,Yong Tan,Chunchen Liu,Mingzhen Zhong,Tong Liao,Zhenxun Wang,Guanghui Yi,Limin Zhang,Xiaoliu Liu,Bo Li,Jinxiang Chen,Lei Zheng
Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, and reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of imipenem encapsulated liposome with gold-shell and lipopolysaccharide (LPS)-targeting aptamer, namely ILGA, is constructed for bacteria elimination. Benefiting from the delicate structure, ILGA exhibits strong affinity and a reliable photothermal/antibiotic therapeutic effect toward multidrug-resistant Pseudomonas aeruginosa (MDR-PA). Furthermore, by incorporating ILGA with a thermosensitive hydrogel poly(lactic-co-glycolic acid)–polyethylene glycol–poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA), a sprayable dressing ILGA@Gel was prepared, which enables a quick on-demand gelation (10 s) for wound hemostasis and offers excellent photothermal/antibiotic efficacy to sterilize the infected wound. Additionally, ILGA@Gel provides satisfactory wound-healing environments by reeducating wound-associated macrophages for inflammation alleviation and forming a gel layer to block exogenous bacterial reinfection. This biomimetic hydrogel reveals excellent bacteria eradication and wound recovery effectiveness, demonstrating its promising potential for managing complicated infected wounds.
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高影响因子
Journal of Materials Chemistry B
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2023
·Vol. 11
·期 19
·4274-4286
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IF 7
Jingge Zhang,Enna Ha,Danyang Li,Shuqing He,Luyang Wang,Shaolong Kuang,Junqing Hu
Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hypoxia, GSH overexpression, etc.). In order to overcome these problems, we designed flower-like Co-doped FeSe2 (Co–FeSe2) nanozymes by a simple wet chemistry method. Co–FeSe2 nanozymes not only exhibit high POD and OXD-mimicking activities for facile kinetics, but also effectively consume over-expressed glutathione (GSH), inhibiting the consumption of generated ROS and destroying the metabolic balance of the tumor microenvironment. These catalytic reactions trigger cell death through apoptosis and ferroptosis dual pathways. More importantly, under the NIR II laser irradiation, the catalytic activities of Co–FeSe2 nanozymes are boosted, confirming the photothermal and catalytic synergistic tumor therapy. This study takes advantage of self-cascading engineering that offers new ideas for designing efficient redox nanozymes and promoting their clinical translation.
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Acta Biomaterialia
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2023
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IF 9.7
Yang Du,Xiaohui Qian,Fenghao Lin,Bingqiang Gao,Weili Wang,Huang Yang,Weilin Wang,Yuan Ding
The therapeutic effects of photothermal therapy (PTT) are dependent on the photothermal conversion efficiency of photothermal agents (PTAs) in tumors and the subsequent activation of the antitumor immune system. However, the insufficient tumor accumulation of current PTAs and the inevitable recruitment of tumor-associated macrophages (TAMs) could further compromise the antitumor activities of PTT. To address these issues, a biomimetic photothermal nanoplatform [email protected] is developed for the targeted remodeling of TAMs, which promotes the antitumor immunity of PTT. Au nanorods with second near-infrared (NIR-II) absorptions are fabricated to serve as PTAs to induce immunogenic cell death in tumor cells. The ferric hydroxide shell coated on Au nanorods can release iron ions to repolarize M2-like TAMs into the tumoricidal M1 phenotype via P38 and STAT1-mediated signaling pathways . Moreover, the surface decoration of platelet membranes endows biomimetic nanoplatform with enhanced tumor targeting ability for precise tumor ablation and TAM regulation. Consequently, [email protected] under NIR-II laser irradiation exhibits significantly higher inhibitory effects in a poor immunogenic 4T1 tumor-bearing mouse model with a 50% complete remission rate compared to conventional PTT (0%). By simultaneously reversing the immunosuppressive tumor microenvironment, this biomimetic nanoplatform offers a promising strategy for enhancing the antitumor efficacy of PTT. Statement of significance The therapeutic effects of current photothermal therapy (PTT) are hindered by the insufficient tumor accumulation of conventional photothermal agents and the recruitment of immunosuppressive tumor-associated macrophages (TAMs) after PTT. Herein, we report a biomimetic iron-based second near-infrared (NIR-II) photothermal nanoplatform ( [email protected] ) for targeted TAMs reprogramming and NIR-II mediated anti-tumor immunity. [email protected] can actively target the tumor site with the help of surface-decorated platelet membranes. Meanwhile, iron ions would be released from [email protected] in acidic lysosomes to reprogram TAMs into tumoricidal M1-like macrophages, which promotes the antitumor responses elicited by NIR-II PTT, thereby contributing to remarkable tumor inhibitory effects, with 50% higher complete remission rate than that of conventional PTT.
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PubMed
高影响因子
RSC Advances
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2018
·Vol. 8
·期 48
·27382-27389
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IF 2.936
Chengwan Xia,Diya Xie,Lang Xiong,Qian Zhang,Yang Wang,Zezheng Wang,Yuxin Wang,Bin Li,Chao Zhang
Herein, we reported nitroxide radical-modified CuS nanoparticles (CuS–NO˙ NPs), and they exhibited a typical absorption peak at 1182 nm. Due to such a long wavelength absorbance, CuS–NO˙ NPs exhibited excellent therapeutic outcome and low damage to normal tissues. Besides, we simultaneously achieved CuS–NO˙ NPs for MRI and CT dual-modal imaging, which successfully provided a new strategy for imaging-guided tumor treatment, thus increasing potential clinical applications for cancer treatment.
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PubMed
高影响因子
JOURNAL OF RARE EARTHS
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2022
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IF 4.632
Yaqun Ma,Zhan Wang,Yanxing Wang,Zhenghao Liu,Yukun Wang,Ruichan Lv
Lanthanide-doped biocompatible nanoparticles have promising applications in near-infrared second region imaging due to their high chemical stability, enhanced photostability and sharp emission bandwidth. However, the weak light absorption capacity limits the application of rare-earth nanoparticles (RENPs) for bioimaging. We prepared a coumarin-derived dye sensitized NaYGdF 4 :Yb,Er nanoparticle probe, in which the organic dye enhances photon absorption through the sensitization process, improving the luminescence efficiency of the rare earth particles near 1000 and 1500 nm. In addition, good water solubility and stability of the probe are imparted by coating the particles with amphiphilic polymers distearoyl phosphatidylethanolamine-polyethylene glycol (DSPE-PEG) and polyacrylic acid. This composite probe with good biocompatibility and NIR II luminescence properties can be used for vascular imaging, providing a tool for the detection of hematologic-related diseases.
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Biomaterials Science
·
2023
·Vol. 11
·期 5
·1876-1894
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IF 6.6
Guoyun Wan,Xuheng Chen,Jiayu Chen,Ruiling Gou,Haijiao Wang,Shuhao Liu,Mingyang Zhang,Hongli Chen,Dan Wang,Qiqing Zhang
Recurrence and metastasis are the main reasons for failure in the treatment of triple-negative breast cancer (TNBC). Phototherapy, one of the most well-known potent cancer treatment models is highlighted by ablating primitive tumors with immunogenic cell death (ICD) and is associated with endoplasmic reticulum (ER) stress to elicit long-lasting anti-tumor immunity. However, the provoked inflammatory response after phototherapy will stimulate angiogenesis, which provides nutrition for tumor recurrence. Here, an ER-targeted nanoplatform was constructed based on hollow mesoporous Cu2−XS (HMCu2−XS) nanoparticles to suppress recurrence and metastasis of TNBC by combining photo-ablation and microenvironment remodeling. Profiting from the metal ion coordination and large hollow space, HMCu2−XS can be easily modified with p-toluenesulfonamide for ER-targeting and quantitatively loaded celecoxib (CXB) as a vascular inhibitor, thus obtaining ER-HMCu2−XS/CXB. ER-HMCu2−XS showed great photothermal and photodynamic efficiency for ablating 4T1 tumors and inducing ICD under NIR-II laser irradiation. Compared with non-ER-targeted nanosystems, the ER-targeted nanosystem elicited stronger ICDs and recruited more immune cells. Moreover, the thermal-responsively released CXB successfully inhibited angiogenesis after photothermal therapy. The data showed that the ER-HMCu2−XS/CXB mediated the triplicate therapeutic effect of photo-ablation, immune response activation, and vascular suppression effectively, preventing the recurrence and metastasis of TNBC. In conclusion, this work provides a synergistic strategy to enhance therapeutic outcomes in TNBC.
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高影响因子
CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Jing Wen,Chang Liu,Ji Liu,Lu Wang,Si Miao,Daquan Chen,Qiyue Wang,Meirong Huo,Yan Shen
At present, NIR-II-triggered photothermal biomedical applications are limited by complex synthesis reactions , mediocre photothermal conversion efficiency, and difficult degradation. Herein, we prepared biodegradable Bi flower-like nanoparticles (phospholipid-modified Bi nanoflowers , BNFs) with high photothermal conversion efficiency (∼33.52 %) in NIR-II by a simple method and then modified them with the red blood cell membrane and dextran 40 (DRBCM) to improve their in vitro stability, to escape macrophages clearance and to enhance tumor accumulation. Dextran coating onto the surface of particles as a dispersant shell stabilizes inorganic particles by maintaining the surface charges and creating steric repulsions upon compression of neighboring polymer chains. In vitro and in vivo experiments proved that combined thermoradiotherapy of DRBCM-BNFs exhibited significantly enhanced tumor inhibition efficacy than monotherapy with good biocompatibility and low toxicity due to its biodegradability . Furthermore, the mechanism studies demonstrated that DRBCM-BNFs could serve as a nano sensitizer to promote the thermoradiotherapy under NIR-II illumination and X-ray irradiation, by downregulating heat shock protein 70 (HSP70) and phosphorylated-p65 (p-p65) to reduce the thermal resistance and radioresistance of tumor cells and increasing the expression of apoptosis-related protein cleaved caspase-3. In conclusion, DRBCM-BNFs could be a promising green delivery platform for the sensitization of synergistic thermoradiotherapy.
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Advanced Therapeutics
·
2023
·Vol. 6
·期 4
·2200350
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IF 4.6
Zhifang Li,Shulong Wang,Jingjin Zhao,Yanni Luo,Hong Liang,Shulin Zhao,Liangliang Zhang
Tumor microenvironment (TME)-responsive imaging and therapy has great potential for application towards precision diagnosis and treatment of cancer. Photoacoustic (PA) imaging with the second near-infrared window (NIR-II) and photothermal therapy are important ways to address high-resolution imaging of in vivo deep tumor tissue and high-effect therapy of cancer. A gold nanocluster (AuNCs) encapsulated nanorod (AuNRs) (AuNRs@MEA/DTGA@AuNCs, hereafter AMDAs) is prepared. The AuNRs are first modified using β-mercaptoethylamine (MEA) to form AuNRs@MEA. Dithioglycolic acid (DTGA) is coupled with AuNRs@MEA to obtain AuNRs@MEA/DTGA (AMD). Finally, AuNCs are attached to AuNRs@MEA/DTGA surface to form AMDAs. In this nanocomposite materials, the encapsulation of the AuNRs by the AuNCs obscures NIR-II PA signal of AuNRs. The high expressed glutathione in the TME react with the AMDAs via redox reaction, the detachment of the AuNCs from the AuNRs surface, and detection of the NIR-II PA signal from the AuNRs, thus enabling NIR-II PA imaging of tumor tissues. In addition, due to the high intensity light absorption of AuNRs in the NIR-II region, the release of AuNRs also enhance tumor photothermal imaging and therapy. This work establishes an accurate and efficient integrated platform for nanodiagnosis and treatment of cancer.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Yang Zhong,Jiayu Gu,Yaoquan Su,Lingzhi Zhao,Yunyun Zhou,Juanjuan Peng
Herbal medicines and dietary supplements are widely used worldwide. However, reports have revealed that a large number of herbal medicines are implicated in the hepatic damage, which is referred to as Herbal medicines-induced liver injury (HILI). Traditional diagnostic methods for HILI include histological and serological assessments, which fail to offer real-time and unambiguous visualization of hepatotoxicity in vivo . Herein, we constructed a second near-infrared (NIR-II) luminescent nanoprobes to achieve accurate, high-efficiency, and non-invasive detection of HILI by the assembly of lanthanide-based NIR-II luminescence nanoparticles with a chromophore with absorption band in the NIR-II region. Specifically, the NIR-II luminescence of the lanthanide nanoparticles can be effectively quenched by the chromophores on the surface of nanoparticles via an absorption competition-induced quenching effect, and subsequently recovered by the pathophysiological biomarker peroxynitrite (ONOO − ) generated in early HILI. It is demonstrated that the nanoprobes are capable for the screening of liver toxins in a noninvasive pattern, which is more convenient than the conventional diagnostic approaches. Finally, our luminescence detection approach offers an immediate testing technique for the identification of hepatotoxic components of herbal medicine such as colchicine, monocrotaline and stibene glucoside, providing a high-throughput screening strategy for herbal medicine-induced hepatotoxicity.
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