CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Xiangjie Tian,Hui Xu,FangFang Zhou,Xiyu Gong,Songwen Tan,Yongju He
Cuproptosis is a newly identified copper-dependent cell death and holds great promise for cancer therapy. However, transporting enough copper into cancer cells is a challenge. Herein, an intelligent cupreous nanoplatform (denoted as CuO2-MSN@TA-Cu2+), consisting of in situ formation of CuO2 within mesoporous silica nanoparticles (MSN) and then deposition with a tannic acid (TA)-Cu2+ complex, is designed and developed to realize on-demand copper delivery for cuproptosis-based combination therapy. CuO2-MSN@TA-Cu2+ exhibits tumor microenvironment-triggered therapeutic activity, wherein the outer TA-Cu2+ complex is readily disassembled to release Cu2+ and liberate the internal CuO2 to produce Cu2+ and H2O2. The overloaded Cu2+ can not only directly convert endogenous H2O2 and self-supplied H2O2 into highly toxic hydroxyl radicals for chemodynamic therapy (CDT) via Cu-based Fenton-like reaction but also undergo glutathione-mediated reduction into Cu+ species to induce potent cellular cuproptosis and enhance CDT. The experimental results indicate that CuO2-MSN@TA-Cu2+ produces remarkable cytotoxicity against cancer cells and significantly suppresses tumor growth by 93.42% in mice-bearing 4T1 breast tumors. This work provides a new paradigm to boost cuproptosis-related therapy and may also inspire the design of advanced therapeutic nanoplatforms.
研究领域:
纳米技术
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癌症生物学
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治疗学
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材料科学
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Sun Tao,Lunhao Zhi,Chong Cheng,Shuang Li,Shudong Sun,Changsheng Zhao
ABSTRACT During the application of extracorporeal membrane oxygenation (ECMO), protein adsorption on the membrane not only leads to a decline in the efficiency of gas exchange but also triggers a series of adverse effects and even blood coagulation. Herein, we provide the hydrophilic and low-surface-energy strategy to prepare a fouling-resistance and fouling-release membrane for ECMO. Polyvinylimide (PEI) was grafted with tannic acid (TA) on the PES membrane to form a hydrophilic coating, on which fluorinated small molecules with low surface energy were subsequently grafted by ring-opening reaction to form low-surface-energy domains. The hydrophilic coating resists fouling adhesion by forming hydration layers, while the low surface energy of the hydrophobic domains facilitates the release of pollutants. Moreover, the introduction of the hydrophobic domains facilitates gas-liquid exchange in the ECMO-simulated environment. After PBS rinsing, BSA and BFG removal improved by 97.81% and 227.83%, respectively. Finally, in our ECMO-simulated gas-liquid circulation detection device, the modified membrane exhibits excellent gas exchange properties (The O 2 and CO 2 exchange rates reach 123.37 and 168.52 mL·min -1 ·m -2 , respectively) and is resistant to plasma leakage. This study provides a new surface modification anti-fouling strategy with simultaneous enhancement of hemocompatibility and gas exchange efficiency.
研究领域:
生物医学工程
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材料科学
·
表面化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Daen Qin,Chengyu Liu,Kaili Song,Seeram Ramakrishna
Hydrogels are ideal for flexible sensors due to their outstanding advantages such as softness, biocompatibility, and unique flexibility. However, the radical polymerization process of hydrogels is usually associated with intensive input of energy. In this study, tannic acid and Fe 3 O 4 nanoparticles were integrated on conductive MXene nanosheets as catalysts to rapidly polymerize to prepare super-stretchable and highly-sensitive Silk Fibroin/Poly-acrylic acid hydrogel sensors. The synergistic effect of TA and Fe 3 O 4 nanoparticles can maintain the dynamic redox cycling between Fe 2+ /Fe 3+ , to enhance the ability of ammonium persulfate to generate free radicals and rapidly forming hydrogel within 5 min. Inspired by the surface morphology of lotus leaves, a biomimetic strategy was employed to construct micro-protrusion structures on the hydrogel surface in order to enhance its sensitivity. The developed sensor showed excellent tensile strain (946 %) and high tensile strength (195 kPa), high sensitivity (GF = 4.05) and stable cycling ability (>100 cycles). The hydrogel sensor demonstrated high linearity (0.99 within the strain range of 150 %–600 %), low detection limit (1 % for strain and 150 Pa for pressure). Moreover, the hydrogel sensor can accurately detect various physiological signals emitted by the human body, making it highly promising for applications as wearable sensors in personalized healthcare.
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高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Chunlin Chen,Xiyi Ma,Guoqing Xiao,Mingtan Wang,Junjie Cao,Jing Gou,Hongxin Yan
Waterborne epoxy coatings are favored for their environmental friendliness and low volatile organic compounds (VOC) emissions. However, traditional waterborne epoxy coatings have limitations in terms of barrier properties and self-healing ability, resulting in poor long-term corrosion protection. To overcome this shortcoming, a novel green composite based on PDA@Ce-MOF@TA-Fe (PCTF) was developed in this study, aiming to construct a high-performance coating system with enhanced corrosion protection, pH responsiveness, and self-healing properties. The EIS measurements demonstrated a significant enhancement in the barrier property and self-healing capability of the waterborne epoxy coating incorporated with the PCTF composite (PCTF/WEC). After 40 days of immersion in corrosive conditions, the impedance of the PCTF/WEC coating remains at 9.82 × 10 8 Ω·cm 2 , which is much higher than that of the WEC coating alone (1.47 × 10 6 Ω·cm 2 ). PCTF/WEC coating also shows excellent pH response in acidic environments (pH = 3). Salt spray tests and UV irradiation tests confirm the coating's good weathering resistance. This study provides a promising strategy for the development of long-lasting and environmentally friendly anti-corrosion coatings.
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Feng Xiong,Hao Deng,Ruoyin Luo,Shaojie Gao,Chenming Fan,Xin Gao,Bing Li
In this study, a dense Ta-based layer with a thickness of 400 nm was fabricated on SS316N bipolar plates (Ta-SS316N) by using a disproportionation reaction of Ta in a K 2 TaF 7 -Ta(powders)-KCl-NaCl molten salt system at 900 °C for 6 h. According to XRD analysis , the Ta-based layer was mainly composed of metallic Ta as well as Ta 2 N 0.86 . In the simulated HT-PEMFC cathode environment, the corrosion current density of Ta-SS316N obtained from the potentiodynamicl polarization curves was 0.96 μA/cm 2 , which meets the 2025 U S. DOE standard. Compared to the SS316N substrate, Ta-SS316N showed two orders of magnitude higher corrosion resistance and nearly 1 V higher self-corrosion potential, with an interfacial contact resistance of 27.5 mΩ∙cm 2 , accounting for about one-quarter that of SS316N substrate. This provides a low-cost, easy-to-operate method to prepare Ta-based layer on stainless steel bipolar plates used for HT-PEMFC.
研究领域:
材料科学
·
电化学
·
能源材料
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表面工程
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燃料电池技术
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Yuting Sang,Zhan Lv,Yuanyuan Yu,Haotian Hu,Jixiang Yang,Le Han,Liang Shen,Zhongbo Zhou
Surface segregation during non-solvent induced phase separation (NIPS) enables in-situ membrane functionalization, yet the inherently rapid and uncontrolled phase separation kinetics typically yield heterogeneous additive distribution. Herein, we presented a hydrogel-facilitated phase separation (HFPS) strategy to achieve controlled surface segregation of tannic acid/polyvinylpyrrolidone (TA/PVP) for subsequent in-situ Ag + reduction and assembly of a functional AgNPs layer. By exploiting delayed phase separation kinetics, physical confinement and interfacial gelation imparted by the hydrogel, HFPS yielded substantially higher and more uniform TA/PVP surface coverage (79.8%) compared to NIPS (60.9%). This uniformly enriched TA/PVP layer enabled high-density, homogeneous AgNP grafting with a narrow size distribution on HFPS membranes. The optimized HFPS membrane—with balanced TA/PVP and Ag + loadings—exhibited superhydrophilicity (water contact angle ~ 40°), high water flux (895 L·m −2 ·h −1 ·bar −1 ), and excellent BSA rejection (>98%)—significantly outperforming its NIPS counterpart (50–65°, 362 L·m −2 ·h −1 ·bar −1 , ~ 98%). In dynamic antifouling tests, it achieved a flux recovery ratio (FRR) of 84.7% with BSA filtration and only 5.3% flux decline during bacterial filtration, substantially exceeding NIPS controls (64.4% FRR, ∼45% decline). Moreover, by utilizing patterned hydrogel templates, surface microstructures were introduced to further enhance flux to 994 L·m −2 ·h −1 ·bar −1 and reduce flux decline to 3.8% for bacterial filtration. Ag + release measurements confirmed a higher total Ag loading of 59.1 μg·cm −2 and a stable release rate of 0.199 μg·cm −2 ·day −1 sustained over 40 days. Overall, this HFPS-guided surface segregation strategy offers a promising platform for fabricating high-performance antifouling membranes for engineering applications.
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高影响因子
MOLECULES
·
2026
·Vol. 31
·期 10
·1737
·
IF 5.1
Juan Xu,Jinju Ma,Lanxiang Liu,Baoshan Tang,Hong Zhang,Wenwen Zhang,Zhengjun Shi
Bamboo is a renewable and fast-growing biomass resource with limited utilization and service life owing to its susceptibility to mold. Conventional nano-modification methods, particularly two-step approaches, are limited by weak interfacial bonding between nanoparticles and the bamboo substrate, complex processing, and an inability to simultaneously enhance antimildew performance and dimensional stability. To address these limitations, we developed a one-step hydrothermal method involving the use of tannic acid (TA) for in situ fabrication of ZnO/TA/Ag composite particles on bamboo surfaces. Process parameters were optimized to 100 °C, 10 h, and a zinc acetate-to-tannic acid molar ratio of 20:1. The modified bamboo was characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscopy coupled with energy-dispersive spectroscopy, and thermogravimetric analysis. We demonstrated that ZnO/TA/Ag composite particles were successfully loaded onto the bamboo surface, thus improving the all-around performance of the bamboo simultaneously. Antimildew activity against Aspergillus niger and Penicillium citrinum increased from grade 4 in untreated bamboo to grades 1 and 0, respectively; water absorption decreased by 52.85%, and anti-swelling efficiency reached 30.41%, indicating improved mold resistance and dimensional stability. Thus, our technique could serve as a green and efficient one-step in situ modification strategy for high-performance functionalization of bamboo, making it suitable for applications in humid outdoor and indoor environments.
✓ 已验证
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2022
·
IF 7.693
Shuzhen Zheng,Wenxiu Qiao,Jianfeng Ma,Yinwen Li,Shoufang Xu,Qianping Ran
Using organic/inorganic nanocomposites to optimize the microstructures of cement hydration products at the micro/nanometre scale is a promising method for improving the mechanical properties of cement-based materials. One type of novel nanohybrid material modified by the flexible autonomous healing polymer poly-TA (thioctic acid) was synthesized and used as a highly efficient mechanical improvement agent for cement paste. The nanohybrids linear LNTS-1 and bulk CNTS-2 were synthesized from silane-coupled nanosilica and alpha thioctic acid. Due to the existence of hydrogen bonds, coordination bonds and dynamic covalent S S bonds, this type of linear poly-TA with a certain amount of calcium content exhibited good self-healing properties. Linear LNTS-1 can effectively improve the macro flexural strength of cement-based materials without a negative effect on their compressive strength. The flexural strength of cement pastes with 1.0‰ LNTS-1 increased by 11.9%, 15.6%, and 16.9% after curing for 3, 7, and 28 d compared with the control cement paste. The results of adsorption experiments show that nanohybrid LNTS-1 has strong adsorption on calcium ions, which affects the formation of cement hydration products.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Hongli Xie,Liguo Shen,Yanchao Xu,Huachang Hong,Lining Yang,Renjie Li,Hongjun Lin
Wettability of membrane is of vital importance for treatment of oily wastewater. In recent years, hydrophilic modifications based on plant polyphenol have been widely investigated to enhance the anti-fouling property of membranes due to their mild conditions, versatility and low cost. However, there are still some problems in improving raw material utilization and hydrophilicity. Herein, a facile method was proposed to optimize tannic acid (TA)-based membrane modification process by synergistically inducing TA deposition by Fe 3+ and SP with the assistance of inkjet printing. The hydrophobicity of polyvinylidene fluoride (PVDF) membrane was converted to hydrophilicity (WCA = 34.6°) and underwater oleophobicity (UOCA = 144.4°) in very short time (10 min). The optimum PVDF/Fe-TA-SP 422 membrane possessed high flux (4968.4–7340.4 L m −2 h −1 ·bar −1 ) for a number of oil/water emulsions with high separation efficiency (>98%), outperforming most state-of-the-art membranes for oil-water separation. Furthermore, the optimized membrane displayed not only high antifouling property and reusability with flux recovery ratio of 89.1%–98.0% after eight-cycle filtration, but also desired stability under near neutral pH conditions during long-term running. The combination of inkjet printing method with these materials proposed in this study is convenient, efficient and low cost, and the prepared membranes are versatility, providing novel insights into preparation of high efficiency membranes for oily wastewater treatment .
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Yuyang Zhou,Jin Zhang,Zhenxing Wang,Fang He,Shaoqin Peng,Yuexiang Li
Tannic acid (TA)-aminopropyltriethoxysilane (APTES) coating has excellent hydrophilicity, and can be applied to a variety of materials. But it has poor stability in the air. To improve its stability, we have developed TA-APTES-Fe(III) coating in our previous work, but there are still some problems remained such as tedious steps, and undesirable anti-crude oil-adhesion performance, etc. Besides, both TA-APTES and TA-APTES-Fe(III) coating cannot realize the hydrophilic modification of the inner surfaces of porous polypropylene (PP) membrane. To solve the above mentioned problems, we developed superhydrophilic and stable TA-APTES- tetraethylorthosilicate (TEOS) coating via one-step process in this study. The new coating can realize the superhydrophilic modification of the inner surfaces of porous PP membrane, and endows the PP membrane with good water permeability, which cannot be realized by our previously reported TA-APTES and TA-APTES-Fe(III) coating. Besides, the stability of the coating is greatly improved by introducing stable alcoholic hydroxyl groups derived from TEOS, and the resultant modified membrane can keep superhydrophilic (CA about 0°) and underwater superhydrophobic (underwater oil CA above 150°) even after being stored in air for more than 6 months, ultrasonic treatment for 10 min, or being rinsed by water for 24 h (3000r/min), exhibiting outstanding stability. More importantly, the crude oil adhesion force of the new coating is as low as 4 μN even under the preload force of 300 μN, showing excellent anti-crude oil-adhesion property. The PP membrane modified by the new coating possesses ultrahigh water flux (10384 L m -2 h -1 bar -1 ) and can realize highly efficient separation of oil-in-water emulsion (above 99%). This work is expected to accelerate the practical application of TA-APTES coating.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Hengrao Liu,Guanhua Liu,Min Zhang,Hao Zhao,Yanjun Jiang,Jing Gao
Tannic acid (TA) is a promising material to prepare nanofiltration membranes due to its multiple interaction abilities with metal ions and zwitterionic polymer via coordination interaction and electrostatic interaction, respectively. Herein, we proposed a multiple layer-by-layer (mLBL) assembly strategy using three assembly materials for the rapid preparation of TA based zwitterionic nanofiltration membranes with enhanced antifouling performance, which was compared with the non-zwitterionic nanofiltration membranes prepared via the conventional layer-by-layer (cLBL) assembly. Among a series of transition metal ions, Fe 3+ was chosen to prepare nanofiltration membranes. The ATR-FTIR and XPS analysis revealed the TA/Fe 3+ layer was formed and the poly(sulfobetaine methacrylate) (PSBMA) polymer was successfully assembled on membrane surface. The prepared zwitterionic nanofiltration membranes showed enhanced hydrophilicity, roughness and zeta potential than the non-zwitterionic nanofiltration membranes. The influence of TA/Fe 3+ bilayer number and PSBMA concentration on membrane performance was systematically studied and the rejection properties of the prepared membranes for dyes and salts were also investigated. Under the optimum preparation condition, the zwitterionic (TA/Fe 3+ ) 1.5 /PSBMA membrane showed water permeability of 40.36 LMH/bar with rose bengal (RB) rejection more than 98% and Na 2 SO 4 rejection about 60%. Because of the introduction of the PSBMA polymer, the zwitterionic (TA/Fe 3+ ) 1.5 /PSBMA membrane showed better antifouling performance than non-zwitterionic (TA/Fe 3+ ) 2.5 membrane with similar rejection properties.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Xinru Wu,Chen Ruan,Siqi Zhou,Lina Zou,Rong Wang,Gaiping Li
Tandem enzyme can catalyze some cascade reactions with high efficiency, and some few tandem enzyme-like mimics have been discovered recently. Further improving the catalytic efficiency of tandem nanoenzymes with facile method may undoubtedly promote and broaden their applications in various fields. In this work, cupric oxide nanoparticles (CuO NPs) with dual-functional enzyme mimics were synthesized using the rapid deposition method in advance, which simultaneously combined with lanthanide infinite coordination polymers (Ln ICPs) during the self-assemble of Tb 3+ , guanine-5′-triphosphate (GTP) and auxiliary ligand terephthalic acid (TA). Excitingly, the obtained Tb-GTP/TA@CuO ICPs, not only displayed obviously enhanced tandem catalytic activity compared with pure CuO NPs, but also provided a versatile ratiometric platform for ultrahigh selective and sensitive detection of glutathione (GSH) under single-wavelength excitation. A good linear relationship between the ratio signal and the GSH concentration was spanning from 0.001 to 20 μM with an impressive detection limit of 0.50 nM. This study opens a new and universal avenue for preparing integrated multifunctional probes by coupling of nanoenzyme catalytic activity with superior luminescent Ln ICPs through facile method.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
生物化学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）