CERAMICS INTERNATIONAL
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2023
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IF 5.2
Meimei Guo,Jiale Han,Qiwen Ran,Mengyuan Zhao,Yunhang Liu,Gan Zhu,Zhankui Wang,Hongyuan Zhao
An efficient ultrasonic-assisted one-pot strategy was applied to prepare the multifunctional nanocomposite of single-wall carbon nanotubes (SWCNT) and mesoporous silica nanoparticles (MSNs). To achieve the sensitive detection of gallic acid (GA), the SWCNT@MSNs/GCE sensor could be fabricated by using the above nanocomposite as electrode sensitizer. For the SWCNT@MSNs nanocomposite, SWCNT with one-dimensional hollow nanostructure could form three-dimensional reinforced carbon conductive network with excellent conductivity property, high specific area, efficient charge transport channels; MSNs with mesoporous structure and large active surface area presented obvious spherical morphology and uniform particle size dispersion, which effectively boosted the accumulation capability of GA on the SWCNT@MSNs/GCE sensor. Moreover, SWCNT with excellent conductivity property could greatly remedy the non-conductivity of MSNs. The synergistic combination of SWCNT and MSNs optimized the electrochemical property of SWCNT@MSNs/GCE sensor for the detection of GA. The SWCNT@MSNs/GCE sensor exhibited good GA electrochemical detection performance (pH = 2.0, linear GA concentration: 0.03–30 μM, limit of detection: 3.806 nM). The relatively low relative standard deviation values can be achieved for the reproducibility, reproducibility and anti-interference measurements. When applied for the detection of GA amount in real tea samples, the satisfactory recoveries of 97.14–101.2% and RSD values of 1.05–4.40 could be obtained at the SWCNT@MSNs/GCE sensor.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2021
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IF 7.963
Lin Shi,Di Zhang,Jinfeng Zhao,Jianliang Xue,Mengnan Yin,Aiping Liang,Bo Pan
The slower adsorption of lower molecular weight organic molecules remains poorly understood. This study investigated the adsorption kinetics of gallic acid (GA) and tannic acid (TA) on kaolinite (Kao), montmorillonite (Mon) and hematite (Hem), with an emphasis on the role of the bound water on the minerals. The lower adsorption of TA and GA on Kao than on Mon attributed to the lower specific surface area of Kao. Because of the electrostatic attraction, the adsorption of TA and GA on Hem was higher than that on Mon, even the specific surface area of the former was much lower than that of the later. The adsorption rates of TA on the three minerals were generally two orders of magnitude higher than those of GA. The adsorption kinetics of GA was strongly diffusion dependent; however, the diffusion process had limited influence on TA adsorption kinetics. The decreased c values of the intraparticle diffusion model of GA with increasing ionic strength provided additional direct evidence for the diffusion-dependent adsorption and the reduced hindrance by bound water via hydration layer compression. However, hydration layer compression had no effect on TA adsorption kinetics. The reduced 1 H NMR relaxation rate of bound water indicated that the bound water quantity on minerals decreased with increasing ionic strength, which proved the occurrence of hydration layer compression. This study highlighted the importance of bound water and the relative sizes of organic molecules in the adsorption kinetics of organic compounds on minerals, which should be carefully considered for their environmental fate studies.
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JOURNAL OF CHROMATOGRAPHY A
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2020
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IF 4.049
Yukui Tong,Baoyue Zhang,Bailin Guo,Wenjie Wu,Yingxue Jin,Fang Geng,Miaomiao Tian
A gallic acid-affinity molecularly imprinted polymer (G-MIP) was first used as an adsorbent for selective identification and capture of luteolin (LTL) in herbal medicine samples. The G-MIP was prepared by using LTL as the template, gallic acid (GA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent, and 2,2′-azobis(2-methylpropionitrie) (AIBN) as the initiator. The properties of G-MIP were characterized by FT-IR, transmission electron microscope, scanning electron microscope, dynamic light scattering, specific surface area, and X-ray photoelectron spectrum. The adsorption conditions were optimized, and the adsorption equilibrium model and adsorption kinetics model of the adsorbent were investigated under the best experimental conditions. The saturated adsorption capacity is 1.24 mg g −1 , which is not only higher than the adsorption capacity of 4-carboxyphenylboronic acid-affinity MIP adsorbent but also superior to those of many reported adsorbents for enriching of LTL. The LTL was quantified by HPLC. The linear range is 0.05–100 mg L −1 , the detection limit is 0.020 mg L −1 . This method was successfully applied in the selective recognition of LTL in herbal medicines with recoveries of 93.9–114.2%, and the relative standards deviations (RSDs) are 0.4–5.6%. Thus, this work provides a potential possibility and practical platform for the determination of LTL in complex matrices.
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Materials Science & Engineering C-Materials for Biological Applications
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2015
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IF 3.088
Feng Gao,Delun Zheng,Hidekazu Tanaka,Fengping Zhan,Xiaoning Yuan,Fei Gao,Qingxiang Wang
A highly sensitive electrochemical sensor for gallic acid (GA), an important polyphenolic compound, was fabricated using the hybrid material of chitosan (CS), fishbone-shaped Fe 2 O 3 (fFe 2 O 3 ), and electrochemically reduced graphene oxide (ERGO) as the sensing matrix. The electrochemical characterization experiments showed that the CS–fFe 2 O 3 –ERGO modified glassy carbon electrode (CS–fFe 2 O 3 –ERGO/GCE) had large surface area, excellent electronic conductivity and high stability. The GA presented a superior electrochemical response on CS–fFe 2 O 3 –ERGO/GCE in comparison with the single-component modified electrode. The electrochemical mechanism and optimal test conditions of GA on the electrode surface were carefully investigated. Under the optimal conditions, the oxidation peak currents in differential pulse voltammetry (DPV) experiments exhibited a good linear relationship with the logarithmic values of GA concentration over the range from 1.0 × 10 − 6 M to 1.0 × 10 − 4 M. Based on signal-to-noise (S/N) characteristic of 3, the detection limit was estimated to be 1.5 × 10 − 7 M. The proposed sensor has also been applied for estimating the antioxidant capacity index of real samples of red and white wines.
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FOOD CHEMISTRY
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2025
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IF 9.8
Jinsong Zhang,Zhiheng Wang,Xinling Wu,Shengyi Piao,Qiang Zhang,Deyi Zhou
Despite existing research on the interaction between zein (Z) and chitosan (CS), the formation and mechanisms of ternary electrostatic coacervates incorporating polyphenols remain unclear. Herein, we covalently and non-covalently modified zein with gallic acid (GA). Comparisons revealed that the covalent coupling of Z with GA (forming Z(GA)) reduced zein's surface potential, enabling them to form tightly bound coacervates with cationic polysaccharide chitosan through electrostatic attraction. Turbidity, ζ-potential, and appearance experiments indicated that the maximum yield of insoluble coacervates was achieved at a Z(GA)/CS mass ratio of 7:1 and pH 6.5. Furthermore, the coacervate properties were evaluated using Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and microscopic structure analysis. Electrostatic attraction between the -COO − groups of Z(GA) and the -NH 3 + groups of CS triggered complex coacervation, which induced structural modifications and enhanced thermal stability. This study fosters the efficient encapsulation and controlled release of nutraceuticals, enhancing human absorption.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Jinyu Chen,Beibei Jia,Siyang Wang,Zhuoling Li,Zhirui Ji,Ximing Li,Zijian Wu
Generally, high levels of natural phenolic antioxidants, which are needed in meat products to exert equivalent antioxidant effects as synthetic antioxidants, can interact with myofibrillar proteins and cause aggregation of the proteins, giving rise to undesirable deterioration of gel quality. In this study, β-cyclodextrin-metal-organic frameworks (K-β-CD-MOFs) were synthesized based on β-CD and K + ions using methanol vapor diffusion method, and used to inhibit excessive covalent and non-covalent interactions between gallic acid (GA) and myofibrillar proteins under oxidative stress without degrading the phenolic antioxidant activity . Results of zeta potential , scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) provided evidence for the formation of GA/K-β-CD-MOFs inclusion complexes. From sulfydryl content, surface hydrophobicity , tryptophan fluorescence, turbidity and particle size analyses, the presence of K-β-CD-MOFs dose-dependently prevented the sulfydryl loss, unfolding of the proteins and formation of insoluble aggregates caused by GA (180 μM/g protein). Dynamic rheology, cooking loss, gel strength, water distribution, microstructure and Raman spectrum were further tested to evaluate effects of K-β-CD-MOFs on the qualities of GA-treated myofibrillar protein gel. Results indicated that more proteins were involved in the formation of a more ordered and homogeneous gel structure with higher gel elasticity and strength, more immobilized water and decreased cooking loss. The overall gel properties of myofibrillar proteins were improved. K-β-CD-MOFs ameliorated the instability of protein structure, manifested as increase in β-sheet content and inter-chain hydrogen bonding and decrease in hydrophobic forces ( p < 0.05). This paper provides a novel method to increase the loading amount of phenolic antioxidants without jeopardizing the gel quality of meat products.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2024
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IF 6
Yuanyi Wu,Yumei Xiao,Yang Ju,Yanque Sun,Jialin He,Tian Liu,Miao He,Kaiyong Wang,Yi Yang
The determination of gallic acid (GA), one of the most prevalent antioxidants in various plants, provides information for food nutrition evaluation. A novel colorimetric, fluorescent, and smartphone multi-mode GA sensing platform based on Fe 3 O 4 @Co/Ni/Al-layered double hydroxide (LDH) nanospheres was designed in this study. The core-shell magnetic Fe 3 O 4 @Co/Ni/Al-LDH nanospheres were synthesized through a simple co-precipitation approach. They showed dominate peroxidase-like activities capable of oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) into a blue colored oxidation oxTMB. Meanwhile, the generated oxTMB could quench the fluorescence of neutral red via the inner filter effect. GA acted as an inhibitor to prevent the oxidation of TMB to oxTMB and restoring the fluorescence of neutral red. Under optimized conditions, the linear ranges were 0.5–120 μmol/L with detection limits of 0.137–0.415 μmol/L. Besides, the sensor exhibited good selectivity toward GA over various interferents. Moreover, it was successfully utilized to analyze GA in tea beverages with ideal recoveries of 92.8–105%, demonstrating good reliability and stability in practical applications. This study provided Fe 3 O 4 @Co/Ni/Al-LDH nanospheres as candidate nanozymes for the construction of biosensors. The multi-mode self-checking function and the “turn on” fluorescent sensing strategy offered this sensor superior anti-interference ability, and opens up a new strategy for the determination of antioxidants in foods.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Yunlong Li,Chunsheng Li,Shuang Liu,Qiang Wang,Zhengyang Tang,Jiawei Qu,Jin Ye,Yong Lu,Jun Wang,Kefen Zhang,Yujie Fu,Jiating Xu
NH 2 -MIL-88B (Fe) (MOF) is a promising photocatalytic material for antitumor therapy because of its distinctive electronic structure. However, inadequate separation of photo-generated electrons and slow reaction rate in low/high-valence iron (Fe) cycles limit their clinical application. In the present study, “electronic storage station” as a ligand-to-metal charge transfer bridge bond was constructed to inhibit recombination of electron/hole under 650 nm laser irradiation. Cupric (Cu) ions and gallic acid (GA) were self-assembled into a MOF (denoted as CGMOF) to create an Fe O(GA) Cu bridge bond. GA, characterized by robust electron delocalization and abundant electron-donating groups, significantly enhances electron transfer efficiency for photodynamic therapy (PDT). CGMOF can respond to endogenous glutathione and release cuprous ions, accelerating the iron ion/ferrous ion cycles for chemodynamic therapy (CDT). The released Fe species can serve as T 2 -weighted magnetic resonance imaging contrast. Extended X-ray absorption fine structure spectra confirmed the presence of GA-containing Fe O Cu bonds in CGMOF. Furthermore, a series of photo-electrochemical tests confirmed that the formation of Fe O(GA) Cu bond prominently elevated the redox capacity and increased the carrier density of CGMOF by 2.74-fold compared to that of MOF. In addition, cinnamaldehyde was grafted onto CGMOF for tumor-responsive hydrogen peroxide self-supply. Concurrently, hyaluronic acid was surface-modified to achieve the targeted delivery of nano-photosensitizers. In summary, this study presents an innovative approach for engineering Fe-based metal–organic frameworks for synergetic PDT/CDT applications.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Xin Guo,Xingling Zeng,Yeqing He,Xiaoxia Zhang,Wenli Shi,Ruimin Ran,Guoying Li
Acute hemorrhage death on battlefields, during clinical surgeries, and in major accidents is a widespread worldwide problem. Clay-based hemostatic materials have received considerable attention for their low cost and reliable clotting activity, especially in cases of severe bleeding, such as QuikClot, which is a kaolin-based hemostatic gauze that is preferred for battlefield resuscitation. However, the easy detachment of clay particles and the associated risk of thrombosis have seriously hindered the development of clay-based hemostatic materials. Here, inexpensive palygorskite (Pal) nanoclay was integrated into the collagen (COL) matrix by loading Ca2+ in the clay and further using gallic acid (GA) to mediate the robust assembly of clay on the COL matrix. This targeted interfacial design is a simple and gentle method that effectively improves the dispersion of the Pal particles and reduces the risk of shedding. Unlike QuikClot where the aqueous solution was significantly turbid after 2 min of ultrasonic washing, the aqueous solution of the composite sponge (Ca-Pal-GA-COL) remained clear and was accompanied by 82.71% of the mass residue after 10 min of ultrasonic washing. The composite sponge also exhibited excellent antibacterial (87.93% inhibition rate of Escherichia coli), antioxidant, and tissue adhesion properties. Importantly, the Ca-Pal-GA-COL sponge exhibited less blood loss (632 mg) and a shorter hemostasis time (151 s) in a rat femoral artery hemorrhage model than the medical gauze (3850 mg and 299 s), pure COL sponge (1627 mg and 201 s), and Pal-COL sponge (1494 mg and 193 s) in a co-mingled mode, which are comparable to those of QuikClot (559 mg and 142 s). Furthermore, certain tissue adhesion properties render the Ca-Pal-GA-COL sponge more suitable than QuikClot for severe femoral artery active bleeding scenarios. Cellular experiments confirmed that the composite dressing has a certain biosafety.
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FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Hongtao Chen,Xiaoyun Fei,Rui Liu,Junhan Zhang,Deming Gong,Xing Hu,Guowen Zhang
This work aimed to investigate the effect of a combination of microwave treatment and covalent binding of gallic acid (GA) on the structural and functional properties of peanut protein isolate (PPI). It was found that PPI exhibited the maximum solubility at microwave power of 480 W, 60 °C for 4 min. The microwave-treated peanut protein isolates (MPPI) had more binding sites than PPI. Of these, the MPPI-GA1.60 conjugate had the highest GA binding content (436.6 nmol/g PPI). GA showed a significant effect on the secondary structure of PPI and MPPI by inducing the transition from α-helix and β-sheet to β-turn and random coil, and their rigid globular structures were disrupted to increase the molecular flexibility. The negative charges (from −39.32 mV to −54.94 mV) and average particle size (from 260.23 nm to 338.53 nm) of PPI/MPPI-GA conjugates were increased with the GA concentration and the dispersibility of conjugates was improved. Moreover, the solubility, emulsion stability and thermal stability of PPI/MPPI-GA conjugates were significantly enhanced, with the MPPI-GA0.80 conjugate being the best. It was shown that the microwave treatment and covalent binding had a synergistic effect on the improvement of the functional properties of PPI. This research may provide a new approach to improving the functional properties of PPI and help to expand the utilization of PPI in the food industry.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Hongyuan Zhao,Mengyuan Zhao,Jing Tang,Xuchun Wang,Zirong Li,Sridhar Komarneni
A novel multifunctional electrochemical sensing electrode sensitizer was designed by integrating the highly conductive graphene nanoplates (CGNP) with large-pore dendritic mesoporous silica nanospheres (DMPS), which was first utilized to construct the gallic acid (GA) electrochemical sensing platform (DMPS@CGNP/GCE). DMPS with large-pore dendritic structure provided abundant internal pore connectivity and material transport channels, increased specific surface area, and expanded pore volume, which presented abundant adsorption sites, significantly improving the enrichment capacity for GA molecules. CGNP with ultra-high purity and few layers presented remarkable conductivity property coupled with exceptionally expansive specific surface area and more electrochemical active sites. The synergistic effect of DMPS@CGNP promoted the interface electron transfer, thereby significantly improving the sensitivity of GA detection. The DMPS@CGNP/GCE platform achieved the ultrasensitive electrochemical analysis of trace GA with low detection of limit of 9.67 nM in a pronounced linear GA concentration range spanning from 0.1 to 30 μM. The designed electrochemical analysis platform demonstrated satisfactory performance in terms of reproducibility, repeatability, and anti-interference performance. The good quantitative analysis property of GA in food samples could be realized at the above DMPS@CGNP/GCE sensor. This research provides a significant reference for the development of highly sensitive GA electrochemical analysis technology.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Chaoting Wen,Jialuo Tang,Dongming Liu,Meidi Fan,Xinying Lin,Guoyan Liu,Li Liang,Xiaofang Liu,Jixian Zhang,Youdong Li,Yuqing Duan,Xin Xu
In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid. The morphological changes of GFPs-GA-SeNPs and their antioxidant activities during simulated gastrointestinal digestion were investigated. The results revealed that the antioxidant capacity of GFPs-GA-SeNPs was significantly enhanced compared to SeNPs and GFPs-SeNPs, with IC₅₀ values for scavenging DPPH, superoxide anion, and hydroxyl radical of 0.45, 0.55, and 0.63 mg/mL, respectively. In addition, GFPs-GA-SeNPs showed a two-stage release pattern in in vitro digestion and had a stronger selenium release capacity. At the cellular level, oxidative stress and apoptosis were aggravated in the model group compared with the control group. Interestingly, compared with SeNPs and GFPs-SeNPs, GFPs-GA-SeNPs can more effectively restore mitochondrial membrane potential, reduce ROS levels, and improve apoptosis. Besides, GFPs-GA-SeNPs can up-regulate the expression of Nrf2 protein ( p < 0.05) which can induce the expression of HO-1, SOD, GSH-Px, CAT, decrease the MDA content. Moreover, GFPs-GA-SeNPs can downregulate NF-κB protein, which can decrease the expression of TNF-α and increase the expression of IL-10. GFPs-GA-SeNPs demonstrated exceptional antioxidant activity and could benefit various industries, including food and health products, and have enormous potential application values.
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