FOOD CONTROL
·
2025
·
IF 6.3
Guangyang Jiang,Wenyang Sheng,Li Yang,Yichen Yang,Tingting Tang,Chenzhi Wang,Yongqiang Tian
Global microbial spoilage highlights the pressing need for advanced packaging solutions. This study introduces a novel Cu-Chlorogenic acid nanoparticles (Cu-CGA NPs) packaging film system, which demonstrates exceptional photothermal antibacterial properties aimed at enhancing fruit preservation. The system utilizes a photoresponsive metal-polyphenol framework (Cu-CGA NPs) synthesized through a spontaneous chelation process under alkaline conditions, and seamlessly integrated with a carrageenan/gelatin (CG) film matrix. This integration capitalizes on the synergistic effects between the photothermal capabilities of Cu-CGA NPs and its inherent chemical antibacterial properties, resulting in the Cu-CGA 0.15 -CG film-where 0.15 denotes the proportion of Cu-CGA in the solution. This film demonstrates enhanced antibacterial efficacy, achieving 99% bacterial killing rates for both Escherichia coli and Staphylococcus aureus under brief near-infrared light (NIR) exposure. Additionally, the CGA component imparts significant antioxidant capacity to the Cu-CGA 0.15 -CG film, with a DPPH radical scavenging rate exceeding 60%. The inclusion of Cu-CGA NPs also enhanced the mechanical strength of Cu-CGA 0.15 -CG film to 25.8 MPa and improved the water contact angle (WCA) to 84.087°. These combined attributes result in a threefold extension of cherry tomato storage life, while maintaining product quality. Safety evaluations, including migration and cytotoxicity tests, confirm the suitability of the Cu-CGA 0.15 -CG film for food contact. Overall, the development of Cu-CGA NPs films represents a substantial advancement in food preservation technologies, offering robust protection for perishable items.
研究领域:
食品科学
·
材料科学
·
微生物学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Ruixian Zhang,Wenjie Chen,Yanfei Gao,Heping Li,Yanyue Lu,Zeguang Zhou
In this study, a novel dynamic polyphenol polymerization method for the preparation of nanofiltration membrane intercalations was proposed. In this method, TA, PEI and Al 3+ could successively form the first polyphenol-amine crosslink network and the second metal-phenol cross-linked network on the surface of the support layer. The dense crosslinked layer of TA-PEI-Al 3+ formed under dynamic conditions maintains high hydrophilicity compared to the crosslinked network formed under a single pH environment. Aluminum ions possess strong electronegativity since they have relatively high valence states and small ionic radius among transition metal ions. Therefore, this is the first time to incorporate Al 3+ into phenol-amine crosslinked networks to form the metal-phenol tri-complexes. The tri-complexes of TA and Al 3+ are more robust, promoting the coordination with more water molecules and forming more stable hydrophilic intermediate layers. When an interfacial polymerization reaction is performed on the intermediate layer, this hydrophilic intermediate layer can store aqueous-phase PIP and slow down the IP reaction rate through electrostatic interactions. This process helps to form a dense PA separation layer on the support layer surface. The prepared TFC-NF membranes can be used to separate dyes, antibiotics, and compound inorganic salts. The outstanding water permeance of the TFC-NF membrane was determined as 18.7 L/m 2 ·h·bar and the removal rate of mixed pollutants can reach 99 %. The firm intermediate layer enables the optimized modified membrane to maintain stable flux and high rejection rate in 72 h separation test. This modification method provides a useful reference for the preparation of high-performance nanofiltration membranes with plant polyphenols.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2024
·
IF 3.2
Cuilian Yi,Chunyan Xu,Xiaoyan Zhao,Chenyi Wang,Hengxue Xiang
Tea polyphenol (TP) is used as a food additive to inhibit lipid peroxidation reactions and extend shelf life, but excessive intake can affect the human immune system. Therefore, developing effective TP detection is significant. Here, pyrene-based polyimide (Py-PI) was synthesized by one-step condensation copolymerization. This polyimide possessed excellent solubility and photoluminescence due to the introduction of pyrene-conjugated groups. It could be used as fluorescent probe for TP detection in solution. In addition, Py-PI fluorescent test paper with different morphology were prepared by electrospinning. As the concentration of the spinning solution was 15 wt%, the bead-like porous polymer electrospun membrane displayed excellent surface wettability which could make the water droplet completely penetrate into the sample within 6 min. The fluorescence enhancement phenomenon could be observed for 5 × 10 −6 mg/mL TP solution on Py-PI test paper. Furthermore, interference investigation of pH on test paper indicated that the sample exhibited a relatively stable fluorescence “turn-on” response in acidic conditions. This work provides a convenient and rapid detection of TP antioxidant in the future.
研究领域:
材料科学
·
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Pingping Tang,Xia Li,Haiyun Li,Jing Li,Bing Tang,Tingting Zheng
Collagen (COL)-hydroxypropyl methylcellulose (HPMC) blended films with apple polyphenol (AP) as cross-linking agent and antioxidant compound were developed to produce biodegradable active packaging film. The effects of AP content on the rheological behavior of the blended solution, the structure, physicochemical and functional properties of the blended film were systematically investigated. The incorporation of AP increased the viscosity and reduced the fluidity of COL-HPMC solution. The results of rheological tests and FTIR analysis manifested the formation of hydrogen bonding interactions between collagen, HPMC and AP, which made the structures of COL-HP-AP films more compact. The mechanical strength, UV-blocking ability, water-resistance performance and thermostability were gradually enhanced as increasing AP content. DPPH free radical scavenging experiment showed that a small amount of AP could efficiently improve the antioxidant activity of COL-HP film, and with increasing AP content to 5 wt%, the scavenging rate was as high as 94.23 %. Active film containing 5 wt% AP showed obvious antibacterial effect on E. coli and S. aureus , and it could effectively prevent the oxidation of vitamin C and reduce the accumulation of MDA on green pepper during the storage. COL-HP-AP films have great potential in food packaging field for extending the shelf life of food .
研究领域:
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Wenhan Li,Shuang Han,Hechun Huang,David Julian McClements,Shuai Chen,Cuicui Ma,Xuebo Liu,Fuguo Liu
Plant proteins are becoming increasingly popular as functional ingredients in foods because of their health, sustainability, and environmental benefits. The functional performance of plant proteins can often be improved by combining them with other food ingredients. For instance, they can be combined with polyphenols and metal ions to form surface active protein-polyphenol-iron complexes with biological activity. In this study, ternary complexes of pea protein isolate (PPI), epigallocatechin-3-gallate (EGCG) and iron (Fe 3+ ) was prepared using a simple molecular self-assembly method. The formation mechanism, characteristics, and functional properties of these complexes were then characterized. Our results showed that PPI, EGCG, and Fe 3+ could spontaneously combine to form nano-sheet networks held together by hydrogen bonds, phenolic hydroxyl coordination bonds, and electrostatic interactions. The addition of Fe 3+ increased the fraction of disordered secondary structures, reduced the thermal denaturation temperature, reduced the surface hydrophobicity, increased the particle size, and altered the surface potential of the proteins in a dose dependent manner. Optimizing the EGCG-to-Fe 3+ ratio in the complexes (1:2 w/w) led to the formation of protein composites with improved surface, antioxidant, and antibacterial activities. This study provided valuable insights into the interaction mechanisms of proteins, polyphenols, and metal ions in ternary complexes. These complexes may be used as multifunctional ingredients in plant-based foods because of their beneficial antioxidant, antimicrobial, nutritional, and emulsification properties.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
Food & Function
·
2019
·Vol. 10
·期 2
·765-774
·
IF 3.241
Taotao Dai,Jun Chen,David Julian McClements,Peng Hu,Xiaoqin Ye,Chengmei Liu,Ti Li
Rice glutelin and procyanidins are often used in functional foods as sources of plant-based proteins and polyphenols, respectively, but little is currently known about the interactions between them. In our research, the interaction between rice glutelin and the B-type procyanidin dimer (PB2) was investigated. The presence of the PB2 decreased the α-helix and random coil structure of the rice protein and reduced its surface hydrophobicity. However, the PB2 did not adversely affect the functional performance of RG in emulsions. Conversely, the antioxidant capacity of the PB2 was enhanced in the presence of the rice protein. Fluorescence spectroscopy confirmed that the protein and PB2 formed molecular complexes, which were primarily the result of hydrophobic attractive forces. Molecular docking analysis provides insights into the nature of the interaction between the rice protein and PB2. This study provides valuable insights into the nature of the interactions between plant proteins and polyphenolic nutraceuticals.
研究领域:
食品科学
·
营养学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2018
·
IF 13.709
Chao Zhang,Deng-Feng Hu,Jing-Wei Xu,Meng-Qi Ma,Huabin Xing,Ke Yao,Jian Ji,Zhi-Kang Xu
Transition metal dichalcogenide (TMD) nanosheets have evoked enormous research enthusiasm and have shown increased potentials in the biomedical field. However, a great challenge lies in high-throughput, large-scale, and eco-friendly preparation of TMD nanosheet dispersions with high quality. Herein, we report a universal polyphenol-assisted strategy to facilely exfoliate various TMDs into monolayer or few-layer nanosheets. By optimizing the exfoliation condition of molybdenum disulfide (MoS2), the yield and concentration of as-exfoliated nanosheets are up to 60.5% and 1.21 mg/mL, respectively. This is the most efficient aqueous exfoliation method at present and is versatile for the choices of polyphenols and TMD nanomaterials. The as-exfoliated MoS2 nanosheets possess superior biomedical stability as nanocarriers to load antibiotic drugs. They show a high photothermal conversion effect and thus induce a synergetic effect of chemotherapy and photothermal therapy to harvest enhanced antibiofilm activity under near-infrared (NIR) light. All these results offer an appealing strategy toward the synthesis and application of ultrathin TMD nanosheets, with great implications for their development.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Yuxin Li,Yiqing Chen,Ping Li,Gen Wang,Jing Wei
The deposition of silver nanoparticles (Ag NPs) on different substrates is promising in antibacterial applications. But it is limited by the aggregation problem and complex deposition procedure of Ag NPs. Herein, facile fabrication of antibacterial substrates with controllable deposition of Ag NPs via polyphenol reduction strategy is presented. Polyphenol with surface independent coating property is used to in situ deposit Ag NPs on diverse substrates (e.g., cotton textile, copper foil, steel sheet, iron sheet, glass slide, rubber and plastic sheet) via the reduction of Ag + . The modified substrate shows several unique properties, including high color maintenance (4.7 % change from the original), sustained and pH-responsive Ag + release behavior (about 40–10 % of Ag + ions at pH values of 4–8 at day 9, respectively), large diameters of inhibition zones (over 1 cm) and low minimum inhibitory concentrations (0.1 mg mL –1 ). The continuous contamination tests (5 cycles with the almost same effectiveness) and long-term stability analysis (over 25 days) manifest excellent recycling performance and stable antibacterial benefits. Finally, the results of practical applications on mask, shoe-pad and fresh box materials show that all the modified materials inhibited E. coli and S. aureus by more than 95 %. This work provides a versatile interfacial polyphenol reduction strategy for depositing Ag nanoparticles on various substrates. Such Ag-deposited product could be used for packaging and clothing sanitation.
研究领域:
材料科学
·
生物学
·
医学
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Rui Chang,Pei Wang,Hongrui Chen,Shih-Jen Chang,Qianyi Chen,Lei Chang,Yajing Qiu,Xiansong Wang,Xiaoxi Lin
Diabetes-associated skin defects represent a significant global health challenge. While flap grafts have been a preferred treatment for soft-tissue injuries in diabetic patients, their survival is often compromised by impaired vascularization, infection, and the adverse diabetic pathological microenvironment. To address these limitations, a hybrid photo-crosslinkable hydrogel (HPC) integrated hemangioma stem cell-derived nanovesicle (HemV)-loaded dual-metal-polyphenol network (dMPN) (HemV@dMPN/HPC) is developed. HemVs, derived from highly vascularized infantile hemangioma tissues, play a key role in promoting cell proliferation and angiogenesis. The dMPN facilitates the gradual release of copper (Cu 2+ ) and magnesium ions (Mg 2+ ), stimulating angiogenesis and mitigating inflammation. The HPC further sustains ion release while preserving the therapeutic efficacy of HemVs. Moreover, both HPC and Cu 2+ act to confer antibacterial properties, further accelerating wound healing. This multifunctional HemV@dMPN/HPC platform offers a promising therapeutic strategy for treating large diabetic skin defects and can potentially improve flap graft survival.
研究领域:
生物医学工程
·
再生医学
·
糖尿病治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCONJUGATE CHEMISTRY
·
2024
·
IF 4
Shoujun Wang,Xinwei Bai,Xiaoya Wang,Jinmiao Wang,Weijie Tao,Ying Gao,Junya Ning,Jie Hao,Ming Gao
Despite the use of surgical resection and chemotherapy in the clinical treatment of oral squamous cell carcinoma (OSCC), the 5-year survival rates of advanced patients are low. Therefore, more efficient strategies are urgently needed. Herein, a chemo/ferroptosis synergistic therapeutic system-DMEFe nanoparticles (NPs) is established for the treatment of OSCC. To create this system, the chemotherapeutic agent doxorubicin (DOX) was loaded into mesoporous silica nanoparticles and further coated with a pH-sensitive metal polyphenol (iron ion and epigallocatechin gallate). These nanoparticles displayed excellent pH-sensitive drug-control release properties, and the release ratio of DOX at pH 5.5 was twice as high than that at pH 7.4. Additionally, DMEF NPs were effectively taken up by the OSCC cell line SSC-25, which greatly impeded the proliferation of these cells. Notably, these nanoparticles increased the intracellular level of reactive oxygen species and effectively exhibited cytotoxity effects. The mechanistic results proved that DMEFe NPs regulated the expression of ferroptosis-related genes to induce ferroptosis of SSC-25 cells. Eventually, this chemo/ferroptosis therapeutic system exhibited remarkable antitumor effects and provided a novel strategy for the treatment of OSCC.
研究领域:
肿瘤学
·
纳米技术
·
药学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Yunfei Tan,Lei Ma,Yixuan Wu,Zeng Yi,Xiaomin Ma,Jiaxin Liu,Ye Cao,Xudong Li
Nonhealing chronic wounds are intractable clinical complications of diabetes and are characterized by high protease activity, severe oxidative stress and sustained inflammatory response. In this case, the development of functional hydrogel dressings to modulate the immune microenvironment is a well-known strategy, where the precise stimuli-responsive and spatiotemporally controlled release of bioactive molecules remains a huge challenge. Herein, we developed responsive hydrogels with self-regulated bioactive molecule release based on the protease activity in diabetic wound sites, to serve as a smart immune microenvironment modulator for accelerating wound healing. The hydrogels were fabricated by grafting oxidized hyaluronic acid with epigallocatechin-3-gallate (EGCG) and gelatin methacryloyl (GelMA) under UV irradiation. Resveratrol nanoparticles were further loaded into the hydrogels before gelation to construct a polyphenol delivery system. The prepared hydrogels could achieve the on-demand release of polyphenol upon degradation by protease, as confirmed via degradation and polyphenol release experiments. The released polyphenol was demonstrated to have the capacity to effectively scavenge excessive free radicals, promote macrophage polarization, reduce proinflammatory factor (TNF-α) expression and augment anti-inflammatory factor (IL-10) expression in vitro. Additionally, in vivo rat wound healing model experiment results confirmed that these hydrogels promoted collagen deposition and granulation tissue regeneration, accelerating diabetic wound healing. Based on the protease-responsive degradation characteristic of the hydrogels and high protease activity in the diabetic wound microenvironment, hydrogels with exquisite polyphenol release controllability are promising candidates as dressings for diabetic wound management.
研究领域:
生物材料学
·
药剂学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Xiaonan Fan,Xin Xu,Shuhuai Xia,Yanrong Cheng,Xia Guo
Polyphenol oxidase (PPO) is the culprit behind the browning of fruits and vegetables. Therefore, how to reduce the thermal deactivation temperature of PPO or use as few safe reagents as possible to inhibit enzymatic browning has practical significance. Mesoporous silica nanoparticles (MSNs) and multiwalled carbon nanotubes (MWCNTs) are stable and have high biosafety. In the present study, efficient PPO inhibitors were developed based on MSNs and MWCNTs. It is found that after modification with a very small amount of dodecyl trimethylammonium bromide (DTAB, ≥60 μg/mL), MSNs can significantly inhibit the activity of PPO although single MSNs and single DTAB show very limited effect on PPO activity. After modification with a very small amount of sodium dodecyl sulfate (SDS, 5.7–9.5 μg/mL), MWCNTs almost completely inactivate PPO. However, SDS@MSN and DTAB@MWCNT cannot decrease PPO activity significantly.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）