DESALINATION
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2022
·
IF 11.211
Guanhua Li,Sheng Li
Wastewater discharge of traditional Chinese medicine production is a serious threat to the environment in China. This study investigated the effectiveness of the UF-FO-MD hybrid system for resources recycle from the TCM wastewater. Real TCM wastewater was treated with the self-assemble UF-FO-MD hybrid system. Moreover, the natural surfactant rejection and the FO fouling impact were evaluated by separate FO operation with synthetic TCM wastewater, and MD wetting was also assessed. Results show that the UF-FO-MD hybrid system successfully isolated the macromolecular substances, bioactive compounds and water in the TCM wastewater for recovering useful resources. Natural surfactants in the TCM wastewater could be effectively rejected by FO, avoiding the subsequent MD wetting problem which has occurred in our previous study on the resource recovering with the UF-MD hybrid system. However, FO membrane fouling might be an issue affecting the recovery efficiency of bioactive compounds from TCM wastewater. The bioactive compounds could not be completely concentrated due to potential adsorption on the fouling layer .
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ACS Sustainable Chemistry & Engineering
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2022
·
IF 9.224
Mei Yang,Shilin Zhang,Tian Wang,Beibei Shi,Jingyan Liu,Yili Tang,Zonglin Xu,Muhammad Tariq Sarwar,Aidong Tang,Huaming Yang
The key to the development of non-noble metal catalysts with high activity and durability for the hydrogen evolution reaction (HER) in alkaline water/seawater conditions is to construct multi-interface electrocatalysts. Herein, the CoMoO4 nanorod arrays grown on foam nickel (NF) was first prepared by a hydrothermal method. Then, Ni(PO3)2-CoP4 with multi-interface was prepared by soaking the nanorod arrays into a nickel nitrate solution and then by phosphating via chemical vapor deposition. The Ni(PO3)2-CoP4/CoMoO4/NF electrode exhibits superior HER electrocatalytic performance under alkaline conditions with an ultralow overpotential of 79 mV@100 mA·cm–2, which outperforms other reported earth–abundant transition-metal phosphide catalysts. It also maintains long-term durability in alkaline water/seawater electrolytes in 60 h at a constant 100 mA·cm–2. In the alkaline natural seawater electrolyte, Ni(PO3)2-CoP4/CoMoO4/NF (−)||NiFe LDH (+) pair has good long-term stability of 60 h for the voltage of only 1.60 V@100 mA·cm–2. The excellent performance is attributed to the plentiful active sites and the rapid electron-transfer rate. This work affords a new path to rationalize the design strategy of low-cost and multi-interface 3D catalysts for alkaline water/seawater electrolysis.
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Biosensors-Basel
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2021
·Vol. 11
·期 10
·378
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IF 5.519
Jinfeng Quan,Yihan Wang,Jialei Zhang,Kejing Huang,Xuemei Wang,Hui Jiang
Arch-cruciform DNA are self-assembled on AuNPs/VS2scaffold as a highly sensitive and selective electrochemical biosensor for michigan cancer foundation-7 (MCF-7) breast cancer cells. In the construction, arch DNA is formed using two single-strand DNA sequences embedded with the aptamer for MCF-7 cells. In the absence of MCF-7 cells, a cruciform DNA labeled with three terminal biotin is bound to the top of arch DNA, which further combines with streptavidin-labeled horseradish peroxidase (HRP) to catalyze the hydroquinone-H2O2reaction on the electrode surface. The presence of MCF-7 cells can release the cruciform DNA and reduce the amount of immobilized HRP, thus effectively inhibiting enzyme-mediated electrocatalysis. The electrochemical response of the sensor is negatively correlated with the concentration of MCF-7 cells, with a linear range of 10~1 × 105cells/mL, and a limit of detection as low as 5 cells/mL (S/N = 3). Through two-dimensional materials and enzyme-based dual signal amplification, this biosensor may pave new ways for the highly sensitive detection of tumor cells in real samples.Keywords:MCF-7 cells;electrochemistry;2-D materials;signal amplification;DNA assembly
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Journal of Physical Chemistry C
·
2021
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IF 4.126
Jian He,Huining Zhao,Xinru Hu,Zhiyong Fang,Jilin Wang,Rui Zhang,Guoyuan Zheng,Bing Zhou,Fei Long
In this study, a new type of 0-dimensional organic–inorganic hybrid perovskite single crystal (2-5-py)2MnBr4 was synthesized using 2-amino-5-methylpyridine (2-5-py) as the organic ligand. The crystal is a center-symmetric P-1 space group with a grain size of 20 mm, which belongs to the triclinic crystal system. It has a strong absorption of violet and blue light as well as excellent thermal stability. Its optical band gap is 2.38 eV, which is in good agreement with the theoretical band gap (2.39 eV) calculated by density functional theory. Under the excitation of a suitable light source, it can emit 526 nm pure bright green lights, which are confirmed by the main peaks to be almost in the green range with a full width at half maximum of 45 nm. As a result, the quantum efficiency and fluorescence lifetime reached a high level of 44.2% and 117 μs, respectively. Based on the good fluorescence performance of the crystal, a white LED with a color rendering index of 97 was finally successfully fabricated, realizing the leap from basic materials to optoelectronic devices.
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MOLECULES
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2021
·Vol. 26
·期 18
·5698
·
IF 4.412
Sennan Qiao,Hansi Zhang,Fei Sun,Zhenyan Jiang
Artemisinin (also known as Qinghaosu), an active component of the Qinghao extract, is widely used as antimalarial drug. Previous studies reveal that artemisinin and its derivatives also have effective anti-inflammatory and immunomodulatory properties, but the direct molecular target remains unknown. Recently, several reports mentioned that myeloid differentiation factor 2 (MD-2, also known as lymphocyte antigen 96) may be the endogenous target of artemisinin in the inhibition of lipopolysaccharide signaling. However, the exact interaction between artemisinin and MD-2 is still not fully understood. Here, experimental and computational methods were employed to elucidate the relationship between the artemisinin and its inhibition mechanism. Experimental results showed that artemether exhibit higher anti-inflammatory activity performance than artemisinin and artesunate. Molecular docking results showed that artemisinin, artesunate, and artemether had similar binding poses, and all complexes remained stable throughout the whole molecular dynamics simulations, whereas the binding of artemisinin and its derivatives to MD-2 decreased the TLR4(Toll-Like Receptor 4)/MD-2 stability. Moreover, artemether exhibited lower binding energy as compared to artemisinin and artesunate, which is in good agreement with the experimental results. Leu61, Leu78, and Ile117 are indeed key residues that contribute to the binding free energy. Binding free energy analysis further confirmed that hydrophobic interactions were critical to maintain the binding mode of artemisinin and its derivatives with MD-2.Keywords:molecular dynamics simulation;myeloid differentiation factor 2;artemisinin;anti-inflammatory;binding free energy
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ACS Biomaterials Science & Engineering
·
2021
·
IF 4.749
Han Sun,Jian Dong,Yangyufan Wang,Siyu Shen,Yong Shi,Lei Zhang,Jie Zhao,Xiaoliang Sun,Qing Jiang
The periosteum plays an important role in vascularization and ossification during bone repair. However, in most studies, an artificial periosteum cannot restore both functions of the periosteum concurrently. In this study, a novel nanofiber that can sustain the release of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) was fabricated to enhance the durability of angiogenesis and osteogenesis during bone regeneration. A cell-free tissue engineered periosteum based on an electrospinning poly-l-lactic acid (PLLA) nanofiber was fabricated, on which VEGF and BMP-2 were immobilized through a polydopamine (PDA) coating conveniently and safely (BVP@PLLA membrane). The results indicated a significantly improved loading rate as well as a slow and sustained release of VEGF and BMP-2 with the help of the PDA coating. BMP-2 immobilized on nanofibers successfully induced the osteogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) in vitro with high expression of runt-related transcription factor 2 (Runx2), osteopontin (OPN), and alkaline phosphatase (ALP). Similarly, angiogenic differentiation of BMSCs with the expression of fetal liver kinase-1 (Flk-1) and vascular endothelial cadherin (VE-cadherin) was observed under the environment of VEGF sustained release. Moreover, an in vivo study revealed that the BVP@PLLA membrane could enhance vascular formation and new bone formation, which accelerates bone regeneration in rat femoral defects along with a massive periosteum defect. Therefore, our study suggests that the novel artificial periosteum with dual growth factor controlled release is a promising system to improve bone regeneration in bone defects along with a massive periosteum defect.
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ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Lungang Chen,Yong Liu,Canshuo Gu,Gang Feng,Xinghua Zhang,Jianguo Liu,Qi Zhang,Chenguang Wang,Longlong Ma
Selective production of 2-butanol from levulinic acid (LA) hydrogenolysis over a non-precious catalyst is long desirable. However, the process requires the precious metal Ru, and the yield of 2-butanol was less than 65%. Herein, we prepared Ni-based bimetallic catalysts, among which the NiMn catalyst exhibited the highest efficiency and reached an 84.5% yield of 2-butanol at 100% LA conversion under optimal conditions. The electronic states and surface properties were characterized by various techniques such as X-ray diffraction, X-ray photoelectron spectroscopy, temperature-programmed desorption, temperature-programmed reduction, and scanning electron microscopy/transmission electron microscopy. The high efficiency of the NiMn catalyst was due to the synergy between Ni0 and Mn2+ species, and the modified surface showed a high basicity and a high affinity to adsorb LA and LA-derived molecules with C═O or COOH. The high affinity of the NiMn catalyst was further confirmed by density functional theory calculations.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Jinming Ma,Huizhen Deng,Zhe Zhang,Lexin Zhang,Zhihui Qin,Yaru Zhang,Lili Gao,Tifeng Jiao
In this study, a series of Ag 3 PO 4 /PPy/PANI ternary composite catalysts were fabricated by adjusting the mixed solution of pyrrole and aniline with different volume ratios of 4:1, 3:2, 1:1, 2:3, and 1:4, and combining with the in-situ synthesis method. The synthesized Ag 3 PO 4 /PPy/PANI nanoparticles were examined by XRD , SEM, TEM and EDX , Raman spectroscopy . When the ratio of pyrrole and aniline is 1:1, the polymerized PPy/PANI acted as the supporting matrix to effectively immobilize and prevent the aggregation of Ag 3 PO 4 nanoparticles. The catalytic performances of the Ag 3 PO 4 /PPy/PANI composites were confirmed for reduction of 2-nitroaniline (2-NA) and 4-nitrophenol (4-NP) in the presence of NaBH 4 at room temperature by UV–vis spectroscopy. Results showed that the catalytic reduction effect of the Ag 3 PO 4 /PPy/PANI (1:1) on 2-NA is obviously better than that on 4-NP, which followed the pseudo-first-order kinetic, and the corresponding rate constants are 0.0053 min −1 and 0.022 min −1 , respectively, indicating that it has potential application in wastewater treatment in industries.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Feiwei Cao,Mingming Liang,Jianxin Liu,Yu Liu,John A. Renye,Phoebe X. Qi,Daxi Ren
Yak yogurt, one of the naturally fermented dairy products prepared by local herdsmen in the Qinghai-Tibet Plateau, contains a diverse array of microorganisms. We isolated and identified a novel Streptococcus thermophilus strain, ZJUIDS-2-01, from the traditional yak yogurt. We further purified and carried out detailed structural, physiochemical, and bioactivity studies of an exopolysaccharide (EPS-3A) produced by S. thermophilus ZJUIDS-2-01. The weight-average molecular weight (Mw) of EPS-3A was estimated to be 1.38 × 10 6 Da by High-Performance Gel Permeation Chromatography (HPGPC). The monosaccharide analysis established its composition to be glucose, galactose, N -acetyl-D-galactosamine, and rhamnose in a ratio of 5.2:2.5:6.4:1.0. The molecular structure of EPS-3A was determined by the combination of permethylation analysis, FT-IR, and NMR spectroscopic techniques. The ζ-potential measurements indicated that EPS-3A had a p K a value of ~4.40. The DSC yielded a melting point (T m ) of 80.4 °C and enthalpy change (ΔH) of 578 J/g for EPS-3A, comparable to those of the xanthan gum (XG), a commercial EPS. EPS-3A exhibited better O/W emulsion stability and flocculating capacity than XG. Furthermore, it also demonstrated similar antioxidant activity to XG and promising in vitro antibacterial properties. This work evidenced that EPS-3A derived from S. thermophilus ZJUIDS-2-01 holds the potential for food and industrial applications.
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Food & Function
·
2021
·Vol. 12
·期 8
·3572-3585
·
IF 5.396
Qifang Wu,Siya Wu,Yang Cheng,Zhongshan Zhang,Genxiang Mao,Shijun Li,Yue Yang,Xu Zhang,Mingjiang Wu,Haibin Tong
Type 2 diabetic mellitus (T2DM) is a complicated metabolic disorder that is now considered as a major global public health problem. Fucoidan exhibits diverse biological activities, especially prevention of metabolic diseases. In this regard, we herein aimed to reveal the beneficial effect of Sargassum fusiforme fucoidan (SFF) on high-fat diet (HFD) and streptozotocin (STZ) induced T2DM mice. We noted that on the one hand, SFF significantly decreased fasting blood glucose, diet and water intake, and hyperlipidemia, while on the other hand, it improved glucose tolerance. Furthermore, SFF reduced epididymal fat deposition, attenuated the pathological changes in heart and liver tissues, and decreased oxidative stress in diabetic mice. To explore the underlying mechanisms of these ameliorative effects, the gut microbiota was analyzed. Notably, SFF highly enriched benign microbes including Bacteroides, Faecalibacterium and Blautia, as well as increased levels of (R)-carnitine and choline in the colon of diabetic mice. This may be a potential mechanism for alleviating T2DM, thus implying the benefits of SFF as an adjuvant agent for T2DM treatment. Taken together, this study demonstrated a promising application of fucoidan as one of the adjuvant agents for the management of T2DM in the future.
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CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Jingwen Zhang,Chuchu Cheng,FangShu Xing,Cheng Chen,Caijin Huang
Engineering semiconductor materials with vacancies and co-catalysts is a valid method to improve their photocatalytic performance. Herein, we prepared S vacancies-rich Mn 0.3 Cd 0.7 S nanorods modified with β-Ni(OH) 2 nanoparticles through solvothermal and co-precipitation strategies. The as-obtained 0D/1D β-Ni(OH) 2 /Mn 0.3 Cd 0.7 S nanorods exhibit excellent visible-light H 2 -production activity up to 71.09 mmol g −1 h −1 , 5.23 times higher than pure Mn 0.3 Cd 0.7 S and better than 1 wt% Pt/Mn 0.3 Cd 0.7 S and most reported Mn x Cd 1−x S-based catalysts. The apparent quantum yield reaches 46.68% at λ = 420 nm. We found that the presence of S vacancies and β-Ni(OH) 2 enhances the transfer/separation of photogenerated carriers and increases reaction sites, which is beneficial to photocatalytic H 2 -production reaction. This work proposes a new idea for the application of metal hydroxide co-catalysts and S vacancies in sulfide materials for photocatalytic H 2 production.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2021
·Vol. 27
·期 42
·10966-10972
·
IF 5.236
Lanqing Li,Wei Gao,Min Lei,Dan Wen
Graphical A simple ex situ wet chemical transformation method of alkali treatment was proposed to prepare Ni(OH) 2 nanostructured flowers with large specific surface areas from Ni-MOF-74. The relationship between concentration of alkali and the structure properties of corresponding Ni(OH) 2 was uncovered. As the results, the catalyst of Ni(OH) 2 -0.25 performed remarkably catalytic properties with lower potential, higher current density and excellent durability towards MOR among various samples. Post treatment of metal-organic frameworks (MOFs) is widely employed to develop efficient electrocatalysts with better catalytic properties. But the complex processes of post treatment generally led to the collapse of the original structures of MOFs, making the preservation of their pristine hierarchical porous structure a great challenge. Herein, we propose the strategy of alkali treatment of Ni-MOF to transform it into Ni(OH) 2 with similar morphology and enhanced electrocatalytic properties for methanol oxidation reaction (MOR). The structure and electrocatalytic properties of as-obtained Ni(OH) 2 nanostructured flowers were seriously depended on the alkali concentrations. As the result, Ni(OH) 2 obtained from Ni-MOF treated by 0.25 M NaOH (noted as Ni(OH) 2 -0.25) performs 1.5 and 2.5 times larger current density than those of Ni(OH) 2 -0.025 and Ni(OH) 2 -0.5 for MOR. Moreover, the electrocatalytic process and mechanism of MOR on the catalyst of Ni(OH) 2 -0.25 are also revealed. Hence, this ex situ conversion strategy of alkali treatment for Ni-MOF uncovered the transformation of MOFs in alkaline solution and develops robust electrocatalyst for practical application of methanol fuel cells.
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