Nature Communications
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2026
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IF 18.1
Wang Siyuan,Kong Fanpeng,Bao Zhengyang,Zhao Xiaozhi,Zhang Lei,Song Zhongxin,Li Junjie,Du Lei,Xu Yongjun,Zhao Bo,Yin Geping,Sun Xueliang
Uniform ionomer distribution and controlled sulfonate adsorption are critical for low-Pt-loading proton exchange membrane fuel-cell membrane electrode assemblies (MEAs), especially at high current density. In conventional Pt/C catalysts, differences between Pt and carbon surfaces promote sulfonate adsorption on Pt and ionomer aggregation on carbon, thereby limiting proton and oxygen transport. Here we show that a single Co atom dipole layer covering Pt/C (SCDC-Pt) regulates the catalyst-ionomer interface through electrostatic attraction between positively charged Co sites and sulfonate groups. The resulting MEA delivers a peak power density of 1.4 W cm −2 and only 26 mV loss at 0.8 A cm −2 after 30,000 square-wave cycles, compared with 0.86 W cm −2 and 75 mV loss for commercial Pt/C under identical conditions. Operando characterization and simulations indicate that surface dipoles promote a more uniform ionomer distribution, suppress sulfonate poisoning of Pt, and stabilize the Pt structure. Electrochemical diagnostics show lower apparent sulfonate coverage ( ~ 8%) and local O 2 transport resistance (38.6 S m −1 ) than those of commercial Pt/C ( ~ 20% and 48.1 S m −1 ).
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Shaoyong Weike,Jiang Shouchuan,Wang Yingqian,Li Wei,Wang Zilong,Yang Yixiao,Du Juan,Liu Zhongjie
Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and intestinal endocrine imbalance. No approved pharmacotherapies effectively treat MASH largely because of the difficulty in reversing fibrosis and restoring extracellular matrix homeostasis. Managing intestinal barrier dysfunction and GLP1 secretion has emerged as a promising therapeutic strategy against the progression of metabolic-associated fatty liver (MAFL) to MASH. This study presents MSN@HTL, fabricated using trehalose and temsirolimus on mesoporous silica nanoparticles (MSNs) and encapsulated with sodium alginate using an electrostatic spraying system. After oral administration, MSN@HTL protects against intestinal barrier injury and GLP1 secretion, consequently inhibiting the progression of MAFL. MSN@HTL stimulated intestinal stem cell self-renewal, proliferation, and GLP1 secretion. Mechanistically, MSN@HTL induces lysosomal autophagy to recycle disrupted mitochondria, increasing mitochondrial fusion and energy metabolism, elevating cAMP concentration, and inducing PKA phosphorylation-mediated intestinal barrier revision and GLP1 secretion, thereby impairing MAFL-to-MASH progression. Given its availability and functionality, our study demonstrates the potential of MSN@HTL as a pharmaceutical agent for managing MAFL-to-MASH progression via the mitochondria/cAMP/PKA signaling pathway in humans. Graphical
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Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Cui Ruopeng,Li Yi,Zhang Xuefei,Duan Zewen,Chen Weihao,Chen Jiangyun,Li Jiaming,Che Renchao,Wan Chunlei
Schottky contacts at (semi)metal/semiconductor heterointerfaces, known for their prominent spatial charge separation effect, have attracted increasing interest for microwave absorber (MAM) applications, but the inappropriate and non-uniform barrier heights between existing polycrystalline semiconducting and (semi)metallic components present a major challenge for achieving high-permittivity dielectric matching, a critical prerequisite for ultrathin high-performance MAMs. Here, we report an amorphization-mediated strategy to tailor Schottky contacts via an innovative intercalation-coprecipitation-annealing process. This yields amorphous TiO 2 (a-TiO 2 ) with isotropic nanostructures and a unified work function, interfacing intimately with large-area reduced graphene oxide (rGO) basal planes. Critically, amorphization suppresses the Schottky barrier height to < 0.2 eV via elevated oxygen vacancies, and eliminates barrier dispersion induced by crystallographic orientations. The resultant rGO/a-TiO 2 heterointerfaces enable high-permittivity dielectric matching, achieving controlled dielectric loss (tan δ e ) at enhanced permittivity ( ε ’), thereby overcoming impedance mismatch via curbing the difference between permittivity and permeability of the material effectively. When integrated with flaky carbonyl iron (FCI) to provide magnetic/dielectric synergy, the rGO/a-TiO 2 /FCI (RTF) nanocomposite can achieve first-class absorption (-79.51 dB) at ultrathin thicknesses (< 1.5 mm). This work demonstrates how amorphization engineering precisely modulates the magnitude and uniformity of Schottky barrier, opening pathways for ultrathin high-performance MAMs and other functional applications.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Wu Zhou-Liang,Li Ling-Rui,Zhou Yu,Yang Di,Liao Shuang-Quan,Mei Jun-Fei,Ding Ai-Wu,Luo Ming-Chao
The reprocessing and recycling of vulcanized rubbers remain challenging because conventional vulcanization networks are irreversible. Here, we designed a modified sulfur crosslinker via inverse vulcanization to regulate the exchange kinetics of vulcanization networks, thereby governing the mechanical recovery behavior of reprocessed rubbers. Copolymers of sulfur and thioctic acid (CSTA), synthesized via inverse vulcanization, were employed to crosslink butadiene-styrene rubber. After vulcanization, thioctic acid (TA) introduces dynamic disulfide bonds into the conventional vulcanization networks, enabling thermally activated network rearrangement while preserving the overall crosslinked structure. Kinetic analysis revealed that increasing the TA content accelerated network exchange and significantly lowered the apparent activation energy for network rearrangements. Correspondingly, the recovery of the mechanical properties after reprocessing improved with increasing TA content. These results establish a clear correlation between vulcanization network exchange kinetics and macroscopic mechanical performance, providing a kinetic basis for the design of reprocessable vulcanization networks and offering a promising route toward recyclable high-performance rubber materials.
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Nature Communications
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2026
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IF 18.1
Chen Haojie,Gao Rui-Ting,Wang Lei,Wu Limin
Photoelectrochemical bipolar systems enable bias-free H 2 O 2 synthesis by integrating light harvesting, water oxidation and oxygen reduction. However, poor selectivity due to competing 4e - pathways, slow charge transfer, and inferior stability severely limit their practical application. Herein, we present a bias-free photoelectrochemical bipolar system for H 2 O 2 production, which integrates a Zn-TiO 2 /BVO/WO 3 photoanode for the 2e - water oxidation reaction and a Ru:CuO/Nb-CBO photocathode for the 2e - oxygen reduction reaction. The photoanode suppresses *OOH intermediates to favor H 2 O 2 formation, achieving a Faradaic efficiency (FE) of 90.2% at 0.6 V RHE . The photocathode stabilizes *OOH intermediates and delivers an FE of 91.9% under the same conditions while maintaining performance for over 50 h. Practical testing under natural sunlight with 36 cm 2 electrodes achieves an FE of 163.37% and a yield of 11.44 mmol L −1 . In situ generated H 2 O 2 achieves over 99% bacterial inactivation within 60 min. This work provides an adaptive platform for solar-driven H 2 O 2 synthesis and energy conversion.
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Nature Communications
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2026
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IF 18.1
Bai Jin,Li Jie,Yang Chen,Lv Weipeng,Jin Yi,Zhang Xuxin,Gao Lei
Flexible implantable neural electrodes have been studied extensively due to their chronic single-unit recording capability over weeks or months. However, high-density stable recording of the same neuronal ensembles over years-long periods remains challenging. Here we address this challenge by developing umbrella-type stretchable electrode arrays, which are anchored to surrounding brain tissue, forming a seamless neuroelectronic interface. We show that the umbrella-type stretchable electrode arrays create a neuroelectronic interface with reduced probe drift and gliosis that can stably track the same neuronal ensembles in head-fixed mice over 80 weeks (approximately 1.5 years). We also demonstrate that orientation-selective neuronal populations in the mouse primary visual cortex can be consistently recorded over 20 weeks. The umbrella-type stretchable electrode arrays with long-term recording capabilities hold significant promise for both fundamental neuroscience research and clinical brain-machine interface systems.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Li Yuyan,Lan Jue,Ran Lingshan,Xie Yulu,Yu Jinmei,Yang Yunxin,Tan Xiaofeng,Qu Xiaodong,Wei Hongxia,Luo Jun,Huang Xiaoyu,Qiu Rongmin
Dental caries, a chronic disease resulting from bacterial demineralization of dental hard tissues, poses a significant global health challenge. Remineralization therapy presents a promising strategy to arrest caries progression and restore tissue integrity. However, simultaneously achieving stable, efficient remineralization and effectively combating plaque biofilm formation remains a critical hurdle. Inspired by the hierarchical “brick-and-mortar” architecture of nacre and the adhesive functionality of mussel foot proteins (Mfps), a novel nanoarchitectonic system was developed via a layer-by-layer biomimetic assembly. This multifunctional system comprises amorphous calcium phosphate (ACP) as a mineral ion reservoir, tannic acid (TA) as a bridging and crystallization-regulating layer mimicking the catechol chemistry of Mfps, and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) as a functional antibacterial outer layer. This bioinspired design yields a stable platform capable of sustained release of calcium and phosphate ions for remineralization while providing long-lasting antibacterial activity against cariogenic biofilms. The system not only forms a durable protective barrier on the enamel surface but also facilitates effective biomimetic remineralization of early carious lesions. This nature-inspired strategy provides a comprehensive and clinically translational approach for hard tissue regeneration and synergistic caries management. Graphical
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PubMed
高影响因子
POLYMER BULLETIN
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2026
·Vol. 83
·期 11
·573
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IF 4.2
Zhang Na,Wang Xiaoyue,Qi Guohui,Shen Sen,Chen Liduo,Li Cuiqin,Wang Jun
Salicylaldiminato and pyridinimine phthalocyanine ligands, along with their corresponding nickel catalysts were synthesized and characterized by 1 H NMR, FT-IR, UV-Vis, elemental analysis, ICP-MS, and TG-DTA. The catalytic performance of imine phthalocyanine nickel-based catalysts in ethylene oligomerization was investigated. Ethylene oligomerization results indicated that under the optimal reaction conditions, the activity of the salicylaldiminato phthalocyanine nickel catalyst (12.54 × 10 5 g/(mol Ni·h)) was greater than that of the pyridinimine phthalocyanine nickel catalyst (10.06 × 10 5 g/(mol Ni·h)), and the products of the two catalysts were mainly butene as well as minor amounts of hexene and octene. The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of the imine phthalocyanine nickel-based catalysts were calculated using density functional theory (DFT). The results showed that the salicylaldiminato phthalocyanine nickel catalyst had larger energy gap value. To further investigate the micro reaction process of ethylene oligomerization, the reaction mechanism of ethylene oligomerization was proposed. The DFT calculation of the catalytic cycle process was carried out by selecting a reasonable molecular model of imine phthalocyanine nickel catalyst. The molecular model of the salicylaldiminato phthalocyanine nickel catalyst had a lower ethylene insertion barrier and β -H elimination barrier, indicating that this molecular model was more conducive to ethylene oligomerization.
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Drug Delivery and Translational Research
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2026
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IF 6.9
Fan Xudong,Luo Jingming,Tang XiaoQian,Zhang Jie,Zhang Ruoying,Cai Xinjun
Lung cancer remains a leading cause of cancer-related mortality worldwide, while the clinical utility of irinotecan-derived therapies is often constrained by poor drug solubility, suboptimal biodistribution, and systemic toxicity. To overcome these limitations, we developed polymeric nanomicelles co-loading 7-Ethyl-10-hydroxycamptothecin (SN38), the active metabolite of irinotecan, and quercetin, a naturally occurring flavonoid with intrinsic antitumor activity, for nebulized inhalation delivery. The dual-drug nanomicelles (SN38/QU-PPM) were prepared by nanoprecipitation and exhibited a uniform particle size distribution, excellent stability, and pH-responsive drug release under acidic conditions. In vitro studies demonstrated that quercetin co-loading enhanced cellular uptake of the nanomicelles and promoted intracellular accumulation of SN38, resulting in significantly greater cytotoxicity against LLC-Luc lung cancer cells compared with SN38-loaded nanomicelles alone. In an orthotopic lung cancer model, nebulized inhalation of SN38/QU-PPM achieved a 3.33-fold higher pulmonary SN38 concentration than intravenous administration at 24 h. Nebulized SN38/QU-PPM also exhibited superior antitumor efficacy, achieving a tumor inhibition rate of 80.7%, accompanied by increased apoptosis, reduced tumor cell proliferation. Histopathological examination and serum biochemical analyses indicated no apparent treatment-related abnormalities following inhalation administration. Collectively, SN38/QU-PPM delivered via nebulized inhalation represents an effective lung-targeted drug delivery strategy that enhances local drug exposure and potentiates the antitumor efficacy of SN38. This dual-drug nanomicelle platform holds considerable promise for the treatment of lung cancer through nebulized inhalation therapy.
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Journal of Neuroinflammation
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2026
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IF 11.5
Hanqi Wang,Yijun Chen,Junna Chang,Zhen Liu,Yang Yu
Depression is one of the most prevalent psychiatric disorders worldwide, yet its pathogenesis remains unclear. Here, we aimed to investigate the effects of formyl peptide receptor 2 (FPR2), a key regulator of innate immunity and inflammation, on lipopolysaccharide (LPS)-induced depression-related behaviors in mice after intraperitoneal administration, and to elucidate its regulatory mechanisms in microglia. FPR2 knockout (Fpr2 -/- ) significantly attenuated LPS-induced depressive and anxiety-like behaviors in mice. LPS markedly increased FPR2 expression in microglia of the prefrontal cortex (PFC) and hippocampus, while only a minimal increase was observed in neurons. FPR2 deficiency alleviated LPS-induced microglial activation and reduced neuronal synaptic alterations. RNA sequencing and validation experiments confirmed that FPR2 deletion substantially decreased LPS-induced microglial NLRP3 inflammasome activation and IL-1β levels in the brain. Mechanistically, FPR2 regulated downstream NLRP3 activation by modulating CSF1, and FPR2/CSF1 activation was governed by its upstream ligand, serum amyloid A (SAA). Analysis of public clinical datasets revealed that SAA1 levels were significantly upregulated in the orbital ventral PFC of patients with major depressive disorder (MDD) and in the plasma of patients with late-life depression. These findings demonstrate that the SAA/FPR2/CSF1/NLRP3 pathway mediates LPS-induced depressive-like behaviors by regulating microglial activation and neuroinflammation.
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PubMed
高影响因子
Advanced Composites and Hybrid Materials
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2026
·Vol. 9
·期 4
·340
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IF 15.5
Wang Yanrong,Chen Qiuling
The strategic integration of metal-organic frameworks (MOFs) with MXenes presents a promising avenue to overcome charge separation bottlenecks in photocatalysis. This study constructs a hierarchical S-scheme heterojunction by in-situ growing ultrafine Zinc–Tetrakis(4-carboxyphenyl) porphyrin (Cobalt-incorporated) Zn-TCPP(Co) MOF nanoparticles (15 nm) on two-dimensional functionalized MXene nanosheets. This unique “particle-on-lamella” architecture is engineered with molecular bridges, establishing a chemically bonded interface via C–Ti–O and N–Ti bonds that facilitate rapid charge transfer. The optimized heterostructure exhibits a narrow bandgap of 1.95 eV, a significantly prolonged charge carrier lifetime of 35.5 ns, and a high photocurrent density of 1.7 µA cm − 2 . By leveraging synergistic S-scheme charge separation, MXene’s metallic conductivity, and molecular single-atom Co sites, the composite achieves an exceptional hydrogen evolution rate of 24.3 mmol g − 1 h − 1 with an apparent quantum efficiency of 10.2% at 420 nm—representing a sixfold enhancement over pristine Zn-TCPP(Co). This performance surpasses many recently reported MOF- and MXene-based photocatalysts. Combined density functional theory calculations and experimental analyses confirm the critical role of the internal electric field in driving the S-scheme mechanism, which effectively preserves strong redox potentials. This work provides a definitive blueprint for high-performance photocatalytic systems through molecular-level interfacial engineering.
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Wen Lei,Li Yuan,Wu Ting,Yu Yue,Wu Yong,Wang Yue,Wang Deguo
Macrophage polarization into M 1 and M 2 phenotypes plays critical roles in homeostasis and disease pathogenesis. M 2 macrophages are characterized by high expression of the mannose receptor (CD206), which specifically binds and internalizes mannosylated ligands. In this study, we developed a novel fluorescent probe by conjugating Rhodamine B (RhB) to mannan isolated from Tremella fuciformis (RhB-mannan). The probe was thoroughly characterized by FTIR, NMR, and fluorescence spectroscopy. Using Raw 264.7 macrophages polarized to M 1 (LPS) or M 2 (IL-4) phenotypes, we demonstrated that the RhB-mannan probe selectively labels M 2 cells, correlating with CD206 expression confirmed by immunofluorescence. The specificity of the probe was further validated by competitive inhibition with free mannose, which abolished the fluorescent labeling. This probe provides a valuable tool for live-cell imaging of M 2 macrophages and studying their role in disease progression.
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