ENERGY & FUELS
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2025
·
IF 5.3
Jinsong Luo,Tianci Xiao,Xiang Li,Qingyu Wang,Xusheng Zheng,Jiuzhong Yang,Chengyuan Liu,Yang Pan
The methanol-to-hydrocarbon (MTH) reaction offers a promising non-fossil fuel pathway for the production of olefins and aromatics. A formaldehyde (HCHO) intermediate has attracted great attention due to its critical role in the aromatization and coking process of the MTH reaction. However, because of the difficulty in the direct detection of HCHO, details on the impact of reaction condition on its formation and conversion were seldom studied. Here, synchrotron radiation photoionization mass spectrometry (SR-PIMS) was applied to thoroughly study the changes in HCHO and other relevant species under different reaction conditions, including contact time, temperature, zeolite acidity, and methanol concentration. It is revealed that higher temperature and acidity promoted the formation of HCHO and its transformation to aromatics and coke, whereas higher methanol concentration mainly enhanced hydrogen transfer reactions, resulting in a higher yield of polyunsaturated species and, consequently, more aromatics. Combining the results from SR-PIMS and soft X-ray absorption spectroscopy of the spent catalyst, it is verified that HCHO formation promoted coke formation, but the presence of olefinic species can shift the methanol conversion pathway toward methylation reactions and then limit the level of HCHO yield. Therefore, we proposed a butanol cofeeding strategy that can limit the contribution of HCHO-induced coke formation and extend the catalyst lifetime by up to ∼60%.
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高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2024
·Vol. 137
·期 3
·1635-1649
·
IF 1.7
Pan Weixing,Chen Hui,Chen Aicheng
A series of low-cost α-Ni(OH) 2 /SiO 2 catalysts were successfully fabricated by the vapor-induced internal hydrolysis method, then the hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) was investigated by using the ethanol as the hydrogen donor over these as-prepared α-Ni(OH) 2 /SiO 2 catalysts. Based on the reaction results, these as-prepared catalysts, which could dispense with extra pre-reduction treatment before reactions, exhibited superior catalytic performance for the HMF hydrogenation to BHMF. A remarkable intrinsic selectivity of BHMF selectivity of almost 100% with about 90% HMF conversion could be obtained under 195 °C for 5 h in an N 2 atmosphere over the α-Ni(OH) 2 /SiO 2 catalyst of 5-Ni(OH) 2 /SiO 2 with about 5 wt% Ni on SiO 2 . The almost constant HMF conversion and BHMF intrinsic selectivity found from the recycling tests can indicate that the catalyst was stable without the obvious loss of its catalytic activity after recycling. Moreover, the mechanism of HMF hydrogenation using ethanol over the α-Ni(OH) 2 /SiO 2 catalysts could be referred to as the mechanism of the Meerwein-Ponndorf-Verley reaction. This work will provide a simple synthesis method for future design and development of high-performance, low-cost, and low-energy consumption catalysts for HMF hydrogenation to BHMF.
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ANALYTICA CHIMICA ACTA
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2013
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IF 4.387
Debin Wan,Hongmei Yang,Fengrui Song,Zhiqiang Liu,Shuying Liu
1-Phenyl-3-methyl-5-pyrazolone (PMP) labeling technique has hitherto proved to be a convenient and sensitive method for separating and detecting oligosaccharides. However, the detailed fragmentation of the derivatives by tandem mass spectrometry has been reported limitedly and no characteristic fragment ions for isomers have been detected. In this study, eight disaccharide isomers were labeled with PMP and analyzed by positive ion electrospray ionization multi-stage tandem mass spectrometry (ESI-MS n ). In comparison with the native disaccharides, PMP labeled disaccharides gave rise to more fragment ions in the tandem mass spectra. The distinctive diagnostic fragment ions formed from cleavage of C C bonds have been detected in the fragmentation of PMP-labeled disaccharide linkage isomers, allowing unambiguous assignment of the position of the glycosidic linkages. This feature is particularly useful for the structural determination of unknown isomeric disaccharides mixed together. In addition, the anomeric configurations can also be easily assigned based on the relative abundance ratios of the selected ion pairs. To verify the feasibility of the method used in the analysis of natural product, water soluble Panax Ginseng extract has been further investigated to identify its unknown disaccharides. The results confirmed that the PMP labeling technique in conjunction with ESI-MS n could offer a powerful and convenient tool for differentiation of structurally closely related isomers, even the unknown mixtures of isomeric disaccharides with different linkage types.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Zuhao Chen,Yongyou Hu,Guanglei Qiu,Donghui Liang,Jianhua Cheng,Yuancai Chen,Guobin Wang,Xiaoqiang Zhu,Jieyun Xie
Inoculating functional bacterial strains is a cost-effective strategy for enhancing treatment of anaerobic digestion liquids in swine wastewater. This study systematically evaluated inoculation of heterotrophic nitrification aerobic denitrification strain Acinetobacter indicus CZH-5 in an internal circulation airlift zeolite sphere-based sequencing batch reactor (IR) for aerobic removal of nitrogen (N), phosphorus (P), and tetracycline (TEC). Inoculation with CZH-5 promoted secretion of quorum sensing signaling molecules, specifically N-acyl-homoserine lactones (C6-HSL and C10-HSL). These signaling molecules enhance quorum sensing and reinforce cooperation among functional bacteria. Under optimal conditions, average removal efficiencies of total nitrogen, total phosphate, and TEC were 92.8%, 88.4%, and 93.1%, respectively. The removal performance in IR exceeded that of the control by 26%–71%. N removal involved complete nitrification-denitrification, while accumulated P was transformed into phosphate monoesters within biofilm. Metagenomic analysis identified Thauera and Acinetobacter as the dominant genera, and Acinetobacter indicus as predominant species. Inoculation enhanced microbial richness and diversity to improve system operational stability. The abundance of functional genes associated with N, P, and TEC transformations significantly increased compared to the control. This study aimed to investigate the characteristics and mechanisms of inoculating a heterotrophic nitrification aerobic denitrification strain into an aerated biofilm system for swine wastewater remediation.
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PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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2014
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IF 1.335
Yuming Dong,Zhengjie Zhou,Hongyan Ding,Shujiang Zhang
Context: High concentration of 5-amino salicylic acid (5-ASA) in the distal ileum and colon is necessary for the treatment of inflammatory bowel disease (IBD). The control of small molecules, drugs, released from a polymeric matrix remains a great challenge.Objective: To study the preparation and properties of a pH-sensitive carrier for targeting delivery of 5-ASA.Materials and methods: The carrier was prepared by ternary blends method based on polyvinyl alcohol (PVA), sodium alginate (SA) and polylactic acid. It was characterized by infrared spectrometry and scanning electronic microscopy. The adsorption and release of 5-ASA in different pH media were investigated.Results: We found out the best ratio of the materials for synthetic carrier. The vector exhibited good performance by the controlled release of the target drug experiment. The adsorption capacity of the carrier for 5-ASA was 70.34% in phosphate buffer saline at pH 1.00, and the release rate was 100.49% in phosphate buffer solution at pH 6.80.Discussion and conclusion: PVA is vector backbone of the carrier, and SA plays key role in its pH performance. It is a promising material to effectively deliver 5-ASA to the specific sites of IBD.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Haoheng Wu,Yanyan Yu,Ying He,Yun Liu
The development of high-performance, multifunctional catalysts capable of effectively addressing nitroarene hydrogenation remains a significant challenge. In this study, we present a novel approach to catalyst design through the controlled carbonization of a copper–furan dicarboxylate metal–organic framework (Cu-FDCA MOF), resulting in two distinct nanocomposites: oxygen-vacancy-rich Cu/Cu 2 O/CuO@C (synthesized in an argon atmosphere) and conventional CuO (prepared by air calcination). Advanced characterizations, including TEM, XPS, EPR, and BET, reveal that Cu/Cu 2 O/CuO@C possesses 2.3 times more oxygen vacancies and a surface area 97 times greater (106.21 m 2 /g vs. 1.09 m 2 /g) than CuO, which directly correlates with its superior catalytic performance. In the context of nitroarene hydrogenation, Cu/Cu 2 O/CuO@C demonstrates an exceptionally high rate constant (k app = 25.33 × 10 -2 s -1 ), outperforming CuO by a factor of 40. Furthermore, Cu/Cu 2 O/CuO@C maintains 90 % of its catalytic activity after five reaction cycles and can be fully regenerated upon treatment at 400 °C. Through a combination of experimental studies and density functional theory (DFT) calculations, we propose a novel water-derived hydrogen transfer mechanism that challenges conventional understanding of the role of NaBH 4 . Notably, Cu/Cu 2 O/CuO@C also exhibits impressive versatility, efficiently degrading organic dye (Congo red/methylene blue/methyl blue) within three minutes. This work establishes MOF-derived oxygen-deficient nanocomposites as promising platforms for both amine synthesis and environmental decontamination.
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EXPERIMENTAL ANIMALS
·
2022
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IF 1.798
Zhanchun SONG,Xiaozeng WANG,Lianqi HE,Liang CHEN,Zhichao REN,Siyu SONG
Myocardial infarction (MI) as the remarkable presentation of coronary artery disease is still a reason for morbidity and mortality in worldwide. Lysosomal-associated protein transmembrane 5 (LAPTM5) is a lysosomal-related protein found in hematopoietic tissues and has been confirmed as a positive regulator of pro-inflammatory pathways in macrophages. However, the role of LAPTM5 in MI remains unknown. In this study, we found that both mRNA and protein expression levels of LAPTM5 were significantly elevated in MI mice. Suppression of LAPTM5 in myocardial tissues decreased cardiac fibrosis and improved cardiac function after MI. At the molecular level, downregulated LAPTM5 dramatically suppressed the macrophage activation and inflammatory response via inhibiting the activation of the NF-κB pathway. Collectively, suppression of LAPTM5 in myocardial tissues inhibits the pro-inflammatory response and the cardiac dysfunction caused by MI. This study indicated that LAPTM5 as a pro-inflammatory factor plays a crucial role in MI disease.
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PubMed
高影响因子
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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2020
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IF 4.873
Liu Tang,Xiao-Lei Li,Zi-Xin Deng,Yao Xiao,Ya-Hong Cheng,Jing Li,Hong Ding
Conjugated linoleic acid (CLA), commonly found in beef, lamb and dairy products, has been reported to exhibit anti-inflammatory and antipruritus effects and to inhibit the release of chemical mediators such as histamine and eicosanoid in laboratory rodents. The chief objective of the study is to assess the efficacy of CLA on atopic dermatitis (AD) in mice and to explore possible mechanisms with CLA treatments . To develop a new therapy for AD, the anti-AD potential of CLA was investigated by inducing AD-like skin lesions in mice using 2,4-dinitrofluorobenzene. We evaluated dermatitis severity; histopathological changes; serum levels of T helper (Th) cytokines (interferon-γ, interleukin-4); changes in protein expression by western blotting and immunohistochemistry staining for cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), toll like receptor 4 (TLR-4), myeloid differentiation factor 88 (MyD88), nuclear factor-κB (NF-κB) and tumor necrosis factor α (TNF-α); and production of the proinflammatory lipid mediators, such as prostaglandin E 2 and leukotriene B4 , in the skin lesions. Treatment with CLA ameliorated the development of AD-like clinical symptoms and effectively inhibited epidermal hyperplasia and infiltration of mast cells and CD4 + T cells in the AD mouse skin. Total serum immunoglobulin E levels and the expression levels of Th1/Th2 cytokines and lipid mediators in dorsal skin were dramatically suppressed by CLA. Furthermore, CLA down-regulated the expressions of COX-2, 5-LOX, TLR4, MyD88, NF-κB and TNF-α. Taken together, our findings demonstrate the potential usefulness of CLA as an anti-inflammatory dietary supplement or drug for the prevention and management of AD skin diseases by modulating the COX-2/5-LOX and TLR4/MyD88/NF-κB signaling pathways .
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高影响因子
Green Energy & Environment
·
2025
·
IF 14.6
Conghao Ku,Lihua Du,Huidu Xu,Xucheng Li,Siyuan Long,Zhengli Liu,Ik Seon Kwon,Jeunghee Park,Weiran Yang
Selective total hydrogenation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)tetrahydrofuran (BHMTHF) under mild condition is crucial in biomass refining, yet dauntingly challenging with non-precious metal catalysts. Herein, the hexagonal-close-packed (hcp) Ni dominated carbon-encapsulated Ni-based catalyst (Ni@C-3) was fabricated via a facile citric acid induced carbonization strategy, which exhibited an outstanding catalytic performance toward the hydrogenation of HMF, achieving a high BHMTHF yield of 95.4% under 70 °C and 2 MPa H 2 . Additionally, even at high HMF concentrations (2500 mM), it maintained an high BHMTHF yield of 89.7%. The carbon layer, derived from the thermal decomposition of citric acid, effectively prevents the agglomeration of Ni nanoparticles and suppresses the phase transition of hcp-Ni to fcc-Ni. The carbon-encapsulated structure ensures the excellent storage stability and reusability of catalysts. Structure-activity relationship studies demonstrated that the hcp-Ni (101) crystal facets effectively reduce the reaction energy barrier of the rate-determining step (furan ring hydrogenation) during the reaction process, thereby promoting the hydrogenation of HMF to BHMTHF. Furthermore, the Ni@C-3 exhibited excellent catalytic activity in the hydrogenation of compounds containing various functional groups. Notably, furfural can also be hydrogenated to tetrahydrofurfuryl alcohol (THFA) under solvent-free conditions, and the yield of THFA can reach 91.2%. This study provides a facile strategy for designing and developing advanced hydrogenation catalysts based on crystal phase engineering, which makes it a promising alternative to noble metal catalysts in biorefineries.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Zhang Dingyue,Xu Xinying,Zhang Rui,Zhang Zhen,Zhang Xiao,Yao Chunli
The depletion of fossil fuel reserves, coupled with the emergence of various pollution issues, has precipitated a surge in demand for research in the domains of bioenergy and biochemical research. 5-Hydroxymethylfurfural (5-HMF) is regarded as a bridge material connecting petrochemical industries and natural biomass resources. Due to the extremely low yield of one-step conversion from cellulose to 5-HMF, most studies have chosen glucose as the starting material. However, glucose isomerization remains one of the challenging steps in the conversion process. Here we successfully prepared a metal chromium-loaded sulfonated mesoporous carbon-based solid acid catalyst (Cr–SO 3 H-CSA) with a large pore size (7.844 nm) and high acidity (14.304 mmol NH3 ·g⁻ 1 cat), as well as a mesoporous silica-based solid acid catalyst (Cr–SO 3 H-MCM41). The catalytic conversion of glucose to 5-HMF over these catalysts afforded yields of 96.43% and 79.45%, respectively. Compared with other types of solid acids reported in the literature, the catalysts prepared in this study exhibit superior catalytic performance for the conversion of glucose to 5-hydroxymethylfurfural (5-HMF). Furthermore, it is demonstrated that the structure of the catalyst support has a significant impact on the catalytic effect. This work expands the choice of catalysts for efficient conversion of biomass into 5-HMF and provides insights into the effect of support structure on catalyst preparation. Graphical
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高影响因子
JOURNAL OF POWER SOURCES
·
2014
·
IF 5.211
Junli Shi,Yonggao Xia,Shaojie Han,Lifeng Fang,Meizi Pan,Xiaoxiong Xu,Zhaoping Liu
Since 5 V lithium ion batteries have attracted more and more attentions and are deemed to be an important tendency in the future, the matched design of the separators has also become a necessary and significant work. In this work, the lithium ionic conducting glass ceramic Li 1.5 Al 0.5 Ge 1.5 (PO 4 ) 3 -polypropylene (PP) based inorganic–organic composite separator (LAGP-PP) is prepared. Compared with the pristine PP separator, the LAGP-PP separator owns enhanced thermal stability and wettability . Meanwhile, the LAGP-PP separator shows higher ion conductivity than the traditional Al 2 O 3 coated PP separator due to the more facile lithium ion diffusion channels in the coating layer . The superior C-rate capacity and cyclability in the LiNi 0.5 Mn 1.5 O 4 based 5 V lithium ion batteries indicate that the LAGP-PP separator is a good alternative for the traditional inert inorganic ceramic coated polyolefin separators and is a kind of promising candidate separator for the high voltage lithium ion batteries.
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高影响因子
Journal of Animal Science and Biotechnology
·
2026
·Vol. 17
·期 1
·169
·
IF 7.9
Li Jiahao,Wang Zhengli,Ma Xiaoxue,Nie Cunxi,Liu Tingting,Li Yuanyuan,Zhang Wenju
Background Diarrhea in suckling lambs is associated with gut microbiota dysbiosis, impaired intestinal barrier function, and enhanced inflammatory responses. However, the specific intestinal microbes and microbial metabolites linked to intestinal homeostasis in suckling lambs remain unclear. Results In this study, diarrheic lambs showed significantly higher serum diamine oxidase (DAO) activity, D-lactate (D-LA), and pro-inflammatory cytokine levels than healthy lambs. We then compared gut microbial composition and metabolite profiles between healthy and diarrheic suckling lambs. Diarrheal lambs exhibited gut microbiota dysbiosis, characterized by an elevated Bacillota (syn. Firmicutes)/Bacteroidota (syn. Bacteroidetes) ratio, reduced abundance of beneficial commensals including Phocaeicola vulgatus and Bacteroides fragilis , and proliferation of the opportunistic pathogen Clostridium perfringens . Metabolomic analysis showed that, in diarrheic lambs, the tryptophan metabolism pathway was reduced with lower levels of indole-3-carboxaldehyde (IAld) and 5-hydroxyindole-3-acetic acid (5-HIAA) than in healthy lambs. Fecal microbiota transplantation experiments showed that transplantation of microbiota from diarrheic lambs partially recapitulated the donor-associated microbial, metabolic, and inflammatory phenotypes in recipient mice. Finally, functional validation using a dextran sulfate sodium (DSS)-induced colitis model revealed that supplementation with IAld and 5-HIAA significantly alleviated DSS-induced intestinal inflammation and barrier damage, accompanied by downregulated expression of genes related to the Tlr4-Myd88-Nfκb signaling pathway. Conclusions Our findings indicate that the gut microbiota-derived tryptophan metabolites IAld and 5-HIAA alleviated inflammation and improved intestinal epithelial barrier function by enhancing tight junction integrity, while also reducing the expression of Tlr4/Myd88/Nfκb pathway-related inflammatory signaling molecules.
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