JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 9
·1-11
·
IF 2.8
Liu Xiang,Deng Yuxin,Wang Ping,Tang Hongyu,Li Shuangqing,Xing Zheng
The utilization of hydrogels in the domain of flexible capacitors (FCs) and multifunctional sensors (MSs) has attained considerable prevalence. However, balancing the various properties of such versatile hydrogels remains a major challenge. In the present study, a novel xIL/PAM/SA dual-network hydrogel composed of polyacrylamide/sodium alginate (PAM/SA) and an ionic liquid (IL) 1-Butyl-3-methylimidazolium hydroxide ([BMIM][OH]) is proposed. The OH − in the IL inhibits the protonation of -NH 2 groups on the polymer chain and avoids the reduction of the number of hydrogen bonds in the system due to the formation of -NH 3+ , thus enhancing the strength of the network. The results showed that the series of tough hydrogels had high tensile strength (386.64 kPa), elongation at break (338.16%), and toughness (670.83 kJ/m 3 ). Moreover, the rich functionality such as capacitive performance (198.5 mF/cm 2 ), water retention performance (LR = 25.4%), temperature sensitivity (GF = 2.12), and strain sensitivity (GF = 4.56), make it have broad application potential. This work improves the traditional dual-network hydrogels by ionic liquids (ILs) and provides a feasible idea for the design of multi-functional tough conductive hydrogels.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-19
·
IF 12.6
Zhang Yi,He Xiong,Mao Xiang,Yang Yukun,Li Faqi,Han Xiaofeng,Lu Hao,Tang Liang,Yang Yujun,Wang Yan,Du Yuling,Xu Wei,Wang Zhenyu
Non-invasive deep transdermal drug delivery is required for conditions such as keloids. However, the skin’s stratum corneum barrier is the primary obstacle for transdermal drug delivery methods. Most energy sources and operational controls are located externally, making it difficult to regulate the deep delivery of a drug once it has penetrated the stratum corneum barrier. Additionally, some transdermal administration methods that provide an internal energy source are frequently invasive and can cause damage. Therefore, achieving non-invasive drug delivery to the deep dermis for such conditions is challenging. Here, we propose sono-phase-change transfersomes (SPCTs) that stably encapsulate perfluoro-n-pentane within transfersomes. These SPCTs, combined with low-frequency and low-intensity ultrasound (LFLIU), are designed to create a two-stage transdermal drug delivery system that integrates passive and active penetration. In the first stage, the deformability of SPCTs enables them to stably and passively penetrate the epidermis. In the second stage, SPCTs undergo a phase change when ultrasound irradiation is applied, transforming into microbubbles. As the microbubbles penetrate deeper, they gradually expand, rupture, and release their encapsulated substances, providing supplementary energy from within to achieve active penetration. Both in vitro and in vivo experiments revealed a significant increase in the efficiency, depth, quantity, and distribution range of the contents entering the dermis. In addition, the SPCTs combined with the ultrasound group in the keloid nude mouse model exhibited the fastest keloid volume reduction, with various indicators demonstrating that its therapeutic effect was significantly better than that of the other control groups. These findings indicate that this two-stage transdermal drug delivery system can non-invasively and safely achieve deeper and higher-dose dermal administration, offering a new strategy for treating diseases such as keloid. Graphical The working principle of the two-stage transdermal drug delivery system.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Zhu Huanle,Qi Yuchen,Hua Shiyuan,Huang Rongrong,Chen Lumin,Zhou Xiaoxuan,He Jian,Hu Hongjie,Niu Zhongfeng
Inorganic nanoparticles play important roles in cancer treatment, but the issues of biodegradable properties, and tumor penetration restricted further clinical application. Aiming at the low efficiency and toxic side effects problems existing in the current clinical treatment of cancer, a biodegradable mesoporous silica nanoparticle (MSN) platform integrating pH-responsive drug release and synergistic chemo-radiotherapy was developed. The doxorubicin hydrochloride (DOX) was loaded in MSNs via electrostatic interactions, with ultra-small hafnium sulfide (HfS 2 ) nanodots were anchored to the surface of MSN. At physiological pH, HfS₂ reinforces DOX retention through steric and electrostatic effects, while in acidic tumor microenvironments, it triggers DOX release. Concurrently, dissociated HfS 2 acts as a radiosensitizer, enhancing X-ray-induced cytotoxicity and promoting deep tumor penetration. Both the in vitro cellular and in vivo animal level results confirmed synergistically enhanced chemoradiotherapy efficiency. Therefore, this research, we believed, will bring a new train of thought and scientific support for more safety and more efficiency in cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS AND STRUCTURES
·
2025
·Vol. 58
·期 7
·1-25
·
IF 3.9
Xue Lutao,Li Yubiao,Li Rui,Yu Wenqiang
The mismatch in physical properties between traditional mortar and the porous substrate of foam concrete (FC) leads to poor adhesion and cracking, limiting the wider application of FC. In order to address this issue and alleviate the storage pressure of low silica iron tailings (LSIT), this study developed an advanced plastering mortar system for foam concrete blocks through systematic optimization of LSIT. A comprehensive evaluation was conducted on six critical parameters, including the water-cement ratio, the aggregate ratio of LSIT to sand, the content of cement, hydroxypropyl methyl cellulose (HPMC), re-dispersible latex powder (RDP), and polypropylene fiber (PPF), establishing their quantitative impacts on mortar performance. The optimal performance was achieved with a water-cement ratio of 0.84, aggregate ratio of 11:3, cement content of 30%, HPMC content of 0.4%, RDP content of 1.5%, and PPF content of 0.15%, yielding a mortar density of 1447.9 kg/m 3 , 28 d compressive strength of 8.21 MPa, and 104 mm consistency, parameters fully compliant with the M8 grade specifications in JC/T 890-2017. Advanced microstructural characterization (XRD, SEM, and hydration heat analysis) demonstrated that LSIT particles refined the granulometric distribution through microaggregate effects. In addition, C 3 S dissociation was retarded by HPMC through Ca 2+ chelation, extending the induction period of hydration. Moreover, the RDP facilitated interfacial cross-linking via transesterification, forming the core–shell structures of C–S–H and polymer, compared with the control sample, the portlandite content was slightly reduced. Furthermore, the PPF reinforcement is achieved through crack-deflection and bridging mechanisms. The modification system of multi-component materials therefore exhibits a three-fold synergistic action, including the gradation optimization of particles, the regulation of hydration kinetics, and the toughening of the interfacial. These findings establish a viable pathway for high-value utilization of iron tailings in construction materials and simultaneously elucidate the physicochemical mechanisms underlying the interactions of composite modifiers in cementitious systems. Furthermore, the modified additive system serves as a viable template for valorizing diverse solid wastes. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Zhang Hongding,Ke Changlu,Xing Zhenhua,Zhao Mengqi,Xiang Xin,Wang Hai-Bo
Although fluorescent probes have been used extensively for alkaline phosphatase (ALP) sensing, most involve a tedious, prolonged, or high-cost synthesis procedure. Thus, it is still necessary to develop convenient and economical fluorescent probes for sensitive determination of ALP. Herein, a facile fluorescent strategy was designed for ALP detection utilizing the fluorogenic response of thiamine (TH) triggered by Cu 2+ (Cu 2+ -TH system). It was found that Cu 2+ facilitated the oxidation of non-fluorescent TH to fluorescent thiochrome (TC) in an alkaline environment, while pyrophosphoric acid (PPi) interacted with Cu 2+ to form PPi-Cu 2+ chelates, preventing the oxidation of TH to fluorescent TC. Consequently, a faint fluorescence output was detected in the system. After adding ALP into this system, PPi was catalyzed to phosphate (Pi), which combined weakly with Cu 2+ . A large amount of TH was oxidized into fluorescent TC by free Cu 2+ , leading to high fluorescence. Therefore, an ALP sensing platform was constructed by utilizing the fluorogenic reaction of the Cu 2+ -TH system as the signal reporter. The assay exhibited favorable analytical performance for ALP measurement. A linear correlation was obtained between the ALP concentration (0.01–1 mU/mL) and the fluorescence intensity of the Cu 2+ -TH system, with a limit of detection as low as 0.0038 mU/mL. Additionally, the assay was further employed for analyzing ALP content in complex biological samples. This work thus advances the science of in situ fluorogenic reaction in the field of biosensing. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Protocols
·
2025
·
IF 16
Ming Jiang,Xie Zheng,Wu Jiaxin,Zhang Fan
The versatility of lanthanide-doped near-infrared (NIR, 700–1,700 nm) luminescent nanoparticles makes them valuable tools in various scientific and technological fields, from bioimaging to information security. However, the luminescence intensity of typical lanthanide-doped nanoparticles is significantly influenced by the efficiency of the sensitizer. The introduction of transition metal ions (such as Cr 3+ , Mn 2+ and Ni 2+ ) can greatly enrich the library of lanthanide NIR luminescence nanoparticles. We have reported a new crystalline nanoparticle, Na 3 CrF 6 , for high-brightness NIR emission from lanthanide activators (such as Er 3+ , Tm 3+ , Yb 3+ or Nd 3+ ). As an emerging luminescent material, a straightforward and scalable synthesis approach for these nanostructures holds promise for their broader application. Here we have refined and standardized the steps for transition metal-sensitized lanthanide luminescent nanoparticles, thereby establishing a library of advanced luminescent materials for researchers engaged in luminescent materials. The Protocol enables the precise preparation of chromium-, manganese- and nickel-trifluoroacetate, the synthesis of three types of transition metal-sensitized lanthanide nanoparticle and the fabrication of chromium-sensitized lanthanide homogeneous and heterogeneous nanostructure. Moreover, we provide verification protocols for each step’s output and guidelines for adjusting synthesis conditions. To aid in the reproducible synthesis of these nanoparticles, we also include a troubleshooting guide of the various stages. The estimated duration for synthesizing transition metal trifluoroacetate, transition metal-sensitized lanthanide nanoparticles and core–shell transition metal-sensitized lanthanide nanoparticles are ~70, 30 and 30 h, respectively. These procedures can be carried out by users with expertise in chemistry or materials science.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Chen Junjie,He Changxiang,Peng Xudong,Li Jin,Xu Xiaosa,Zhou Yin,Shen Jiadong,Sun Jing,Li Yiju,Zhao Tianshou
Developing safe and high-voltage solid-state polymer electrolytes for high-specific-energy lithium metal batteries holds great promise. However, low ionic conductivity, limited Li + transference number, narrow voltage window, and high flammability greatly hinder their practical applications. Herein, we propose a puzzle-like molecular assembly strategy to construct a solid-state polymer electrolyte via in situ polymerization. The triallyl phosphate and 2,2,3,3,4,4,4-heptafluorobutyl methacrylate segments are spliced into the vinyl ethylene carbonate matrix to enhance anion affinity and promote lithium salt dissociation, resulting in a high ionic conductivity of 0.432 mS cm -1 and a Li + transference number of 0.70 at 25 °C. Meanwhile, the polymer electrolyte exhibits a high oxidation voltage of 5.15 V, enabled by its intrinsic high-voltage tolerance and the formation of a robust inorganic-rich interphase. As a result, the Li||LiNi 0.6 Co 0.2 Mn 0.2 O 2 cell maintains stable performance for 300 cycles and reliably cycles even with an application-oriented mass loading of 15.8 mg cm -2 . The 2.6-Ah Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 pouch cell reaches a high specific energy of 349 Wh kg -1 . Furthermore, the developed polymer electrolyte displays superior nonflammability and the Li||LiFePO 4 cell exhibits stable cycling for over 120 cycles at 100 °C. Both accelerating rate calorimetry and nail penetration tests verify the high safety of the pouch cells using the designed polymer electrolyte, showing the potential for practical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Gong Shanhe,Zhai Yanjie,Jin Chengkai,Xu Han,Xia Qing,Li Weisong,Ying Yiran,Wu Jie,She Xiaojie,Wang Zhaolong,Lv Xiaomeng,Wu Chundu,Chan Kangcheung,Zhao Xunhua,Zhang Xiao,Lau Shu Ping
Electrochemical carbon dioxide reduction reaction (CO 2 RR) under strongly acidic conditions enables high CO 2 utilization. However, especially in proton exchange membrane (PEM) electrode assembly reactors, achieving selective CO 2 RR in such environments remains challenging due to uncontrolled interfacial water diffusion at high current densities. Here, we develop a nickel-based heterogeneous molecular electrocatalyst (NiPc-NH 2 /CNT-SHP) featuring amino (-NH 2 ) functional groups and grafted long-chain hydrophobic molecules. Under acidic conditions, -NH 2 is in situ protonated to form amino cations (-NH 3 ⁺). The positively charged -NH 3 ⁺ groups and hydrophobic molecules effectively disrupt the protonated water (H 3 O + )-rich network, inhibiting the invasion of H 3 O + and thereby suppressing the hydrogen evolution reaction, while enhancing selectivity for acidic CO 2 RR. The catalyst achieves nearly 100% Faradaic efficiency for CO at current densities from 50 to 400 mA cm −2 , with approximately 76% CO 2 utilization efficiency in a flow cell, and sustains over 80% selectivity for more than 200 h in a self-designed PEM–porous solid electrolyte reactor. These findings highlight interfacial water management as a key design principle for efficient acidic CO 2 electroreduction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-20
·
IF 15.7
Bi Guoshu,Liang Jiaqi,Bian Yunyi,Shan Guangyao,Ren Shencheng,Shi Haochun,Huang Xiaolong,Zhu Junkan,Wang Qun,Jiang Wei,Gan Boyi,Zhan Cheng
Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN’s oxidoreductase function by occluding its active site. We also show that either restoring ALDH16A1 levels or inhibiting TXN significantly enhances the effectiveness of chemo/immunotherapy in a ferroptosis-dependent manner in SMARCA4-deficient NSCLC. Collectively, our findings elucidate an intricate SMARCA4-ALDH16A1-TXN stability/function dual regulatory axis that governs ferroptosis and informs a therapeutic strategy for overcoming resistance to chemotherapy or immunotherapy in SMARCA4-deficient NSCLC.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2025
·
IF 3.3
Gahlot Himanshi,Kang Sun Chul
Synergistic therapy is unwaveringly developing as a potential approach to enhance the effectiveness of anticancer medications in chemotherapy. Incorporating adjuvants alongside conventional anticancer medications has demonstrated selective cytotoxicity toward cancer cells while mitigating adverse effects such as DNA damage and systemic toxicity in normal cells. The extended use of 5-FU, a synthetic medicine used in chemotherapy, has many adverse effects, which limit its long-term use in clinical settings. Numerous investigations have demonstrated that luteolin exhibits anticancer effects and alleviates inflammation in mammalian cells. In this study, we provide the first experimental evidence of the synergistic interaction between luteolin and 5-FU in murine melanoma (B16F10) cells, compared to monotherapies (luteolin and 5-FU alone). Using MTT assay for cell viability, flow cytometry for cell cycle analysis, and Western blotting for apoptosis markers, we demonstrate that simultaneous exposure to luteolin and 5-FU speeds up oxidative stress and enhances the production of endogenous ROS. The combination therapy induced the G1-phase cell cycle arrest (65.39%) and decreased the cell viability of B16F10 cells to 34.6%. This, in turn, activates the DNA damage response and initiates the apoptotic pathway by suppressing autophagy and the DNA repair system. Further, the co-treatment of luteolin and 5-FU significantly decreases the mitochondrial membrane potential and reduces ATP production. The results indicate that the combination of luteolin and 5-FU may improve treatment efficacy while potentially decreasing the necessary dosage of 5-FU, therefore reducing its toxicity in clinical settings.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
·
IF 3.1
Ma SongYuChen,Li YinHui,Di Yang,Liu Tao,Wang DeQi,Shi WenJing,Ling ZhiGang,Li FengSheng,Liu Jie
To enhance the safety performance and thermal stability of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexazepane (CL-20), a core–shell composite was synthesized via in situ polymerization of aniline on polyethyleneimine (PEI)-modified CL-20. PEI modification introduced –NH 2 groups onto CL-20 surface, providing active sites for aniline polymerization and inhibiting its self-polymerization, thus forming dense polyaniline (PANI) shells with uniform thickness (about 2.8 mass%) while maintaining the high-energy crystal structure of CL-20. Compared to pure CL-20, CL-20-P@PANI showed a 15.8 °C increase in phase transition temperature (185.5 °C) and a 4 °C rise in thermal decomposition temperature (247.21 °C), attributed to the thermal barrier effect of PANI shells. The results of the mechanical sensitivity test indicate that the dense polyaniline shell layer effectively dissipates external forces, leading to a 51.43% reduction in impact sensitivity and a 20% decrease in friction sensitivity. This study provides a novel modification approach for high-energy materials by combining PEI-mediated interface engineering with in situ polymerization, ensuring both safety and energy characteristics. Graphic abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Zhao Hongling,Fang Ranjie,Hu Maosong,Luo Jianqiang,Meng Cheng,Liu Shujuan,Ma Jianguo
In this work, a novel Fe/ND-CN composite was synthesized by anchoring iron single atoms onto nitrogen-deficient g-C 3 N 4 (ND-CN) using Fe-ZIF-8 as a precursor via calcination. This material served as a photoelectrocatalytic working electrode for U(VI) reduction under light and applied voltage. Remarkably, it achieved near-complete U(VI) removal (99.2%) at pH 5.0. The elucidated mechanism provides a highly efficient technique and theoretical foundation for low-concentration uranium wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）