ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 23
·5941-5950
·
IF 3.307
Peng Huanjun,Wang Xiang,Peng Jingdong,He Yan,Chen Yu,Chen Fang,Li Shiyu
4-Hydroxy- d -phenylglycine was modified with methacrylic anhydride and then immobilized on silica through thiol-initiated surface polymerization; the prepared material was applied as stationary phase for HPLC. The obtained stationary phase was characterized by elemental analysis, infrared spectroscopy, and thermogravimetric analysis. The chromatographic performance of the packed column was evaluated in reversed-phase liquid chromatograph (RPLC) and hydrophilic interaction liquid chromatograph (HILIC) mode; this column has shown excellent selectivity to both the hydrophobic and hydrophilic solutes. The selectivity towards polycyclic aromatic hydrocarbons relative to that towards alkylbenzenes exhibited by the prepared column was higher than the corresponding selectivity exhibited by commercial C18 column, which could be explained by electronic π-π interaction between phenylglycine and electron-rich aromatic rings. On the other hand, the prepared column has also shown better selectivity for polar compounds, which was based on the multiple interaction and retention mechanisms. It was also used to separate sulfonamides and organic acid compared with a commercial C18 and HILIC column; the results show its great chromatographic performance with distinctive selectivity. All the results indicated the prepared column had potential application in a wide range.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 28
·期 2
·2400-2414
·
IF 3.056
Luo Bin,Huang Guohe,Yao Yao,An Chunjiang,Li Wei,Zheng Rubing,Zhao Kai
Sulfonamide antibiotics have highly toxic effects on humans and other organisms within the food chain. Adsorption by various carbonaceous materials is an effective method for removing them from the aqueous environment. Batch adsorption experiments were conducted between adsorbents and sulfamethoxazole (SMX) by studies of characterization, isotherm model, and kinetic model. The adsorption performances and mechanism of fifteen carbonaceous materials to remove SMX have been comprehensively evaluated. Results of the characterization showed that not only porosity, but also surface chemistry plays an important role in the adsorption process. Changes in the type and quantity of functional groups before and after adsorption are positive for the recyclability of carbonaceous materials. Moreover, kinetic studies showed that the adsorption process followed the pseudo-second-kinetic model and the intra-particle diffusion model. Four adsorbents (i.e., W-GAC, 3M-GAC, GP, and PAC) in this study have the best performance in each corresponding category in terms of the adsorption of SMX. Therefore, the results provide an indispensable reference for evaluating the adsorption performances of a variety of carbonaceous materials, and thus can support the selection of adsorbents for different applications.
Graphical abstract
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Collagen and Leather
·
2025
·Vol. 7
·期 1
·1-10
·
IF 9.2
Li Ruibin,Yang Chen,Liu Yuanqing,Yu Yue
Fatliquor migration within the leather matrix may lead to the formation of fatty spew, oil patches and fogging, posing challenges to the production of high-quality leather. Currently, it lacks a straightforward and effective method for analyzing fatliquor migration behavior. This investigation introduces a novel approach for analyzing fatliquor migration by measuring its spreading area on collagen fiber membranes. By applying 300 mg of fatliquor onto 0.5 mm square membranes (10 cm × 10 cm), distinct oil spots were observed, enabling analysis of migration behavior. Using stearic acid as a standard reference compound effectively minimized the influence of different leather sections on fatliquor migration. Fatliquors with low molecular weight, low melting point and high aliphatic ester content exhibited obvious migration potential. Organic-tanned leathers and sulfated fatliquors displayed weak interactions, resulting in easy fatliquor migration within the leather. Conversely, metal-tanned leathers and phosphorylated fatliquors demonstrated strong interactions, effectively hindering migration. This research provides valuable practical and theoretical insights for developing effective strategies to prevent and control fatliquor migration in leather production. Graphical abstract
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Neuroscience Bulletin
·
2025
·
IF 5.8
Gu Yuang,Yao Yu,Lou Qiuwen,Zhu Xinyan,Lan Ju,Gao Chenshu,Wu Shuangshuang,Liang Jingjia,Xu Cenglin,Wang Yi,Cheng Heming,Chen Zhong
Epilepsy is one of the most prevalent and severe neurological disorders, and it is inadequately controlled with currently available medications. While cinnabar (mercury(II) sulfide)—a traditional Chinese medicine—has historical application in epilepsy treatment, its therapeutic efficacy and underlying mechanisms are unclear. In this study, we find that cinnabar exerts model-dependent antiseizure efficacy in mice. Specifically, it significantly attenuates acute seizures, enhances the termination of diazepam-resistant status epilepticus, and reduces spontaneous seizures in the kainic acid (KA)-induced seizure model. Conversely, no therapeutic effect was found in the maximal electroshock-, pentylenetetrazole-, or kindling-induced seizure model. Fiber photometry revealed that cinnabar normalizes KA-induced hippocampal neurotransmission imbalances by simultaneously decreasing glutamate hyperactivity and γ-aminobutyric acid hypoactivity. Furthermore, cinnabar has neuroprotective effects and alleviates comorbid anxiety-like behaviors, while showing no alterations in motor function. Our findings suggest cinnabar's potential as a therapeutic agent for seizure management, via a mechanism associated with the reversal of the hippocampal excitatory/inhibitory imbalance.
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PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Wang Xingyu,Fan Qi,Liu Ziheng,Zhu Xinyue,Yang Mei,Guo Zhiyuan,Chen Yuting,Wang Liuqi,Jing Yu,Xia Hui
The ether-based electrolytes are acknowledged for their compatibility with a diverse array of sodium-ion battery anodes, as well as their capability to enable efficient and reversible electrochemical reactions. However, they encounter a challenge of oxidation at high voltages. We find that a standard diglyme-based electrolyte starts to oxidize and break down at voltages exceeding 3.9 V (vs. Na + /Na). This deterioration is attributed to the nucleophilic nature of the diglyme solvent and the presence of oxygen atoms that possess two unpaired electrons. To address this issue, we incorporate foreign anions into the electrolyte system to passivate the reactive sites of terminal H on diglyme solvents, inhibiting further dehydrogenation and oxidation during battery operation. The constructed cathode electrolyte interphase, enriched with NaF and NaN x O y , substantially boosts the oxidation resistance of electrolyte to over 4.8 V (vs. Na + /Na), expanding the stability window and rendering it feasible for various high-voltage cathode materials. Our approach also ensures compatibility with either hard carbon or commercial graphite anodes, guaranteeing operation in pouch cells. This study elucidates the relationship between interfacial chemistry and oxidation tolerance at high voltages, offering an approach to the development of practical ether-based electrolytes for high-energy-density battery technologies.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 9
·1-11
·
IF 2.8
Wang Jiatai,Li Yuanyuan,Fan Chao,Li Jiting,Wen Xi,Liu Hongyun,Zhang Xuchao,Ma Xiaohong,Hu Jingfu,Li Jian
High-nickel LiNi 0.9 Co 0.01 Mn 0.09 O 2 cathode materials demonstrate significant potential for next-generation lithium-ion batteries (LIBs) due to their high energy density and low cost. However, the reduced cobalt content in these high-nickel materials often results in structural degradation and poor cycling stability. In this work, the material referred to as NCM919 was prepared through a homogeneous co-precipitation method, followed by the introduction of W 6+ doping to enhance cycling stability. The electrochemical performance results indicate that the cathode doped with 1.0 mol% W 6+ (NCM-1.0 W) exhibits improved electrochemical characteristics. NCM-1.0 W shows an initial discharge capacity of 182.74 mAh/g at a rate of 0.5 C, with 97.86% of the initial capacity retained after 100 cycles within a voltage range of 2.5 ~ 4.3 V. Additionally, NCM-1.0 W achieves an initial discharge capacity of 197.99 mAh/g at a rate of 1.0 C, with 85.68% of the initial capacity maintained after 100 cycles in a voltage range of 2.5 ~ 4.5 V.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10075
·
IF 15.7
Jin Hao,Zhu Xuanqi,Zhang Mengsi,Zheng Hao,Chen Yang,Yao Dong,Liu Shuwei,Zhang Hao
Superoxide dismutase (SOD), featured with unique metal catalytic sites, is the first defense against reactive oxygen species (ROS) damage in vivo and well used in the treatment of oxidative stress-related diseases. However, the catalytic activity of natural SOD is limited by the metal ion coordination with rigid amino-acid residues. Inspired by the Cu 2+ /histidine residue coordination in Cu-Zn-SOD, in this work, the Gibbs free energy change of the break/reform of coordination bonds in the tetracoordinated structure formed by Cu 2+ and different groups in histidine is calculated, which reveals that in comparison to the Cu catalytic site coordinated with four imidazolyls, the coordination with one amino, one carboxyl and two imidazolyls possesses the lowest overall energy as well as the lowest breaking energy of one of the coordination bonds. Thus, catalytic site stability and catalytic reaction activity can be balanced sufficiently. Accordingly, the as-prepared Cu/Zn/histidine (CuZnHis) supramolecular assemblies with optimized Cu catalytic site present a significantly enhanced SOD activity up to 37900 Unit/mg, which is at least 5.4 times higher than that of natural Cu-Zn-SOD. As a proof of concept in treating oxidative stress-related diseases, the CuZnHis assemblies promote macrophage polarization from M1 to M2 phenotype and the expression of anti-inflammatory factors, and inhibit the periodontitis in male animal models.
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Cell and Bioscience
·
2025
·Vol. 15
·期 1
·159
·
IF 6.2
Sun Weikang,Zhang Mengyu,Wang Ruilin,Yang Jie,Rasool Ameena Tur,Luo Renjie,Liu Xiangdong,Cao Peng,Li Erguang
Background The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in virus infection is undefined. Results We show that genetic ablation of PTBP1 renders cell resistant to herpes simplex virus 1 (HSV-1) infection. HSV-1 utilizes 3-O-sulfated heparan sulfate proteoglycans (HSPGs) for attachment and for infection of epithelial cells. We found that knockout of PTBP1 expression resulted in loss of HS3ST3A1 and HS3ST3B1, heparan sulfate glucosaminyl 3-O-sulfotransferase genes for 3-O-sulfation of the heparan sulfate (HS) chains of HSPGs. Each of the HS3ST3A1/HS3ST3B1 genes is composed of 2 exons separated by an extraordinarily long intron whose removal requires PTBP1-associated looping. We found that PTBP1 interacted with the intronic region of HS3ST3A1/HS3ST3B1 pre-mRNAs and modulated their processing to mRNA. The essential role of PTBP1 in functional HS3ST3A1 expression and in HSV-1 infection was demonstrated by ectopic re-expression in the knockout (ko) cells. In addition, we showed that targeting PTBP1 expression by microRNA mimics reduced disease symptoms in a mouse herpetic stromal keratitis (HSK) model. Conclusions The results demonstrate that PTBP1 mediates HSV-1 infection of epithelial cells through splicing regulation of HS3ST3A1/HS3ST3B1. These studies provide a new area for novel therapeutic strategies through splicing regulation. Graphical abstract By Sun et al. RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression.
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CHEMICAL PAPERS
·
2025
·
IF 2.5
Xu Hongqing,Ma Xiaofei,Guan Xiaomin
The synergistic effects between deep eutectic solvents (DESs) and chiral selectors in aqueous capillary electrophoresis (CE) for enantioseparation has been well validated. However, such synergistic effects have not been thoroughly validated in nonaqueous capillary electrophoresis (NACE). In this work, two amino acid deep eutectic solvents (AADES) were prepared as additives in NACE and the synergistic separation systems with native β-cyclodextrin (β-CD) for the enantioseparation of several dansyl amino acids (Dns-AA). Compared to the unmodified β-CD system, the separation of Dns-AA was significantly improved in the synergistic system. We optimized several key separation parameters and explored the chiral recognition mechanism using molecular modeling technique. Additionally, we calculated the binding constants of the enantiomers with β-CD in the two systems using dansyl alanine as a model analyte. In the presence of AADES, the Dns-AA enantiomers formed tighter complexes with β-CD. This study demonstrated that the proposed AADES exhibited good synergistic effects with β-CD in NACE, and they were proved to be promising additives for enantioseparation. Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Li Yinjun,Wang Jing,Zhang Pei,Xia Zhenzhen,Luo Zewei,Yang Jie
Apparent amylose content is a key determinant of rice flavor quality, yet traditional detection methods are often costly and time-consuming. To address this, we developed Ce-UiO66 nanozyme-based microfluidic paper-based analytical devices (μPADs) for the rapid quantification of apparent amylose. The sensing mechanism relies on the formation of a blue-purple apparent amylose-iodine complex via in situ catalytic oxidation, which is quantified through smartphone-based grayscale analysis. Mechanistic studies reveal that the catalytic activity of Ce-UiO66 is driven by O 2 − and H 2 O 2 intermediates. The tri-zonal design of the μPADs (droplet, reaction, and detection zones) effectively minimizes in situ reaction interference. Under optimized conditions, the method achieved a linear range of 0–40% within 15 min, showing excellent agreement with flow injection analysis. This Ce-UiO66@μPAD platform demonstrates significant potential as a low-cost, portable tool for rapid monitoring of apparent amylose in rice. Graphical abstract
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Science China-Materials
·
2026
·
IF 7.7
He Ping,Qi Cheng-Zhang,Ping Kai,Mu Hongfei,Yu Zhong-Zhen,Min Peng,Zhang Hao-Bin
Modern reconnaissance systems integrate optical, infrared (IR), and radar technologies for cross-band cooperative detection, rendering multispectral camouflage essential for battlefield survivability. However, in complex or extreme operational environments, current camouflage materials remain limited by insufficient environmental stability, high weight, and inadequate mechanical flexibility, constraining their long-term and reliable performance. Herein, we design a multilayer composite consisting of a colorful yet IR-transparent visible reflection layer (VR), a low-emissivity (low- ε ) graphene (LEG) layer for bothIR camouflage and electromagnetic interference (EMI) shielding, and an aramid nanofiber aerogel (ANF) layer for thermal insulation and flexibility. The VR layer provides widely tunable visible colors, enabling visual camouflage without disturbing the low- ε feature of the underlying LEG. The LEG layer provides both IR camouflage and EMI shielding capabilities, while the ANF aerogel reduces thermal conduction to the camouflage surface. Through the synergistic effect of thermal insulation and low- ε , the multilayer composite reduces the IR radiation intensity by 40% with tunable colors, efficiently realizing visual/IR dual-band camouflage. Furthermore, the multilayer composite demonstrates effective EMI shielding performance and environmental stability against corrosive media, including acid, alkaline, seawater, and organic environments. This work provides a novel strategy for environmentally robust multispectral camouflage materials suitable for harsh environments.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 11
·747
·
IF 5.4
Zhang Zhilin,Pu Jin,Peng Yong,Tan Hongliang,Xu Fugang
A noble-metal-free, aggregation-independent surface-enhanced Raman scattering (SERS) platform is reported based on a bifunctional α-MoO 3−x -CuCl 2 nanocomposite for the sensitive and selective detection of phosphate species. The defect-rich α-MoO 3−x provides strong SERS enhancement, and the introduction of CuCl 2 not only enhances its peroxidase like activity, but also endows it selective response to phosphate species. The composite α-MoO 3−x -CuCl 2 can efficient catalytic oxidation of colorless tetramethylbenzidine (TMB) to blue oxidized TMB (ox-TMB), which yields a strong SERS signal. At the assay pH of 4.0, the protonated phosphate species (mainly H 2 PO 4 ⁻) selectively coordinate with Cu 2+ , suppressing the nanozyme activity and causing a dose-dependent decrease in both colorimetric and SERS responses. Under optimized conditions, the method exhibits a linear detection range from 8.0 × 10 − 9 M to 8.0 × 10 − 5 M and a limit of detection as low as 2.0 × 10 − 9 M. The platform also demonstrates good anti-interference capability against common coexisting ions and satisfactory recoveries (103.75%–107.5%) in spiked lake water and tap water samples. This work provides a low-cost, reliable, and reproducible strategy for indirect SERS detection of phosphate species without reliance on noble metals or nanoparticle aggregation. Graphical abstract
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