JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2018
·Vol. 56
·期 9
·968-976
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IF 2.588
Hui Li,Lin Gu
Controllable synthesis of bio-based polylactide (PLA) diols was realized by the ring-opening polymerization (ROP) of lactide (LA) in the presence of 1,4-butanediol (BDO) using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organocatalyst in solvent-free conditions. The catalytic activity and conversion of LA could reach ∼1 kg g −1 DBU and >97%, respectively, and the polymerization yielded polymers with narrow polydispersity index (PDI) (1.15–1.29). Interestingly, the number average molecular weight ( M n ) of the obtained PLA diol was in excellent linear relation with the molar ratio of LA and BDO, and hence can be precisely controlled. The structure of the diol was clearly confirmed by 1 H and 13 C NMR, FTIR, and MALDI-TOF mass spectra, proving BDO as an initiation-transfer agent to participate in the polymerization. Kinetic study of the ROP demonstrates a pseudo-first-order kinetic model and a controlled “living” nature. Notably, it is found that the glass transition temperature ( T g ) of the diol significantly depends on the M n . Furthermore, various chain transfer agents and organocatalysts can also be used to successfully synthesize well-defined PLA diols. Especially, functional bio-based dihydric alcohols such as 2,5-furandimethanol (FDMO)-initiated ROP in this system could result in fully bio-based PLA diols with functionality. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 968–976
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Biofilm
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2024
·
IF 5.9
Shi-Liang Xiang,Kai-Zhong Xu,Lu-Jun Yin,Yong Rao,Bo Wang,Ai-Qun Jia
Pseudomonas aeruginosa is recognized globally as an opportunistic pathogen of considerable concern due to its high virulence and pathogenicity, especially in immunocompromised individuals. While research has identified several endogenous quorum sensing (QS) signaling molecules that enhance the virulence and pathogenicity of P. aeruginosa , investigations on exogenous QS signaling molecules or modulating factors remain limited. This study found that dopamine serves as an exogenous QS signaling molecule or modulating factor of P. aeruginosa PAO1, enhancing the production of virulence factors and biofilms. Compared to the control group, treatment with 40 μM dopamine resulted in a 33.1 % increase in biofilm formation, 68.1 % increase in swimming mobility, 63.1 % increase in swarming mobility, 147.2 % increase in the signaling molecule 3-oxo-C12-HSL, and 50.5 %, 28.5 %, 27.0 %, and 33.2 % increases in the virulence factors alginate, rhamnolipids, protease, and pyocyanin, respectively. This study further explored the mechanism of dopamine regulating the biofilm formation and virulence of P. aeruginosa PAO1 through transcriptome and metabolome. Transcriptomic analysis showed that dopamine promoted the expression of virulence genes psl, alg, lasA, rhlABC , rml , and phz in P. aeruginosa PAO1. Metabolomic analysis revealed changes in the concentrations of tryptophan, pyruvate, ethanolamine, glycine, 3-hydroxybutyric acid, and alizarin. Furthermore, KEGG enrichment analysis of altered genes and metabolites indicated that dopamine enhanced phenylalanine, tyrosine, and tryptophan in P. aeruginosa PAO1. The results of this study will contribute to the development of novel exogenous QS signaling molecules or modulating factors and advance our understanding of the interactions between P. aeruginosa and the host environment.
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Materials Horizons
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2025
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IF 10.7
Jin Zhang,Lingzhuang Meng,Yinan Jia,Jianshu Li,Xinyuan Xu,Xin Xu
Periodontitis, a chronic inflammatory disease triggered by dental plaque, often presents challenges in management, particularly in severe cases where mechanical debridement alone may be insufficient. As a result, adjunctive therapies, particularly localized drug delivery systems with both antimicrobial and anti-inflammatory properties, are essential to enhance the efficacy of periodontitis management. In this study, we developed a multifunctional hydrogel by incorporating a salicylic acid–choline deep eutectic solvent (DES) into a chitosan/β-glycerol phosphate sodium (CS/GP) hydrogel matrix for the treatment of periodontitis. The DES-CS/GP hydrogel demonstrated favorable physicochemical properties, including gelation and injectability, making it highly suitable for application in the oral cavity. The hydrogel effectively inhibited the growth of key periodontal pathogens, Porphyromonas gingivalis and Fusobacterium nucleatum, and significantly downregulated the expression of pro-inflammatory cytokines TNF-α and IL-1β in vitro. Cytocompatibility assessments showed over 80% cell viability in human gingival fibroblasts, human gingival epithelial cells, and human oral keratinocytes over 5 days treated with DES-CS/GP, with fluorescence microscopy confirming robust cytoskeletal integrity. Furthermore, the hydrogel enhanced permeability through gingival tissues in vitro. In a rat model of periodontitis, the hydrogel significantly mitigated bone loss, reduced bacterial loads of P. g, and suppressed TNF-α and IL-1β expression in gingival tissues. These findings underscore the hydrogel's potential as a safe and effective adjunctive therapy for periodontitis, offering a combination of antimicrobial, anti-inflammatory, and tissue-permeating properties with high biosafety and ease of application.
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FOOD CHEMISTRY
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2025
·
IF 9.8
Shufang Yang,Xiaoxue Jiang,Ruoxuan Xu,Yanyan Zhang,Rongxia Liu
Syzygium aromaticum is an aromatic plant that has been widely introduced to tropical regions worldwide. S. aromaticum bud (SAB), as a valuable spice, has been used for centuries, owing to its exceptional health benefits and economic value. The fruit of S. aromaticum (SAF) is not a commonly used component and its phytochemical properties and bioactivities have seldom been analyzed. Herein, ultra-performance liquid chromatography-high-resolution mass spectrometry combined with feature-based molecular networking analysis was applied to characterize the phytochemical constituents of these two parts individually. The bioactivities of SAB and SAF were innovatively evaluated, including their hypolipidemic activity on human hepatocellular carcinoma cells, anti-inflammatory activity on RAW264.7 cells, and anti-proliferative activity on vascular smooth muscle cells. Initially, 75 components from SAB and SAF extracts were identified. Subsequently, activity experiments indicated that both SAB and SAF extracts showed significant activities in these cell types. Intriguingly, they showed similar hypolipidemic effects but different anti-inflammatory and anti-proliferative effects. Then, 14 differential markers were screened for further quantitative analysis to explore the material basis for the difference in bioactivity between SAB and SAF. Finally, using correlation analysis, 10 compounds were identified as biomarkers that contributed to the difference in activity between SAB and SAF. These results suggest that SAF is rich in natural metabolites, showing potential as a natural plant component with hypolipidemic, anti-inflammatory, and anti-proliferative effects. This study could contribute to the targeted selection of different parts of S. aromaticum and serve as a foundation for the development and utilization of SAF.
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DEVELOPMENTAL CELL
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2024
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IF 10.7
Xinyue Lu,Qiyan Zhang,Zejia Wang,Xuanzhi Cheng,Huiru Yan,Shuyi Cai,Huawei Zhang,Qikun Liu
Plants demonstrate a high degree of developmental plasticity, capable of regenerating entire individuals from detached somatic tissues—a regenerative phenomenon rarely observed in metazoa. Consequently, elucidating the lineage relationship between somatic founder cells and descendant cells in regenerated plant organs has long been a pursuit. In this study, we developed and optimized both DNA barcode- and multi-fluorescence-based cell-lineage tracing toolsets, employing an inducible method to mark individual cells in Arabidopsis donor somatic tissues at the onset of regeneration. Utilizing these complementary methods, we scrutinized cell identities at the single-cell level and presented compelling evidence that all cells in the regenerated Arabidopsis plants, irrespective of their organ types, originated from a single progenitor cell in the donor somatic tissue. Our discovery suggests a single-cell passage directing the transition from multicellular donor tissue to regenerated plants, thereby creating opportunities for cell-cell competition during plant regeneration—a strategy for maximizing survival.
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Reaction Chemistry & Engineering
·
2024
·
IF 3.4
Shujin Shi,Yu Fan,Chunsheng Zhao,Yihan Shan,Jiaqi Yan,Anwei Wang,Junfeng Qian,Mingyang He,Weiyou Zhou
In an umbrella-shaped microchannel reactor, the continuous selective aerobic oxidation of toluene derivatives to aromatic aldehydes over a Co/Mn/Br catalytic system using acetic acid/water as the solvent was studied. Taking the oxidation of p-nitrotoluene (PNT) to p-nitrobenzaldehyde (PNBD) as a model, the effects of the Co2+(Mn2+) amount, ratio of Co2+, Mn2+ and Br−, reaction temperature, reaction pressure, oxygen flow rate, residence time and water content on the reaction were systematically investigated. Under the optimized reaction conditions, an 11.8% conversion could be achieved with a good selectivity of 67.1% to PNBD, significantly superior to the results obtained in a kettle reactor. In addition, various toluene derivatives could be tolerated by the present reaction process. This aerobic oxidation over the microchannel reaction technology has the features of an easy-to-operate process and easily controlled reaction parameters, providing an economical and environmentally friendly protocol for the synthesis of aromatic aldehydes.
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JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
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2024
·
IF 1.9
Wenlin Li,Sen Lin,Dongming Lan,Yonghua Wang
Vitamin E succinate has gained substantial attention as a potential therapeutic agent for cancer treatment due to its biomedical activities. One of the prominent methods of synthesizing vitamin E succinate is through enzymatic processes, which, although advantageous, presents inherent challenges related to optimization, scalability, and particularly, the poor stability of lipases in organic solvents. Our study addresses these challenges by conducting a comprehensive comparative analysis between Lipase UM1 and three other immobilized commercial lipases, demonstrating Lipase UM1's enhanced resistance to organic solvents and its superior efficiency in vitamin E succinate production. Further optimization experiments with Lipase UM1 led to an unprecedented conversion of 99%. Additionally, we scaled the reaction to a proof-of-concept industrial level. The synthesized product was verified using Fourier transform infrared spectroscopy and nuclear magnetic resonance analysis, ensuring its quality and consistency. This study validates Lipase UM1 as an efficient catalyst for vitamin E succinate synthesis, offering a promising avenue for industrial production with potential applications in cancer therapy and beyond. Graphical Vitamin E succinate (VES) was synthesized through the catalysis of the organic solvent-stable Lipase UM1, resulting in an exceptional conversion.
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Molecular Catalysis
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2024
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IF 3.9
Xiaoyuan Zhang,Yunjian Ma,Bo Ouyang,Yonghua Wang,Fanghua Wang
Ceramide III (CER III) series compounds are essential constituents in cosmetic formulations and dermatological applications. As the cosmetics industry trends toward more sustainable practices, the development of an eco-friendly synthesis method for these vital compounds is increasingly critical. This research introduces a sustainable technique for producing CER III series compounds, using lipase-catalyzed amidation of phytosphingosine with various fatty acid esters or natural oils in an eco-compatible solvent. Through an extensive examination of various lipases and eco-friendly solvents, we first identified Novozym 435 as the most efficient biocatalyst and cyclopentyl methyl ether (CPME) as the preferred solvent. This combination established a high-efficiency reaction system for CER III series compounds synthesis. We further optimized the enzymatic conditions - a substrate molar ratio of 1:1, lipase loading at 30 wt%, at 65 °C, which presented an impressive yield of 94 % for ceramide IIIB (CER IIIB). We also investigated the reusability of enzymes in this synthetic system and further extended the scope of acyl donors using natural oils, results indicating the method excellent potentiality in industrial settings. In summary, this study provides a green and efficient pathway for synthesizing CER III series compounds, aligning with the growing eco-conscious trends in cosmetic science and technology.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2024
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IF 4.1
Shun Cao,Jianbang Ge,Biwu Cai,Yang Gao,Zichen Zhang,Zhihao Cheng,Zhijing Yu,Xin Lu,Shuqiang Jiao
Molten salt electrochemistry has been widely applied in fields such as electrochemical metallurgy, nuclear material processing, and low carbon techniques. The metal or carbon electrode are generally used as working electrode to reveal the electrochemical reaction mechanism or measure the reaction kinetics. However, these electrodes in high-temperature molten salts may suffer corrosion or oxidation due to the harsh environment, which resulted in errors in electrochemical measurements. In most cases, an insulating film was formed on the electrode surface. Herein we showed the influence of an insulating film on the electrochemical signals based on the experimental tests and numerical simulations. The apparent reaction kinetics gradually became sluggish with the increasing film resistance. The ultra-high film resistance led to the linear potential-current behavior during cyclic voltammetry. Moreover, several typical molten salt electrochemical systems with the existence of an insulating film have also been discussed.
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NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 20
·9185-9195
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IF 2.7
Shikai Xue,Dongying Zhu,Qing Zuo,Shuangfeng Yang,Haiyan Wang,Qiujun Lu,Guoxing Yin,Guihua Ruan,Fuyou Du
A novel MIL-101(Fe)/ZnCrZr-LBMO heterojunction was successfully constructed and used for the removal of ciprofloxacin (CIP) in this work. The MIL-101(Fe)/ZnCrZr-LBMO composite exhibited significantly enhanced photocatalytic degradation activity, with reaction rates approximately 3.4 and 3.1 times faster than those observed with pristine MIL-101(Fe) and ZnCrZr-LBMO, respectively. The effect of different amounts of ZnCrZr-LBMO, sample pH, CIP concentration, inorganic cations, and anions on CIP removal was investigated, and the possible intermediates and degradation pathways of CIP were speculated. The·O2− radicals dominated CIP degradation, with minor contributions from 1O2, h+, and ·OH radicals. The composite exhibited high removal rates for CIP (94.7%), ofloxacin (86.8%), and tetracycline (96.3%), respectively, within 60 min of light irradiation, and excellent reusability, retaining over 85.1% CIP degradation rate after five cycles. Our work provides a new reference to construct highly efficient and easily recyclable MIL-101(Fe)/ZnCrZr-LBMO photocatalysts for the removal of antibiotic pollutants, promising advancements in real water treatment applications.
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Journal of Energy Storage
·
2024
·
IF 8.9
Wenshuang Tian,Xiong Zheng,Yang Xiao,Guangzhao Qin
Photovoltaic (PV) power generation technology is currently one of the most effective ways in solar energy utilization, while current PV panels are facing a serious issue of electrical efficiency reduction and potential structural damage caused by the accumulated heat during operation. To solve this issue, we proposed a novel hybrid system containing PV cell, thermoelectric generation (TEG) module, and phase change composite (PCC), which can achieve a power enhancement of 29.8 % compared with individual PV cell. The fabricated chitosan-based PCC has a high anisotropy degree of 4.10 and melting enthalpy of 133.2 kJ·kg −1 , which promote the effective heat transport and storage between PV cell and TEG module, and the excellent mechanical strength and thermal stability ensures its long-term endurance. Owing to excellent thermal properties of the PCC, not only the power of PV cell is increased by 55.9 mW, but the TEG module also continuously outputs 4.1 mW of power. Besides, the hybrid system can produce 5.185 kW·h·m −2 electricity per day in the actual environment. Looking ahead, the integration of advanced materials and hybrid systems like the PV + PCC + TEG approach holds great promise for further enhancing solar energy efficiency and sustainability in real-world applications.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-6
·
IF 3.9
Li Wenfang,Lu Yuze,Wang Jiajun,Li Chuanbi
In this study, a novel artificial enzyme Zn(II)-SMM with simple organic structure for PNPA-directed hydrolysis is proposed. The introduction of hydrophobic quinoline and dipyridinium in Zn(II)-SMM system demonstrates high activity for the complexation of Zn 2+ and hydrolysis of PNPA, and the catalytic rate (k cat /k uncat ) exceeds 5239 times that of non-catalytic systems. The newly designed small molecule organic complex effectively binds to and catalyzes the hydrolysis of substrate PNPA in accordance with Michaelis-Menten kinetics. The mechanism with activation by single Lewis acid provides fundamental insights for the development of small molecule hydrolases.
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危险品化学品经营许可证（带存储）