SOLAR ENERGY
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2019
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IF 4.674
Nasir Ali,Xiaoyu Wang,Sajid Rauf,Sanam Attique,Amir Khesro,Shahid Ali,Naveed Mushtaq,Haibo Xiao,Chang Ping Yang,Huizhen Wu
Owing to their high efficiency and extended environmental stability, hybrid 2D/3D-perovskites (HPVKs) are gaining an increasing interest in the field of organometal halide perovskite solar cells (PSCs). In HPVKs, the 3D component acts as an active material, where its 2D-counterpart provides protection against environmental factors. Here in, we add dodecylammonium-chloride (DACl) into the precursor solution of 3D-perovskites (FAMAPbI 3 ) to achieve HPVKs. The formation of HPVK is confirmed by XRD, optical absorption, and Fourier-transform infrared (FTIR) spectroscopies. The structural and optical analysis affirmed that in the case of HPVKs, not only the crystallinity of perovskites is improved significantly but also a variation in its structural properties and optical bandgap have occurred. It is also observed that the surface morphologies of HPVK films are considerably improved with the incorporation of DACl. A minute amount of CsI is also added into the precursor solution of HPVKs, which further assist the formation of HPVKs and consequently causes a significant increase in the carrier lifetime. Finally, a solar cell made of HPVKs shows an improved PCE than pure 3D-perovskites. All HPVKs films and solar-cells are prepared in the ambient humidity and found to be more hydrophobic and stable, not only under relative humidity >50% but also under high thermal stress of 85 ℃.
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CARBOHYDRATE POLYMERS
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2019
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IF 6.044
Ping Liu,Nana Chen,Lei Yan,Fei Gao,Dongsheng Ji,Shijiao Zhang,Litao Zhang,Yuqin Li,Yuliang Xiao
The purpose of this study was to ascertain the effect of chondroitin sulphate-modified doxorubicin (Dox) nanoparticles on enhancing the tumour-targeting effect and tumour growth inhibition effect of doxorubicin both in vitro and in vivo . The chondroitin sulphate-doxorubicin conjugate and its poly(lactic-co-glycolic acid) (PLGA) nanoparticles (CS-Dox-PLGA) were successfully synthesised, and then characterized by Fourier-transform infrared spectroscopy (FTIR), proton magnetic resonance ( 1 HNMR), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), transmission electron microscope (TEM), zeta potential and laser light scattering. Taking advantage of the enhanced permeability and CD44-mediated endocytosis, CS-Dox-PLGA showed excellent capacity for penetrating the peripheral tumour barrier and into the nucleus of tumour cells. The CS-Dox-PLGA cellular uptake was improved and exhibited a significantly higher level of cytotoxicity in U251 cells. After intravenous administration, the CS-Dox-PLGA showed good pharmacokinetic properties and excellent U251-induced tumour inhibition with low cardiac toxicity. Therefore, CS-Dox-PLGA with low cardiac toxicity and good anti-tumour ability might be a better choice for Dox in clinical practice.
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PubMed
高影响因子
PHYTOMEDICINE
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2019
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IF 4.18
Licong Zhao,Jiaqi Zhang,Lingyun Pan,Long Chen,Yu Wang,Xinhua Liu,Lisha You,Yiqun Jia,Cheng Hu
Background Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinic. Fisetin (FST) is a phenolic compound that has been isolated from many natural products. Purpose Our aim is to study the protection effect and mechanisms of FST on APAP-induced hepatotoxicity in endogenous metabolism and metabolomics in vitro and in vivo . Methods FST was i.g. administered to mice at 10 , 20 and 40 mg/kg for 7 days and a single dose of APAP (400 mg/kg) was given on the last day. Serum and tissue were collected for biochemical analysis . L-02 cells were used to assess cell viability . LC–MS was used to study the metabolic fingerprinting in vivo and vitro . PCA and OPLS-DA were used to search the potential biomarkers (VIP > 1, p < 0.05). The pathway analysis was conducted on Metaboanalyst 4.0. Then liver oxidative stress indices and glutathione markers were examined using PCR and kits. Results ALT , AST, liver histological observation and cell viability results showed that FST could reverse APAP induced toxicology in mice and L-02 cells. In metabolomics study, 26 metabolites in vitro and 60 metabolites in vivo were identified by searching in the library and most of them decreased to normal level in FST treatment . It is observed in pathway analysis that the most significant pathway was glutathione metabolism. Furthermore, the results of mRNA and immunofluorescence showed that FST suppressed ROS formation in liver tissue and L-02 cells, as well as restored the expression of GPX1 , GST and other antioxidative enzymes genes. Conclusion Our results indicate that FST prevented APAP-induced hepatotoxicity by regulating glutathione metabolism and the expression of related antioxidative signals.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2019
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IF 3.206
Lanyun Fang,Yumei Zhang,Beibei Lu,Li Wang,Xunping Yao,Ting Ge
The present paper proposed an analytical method for speciation analysis of inorganic antimony in inhalable particulate matter, PM2.5, using high performance liquid chromatography coupling with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). A new extraction method consisted of reducing extraction and oxidizing extraction using EDTA as the key component in the extractant has obtained better extraction yield and preserves stability of both species during the extraction process. Stability of Sb species in EDTA-saturated nitric or tartric acid solution and in aqueous solution were carefully investigated. Using the optimized conditions, the method allows for the determination of Sb(III) and Sb(V) in PM2.5 samples with limits of 0.10 and 0.06 ng m −3 , respectively. The precision, expressed as relative standard deviation (RSD), was always lower than 8.5% and 6.6% for Sb(III) and Sb(V), respectively. The spiked recovery rates of Sb species at three different concentration levels were in the range of 90.0–110.0%. The extraction yield of the sequential extraction process confirmed by analysis of a certified reference material of urban particulate matter, NIST1648a, furnished by National Institute of Standards and Technology was 60%. This method was applied to determine Sb(III) and Sb(V) in PM2.5 samples collected in urban area in Ningbo City, China. The results showed that both Sb(V) and Sb(III) were found in most of the samples analyzed, Sb(V) being the main one, which represents 69–87% of the total Sb extracted in the considered samples, whereas Sb(III) represents the remaining 13–31%.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2019
·Vol. 26
·期 10
·10148-10158
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IF 2.914
Du Fan,Wang Lin,Yang Zhaoguang,Liu Peng,Li Deliang
Freshwater aquatic environment close to cities and industrial areas is more sensitive than marine environment. The freshwater shellfish Semisulcospira cancellate was introduced as a bioindicator to monitor the heavy metal contamination in the river through ionomic profiles and arsenic speciation. The shellfish samples were collected near four cities along the Xiang River in China. The concentrations of elements including Mg, Al, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Sr, Cd, Sn, Sb, Ba, and Pb were determined using ICP-MS. Multivariate statistical analyses such as Pearson’s correlation analysis and principle component analysis (PCA) were employed to identify the possible sources of the elements in the shellfish samples. Three principle components were extracted from the ionomic matrix and were associated with natural existence, biological pathways, and mining and smelting activities, respectively. The ionomic profiles of the shellfish samples were evaluated through hierarchical cluster analysis (HCA) which was exhibited in the form of heatmap. The shellfish samples were categorized according to the sampling sites with different contamination levels. Six As species including arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB), and arsenocholine (AsC) were separated and quantified using HPLC-ICP-MS. The concentrations of As(III) and As(V) were linearly increased with total As concentration increasing. However, the proportion of AsB was decreased with total As while the AsB concentration was irrelevant to total As.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2018
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IF 2.631
Suping Ding,Qiuxiang Yin,Wei Du,Xiaowei Sun,Guiping Li,Yafei Mao,Hongxun Hao
The separation of phenanthrene (PHE) and carbazole (CAR) has been a tough job since the formation of solid solutions. Development of new separation strategy for PHE-CAR mixture highly depends on their phase equilibrium behaviour. In this work, ternary phase diagrams of phenanthrene (PHE) and carbazole (CAR) in dimethylformamide (DMF), acetone, acetonitrile (MeCN) and toluene at T = 308.15 K under normal atmosphere were determined through wet residue method. It was found that PHE-rich solid solution α was formed in the particular composition range of PHE-end. On the contrary, no CAR-rich solid solution was formed in CAR-end. These results were further verified through powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC). Based on the ternary phase diagrams, a difference coefficient of solubility ( Ds ) was put forward to assist screening and evaluation of solvents for solution crystallization. Among the four tested solvents, toluene is the most suitable one for separating PHE-CAR mixture.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
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IF 11.698
Hongxia Wang,Yanwei Wang,Lixing Tan,Ling Fang,Xiaohui Yang,Zhengyong Huang,Jian Li,Huijuan Zhang,Yu Wang
Rational structure design and component-controlled synthesis are attractive and challenging methods to develop materials with unique function for renewable energy conversion such as hydrogen production via water splitting. The earth-abundant and affordable transition metals have been regarded as ideal alternatives to precious platinum. Herein, we report the designed synthesis of component-modified cobalt telluride nanoparticles encapsulated in the nitrogen-doped carbon frameworks with the feature of high surface area and great electron conductivity. Compared with CoTe 2 /C and CoTe/C, the Co 1.11 Te 2 /C presents the highest catalytic activity for HER in 1M KOH due to its structural and component advantages. After a continuous reaction for 20 h or cycling for 1000 cycles, Co 1.11 Te 2 /C shows only a little performance loss. This work provides an effective approach to synthesize low-cost and efficient electrocatalysts for HER via rational structural and component design.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2019
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IF 7.149
Zhou Fang,Kexin Li,Yuan Li,Hao Zhang,Kevin C. Jones,Xinyu Liu,Shengyu Liu,Lena Q. Ma,Jun Luo
Psychiatric pharmaceuticals are widely distributed in the aquatic environment and have attracted recent attention due to their potential for environmental effects. A robust and reliable in situ passive sampling approach, the diffusive gradients in thin-films (DGT) technique, is developed here to measure 14 psychiatric pharmaceuticals. A new binding material, mixed-mode cation exchange resin (Poly-Sery MCX, 40 μm, CNW, Germany), was used for the first time in DGT and compared to XAD and HLB. Reliable elution efficiencies of the pharmaceuticals from the binding gels were obtained in methanol/ammonia, and diffusion coefficients for all the compounds were determined. The influence of diffusive layer thickness (0.515–2.015 mm), deployment time (3–168 h), and important environmental conditions—pH (3.02–9.45), ionic strength (0.0001–0.5 M), and dissolved organic matter (0–20 mg L–1)—were evaluated. The capacity of XAD, HLB, and MCX gels for binding all the test pharmaceuticals was ∼335 μg per disc, meaning that DGT could theoretically be deployed for over 30 months if there are no competitive effects or confounding factors. The uptake kinetics of psychiatric pharmaceuticals onto MCX gel were much faster than those onto XAD and HLB gels in the first hour. DGT measured concentrations of test pharmaceuticals at two sample points in a river (over 6 days) were comparable to those obtained by grab sampling. This study demonstrates the accuracy and reliability of DGT for measuring psychiatric pharmaceuticals across a wide range of freshwater conditions found in the natural environment.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
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IF 3.131
Fan Ye,Xia Jiang,Yuanzhu Mi,Jiazhe Kuang,Zhiming Huang,Fan Yu,Zejun Zhang,Huaikui Yuan
In order to reduce the cost of demulsifiers and improve the demulsification performance of carbon material demulsifier, the nano-SiO 2 was grafted onto the surface of oxidized carbon black (Ox-CB) by sol-gel method in current study. The novel composite demulsifier was analyzed by fourier transform infrared spectroscopy (FT-IR), field-emission scanning electron microscope (FE-SEM), energy dispersive X-ray (EDX) and X-ray diffraction spectra (XRD) which confirmed the partial grafting of SiO 2 on the oxidized carbon black (Ox-CB).The influences of temperature, settling time, and concentration of the composite demulsifier on the efficiency for breaking up water-in-oil emulsions were investigated in detail by bottle test. It was found that the best operating conditions to remove more than 90% of the water from the original emulsion were a temperature of 75 ℃ and a demulsifier concentration of 500 mg/L. The wettability , oil-water interfacial tensions (IFT) and interfacial activity of the demulsifier were further measured to explore the demulsification mechanism. Possible demulsification mechanism showed that the composite demulsifier could lead to the breakup of water-in-oil emulsions by bridging, flocculation and coalescence. The high interfacial activity is the main factor affecting the demulsification.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
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IF 3.973
Jian-Tao Lin,Hua Chen,Dan Wang,Liang Xiong,Jia-Zhu Li,Gui-hong Chen,Guang-Bin Chen
The nucleus is one of the most important cellular organelles. Chitosan-grafted poly-(N-3-carbobenzyloxy-lysine) (CCL) decorated with human immunodeficiency virus-1 transactivator of transcription (TAT) can co-deliver p53 and doxorubicin into the nucleus simultaneously, such that their antitumor functions are exerted. However, TAT-CCL has been shown to have an anti-tumor effect only in vitro; the effect in vivo was unsatisfactory. Here, a unique nucleus-targeted delivery system based on amidized TAT (aTAT)-CCL with aTAT functional on the surface was designed to achieve a highly efficient nucleus-targeting gene and drug delivery system for effective cancer cell elimination in vitro and in vivo. In this delivery system, TAT is amidized to inhibit its nonspecific interactions. Confocal laser scanning microscopy observations revealed that if aTAT-CCL was incubated in pH 5.0 acetate buffer solution for 24 h before use (named aTAT-CCL-HB), more aTAT-CCL-HB entered the nucleus compared with aTAT-CCL or CCL. aTAT-CCL-HB can also achieve high gene transfection and drug delivery efficiencies and low viability in HepG2 cells. However, only aTAT-CCL achieved extensive circulation in the blood compartment and high antitumor activity in vivo. Amidization of TAT in vectors may become a promising strategy for nucleus-targeted delivery systems, especially in in vivo applications.
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ACS Biomaterials Science & Engineering
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2019
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IF 4.511
Kun Lei,Qi Zhu,Xinling Wang,Haijun Xiao,Zhen Zheng
Biocompatible bone adhesive is a kind of promising biomaterial in orthopedic and trauma surgery. However, despite the urgent need, there is no appropriate system that can meet all the requirements for bone adhesive. In this study, a porous polyurethane adhesive (PUA) was fabricated, and the effects of water, polyisocyanate, and β-tricalcium phosphate (β-TCP) on the physicochemical and mechanical properties of PUAs were investigated. By varying the water content, PUAs with different surface morphologies and porosities were prepared. The adhesion strength and mechanical property of the adhesives could be enhanced by the addition of polyisocyanate and β-TCP. The adhesion strength of the PUA to bone was 2 times higher than that of clinical poly(methyl methacrylate) bone cement. The in vitro cell culture and attachment assays indicated good biocompatibility of the PUAs. In vivo analysis in a rabbit model demonstrated that the porous structure of the PUA could facilitate the growth of cells and bone tissues.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2018
·Vol. 42
·期 5
·3851-3856
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IF 3.201
Shuyun Zhu,Cuihua Lei,Yue Gao,Jing Sun,Hongwei Peng,Han Gao,Ruixue Zhang,Rui Wang,Xian-En Zhao,Hua Wang
Ascorbic acid (AA), as one of the most important neurochemicals in cerebral systems, plays a vital role in many physiological and pathological processes. Herein, a facile, label-free, and ultrasensitive fluorescence sensing system was developed for the determination of AA based on the Ag+–o-phenylenediamine (OPD) interaction. OPD could be oxidized by Ag+ to generate fluorescent 2,3-diaminophenazine (OPDox). When AA was introduced, on the one hand, AA can inhibit the oxidation process due to its strong reducing capability. On the other hand, AA can be oxidized to dehydro-AA with an absorption peak at 380 nm, which has a good spectral overlap with the emission of OPDox. Thus, the inner filter effect (IFE) between dehydro-AA and OPDox may occur. Therefore, the introduction of AA can intensively suppress the fluorescence of the Ag+–OPD system. Benefitting from the remarkable synergistic effect of the reducing capability of AA and IFE, a facile and ultrasensitive sensor was constructed successfully for AA sensing. The whole detection procedure was achieved within 10 min. The linear response range of AA was obtained from 0.05 to 40 μM with a detection limit of 10 nM. This developed method has many merits including more simplicity, good selectivity, excellent biocompatibility, and more cost-effectiveness without using any nanomaterials. Notably, the proposed method was successfully applied to detect AA in rat brain microdialysates in the presence of catecholamines, thus providing a new route for AA detection in physiological and pathological fields.
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