OPTICS AND LASER TECHNOLOGY
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2018
·
IF 2.503
Qi Wang,Botao Wang
A sensitivity enhanced surface plasmon resonance (SPR) immunosensor based on Graphene oxide (GO) composite and staphylococcal protein A (SPA) co-modified photonic crystal fiber (PCF) is developed for human IgG detection. The PCF spliced between two section of multimode fibers (MMFs) is sputtered with gold film, which was then modified with graphene oxide and SPA for further immunosensing. Graphene oxide with abundant functional groups has a large surface area for more biomolecules immobilization and can enhance the interaction between Au film and external medium, leading to the sensitivity increased greatly. SPA can specifically bind the Fc region of the antibodies and has a high degree of orientation for capturing antibodies. Experimental results indicated that the refractive index (RI) sensitivity of graphene oxide modified Au-PCF SPR sensor reaches 4649.8 nm/RIU, which is about 1888 nm/RIU higher than that without graphene oxide film and the human IgG detection limit reaches as low as 10 ng/mL. Such a sensitivity enhanced immunosensor based on graphene oxide and SPA co-modified PCF shows a great promise in biosensing.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2018
·Vol. 18
·期 6
·4196-4203
·
IF 1.354
Wu Jinzhu,Feng Yaxiu,Shao Yanbin,Sun Yanchun
Nitrogen and silicon co-doped carbon nanodots (N/Si-CDs) were synthesized by one-step hydrothermal carbonization of folic acid and 3-aminopropyl trimethoxy silane with the assistance of glycerol. The resultant N/Si-CDs present intense excitation-independent photoluminescence (PL) emission
owing to their monodisperse sizes and specific surface states. In comparison to nitrogen single doped CDs (N-CDs), the co-doped N/Si-CDs possess better PL properties following different emission manner due to the synergistic effects of the nitrogen and silicon dopants. Besides, the functionalized
surfaces of N/Si-CDs endow them with superior solubility and stability. The as-synthesized N/Si-CDs demonstrate selective and sensitive fluorescence response to Fe3+, which could be explained by the PL quenching effects of Fe3+ on N/Si-CDs. Based on this finding, the
quantitative analysis of aqueous Fe3+ by N/Si-CDs was established, showing good linearity in a range of 10 nM~45 μM and good sensitivity with a detection limit of 3.8 nM, so did for the detection of Fe3+ in fetal bovine serum (FBS) spiked samples. Therefore,
the N/Si-CDs as a novel fluorescence probe hold promising for monitoring environmental and clinical Fe3+.
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RSC Advances
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2018
·Vol. 8
·期 20
·11119-11126
·
IF 2.936
Faqin Tong,Shuangshuang Chen,Zhao Chen,Xuemin Lu,Qinghua Lu
Enhancing the azimuthal anchoring energy of the aligning film is a key requirement to improve the quality of liquid-crystal displays. Based on the assumption of mesogenic side groups being able to align liquid-crystal (LC) molecules, we have designed a novel transparent polyimide bearing cyanobiphenyl mesogenic side chains, which has a similar structure to that of liquid crystal 5CB. A pyrimidyl diamine monomer with a cyanobiphenyl mesogenic unit was first synthesized, and then co-polymerized with 4,4′-diaminodiphenyl ether and 4,4′-oxydiphthalic anhydride. The obtained polyimide (PI) exhibited good thermal stability and mechanical properties, as well as high optical transparency with transmittance of up to 86% in the wavelength range 450–700 nm. By evaluating the adhesion force between PI films and LCs with a super-sensitive microelectro-mechanical balance system, we have verified that appending mesogenic groups on the side chains of PI strengthens intermolecular interactions between the LC and PI surfaces, thereby enhancing the surface anchoring energy. Compared with the unmodified PI, the anchoring energy of the derivatized PI was improved more than 2.2-fold. By virtue of its good transparency and strong anchoring energy, this PI would seem to be an ideal candidate as a LC alignment film, and the concept of mesogens aligning LCs may open a new door in the design of LC alignment films.
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Journal of Materials Chemistry B
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2018
·Vol. 6
·期 15
·2217-2229
·
IF 4.776
Shengnan Huang,Ying Liu,Xin Xu,Mengfei Ji,Yuanmin Li,Chengjun Song,Shaofeng Duan,Yurong Hu
A combination of different therapy strategies has great potential to efficaciously treat malignant tumors, by virtue of their synergetic effects. Herein, a co-delivery system based on gold nanocages (AuNCs) was designed to deliver both doxorubicin (DOX) and microRNA-122 mimic (miR-122) for an enhanced cancer therapy. DOX was loaded into the AuNCs and miR-122 was condensed onto the surface of the functionalized AuNCs by an electrostatic interaction. Polyethyleneglycol (PEG) and hyaluronic acid (HA) were also introduced to the co-delivery system for targeted drug delivery. We evaluated the cellular uptake, biodistribution and anti-tumor effect in vitro and in vivo. Our results demonstrated an effective delivery of DOX and miR-122 into tumor cells and the tumor tissue. Importantly, the triple therapy, namely the combination of chemotherapy, gene therapy and photothermal therapy, mediated by this multifunctional drug delivery system, exhibited better anti-tumor effect than any single therapy, both in vitro and in vivo. Additionally, this drug delivery system caused insignificant toxicity to the major organs and had no obvious effect on the body weight of the mice. It could be concluded that multifunctional AuNCs are promising as a co-delivery vector for an enhanced anti-tumor effect.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2018
·
IF 3.141
Yuan Cai,Xiaofeng Xu,Hu Wang,Lei Wang,Lulu Chen,Rui Li,Jing Ding,Hui Wan,Guofeng Guan
Production of alternative, clean aviation fuel from biomass synthesis gas via Fischer–Tropsch (FT) synthesis has attracted much attention. In this paper, Al-SBA-15 supported cobalt catalysts with different Al/Si ratios were successfully prepared for the production of aviation fuel by FT synthesis. The physical and acidic properties of the Co/Al-SBA-15 catalysts were characterized by XRF, XRD, N2 adsorption–desorption, TEM, H2-TPR, 27Al NMR, NH3-TPD, and Py-FTIR. The formation of long-chain hydrocarbons was inhibited by the ordered mesoporous structure. Fischer–Tropsch activity and selectivity were demonstrated to be affected by the acidity of the Al-SBA-15 supports. The selectivity turned to lighter iso-paraffin products. Co-based catalyst with Al/Si ratio of 0.01 exhibited the highest selectivity (52.4%) for aviation fuel (C8–C18 products) and much higher ratio of iso-paraffin/normal-paraffin (iso/n) (20.2%). This study might provide useful information for the selective production of aviation fuel via FT synthesis.
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CATALYSIS TODAY
·
2018
·
IF 4.667
Xiao Dong,Peng Zheng,Ai-Guo Zheng,Hui-Feng Li,Guo-Fu Xia,Ming-Feng Li,Ren-Yang Zheng,Bo-Qing Xu
Pt-Co/SiO 2 and Pt-Ir-Co/SiO 2 catalysts were prepared via galvanic replacement (GR) and employed for the hydrogenolytic ring-opening of methylcyclopentane (MCP). Selective deposition of the noble metals at the less expensive Co nanoparticle (NP) surface by GR greatly enhanced the utilization efficiency of the more active Pt or Pt and Ir atoms for the selective catalysis to the ring-opening reaction of MCP, as justified by comparison with catalysts from conventional impregnation preparation. The chemistry of GR was quantitatively studied by comprehension of the composition changes both in the preparation solution and in the solid samples. The structural features of GR catalysts were characterized as highly dispersed Pt or Pt and Ir clusters selectively deposited on Co NP surface. Compared to their counterparts from impregnation preparation, the GR catalysts showed much higher mass-specific activity normalized by overall noble metal loading (MSA NM ), due to the significantly enhanced utilization efficiency of Pt or Pt and Ir. In addition, the trimetallic Pt-Ir-Co/SiO 2 catalyst showed a distinctly higher MSA NM than the bimetallic Pt-Co/SiO 2 and Ir-Co/SiO 2 ones. This observation features a synergy between the highly dispersed Pt and Ir clusters in the catalysis, besides the enhanced noble metal utilization efficiency. Our catalytic data seem to suggest that a dicarbene mechanism was prevailing over the GR catalysts for the ring-opening reaction of MCP.
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Yangqin Gao,Yandong Li,Guoqing Yang,Songsong Li,Nan Xiao,Boran Xu,Shuang Liu,Ping Qiu,Shijie Hao,Lei Ge
Fe2TiO5 was synthesized via the solvothermal method and adopted as co-catalyst to improve the photoelectrochemical (PEC) water splitting performance of BiVO4 photoanode. After surface modification by Fe2TiO5, the BiVO4/Fe2TiO5 photoanode shows a 300 mV cathodic shift in onset potential and 3 times enhancement in photocurrent, which delivers a photocurrent density of 3.2 mA/cm2 at 1.23 V vs reverse hydrogen electrode. Systematic optical, electrochemical, and intensity-modulated photocurrent spectroscopy characterizations were performed to explore the role of Fe2TiO5 and reveal that the enhanced PEC performance is mainly caused by the surface passivation effect of Fe2TiO5.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Zhi Zhu,Xu Tang,Wenqian Fan,Zhi Liu,Pengwei Huo,Tianshuai Wang,Yongsheng Yan,Chunxiang Li
A new Co-doped and Fe 3 O 4 quantum dots (QDs) decorated g-C 3 N 4 (CN) photocatalyst applied in the tetracycline degradation under visible light irradiation, is designed and synthesized. The Fe 3 O 4 -QDs@Co CN enhanced photocatalytic activity and cycling ability in comparison with individual CN significantly. It revealed a synergistic effect between the formation of Fe 3 O 4 -QDs and Co-doping. Results of characterization insight into the reason that Co-doped can regulate the band gap of CN, which has been proved by XPS and density functional theory (DFT). Moreover, the oxidation-reduction centre of Fe 3 O 4 -QDs with quantum effect can significantly boost the absorption of visible light and utilization electrons. Therefore, this work provides a broadening window for photo harvesting, charge using and separation during photocatalytic reactions.
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Chen Jiao,Yuanyuan Chen,Tianqi Liu,Xin Peng,Yaxin Zhao,Jianan Zhang,Yuqing Wu,Huiliang Wang
Shape memory hydrogels (SMHs) have a wide range of potential practical applications. However, the mechanically weak and soft nature of most SMHs strongly impedes their applications. Here, we report a novel kind of thermal-responsive SMH with high tensile strength and high elastic moduli. Organogels are first prepared by the copolymerization of a hydrophilic monomer N-vinylpyrrolidone (NVP) and a hydrophobic monomer acryloxy acetophenone (AAP) in N,N′-dimethylformamide (DMF) solutions, and then, poly(vinylpyrrolidone-co-acryloxy acetophenone) [poly(NVP-co-AAP)] hydrogels are obtained by solvent exchange with water. Because of the strong and reversible hydrophobic association and π–π stacking of acetophenone groups, the poly(NVP-co-AAP) hydrogels exhibit tensile strengths up to 8.41 ± 0.83 MPa and Young’s moduli up to 94.2 ± 1.3 MPa, which are more than 1 or 3 orders of magnitude higher than those of the organogels, respectively. The poly(NVP-co-AAP) hydrogels exhibit good shape memory behaviors, with a complete fixation ratio and a recovery ratio of 74–89%, as well as very fast shape-fixing and recovering rates (in seconds). These rigid and strong hydrogels are demonstrated to be an ideal shape memory material for surgical fixation devices to wrap around and support various shapes of limbs.
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ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Mingquan Liu,Silu Huo,Min Xu,Linlin Wu,Mingjie Liu,Yifei Xue,Yi-Ming Yan
Nitrogen and sulfur co-doped carbon (NSC) is considered as a promising electrode material for supercapacitors (SCs). However, the specific capacitance and the rate performance of NSC are not satisfied for practical applications due to its inappropriate structural properties. Herein, we report the structural engineering of NSC by optimizing pore structure to obtain an ordered hierarchical pore network. The as-prepared NSC possesses a high gravimetric capacitance of 322 F g -1 at the current density of 1.0 A g −1 and retains 206 F g −1 (64% of its capacitance at 1.0 A g −1 ) at the high current density of 100 A g −1 . Moreover, it reveals an excellent cycling performance with ∼93.4% capacitance retention after 10000 cycles at the current density of 20 A g −1 . An assembled symmetric supercapacitor (SC) shows a remarkable energy density of 11.4 Wh kg −1 and a high power density of 12.9 kW kg −1 . The outstanding performances of NSC electrodes benefit from the efficient ion diffusion and fast charge transfer. This work paves a way to rationally design and engineer the structure of NSC for achieving both high rate capability and high specific capacitance for SCs applications.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2018
·Vol. 165
·期 7
·H348
·
IF 3.662
Le Wang,Hangjia Shen,Sanshuang Gao,Xamxikamar Mamat,Guangzhi Hu
As an excellent catalyst toward hydrogen peroxide reduction, Fe-based nanomaterial like Fe-N-C configuration is promising candidate to be used for H2O2 sensing. In this work, a novel N-doped mesoporous carbon by atomically dispersed Fe-N dopant composite modified electrode (Fe/NOMC) was prepared by hard template approach and then fabricated non-enzymatic sensor was used for H2O2 determination. The morphology and property of Fe/NOMC composite were characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), small angle X-ray diffraction (XRD) spectrum and nitrogen-sorption measurement, respectively. The electrochemical sensing performance of the Fe/NOMC composite modified glassy carbon electrode (GCE) was studied by cyclic voltammetry and chronoamperometry methods. An excellent performance toward hydrogen peroxide reduction was achieved in a wide range of 8–23000 μM, with limitation of detection (LOD) about 5 μM and a correlation coefficient of 0.998, as well as a short response time (2 s) and good selectivity.
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RSC Advances
·
2018
·Vol. 8
·期 4
·2082-2091
·
IF 2.936
Yangui Chen,Xiaoxia Li,Hong Xiao,Jinpeng Xiao,Bo Li,Xiaoyan Chen,Yong Wang,Du Cheng,Xintao Shuai
Owing to the complexity of tumorgenesis, combination therapy has proven to be a viable strategy for cancer treatment in recent years. However, the delivery and site-specific release of different therapeutic agents remain a major challenge in combination therapy. In this study, a polymeric nanovesicle based on a copolymer of polyethylene glycol and a polypeptide derivative was introduced as a vector to simultaneously deliver hydrophobic gefitinib and hydrophilic doxorubicin hydrochloride for multi-target combination therapy. The vesicle incorporating the two drugs exhibited prominent pH/reduction sensitivities to trigger the release of gefitinib and doxorubicin inside cancer cells. The two drugs co-delivered by the polymeric nanovesicle exhibited a joint anticancer effect both in vitro and in vivo. In particular, a remarkable therapeutic effect was demonstrated in animal studies using a mouse N2a neuroblastoma model. This study reveals the potential of reduction and pH dual-responsive nanovesicles bearing gefitinib and doxorubicin as an effective nano-medicine for cancer treatment.
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