JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Zhang Dingyue,Xu Xinying,Zhang Rui,Zhang Zhen,Zhang Xiao,Yao Chunli
The depletion of fossil fuel reserves, coupled with the emergence of various pollution issues, has precipitated a surge in demand for research in the domains of bioenergy and biochemical research. 5-Hydroxymethylfurfural (5-HMF) is regarded as a bridge material connecting petrochemical industries and natural biomass resources. Due to the extremely low yield of one-step conversion from cellulose to 5-HMF, most studies have chosen glucose as the starting material. However, glucose isomerization remains one of the challenging steps in the conversion process. Here we successfully prepared a metal chromium-loaded sulfonated mesoporous carbon-based solid acid catalyst (Cr–SO 3 H-CSA) with a large pore size (7.844 nm) and high acidity (14.304 mmol NH3 ·g⁻ 1 cat), as well as a mesoporous silica-based solid acid catalyst (Cr–SO 3 H-MCM41). The catalytic conversion of glucose to 5-HMF over these catalysts afforded yields of 96.43% and 79.45%, respectively. Compared with other types of solid acids reported in the literature, the catalysts prepared in this study exhibit superior catalytic performance for the conversion of glucose to 5-hydroxymethylfurfural (5-HMF). Furthermore, it is demonstrated that the structure of the catalyst support has a significant impact on the catalytic effect. This work expands the choice of catalysts for efficient conversion of biomass into 5-HMF and provides insights into the effect of support structure on catalyst preparation. Graphical
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Journal of Animal Science and Biotechnology
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2026
·Vol. 17
·期 1
·169
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IF 7.9
Li Jiahao,Wang Zhengli,Ma Xiaoxue,Nie Cunxi,Liu Tingting,Li Yuanyuan,Zhang Wenju
Background Diarrhea in suckling lambs is associated with gut microbiota dysbiosis, impaired intestinal barrier function, and enhanced inflammatory responses. However, the specific intestinal microbes and microbial metabolites linked to intestinal homeostasis in suckling lambs remain unclear. Results In this study, diarrheic lambs showed significantly higher serum diamine oxidase (DAO) activity, D-lactate (D-LA), and pro-inflammatory cytokine levels than healthy lambs. We then compared gut microbial composition and metabolite profiles between healthy and diarrheic suckling lambs. Diarrheal lambs exhibited gut microbiota dysbiosis, characterized by an elevated Bacillota (syn. Firmicutes)/Bacteroidota (syn. Bacteroidetes) ratio, reduced abundance of beneficial commensals including Phocaeicola vulgatus and Bacteroides fragilis , and proliferation of the opportunistic pathogen Clostridium perfringens . Metabolomic analysis showed that, in diarrheic lambs, the tryptophan metabolism pathway was reduced with lower levels of indole-3-carboxaldehyde (IAld) and 5-hydroxyindole-3-acetic acid (5-HIAA) than in healthy lambs. Fecal microbiota transplantation experiments showed that transplantation of microbiota from diarrheic lambs partially recapitulated the donor-associated microbial, metabolic, and inflammatory phenotypes in recipient mice. Finally, functional validation using a dextran sulfate sodium (DSS)-induced colitis model revealed that supplementation with IAld and 5-HIAA significantly alleviated DSS-induced intestinal inflammation and barrier damage, accompanied by downregulated expression of genes related to the Tlr4-Myd88-Nfκb signaling pathway. Conclusions Our findings indicate that the gut microbiota-derived tryptophan metabolites IAld and 5-HIAA alleviated inflammation and improved intestinal epithelial barrier function by enhancing tight junction integrity, while also reducing the expression of Tlr4/Myd88/Nfκb pathway-related inflammatory signaling molecules.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Minghao Shi,Jihui Yang,Mingjia Zhang,Shule Zhang,Qin Zhong
The Ce-based catalysts show promising activity in the selective reduction of NO x with NH 3 (NH 3 -SCR) at medium and low temperatures, yet their limited sulfur tolerance hinders broader application. We have developed a catalyst by confining CeO 2 within the mesopores of ZSM-5 zeolite (CeO 2 @ZSM-5), resulting in uniform dispersion and ultra-small CeO 2 nanoparticles (<10 nm). This distinctive structure enhances the interaction between the carrier and active species, reducing the catalyst's surface basicity and its affinity for acidic SO 2 gas. Additionally, the small CeO 2 particle size leads to an increased Ce 3+ concentration, which inhibits the reaction between Ce active sites and SO 2 . Employing a dual strategy of reducing adsorption and inhibiting reactions, we significantly minimized the impact of SO 2 on NH 3 -SCR. Impressively, common Ce-based catalysts become deactivated due to the formation of corresponding sulfates through reaction with SO 2 , however, CeO 2 @ZSM-5 achieves NO x conversion above 98% and N 2 selectivity of 100% within the temperature range of 250 °C to 450 °C. The addition of 100 ppm SO 2 does not significantly affect NH 3 -SCR activity. This study provides an effective approach to mitigate SO 2 adsorption and reactions, offering a valuable strategy for the development of highly efficient sulfur-resistant catalysts.
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JOURNAL OF POWER SOURCES
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2014
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IF 5.211
Junli Shi,Yonggao Xia,Shaojie Han,Lifeng Fang,Meizi Pan,Xiaoxiong Xu,Zhaoping Liu
Since 5 V lithium ion batteries have attracted more and more attentions and are deemed to be an important tendency in the future, the matched design of the separators has also become a necessary and significant work. In this work, the lithium ionic conducting glass ceramic Li 1.5 Al 0.5 Ge 1.5 (PO 4 ) 3 -polypropylene (PP) based inorganic–organic composite separator (LAGP-PP) is prepared. Compared with the pristine PP separator, the LAGP-PP separator owns enhanced thermal stability and wettability . Meanwhile, the LAGP-PP separator shows higher ion conductivity than the traditional Al 2 O 3 coated PP separator due to the more facile lithium ion diffusion channels in the coating layer . The superior C-rate capacity and cyclability in the LiNi 0.5 Mn 1.5 O 4 based 5 V lithium ion batteries indicate that the LAGP-PP separator is a good alternative for the traditional inert inorganic ceramic coated polyolefin separators and is a kind of promising candidate separator for the high voltage lithium ion batteries.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xin Meng,Yaochun Yan,Zeyu Chen,Mengting Xu,Zhaoyang Fei,Ming Xia,Xian Chen,Hui Shi,Xu Qiao,Qing Liu
Catalytic oxidation is a promising technology for the deep cracking of chlorinated organic compounds (COCs) in pharmaceutical waste salts. The critical challenge lies in the development of catalysts that can synergistically activate C Cl bonds and promote highly efficient oxidation. Herein, this study employed a B-site doping strategy to develop a series of perovskite-type catalysts that successfully achieved the synergy of acidic and redox sites. Among them, the LaMn 0.8 Cr 0.2 O 3 /ZSM-5(25) catalyst exhibited the optimal performance in the catalytic cracking-oxidation of the model pollutant 1-chloro-3-phenylpropane. It achieved a T 90 of 260 °C, representing a significant reduction of 48 °C compared to the undoped catalyst. Moreover, it retained around 90% conversion over 60 h. In-depth mechanism study indicated that the pronounced electron transfer between Cr and Mn ions (3Cr 2+ +3Mn 4+ → 2Cr 3+ +Cr 6+ +3Mn 2+ ) not only increased the oxygen vacancy concentration but also significantly enhanced the activity of both chemisorbed oxygen (0.37 mmol·g cat −1 ) and lattice oxygen (0.23 mmol·g cat −1 ). Concurrently, the metal doping effectively exposed the inherent Si-OH-Al acidic sites in the ZSM-5 framework without altering their intrinsic nature. This synergistic mechanism drives the efficient cracking-oxidation of COCs by accelerating the steps of C Cl bond cleavage and deep oxidation of intermediates, rather than altering the reaction pathway. This work provides a solid theoretical basis and profound insights for designing multi-site synergistic catalysts for the purification of COCs.
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ANALYTICA CHIMICA ACTA
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2023
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IF 6.2
Yuanyuan Yue,Songtao Wang,Qiang Jin,Nan An,Lina Wu,He Huang
Lead ions (Pb 2+ ) are a well-known toxic heavy metal that poses a significant threat to human health. Therefore, the development of a simple and ultrasensitive technique for detecting Pb 2+ is essential. With their trans -cleavage properties, the newly discovered CRISPR-V effectors have become a potential high-precision biometric tool. In this regard, a CRISPR/Cas12a-based electrochemical biosensor (E-CRISPR) has been developed, which is combined with the GR-5 DNAzyme that can specifically recognize Pb 2+ . In this strategy, the GR-5 DNAzyme acts as a signal-mediated intermediary, which can convert Pb 2+ into nucleic acid signals, thereby becoming single-stranded DNA that triggers strand displacement amplification (SDA) reaction. This is coupled with following activated CRISPR/Cas12a cleavage of the electrochemical signal probe, enabling cooperative signal amplification for ultrasensitive Pb 2+ detection. The proposed method has a detection limit as low as 0.02 pM. Therefore, we have developed an E-CRISPR detection platform with GR-5 DNAzyme as a signal medium (called SM-E-CRISPR biosensor). This provides a method for the CRISPR system to specifically detect non-nucleic substances by converting the signal using a medium.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2023
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IF 2.6
Lingli Zhang,Chunjuan Huang
The solubility of 2-amino-5-bromopyrazine in the co-solvent mixtures of methanol, ethanol, isopropanol, and propylene glycol (PG) plus water and 10 monosolvents (methanol, ethanol, isopropanol, N,N-dimethylformamide (DMF), n-propanol, n-butanol, acetone, ethylene glycol (EG), PG, and water) was experimentally measured by the isothermal method at 278.15–323.15 K under 101.2 kPa. The temperature dominated the trend of solubility of 2-amino-5-bromopyrazine in pure and mixed solvents, especially high temperatures had a positive effect on dissolution. For the pure solvent system, the maximum solubility was obtained in DMF. For the mixed systems, isopropanol + water was superior to the other three combinations. The Apelblat model, van’t Hoff model, and NRTL model were used to correlate the solubility of 2-amino-5-bromopyrazine in 10 monosolvents. Furthermore, three thermodynamic co-solvency models including the Jouyban–Acree (JA) model, the Van’t Hoff–Jouyban–Acree (VJA) model, and the modified Apelblat–Jouyban–Acree (AJA) model were used to calculate the solubility data. This study would be helpful to the synthesis and purification processes of the final product.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Guangping Lei,Yang Lu,Zihan Liu,Yayun Zhang,Guojun Xi,Huiyuan Cheng,Wenji Rao,Xuhuan Guo
The greenhouse effect associated with excessive CO 2 emission has led to a series of environmental issues, thus developing excellent adsorbents for CO 2 capture from flue gas offers a sustainable approach. To combine the merit of multiple functional components, novel FeTPP@MIL-101(Cr) was prepared by incorporation of 5,10,15,20-tetrakis(4-methylphenyl)porphyrinato iron (III) chloride (FeTPP) into MIL-101(Cr) cages via in-situ packaging strategy. The cage-confined FeTPP can both regulate the pore structures of MIL-101(Cr) and provide additional binding sites for CO 2 adsorption. Profiting from extra interactions for CO 2 component and the “sieving effect” for N 2 component induced by incorporation of FeTPP, the discrepancy of isosteric heat for CO 2 and N 2 was largely amplified. Notably, the CO 2 /N 2 selectivity (15/85, v / v ) calculated by ideal adsorbed solution theory (IAST) increased from 17.1 (MIL-101 (Cr)) to 41.8 (FeTPP@MIL-101 (Cr) with FeTPP loading of 4.98 wt%) at 273 K, 100 kPa, which is 2.44 times larger than that of pristine MIL-101 (Cr) and also exceeds most reported adsorbents.
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INORGANIC CHEMISTRY
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2023
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IF 4.6
Guangxin Ren,Baocang Liu,Liang Liu,Minghao Hu,Junpeng Zhu,Xuan Xu,Peng Jing,Jinfang Wu,Jun Zhang
Biomass is a sustainable and renewable resource that can be converted into valuable chemicals, reducing the demand for fossil energy. 5-Hydroxymethylfurfural (HMF), as an important biomass platform molecule, can be converted to high-value-added 2,5-furandicarboxylic acid (FDCA) via a green and renewable electrocatalytic oxidation route under mild reaction conditions, but efficient electrocatalysts are still lacking. Herein, we rationally fabricate a novel self-supported electrocatalyst of core–shell-structured copper hydroxide nanowires@cerium-doped nickel hydroxide nanosheets composite nanowires on a copper mesh (CuH_NWs@Ce:NiH_NSs/Cu) for electrocatalytically oxidizing HMF to FDCA. The integrated configuration of composite nanowires with rich interstitial spaces between them facilitates fast mass/electron transfer, improved conductivity, and complete exposure of active sites. The doping of Ce ions in nickel hydroxide nanosheets (NiH_NSs) and the coupling of copper hydroxide nanowires (CuH_NWs) regulate the electronic structure of the Ni active sites and optimize the adsorption strength of the active sites to the reactant, meanwhile promoting the generation of strong oxidation agents of Ni3+ species, thereby resulting in improved electrocatalytic activity. Consequently, the optimal CuH_NWs@Ce:NiH_NSs/Cu electrocatalyst is able to achieve a HMF conversion of 98.5% with a FDCA yield of 97.9% and a Faradaic efficiency of 98.0% at a low constant potential of 1.45 V versus reversible hydrogen electrode. Meanwhile, no activity attenuation can be found after 15 successive cycling tests. Such electrocatalytic performance suppresses most of the reported Cu-based and Ni-based electrocatalysts. This work highlights the importance of structure and doping engineering strategies for the rational fabrication of high-performance electrocatalysts for biomass upgrading.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2022
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IF 7.926
Qingxiang Shu,Zhenhua Sun,Ganyu Zhu,Chenye Wang,Huiquan Li,Fang Qi,Qikun Zhang,Shaopeng Li
The increased production of coal gasification coarse slag (CGCS) has placed a significant environmental load on the environment. In this research, one-step microwave synthesis employing coal gasification coarse slag desilication solution as the major source of Si and Na increased the nucleation and crystallization rate of ZSM-5 zeolite . The optimum synthesis conditions were 180 °C, 4 h, Na 2 O/SiO 2 molar ratio of 0.2, and SiO 2 /Al 2 O 3 molar ratio of 200, which led to a relative crystallinity of ZSM-5 zeolite higher than 100 % and a specific surface area of 344.27 m 2 •g −1 . The resulting high-purity ZSM-5 zeolite not only has high SiO 2 /Al 2 O 3 molar ratio, good specific surface area, and regular hexagonal prism structure, but also has high crystallinity, smooth crystal surface and great grain homogeneity because of the microwave process. Its static adsorption capacities toward p -xylene and butyl acetate were 106.84 and 115.47 mg•g −1 , respectively, and the dynamic adsorption capacities were 81.44 and 176.14 mg•g −1 , respectively. The preparation method of ZSM-5 zeolite with high efficiency and low cost proposed in this paper not only contributes to the high-value utilization of CGCS, but also provides an effective method and practical guidance for the removal of volatile organic compounds (VOCs).
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INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Xin-jie Cheng,De-zhi Kong,Ya-hui Li,Guang-li Bian,De-qiang Li
Screening and developing dual-target inhibitors of natural 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) as anti-inflammatory drugs with higher efficacy and fewer side effects is becoming increasingly popular. In the current study, an approach by off-line two-dimensional liquid chromatography combined with mass spectrometry (2D-LC-MS) was built and verified, and was used to rapidly screen 5-LOX/COX-2 inhibitors in the extracts of Oroxylum indicum . First, the extracts were incubated with 5-LOX/COX-2 to optimize the incubation conditions. Then, off-line 2D-LC-MS screening was performed on the mixture, and the potential inhibitors were analyzed by comparing the chromatograms of the active group, blank group, and inactivated 5-LOX/COX-2 group. In addition, in vitro enzyme inhibition experiments, LPS-stimulated RAW 264.7 cells experiment and molecular docking technology were employed to confirm the findings. As a result, a total of nine compounds were confirmed as possible 5-LOX/COX-2 inhibitors, and in vitro activity assays showed that oroxin B, baicalein, oroxin A, and chrysin possessed strong inhibitory effects on 5-LOX/COX-2 (IC 50 ≤154.6 μM). Meanwhile, the possible mechanism of interaction between ligands and enzyme active sites was further elucidated by molecular docking technology. The results demonstrated that off-line 2D-LC-MS was a fast, efficient, and accurate method for screening and analyzing bioactive compounds from natural products.
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Current Research in Food Science
·
2022
·
IF 6.269
Huiyu Hu,Yuting Wang,Mingyue Shen,Yousheng Huang,Chang Li,Shaoping Nie,Mingyong Xie
Maillard reaction during food processing contributes to the formation of some unpleasant heat-induced toxicants including advanced glycation end products (AGEs) and 5-hydroxymethylfurfural (HMF), which have been linked to various health risks. The effects of baking factors and recipes, such as baking temperature (130°C–180 °C) and time (8 min–15 min), sucrose levels (0 g–20 g), butter levels (0 g–20 g) and egg liquid levels (0 g–12 g) on the formation of free N ε -(carboxymethyl)lysine (CML), free N ε -(carboxyethyl)lysine (CEL), protein-bound CML, protein-bound CEL, HMF, glyoxal (GO), methylglyoxal (MGO), 3-deoxyglucosone (3-DG) and on the sensory qualities were investigated in butter cookies. The results suggested that the levels of AGEs initially increased and then followed by decrease as baking temperature and time increased, HMF is very sensitive to baking temperature and time and grows sharply. The changes of protein-bound AGEs are lagging behind that of free AGEs. The proportions of sucrose, butter and egg liquid in butter cookies were positively correlated with AGEs, with sucrose greatly promoting on the formation of HMF and 3-DG. In addition, the high level of sucrose and butter in cookies is preferred by panelists, especially in terms of appearance, taste and smell.
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