RARE METALS
·
2025
·
IF 11
Jiang Xue,Qu Dan-Yao,Zhang Jun-Nan,Kloper Viki,Zhang Ke-Fan,Zhang Guang-Jian,Wang Lei,Pan Ming-Hu,Guo Quan-Min,Chen Li,Huang Wei-Tian,Gao Jian-Zhi,Haick Hossam,Wu Wei-Wei
The field of disease smelling diagnosis has experienced a major breakthrough with the development of the electronic nose (E-nose) that utilizes thiol-capped gold nanoparticles (GNPs). This study focuses on overcoming the challenges of sensors to detect VOCs stably confounding with interferents of humidity and pressure, and clarifying their essential mechanism. An innovative and straightforward method for synthesizing GNPs and modifying their surface has been developed. This unique approach deviates from the conventional Brust method by completely removing any traces of tetraoctylammonium bromide (TOAB), ensuring reproducibility and simplicity of use. This modification enhances the sensor’s responsiveness to both polar and non-polar VOCs, as well as strengthen selectivity and anti-interferant capabilities. The mechanism of generating sensing cross-talk from TOAB residue is proposed through rigorous sensing experiments, X-ray photoelectron spectroscopy (XPS) results, and theoretical analysis. Thus, this study enhances the responsiveness of the sensor to both polar and non-polar VOCs, while also strengthening its selectivity and anti-interferent capabilities. This could potentially revolutionize the practical applications of E-nose in smelling diagnosis. Graphical abstract
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Water Conservation Science and Engineering
·
2025
·Vol. 10
·期 3
·1-16
·
IF 1.9
Li Zhengjie,Fang Chunxia,Ma Xilong,Liu Yixian,Xie Juan,Li Pengfei,Zhang Zhikun,Zhao Xudong,Sun Hua,Han Jilong
Herein, a facile and rapid preparation method was developed to synthesize Ce-doped UiO-66-NH 2 through a one-pot solvothermal method. This approach simultaneously introduces functional groups onto organic ligands and incorporating a novel metal into metal clusters. The incorporation of Ce ions effectively enlarged the pore size and increased the pore volume, thereby facilitating the diffusion of specific adsorbate molecules into the inner adsorption sites provided by the –NH 2 groups. Due to the favorable pore structures and more exposed adsorption sites, the safranine T (ST) adsorption capacity of Ce-doped UiO-66-NH 2 was ten times higher than the pristine UiO-66-NH 2 and reached 1340 mg/g at optimal adsorption conditions, surpassing most of the reported porous adsorbents. The kinetic and isotherm fitting results showed that the pseudo-second-order and Langmuir models described the adsorption behaviors of ST best, indicating a homogeneous, endothermic, and spontaneous monolayer adsorption process. The adsorption mechanism showed that the hydrogen bonding interaction and pore filling effect are identified as the main mechanism whilst electrostatic attraction interaction further enhances the adsorption capacity at optimal pH. Therefore, Ce-doped UiO-66-NH 2 can serve as a promising adsorbent for the removal of cationic dyes from textile wastewater, and the developed facile and rapid method offers a viable strategy to construct novel MOF-based adsorbents.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 9
·1-11
·
IF 2.4
Du Yuhao,Hu Dawei,Wang Zhen,Hu Anpeng,Han Wei,Pu Ning
The hydrotreating of residual oil is crucial for producing cleaner fuels, as catalyst deactivation due to metal deposits, particularly nickel (Ni) and vanadium (V), remains a significant challenge. Contrary to the conventional view that metal deposits invariably poison catalysts, our recent studies have observed an unexpected enhancement in the activity of commercial NiMo/Al 2 O 3 catalysts during industrial operation. This study systematically investigates the mechanism behind this counter-intuitive phenomenon, with a particular focus on the effects induced by nickel. X-ray photoelectron spectroscopy (XPS) analysis revealed that low-concentration of Ni deposits preferentially formed highly active NiMoS phases during the reaction process, thereby minimized the formation of NiS x , a typical poisoning species. This increases the number of reactive sulfur sites, boosting the hydrodesulfurization (HDS) activity for 4,6-dimethyldibenzothiophene (4,6-DMDBT), with the conversion rate rising from 17.1 to 73.3%. Similar promoting trends were also observed in conventional NiMo/Al 2 O 3 catalysts upon Ni deposition, demonstrating the generality of this effect. Our findings not only provide new insights into the dual role of Ni deposits in catalyst performance but also offer a promising strategy designing industrial metal-poisoning-resistant catalysts with significantly enhanced operational lifespan as well as catalytic performance.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Zhao Hongling,Fang Ranjie,Hu Maosong,Luo Jianqiang,Meng Cheng,Liu Shujuan,Ma Jianguo
In this work, a novel Fe/ND-CN composite was synthesized by anchoring iron single atoms onto nitrogen-deficient g-C 3 N 4 (ND-CN) using Fe-ZIF-8 as a precursor via calcination. This material served as a photoelectrocatalytic working electrode for U(VI) reduction under light and applied voltage. Remarkably, it achieved near-complete U(VI) removal (99.2%) at pH 5.0. The elucidated mechanism provides a highly efficient technique and theoretical foundation for low-concentration uranium wastewater treatment.
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Nature Protocols
·
2025
·
IF 16
Ming Jiang,Xie Zheng,Wu Jiaxin,Zhang Fan
The versatility of lanthanide-doped near-infrared (NIR, 700–1,700 nm) luminescent nanoparticles makes them valuable tools in various scientific and technological fields, from bioimaging to information security. However, the luminescence intensity of typical lanthanide-doped nanoparticles is significantly influenced by the efficiency of the sensitizer. The introduction of transition metal ions (such as Cr 3+ , Mn 2+ and Ni 2+ ) can greatly enrich the library of lanthanide NIR luminescence nanoparticles. We have reported a new crystalline nanoparticle, Na 3 CrF 6 , for high-brightness NIR emission from lanthanide activators (such as Er 3+ , Tm 3+ , Yb 3+ or Nd 3+ ). As an emerging luminescent material, a straightforward and scalable synthesis approach for these nanostructures holds promise for their broader application. Here we have refined and standardized the steps for transition metal-sensitized lanthanide luminescent nanoparticles, thereby establishing a library of advanced luminescent materials for researchers engaged in luminescent materials. The Protocol enables the precise preparation of chromium-, manganese- and nickel-trifluoroacetate, the synthesis of three types of transition metal-sensitized lanthanide nanoparticle and the fabrication of chromium-sensitized lanthanide homogeneous and heterogeneous nanostructure. Moreover, we provide verification protocols for each step’s output and guidelines for adjusting synthesis conditions. To aid in the reproducible synthesis of these nanoparticles, we also include a troubleshooting guide of the various stages. The estimated duration for synthesizing transition metal trifluoroacetate, transition metal-sensitized lanthanide nanoparticles and core–shell transition metal-sensitized lanthanide nanoparticles are ~70, 30 and 30 h, respectively. These procedures can be carried out by users with expertise in chemistry or materials science.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Chen Junjie,He Changxiang,Peng Xudong,Li Jin,Xu Xiaosa,Zhou Yin,Shen Jiadong,Sun Jing,Li Yiju,Zhao Tianshou
Developing safe and high-voltage solid-state polymer electrolytes for high-specific-energy lithium metal batteries holds great promise. However, low ionic conductivity, limited Li + transference number, narrow voltage window, and high flammability greatly hinder their practical applications. Herein, we propose a puzzle-like molecular assembly strategy to construct a solid-state polymer electrolyte via in situ polymerization. The triallyl phosphate and 2,2,3,3,4,4,4-heptafluorobutyl methacrylate segments are spliced into the vinyl ethylene carbonate matrix to enhance anion affinity and promote lithium salt dissociation, resulting in a high ionic conductivity of 0.432 mS cm -1 and a Li + transference number of 0.70 at 25 °C. Meanwhile, the polymer electrolyte exhibits a high oxidation voltage of 5.15 V, enabled by its intrinsic high-voltage tolerance and the formation of a robust inorganic-rich interphase. As a result, the Li||LiNi 0.6 Co 0.2 Mn 0.2 O 2 cell maintains stable performance for 300 cycles and reliably cycles even with an application-oriented mass loading of 15.8 mg cm -2 . The 2.6-Ah Li||LiNi 0.8 Co 0.1 Mn 0.1 O 2 pouch cell reaches a high specific energy of 349 Wh kg -1 . Furthermore, the developed polymer electrolyte displays superior nonflammability and the Li||LiFePO 4 cell exhibits stable cycling for over 120 cycles at 100 °C. Both accelerating rate calorimetry and nail penetration tests verify the high safety of the pouch cells using the designed polymer electrolyte, showing the potential for practical applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-20
·
IF 15.7
Bi Guoshu,Liang Jiaqi,Bian Yunyi,Shan Guangyao,Ren Shencheng,Shi Haochun,Huang Xiaolong,Zhu Junkan,Wang Qun,Jiang Wei,Gan Boyi,Zhan Cheng
Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN’s oxidoreductase function by occluding its active site. We also show that either restoring ALDH16A1 levels or inhibiting TXN significantly enhances the effectiveness of chemo/immunotherapy in a ferroptosis-dependent manner in SMARCA4-deficient NSCLC. Collectively, our findings elucidate an intricate SMARCA4-ALDH16A1-TXN stability/function dual regulatory axis that governs ferroptosis and informs a therapeutic strategy for overcoming resistance to chemotherapy or immunotherapy in SMARCA4-deficient NSCLC.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Gong Shanhe,Zhai Yanjie,Jin Chengkai,Xu Han,Xia Qing,Li Weisong,Ying Yiran,Wu Jie,She Xiaojie,Wang Zhaolong,Lv Xiaomeng,Wu Chundu,Chan Kangcheung,Zhao Xunhua,Zhang Xiao,Lau Shu Ping
Electrochemical carbon dioxide reduction reaction (CO 2 RR) under strongly acidic conditions enables high CO 2 utilization. However, especially in proton exchange membrane (PEM) electrode assembly reactors, achieving selective CO 2 RR in such environments remains challenging due to uncontrolled interfacial water diffusion at high current densities. Here, we develop a nickel-based heterogeneous molecular electrocatalyst (NiPc-NH 2 /CNT-SHP) featuring amino (-NH 2 ) functional groups and grafted long-chain hydrophobic molecules. Under acidic conditions, -NH 2 is in situ protonated to form amino cations (-NH 3 ⁺). The positively charged -NH 3 ⁺ groups and hydrophobic molecules effectively disrupt the protonated water (H 3 O + )-rich network, inhibiting the invasion of H 3 O + and thereby suppressing the hydrogen evolution reaction, while enhancing selectivity for acidic CO 2 RR. The catalyst achieves nearly 100% Faradaic efficiency for CO at current densities from 50 to 400 mA cm −2 , with approximately 76% CO 2 utilization efficiency in a flow cell, and sustains over 80% selectivity for more than 200 h in a self-designed PEM–porous solid electrolyte reactor. These findings highlight interfacial water management as a key design principle for efficient acidic CO 2 electroreduction.
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Nature Physics
·
2025
·
IF 18.4
Liu Song,Sun Pengcheng,Wang Mingyue,Jiang Yujie,Li Jiaqi,Jia Yuyu,Sun Zhenhuan,Yang Yuting,Liu Hai,Lu Haojian,Wang Zuankai
Droplet microfluidics, a versatile technique for the precise manipulation of discrete droplets, has revolutionized biological and chemical research. So far, the successful implementation of droplet microfluidics necessitates the choice of non-wetting surfaces with minimal pinning forces, which hinders its broader adoptions in clinical applications. Here we report acousto-dewetting, a liquid dewetting principle that enables the three-dimensional, remotely controllable and precise operation of droplets on surfaces of any wettability, including superhydrophilic surfaces. This principle originates from the intricate interplay between acoustic streaming and droplet dynamics due to the extreme confinement of ultrasound within droplets, with an enhancement in pressure gradient of three orders of magnitude compared with traditional ultrasound-based approaches. We show that on superhydrophilic surfaces, acousto-dewetting achieves a contact line moving velocity that is two orders of magnitude higher than the previous limit and eliminates the undesired viscous film stemming from viscous dissipations. We developed a droplet microfluidics approach that achieves versatile droplet manipulation in various extreme scenarios associated with superhydrophilic surfaces, and applied it to an in vivo clinical setting for the rapid and safe removal of thrombus as well as drug delivery.
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Probiotics and Antimicrobial Proteins
·
2025
·
IF 4.4
Huang Fang,Lu Yun-hui,Xiong Jie,Zeng Xin-an,Huang Yan-yan,Wang Lang-hong
The escalating global burden of hyperuricemia, driven by modern dietary patterns and sedentary lifestyles, has prompted urgent exploration of novel therapeutic strategies, with particular emphasis on developing targeted probiotic interventions as a potential alternative to conventional pharmacological approaches. This study successfully isolated Limosilactobacillus fermentum FOSU YHD19 from fermented foods, demonstrating remarkable in vitro uric acid reduction of 12.90% along with high-level degradation of nucleosides. A comprehensive safety evaluation confirmed the absence of harmful enzymatic activities (including nitroreductase, decarboxylase and tryptophanase), hemolytic properties, or antibiotic resistance. The strain exhibited strong stress tolerance, surviving in acidic conditions (pH 2.0), with exposure to gastric juice, and when in the presence of 0.1% bile salts. Additionally, YHD19 demonstrated potent antibacterial activity against multiple pathogenic strains, including E coli , S. aureus , L. monocytogenes , and S. enteritidis . Genomic analysis revealed three nucleoside hydrolases and six transporter systems that collectively facilitate the hypouricemic activity. By ruling out the presence of key uric acid-synthesizing enzymes (xanthine dehydrogenase/oxidase and guanine deaminase), we can attribute the hypouricemic effect primarily to a nucleoside-scavenging mechanism. In addition, the genome harbors 91 stress-responsive genes implicated in acid/base adaptation, thermal shock response, and oxidative defense mechanisms, underscoring the strain’s resilience under gastrointestinal stresses. These findings position YHD19 as a safe and effective probiotic candidate for functional foods aimed at managing hyperuricemia, supporting its safety profile for potential probiotic applications.
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AQUACULTURE INTERNATIONAL
·
2025
·Vol. 33
·期 7
·1-22
·
IF 2.4
Chen Zhengxu,Jing Futao,Zhang Tengwen,Yu Xin,Liao Liwen,Li Yaobing,Wen Yuxin,Pan Luqing
This study integrates network pharmacology, molecular docking, and a 56-day feeding trial to evaluate the effects of dietary pterostilbene (PTE) on growth, physiological status, and underlying regulatory pathways in Litopenaeus vannamei . The results indicate that dietary supplementation with a specific dose of PTE enhances shrimp growth, improves metabolic capacity, boosts antioxidant defenses, strengthens immune responses, and reduces inflammation. The regulatory mechanism of PTE involves targeting and binding to key proteins in lipid metabolism-related signaling pathways, including AKT , INSR , and SIRT1 within the insulin and SIRT1 - AMPK pathways. This binding significantly increases the gene expression levels of these targets ( P < 0.05), thereby activating the respective signaling pathways and enhancing glycolipid metabolism capacity. In terms of immune function, PTE targets and binds to key antioxidants and immune proteins, including Nrf2 , Relish , and Dorsal , resulting in a significant increase in the expression levels of these genes ( P < 0.05). Consequently, the expression of downstream antioxidant enzymes associated with Nrf2 ( SOD , CAT , GPX ) was significantly elevated ( P < 0.05), enhancing antioxidant capacity. Additionally, the expression of antibacterial lysosomal factors ( PEN3 , CRU , ALF , and LYC ) also increased ( P < 0.05), thereby strengthening immune function. Moreover, dietary PTE reshapes the structure of gut microbiota and increases the abundance of beneficial bacteria. This study elucidates the molecular mechanisms and optimal dosage of dietary PTE in improving the physiological function of shrimp by combining molecular docking with in vivo findings, providing a theoretical basis for the development of efficient and safe aquaculture feed additives.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·39418
·
IF 3.9
Liu Huan,Zou Qin,Xiang Tao,Zhu Rui,Chen Zigui,Chen Rui
Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease that can lead to cognitive impairment. Although tetrandrine (Tet) has been proposed as a potential therapeutic agent, its efficacy in the treatment of SAH has not been fully explored. To investigate Tet effects on SAH, a rat model was established and divided into an SAH + vehicle and an SAH + Tet group. Cognitive function and behavioral performance were assessed using the Morris water maze and open field tests. Inflammatory cytokine levels were measured by ELISA, and hippocampal injury was evaluated by hematoxylin-eosin (HE) staining. Neuronal loss was quantified using Nissl staining, while neuronal density was assessed via immunofluorescence. The expression of the TLR4/NF-κB signaling pathway related-proteins was examined by Western blotting, and 16 S rRNA sequencing was conducted to determine differences in gut microbiota composition across the groups. Tet treatment significantly reduced mNSS and SAH assessment scores in SAH rats, suggesting an improvement in neurological and cognitive function. Behavioral analysis demonstrated that Tet increased escape latency, movement speed, and total distance in the Morris water maze. Histological staining revealed attenuated hippocampal damage and decreased neuronal death in the Tet-treated group. These neuroprotective effects were accompanied by reduced expression of TLR4 and NF-κB pathway components, as well as decreased secretion of LPS, TNF-α, IL-1β, and IL-6. Notably, Tet modulated the gut microbiota, restoring microbial diversity and abundance, and this modulation was associated with changes in the CYP51 metabolic pathway. Tet improves cognitive function and reduces neuronal injury in SAH rats by regulating the gut microbiota and its associated CYP51 metabolic pathway, thereby suppressing activation of the TLR4/NF-κB signaling cascade.
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