Cell Death & Disease
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2025
·Vol. 16
·期 1
·1-16
·
IF 9.6
Cui Zichen,Gu Guanghui,Chen Fei,Li Jianyi,Du Xiaofan,Chen Shuqing,Zhang Han,Li Chenxu,Shao Jiale,Xi Jiayi,Du Yukun,Zhao Qinghua,Xi Yongming
The accumulation of reactive oxygen species (ROS) leads to enhanced osteoclast activity, causing severe bone destruction in postmenopausal osteoporosis. Immunity-related GTPase family M member 1 (Irgm1) plays an essential role in affecting the production of intracellular ROS. To detect whether deletion of Irgm1 could suppress osteoclastogenesis through cellular redox regulation, we first evaluated whether the Irgm1 level was significantly elevated in mice bone marrow-derived monocytes/macrophages (BMDMs) from ovariectomy (OVX)-induced osteoporosis mice. Moreover, bioinformatics network analysis was performed to identify Irgm1 as a key upregulated gene during osteoclast differentiation. Next, we found that macrophage-specific Irgm1 knockout (Irgm1-cKO, Lyz2-Cre; Irgm1 flox/flox ) in OVX mice resulted in slower bone loss compared with OVX mice from the control group (Irgm1 flox/flox ). We then demonstrated that loss of Irgm1 inhibited osteoclast differentiation and bone resorption function via suppressing ROS accumulation. Further mechanism revealed that Irgm1 could endogenously bind to kelch-like ECH-associated protein 1 (Keap1) and keep Keap1 from ubiquitination and degradation. In the absence of Irgm1, Keap1 was downregulated and causing nuclear factor erythroid 2-related factor 2 (Nrf2) to translocate to the nucleus, thereby activating the level of the antioxidant system to combat oxidative stress. Moreover, Irgm1 deficiency in RAW264.7 promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through inhibiting the M1 phenotype polarization. Taken together, our results revealed that loss of Irgm1 significantly alleviates OVX-induced bone loss, thus laying the foundation for exploring Irgm1 as a novel targeting approach for the treatment of osteoporosis.
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高影响因子
Microsystems & Nanoengineering
·
2025
·Vol. 11
·期 1
·1-14
·
IF 9.9
Liang Shan,Liu Shiwei,Long Zhihe,Li Xiaojiao,Han Qian,Wei Xianhao,Xing Lili,Xue Xinyu,Chen Meihua
Atopic dermatitis is a chronic inflammatory skin condition that typically manifests in infancy and is characterized by dry, irritated skin. Here, we propose a self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis. The patch is composed of piezoelectric generator, hydration sensing unit, microneedle treatment module and flexible circuit. The piezoelectric PZT generator can achieve self-powering by harvesting mechanical energy from patient activities, allowing for long-term work of the system without external power sources. The hydration sensing unit can rapidly and accurately detect changes in skin hydration by estimating the thermal conductivity. Upon detecting abnormal skin hydration levels for 65 s, the treatment module is automatically activated, heating hyaluronic acid-based microneedles (~42 °C) to release dexamethasone sodium phosphate (DEX), thereby providing timely targeted therapy and moisturization to the affected area within minutes. Therapeutic results in mice model of atopic dermatitis demonstrate that our patch can effectively treat this skin disease, improving the epidermal thickness, IL-4, spleen size and mass. The system achieves closed-loop detection and treatment of atopic dermatitis without external intervention, offering a novel approach to managing skin disease and expanding the scope of self-powered biomedical engineering systems. A self-powered hydration-monitoring and drug-delivery skin patch is designed for closed-loop treatment of atopic dermatitis. The patch composes of piezoelectric generator, hydration sensing unit, microneedle treatment module, and flexible circuit. This integrated system achieves closed-loop detection and treatment of atopic dermatitis without external intervention, offering a novel approach to managing skin disease and expanding the scope of self-powered biomedical engineering systems
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MOLECULAR DIVERSITY
·
2025
·
IF 3.8
Li Yong,Wu Taotao,Chen Guobin,He Jian,Zhang Yong,Zhang Qin,Zhou Pengfei,Chen Wenzhang,Fan Lingling
Twenty-eight novel phthalide derivatives incorporating thiazole, 1,3,4-oxadiazole, and oxime ether moieties were designed and synthesized using a pharmacophore hybridization strategy. Bioactivity assays demonstrated that compounds 1b , 1c , 4a , 4b and 4c exhibited moderate to excellent inhibitory activity against several specific fungi. Notably, compound 1b displayed superior antifungal efficacy against F. solani , F. oxysporum , B. dothidea , and V. mali compared to the commercial fungicides hymexazol and boscalid , with EC 50 values of 15.0 μ g/mL , 10.0 μ g/mL, 6.1 μ g/mL, and 11.4 μ g/mL, respectively. Additionally, compound 1b provided superior protective efficacy against B. dothidea- infected apples compared to boscalid. Preliminary mechanistic studies revealed that compound 1b could exert its antifungal activity by compromising the integrity of the hyphal cell membrane. This study highlights the potential of phthalide derivatives bearing dihalocarbonyl and oxime moieties as effective antifungal agents for controlling plant pathogenic fungi, warranting further investigation in the future. Graphical
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Natural Products and Bioprospecting
·
2025
·Vol. 15
·期 1
·1-17
·
IF 4.9
Zhao Huimin,Wang Yuyang,Liu Zining,Lin Lin,Xiang Jiasi,Zhu Zihao,Yang Xiongli,Fang Yongsheng,Kong Lingmei,Li Yan
Natural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical development as an anticancer agent. Herein, twenty novel tanshinone I-pyridinium salt derivatives and a pyridinium salt precursor were designed and synthesized, and their antitumor activities were evaluated. Among these tanshinone I-pyridinium salts, compound a4 , bearing a 4-bromobenzoylmethyl substituent at the N -1 position of the pyridine ring, showed the most potent cytotoxicity against breast cancer (MDA-MB-231), hepatocellular carcinoma (HepG2), and prostate cancer (22RV1) cell lines, with IC 50 values of 1.40–1.63 μM. Preliminary mechanistic studies suggest that a4 targets PI3Kα with the IC 50 of 9.24 ± 0.20 μM and exerts effective inhibition of the phosphorylation of key PI3K/Akt/mTOR signaling proteins. Besides, a4 significantly downregulates the expression of the immune checkpoint protein PD-L1, indicating its potential to activate tumor immunity. These findings demonstrate that tanshinone I-pyridinium salt derivative a4 is a novel PI3Kα inhibitor, providing a solid foundation for further development of antitumor agents. Graphical
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Lin Simin,Wang Xubin,Li Huisi,Zhou Jiancheng,Wen Ruijuan,Ma Jianfei,Yin Shiwei,Peng Ling-Ya,Peng Haonan,Fang Yu
Excitation-dependent multicolor emission from a single-component system, independent of aggregation, remains a fundamental challenge due to inherent difficulties in innovative principles. Herein, we propose a molecular symmetry-breaking strategy to enrich electronic processes, enabling the molecule to exhibit excitation-dependent multicolor emissions from one chemical entity. A star-shaped molecule, 1,3,5-(4- tert -butylphenyl- o -carboranyl-4-phenyl)benzene (Ph-3CP) is designed, where spatial restriction induces inequivalence among three bulky, non-planar branches. This asymmetry gives rise to a broad excitation-dependent emission range of nearly 175 nm across solution, amorphous, and crystalline states. Crystallization from different solvents successfully traps distinct asymmetric conformers of Ph-3CP, providing direct experimental evidence for the predicted symmetry-breaking structures from theoretical calculations. Structure-property relationship studies further reveal two distinct relaxation pathways that dominate the emission behavior of this molecular system. Leveraging these properties, we develop a single-component fluorescence sensor array that enables rapid and selective identification of chlorinated hydrocarbon vapors. This work provides a general strategy for designing multifunctional luminescent materials through symmetry-controlled excited-state engineering.
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EXPERIMENTAL AND MOLECULAR MEDICINE
·
2025
·
IF 12.9
Yang Qihao,Wu Jianqun,Huang Songqiang,Zeng Jing,Jing Yihan,Wang Zhiyong,Zhang Chi,Wu Zenghui,Liu Song,Wang Zhao
Here we investigate the effects and mechanisms of eicosapentaenoic acid (EPA) in regulating chondrocyte mechanics during inflammation in the progression of osteoarthritis (OA). Primary porcine chondrocytes and human OA chondrocytes were isolated and cultured. Cell mechanical properties were measured using atomic force microscopy. RNA sequencing, immunocytochemistry, quantitative PCR and western blotting were used to elucidate associated signaling mechanisms. Porcine cartilage and human OA cartilage explants were collected. Human articular cartilage samples were obtained from ten donors. Anterior cruciate ligament transection surgery was performed to induce OA in male C57BL/6J mice. The therapeutic effects of EPA and activation of associated signaling were evaluated using histology, immunohistochemistry and micro-computed tomography. EPA reduced F-actin intensity and Young’s modulus in IL-1α-treated porcine chondrocytes and in human OA chondrocytes. Mechanistically, EPA inhibited IL-1α-induced increase in CD44 expression in porcine chondrocytes by suppressing phosphorylation of NF-κB subunits p65. In addition, EPA alleviated articular cartilage degeneration and decreased the expression of p-p65 and CD44 in IL-1α-treated porcine and human OA cartilage explants. Moreover, EPA suppressed the increase in Young’s modulus induced by CD44 ligands (A6 peptide and low-molecular-weight hyaluronic acid) in porcine chondrocytes. Finally, intraarticular injection of EPA emulsion-integrated hyaluronic acid injection attenuated OA-associated alterations in articular cartilage and subchondral bone and decreased CD44 expression in mice. Our data not only provide new insights into EPA’s chondroprotective actions and underlying mechanisms but also offer new evidence supporting the therapeutic efficacy of a novel EPA emulsion-integrated hyaluronic acid injection for OA treatment.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Lu Chunxiao,Zhao Ye,Zhang Qiwei,Li Shuai,Li Pengyu,Guo Yu,Li Yong,Zhang Liwen,Hao Xihong
Transparent ferroelectric ceramics, emerging as innovative photoelectric multifunctional coupling material, demonstrate significant potential for applications in optical storage and smart windows. However, achieving high transparency via manipulation of the preparation process, microstructure, and phase structure poses a considerable challenge. Here, we employ multiple strategies, including the fabrication technology regulation and donor doping of La 3+ and Tb 3+ at the A-site of K 0.5 Na 0.5 NbO 3 to fabricate exceptional transparent ceramics coupled with multi-mode reversible modulations of transparency, photochromism, and photoluminescence. This research offers a novel perspective on the design of transparent multifunctional materials.
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高影响因子
IONICS
·
2025
·
IF 2.6
Liu Baochang,Wang Jianxin,Wang Bo,Kang Chongqing
Rechargeable aqueous zinc-ion batteries (RAZIBs) have emerged as promising candidates for large-scale energy storage systems, owing to their low cost, high safety, and environmental benignity. However, their practical application is hindered by intrinsic limitations of cathode materials, including sluggish Zn 2+ diffusion kinetics, poor electrical conductivity, and structural degradation during cycling. Herein, we report a facile hydrothermal strategy to synthesize Ag-doped MnO 2 cathode with uniform urchin-like nanostructures surrounded by nanowires as high-performance cathodes for RAZIBs. The optimal 5 wt% Ag doping yields denser nanowire arrays, namely 5Ag/MnO 2 , increases accessible active sites, and introduces lattice defects while preserving the tetragonal MnO 2 crystal structure ( I 4 /m ). The electrochemical characterization demonstrated that 5Ag/MnO 2 exhibited significantly enhanced kinetics, including lower charge-transfer resistance, reduced polarization, and higher Zn 2+ diffusion coefficient. Consequently, the 5Ag/MnO 2 cathode delivered a high initial discharge capacity of 153.4 mAh g −1 at 1 A g −1 and superior long-term cycling stability (the discharge specific capacity remained at 135.5 mAh g −1 and 88.3% capacity retention after 500 cycles). Mechanism studies via ex situ XRD, XPS, and CV reveal a reversible Zn 2+ /H + storage mechanism involving phase transformation between MnO 2 and ZnMn 2 O 4 , with mixed capacitive and intercalation behavior. The enhanced performance is attributed to Ag doping facilitating rapid ion diffusion, improving electronic conductivity, and stabilizing the hierarchical structure. This work provides a viable strategy for designing high-performance MnO 2 -based cathodes for advanced zinc-ion batteries, advancing the practical application of RAZIBs.
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RARE METALS
·
2025
·Vol. 44
·期 6
·3795-3805
·
IF 11
He Kang-Qiang,Liao Xin-Gan,Lian Hao-Jian,Guan Xiang,Chen Da-Zhu,Su Yi-Kun,Li Robert K. Y.,Liu Chen
Solid-state sodium batteries offer new opportunities for emerging applications with sensitivity to safety and cost. However, the prevailing composite electrolyte structure, as a core component, is still poorly conductive to Na ions. Herein, a 3D architecture design of Na + conductive Na 3 Zr 2 Si 2 PO 12 framework is introduced to in situ compound with polymer electrolyte, subtly inducing an anion-enriched interface that acts as rapid ion immigration channel. Multiple continuous and fast Na + transport pathways are built via the amorphization of polymer matrix, the consecutive skeleton, and the induced anion-adsorbed interface, resulting in a high ionic conductivity of 4.43 × 10 −4 S·cm −1 . Notably, the design of 3D skeleton not only enables the content of inorganic part exceeds 60 wt% without any sign of agglomeration, but also endows the composite electrolyte reach a high transference number of 0.61 by immobilizing the anions. The assembled quasi-solid-state cells exhibit high practical safety and can stably work for over 1500 cycles with 83.1% capacity retention. This tactic affords new insights in designing Na + conductive composite electrolytes suffering from slow ion immigration for quasi-solid-state sodium batteries. Graphical abstract
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RARE METALS
·
2025
·Vol. 44
·期 5
·3069-3079
·
IF 11
Zhang Si-Yu,Guo Xing,Xu Yu-Meng,Jiao Yong,Lin Zhen-Hua,Zhang Jin-Cheng,Ouyang Jian-Yong,Guo Li-Xin,Hao Yue,Chang Jing-Jing
CsPbBr 3 perovskite solar cells (PSCs) have attracted significant interest for their remarkable stability under high temperatures and humidity. However, challenges such as energy loss at the CsPbBr 3 /oxide buried interface and imperfect band alignment have impeded further efficiency enhancements. In this study, TiO 2 , SnO 2 , or ZnO was employed as electron transport layer (ETL) materials, respectively, in CsPbBr 3 -based PSCs to optimize the band alignment at the ETL/CsPbBr 3 interface and enhance the film quality of CsPbBr 3 materials. The research findings indicate that the power conversion efficiency (PCE) of PSCs is influenced by the choice of ETL material. Specifically, TiO 2 -based PSCs achieved a PCE of 10.37% efficiency, higher than SnO 2 - or ZnO-based PSCs. This disparity in PCE can be attributed to variations in open-circuit voltage, which stem from different band alignments at the ETL/CsPbBr 3 interface. Notably, superior photovoltaic performance was consistently observed in TiO 2 -based PSCs due to the substantial conduction band offset (∆ E c ) at the TiO 2 /CsPbBr 3 interface and the high quality of the CsPbBr 3 film. This not only enhances electron extraction at the TiO 2 /CsPbBr 3 interface but also diminishes non-radiative recombination at the interface, as confirmed by density functional theory (DFT) calculations and experiments. Furthermore, photodetectors (PDs) based on TiO 2 /CsPbBr 3 heterojunction exhibit high photoresponse and photodetectivity. In conclusion, this study underscores the critical importance of the buried interface contact in CsPbBr 3 and offers a direct approach for fabricating efficient and stable inorganic PSCs and PDs. Graphical abstract
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COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Wang Ying,Yang YunXia,Zhu Daliang,Zhang Hongmei,Wang Yanqing
Polysaccharide-based drug delivery systems have gained significant attention due to their biocompatibility and potential for targeted therapy. In this study, we utilized Ganoderma lucidum polysaccharides (GLP) as a macromolecular carrier to synthesize polysaccharide drug conjugates by forming ester bonds with 5-fluorouracil (5-FU) derivatives (5-FUAC). This not only improves the solubility and stability of 5-FU but also enhances its targeted delivery to tumor tissues, potentially reducing systemic toxicity. Utilizing Ganoderma lucidum polysaccharides (GLP) as a macromolecular carrier, we successfully synthesized GLP-5-FU conjugates by forming ester bonds with 5-fluorouracil derivatives (5-FUAC). These conjugates were then characterized using spectrum analysis technologies. The drug loading capacities of 5-FU in the GLP-5-FU conjugates were found to be approximately 4.7%. Morphological observations revealed that the GLP-5-FU conjugates had a regular spherical shape. In terms of drug release, 5-FU was found to be released faster at pH 6.8 compared to pH 7.4. To investigate the dynamic viscoelastic behavior of GLP and GLP-5-FU conjugates in water, dynamic rheology analysis was conducted. In terms of cytotoxicity, the GLP-5-FU conjugates exhibited greater inhibition of proliferation compared to 5-FU and GLP alone in HeLa, 786-O, and SKOV3 cells. Furthermore, the GLP-5-FU conjugates showed lower cytotoxicity to 293A cells. Graphical
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RARE METALS
·
2025
·
IF 11
Wu Jing,Rong Jian,Chen Wang-Yi,Wang Chao-Sheng,Feng Chu-Jun,Ao Huai-Sheng,Zhu Cheng-Zhang,Zhang Yu-Zhe,Li Zhong-Yu
Regulating the electronic structure and oxygen-containing intermediates adsorption behavior on Fe-based catalysts is of great significance to cope with the sluggish oxygen reduction reaction (ORR) kinetics, but it still remains a great challenge. In this work, Fe atom clusters (Fe AC ) modified by high-density Cu single atoms (Cu SA ) in a N,S-doped porous carbon substrate (Fe AC /Cu SA @NCS) is reported for enhanced ORR electrocatalysis. Fe AC /Cu SA @NCS exhibits excellent ORR performance with a half-wave potential ( E 1/2 ) of 0.911 V, a high four-electron process selectivity and excellent stability. The ORR performance is also verified in the Fe AC /Cu SA @NCS-based Zn-air battery, which shows a high peak power density of 192.67 mW cm −2 , a higher specific capacity of 808.3 mAh g −1 and impressive charge–discharge cycle stability. Moreover, density functional theory calculations show that Cu single atoms synergistically modulate the electronic structure Fe active atoms in Fe atomic clusters, reducing the energy barrier of the rate-determining step (i.e., * OH desorption) on Fe AC /Cu SA @NCS. This work provides an effective way to regulate the electronic structure of Fe-based catalysts and optimize their electrocatalytic activity based on the introduction of a second metal source. Graphical abstract
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危险品化学品经营许可证（带存储）