JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2025
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IF 1.6
Li Haozhe,Zhang Zhenyi,Zhou Fanglue,Huang Jiang
This study presents a modular adsorbent platform for uranium recovery using electron beam (EB) irradiation. A decoupled two-step synthesis involves initiator-free EB grafting of ionic liquids onto hollow mesoporous silica, achieving tunable grafting density (0.89 mmol/g at 50 kGy), followed by functionalization with uranyl-targeting groups. The optimal adsorbent HMS@IL-R1 demonstrates a uranium adsorption capacity of 185.9 mg/g, stable operation across pH 3–11, and 95.1% capacity retention after five cycles. Monte Carlo-optimized reactors enable scalable 100 g-batch synthesis, highlighting the efficacy and scalability of EB technology for a modular and practical pathway for nuclear resource recovery.
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Collagen and Leather
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2025
·Vol. 7
·期 1
·42
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IF 9.2
Yi Xueling,Luo Duanyang,Liu Siqi,Chen Yanxu,Guo Jin,Yan Qingyu,Mao Hui
Antibiotic contamination has been a concerning environmental issue due to its potential threats to the development of drug-resistant bacteria and genes. Plant polyphenols were employed as biomolecule chelating ligands to graft onto collagen fibers, followed by the chelative immobilization of Fe ions. The as-obtained environmentally benign chelative biosorbent (CFBT-Fe) features a classic fibrous structure, excellent distribution and reservation of Fe ions, increased thermal stability, and inhibited swelling behavior owing to the introduction of bayberry tannin. An exceptional adsorption capacity of tetracycline on CFBT-Fe is exhibited across a broad pH range (3.0–10.0). Optimal adsorption capacity (31.30 mg/g) occurs at neutral pH 7.0, which is higher than many other similar biosorbents reported in the literature. The CFBT-Fe exhibits exceptional recyclability with sixth-cycle adsorption performance at 25.27 mg/g. The environmentally benign coordinative biosorbent is considered a promising candidate for the effective adsorptive removal of tetracycline from aquatic environments across a wide pH range. Graphical
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Microfluidics and Nanofluidics
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2025
·Vol. 30
·期 2
·9
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IF 2.5
Zhang Zelong,Feng Shi,Li Hao,Ding Tianshun,Tao Shengyang
Microfluidics is pivotal in producing monodisperse microemulsions and microspheres. However, lower output efficiency hinders its practical application. Although multichannel droplet generators offer a promising solution for increased productivity, their design is inherently complex, and achieving uniform fluid distribution across channels is a significant challenge. Hence, in this paper, a novel rapid-design approach is introduced for multichannel droplet generators and employs topology optimization to enhance the structure, leading to significant improvements in droplet generation efficiency and uniformity. It can automatically generate a multichannel droplet generator structure that meets experimental conditions within five hours and is compatible with 3D printing technology. By employing topology optimization, the design achieves an average inter-channel flow rate variation of less than 1%, even with 81 channels, while reducing the inlet-outlet pressure drop by 19.75% compared to unoptimized configurations. The optimized device can produce both water-in-oil (W/O) and oil-in-water (O/W) droplets at a maximum throughput of 65 mL·min⁻¹, with a coefficient of variation (CV) below 5%, ensuring excellent monodispersity. Moreover, the topology optimization approach provides a comprehensive analytical framework for droplet generators with a matrix of microchannels, thereby facilitating rational design and scalability. Graphical abstract
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Nature Communications
·
2025
·
IF 15.7
Ren Yuqi,Cheng Miao,He Hongbin,You Changjun,Duan Lunbo,Sun Zhenkun,Peng Ruoxuan,Zhu Yuan-Hao,Zhang Hongyang,Zhou Jiancheng,Huang Kai,Guan Jie,Li Naixu
CO 2 -to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O 2 partial pressures and sluggish C 2 -product formation. Herein, Ru 0.6 Cu 1 (Cu 0 –Cu 1+ )/CeO 2 catalysts with adaptive O 2 tolerance are prepared by O 2 -mediated dynamic interfacial reconstruction. Single-atom Ru doping at Ce lattice sites creates a trigonal prismatic coordination configuration, enabling proton-coupled electron transfer and accelerating H 2 O dissociation. Photothermal effect promotes O 2 -driven self-assembly of Cu 0 –Cu 1+ charge-gradient interfaces within Ru/Cu alloy clusters, thereby optimizing the adsorption behavior of * CHOCO intermediates and restructuring the C–C coupling pathway. Interfacial charge cascade transfer and geometric site synergy thermodynamically shift the product selectivity from C 1 to C 2 , as determined by operando spectroscopy and electronic structure analysis. Under concentrated solar irradiation, the catalyst produces 549 ± 20 μmol·g −1 C 2 H 4 with 74.3% selectivity and 0.5% solar-to-chemical energy conversion efficiency—25-fold higher than that in non-concentrated systems. Dynamic interfacial regulation facilitates precise carbon chain synthesis in complex reaction networks.
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MICROCHIMICA ACTA
·
2025
·Vol. 193
·期 1
·15
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IF 5.3
Zhang Yan,Yan Yuting,Huang Yue
An innovative electrochemical biosensor is proposed for the sensitive detection of ofloxacin (OFL) by integrating exonuclease I (Exo I)–assisted recognition-transduction strategy into the MXene/AuNP-enhanced electrochemical platform. Through ingenious design, the presence of OFL triggers the competitive displacement reaction and enables Exo I to hydrolyze the released single-stranded DNA probe containing the sequence of Pb 2+ -DNAzyme, protecting the signal probes on the electrode surface from DNAzyme cleavage, which eventually brings about a remarkable electrochemical signal positively related to the concentration of OFL. MXene/AuNPs with excellent conductivity, large specific surface area, and good chemical stability are employed as the electrode substrate to efficiently accelerate charge transfer and increase the loading capacity for signal probes, leading to the enhancement of signal output and endowing the biosensor with high sensitivity, rapid response, and fine robustness. Taking advantage of OFL recognition–initiated Exo I hydrolysis to DNAzyme, the electrochemical platform with “signal-off/on” mode can detect OFL with good specificity and reduced background interference. Benefiting from the synergistic effect of the involved sensing elements, the developed electrochemical biosensor achieves a low detection limit of 0.47 pg mL −1 with a broad linear range and exhibits satisfactory detection performance in real food samples, indicating potential practical applicability in food safety monitoring. Graphical
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CELLULOSE
·
2025
·
IF 4.8
Liang Long,Shao Xinyi,Zhou Huyi,Han Shanming,Li Hongbin,He Zhibin,Shen Kuizhong,Fang Guigan,Wu Ting
Rice straw can be a valuable fiber raw material as a substitute of wood for the pulp and paper industry. However, rice straw is underutilized due to technical challenges in the pulping processes. In this study, a novel bio-chemi-mechanical pulping combines high-temperature aerobic fermentation pretreatment with alkaline hydrogen peroxide impregnation and two-stage mechanical refining. Firstly, aerobic fermentation destroyed the fiber structure of rice straw, loosened the connecting bond between carbohydrates and lignin and made the surface of rice straw rough and porous through microbial decomposition of lignocellulose. Subsequently, the molecular structure of rice straw was further altered by the synergistic action of NaOH and H 2 O 2 , and the efficiency of mechanical refining was further improved based on aerobic fermentation pretreatment at high-temperature (max. ~ 65–70 °C). Experimental results show that under the optimal process conditions, the fermentation pre-treatment resulted in about 65% energy saving, 27% water retention value improvement, and 112% increase in tensile strength at a given pulp freeness. The objective of this study is to transform rice straw lignocellulosic biomass into high-quality pulp with improved physical properties, while simultaneously lowering energy consumption.
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JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Wang Yanting,Song Shiyu,Liao Xilin,Zhou Pei wen,Li Runchuan,Xing Mengxing,Lin Jia-Horng,Li Liang,Liu Rangtong
The rapid development of science and technology has led to the aggravation and complexity of electromagnetic radiation pollution. Therefore, multifunctional electromagnetic interference shielding materials have become increasingly indispensable. Based on the advantages of textile materials, the modular coupling assembly strategy was utilized to achieve the structural regulation of the multifunctional PP conductive composite film and effectively endowed it with excellent EMI shielding performance. In this study, the adhesive property of polydopamine was utilized to enhance the chemical reactivity of PP films. The construction of porous conductive structures and core–shell conductive structures of PPy inside and outside PP fibers was achieved by controlling the polymerization rate of pyrrole in a low-temperature environment. The macroscopic encapsulation of the hydrophobic layer enhanced the bonding strength between the PP substrate and the conductive layer. The results show that different concentrations of pyrrole affected the microstructure and EMI shielding performance. When the concentration of pyrrole was 0.8 mol/L, the surface contact angle and surface resistance of the PP composite film were 138.42° and 73 Ω, respectively. In addition, the shielding value of the PP composite film was as high as 28.02 dB, which could effectively shield 99.84% of electromagnetic waves. This preparation strategy of coupling multiple functional layers to realize multifunctional composite films provides research ideas for the structural design of multi-purpose smart wearable electromagnetic protection composite materials.
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Cell Death & Disease
·
2025
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IF 9.6
Huang Hongli,Chai Yihan,Wu Xuewei,Wang Sen,Li Binglin,Wang Yanyan,Zheng Wen,Wu Yuefeng,Meng Di,Wang Hua,Tu Zhengliang,Du Chengli,Lyu Xiayi,Li Guiying,Guo Wei
Non-genetic resistance of cancer remains poorly understood in clinical research and practice. To better understand resistant cancer cell heterogeneity, we isolated a novel riboflavin + NOTCH1 + population from cisplatin-naïve and -resistant lung cancer cell lines and patient specimens with or without immunotherapy and chemotherapy. This population was also identified as SLC52A2 (one of the riboflavin transporters) + NOTCH1 + cells in single-cell RNA sequencing (scRNA-seq) data derived from advanced lung tumors before therapy. Despite its therapy-naïve origin, the population, designated as stably resistant cancer cells (SRCC), exhibited the epithelial state, innate and stable resistance to therapy (chemotherapy, targeted therapy and immunotherapy), cell dormancy, elevated reactive oxygen species (ROS), and anti-apoptotic and anti-ferroptotic survival. These cellular and molecular characteristics distinguished SRCC from other resistant populations, including cancer stem-like cells (CSC), epithelial-mesenchymal transition (EMT) cells, and drug-tolerant persisters (DTP). The non-canonical NOTCH1 pathway, but not the inactivated canonical NOTCH1 pathway, played a critical role in the resistance of SRCC. Specifically, it modulates cell cycle, iron metabolism, EMT, and ferroptosis vulnerability in SRCC at the transcriptional level. It also controls the initiation of ferroptosis in lysosomes via a posttranslational NOTCH1-AKT-BAX axis. Inhibition of the non-canonical NOTCH1 pathway re-sensitizes these dormant and resistant cells to cisplatin-induced cell death in vitro and in vivo, including ferroptosis, apoptosis, and necroptosis. Our study contributes to a deeper understanding of cancer resistance and promotes the development of more effective therapeutic strategies against resistant cancer cells.
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JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 24
·期 1
·113
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IF 12.6
Guan Shujuan,Yang Ruyue,Deng Danning,Long Huilin,Ou Zihao,Ge Xiaoxue,Jiang Xiujuan,Hu Xiumei,Chen Dingqiang
Bloodstream infections (BSIs) are life-threatening conditions with rising mortality, urgently requiring rapid pathogen identification to guide timely antibiotic therapy. Current methods (phenotypic identification, MALDI-TOF MS, molecular techniques) are faced with limitations in cost, turnaround time and accessibility. In this study, it was discovered that the drying of microbial suspensions on slides could lead to species-specific desiccation patterns, which reflects the physicochemical properties and complex interactions of microorganisms during evaporation. Inspired by this interesting phenomenon, an AI-powered platform is proposed for rapid pathogen identification through automated analysis of these patterns. By establishing an image dataset comprising 10,055 desiccation patterns of common BSIs pathogens ( Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecium and Candida albicans ), a ResNet-34 deep learning model is trained, achieving a classification accuracy of 91.8% and an area under the receiver operating characteristic curve (AUC-ROC) of 0.99. Following pure culture, identification is completed within 5 min after a simple drying step at 40 °C. With its minimal sample requirement, low cost, and operational simplicity, this platform demonstrates significant potential as a point-of-care diagnostic tool, particularly in resource-constrained regions. This technology offers a promising strategy to combat BSIs and improve patient outcomes. Graphical
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FOOD SCIENCE AND BIOTECHNOLOGY
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2025
·
IF 3.1
Park Chan-Hyeok,Ganbat Chinbat,Han Jung-Ah
Orally disintegrating films (ODFs) were prepared from five natural polymers—starch (STA), hyaluronic acid (HA), pectin (PEC), chitosan (CHI), and gelatin (GEL)—using literature‑based, polymer‑specific protocols. All films were cast to a uniform thickness of 1.00 ± 0.01 mm and then evaluated for physicochemical, mechanical, and dissolution properties, alongside a sensory assessment. STA, PEC, and CHI required glycerol as a plasticizer and consequently showed higher moisture contents, whereas GEL and HA formed stable films without plasticizers and exhibited higher tensile strength (51.70 and 76.77 MPa). STA displayed the highest opacity, moisture content (25.44%), and water‑vapor permeability (6.63 g·mm·m -2 ·h -1 ·kPa -1 ), indicating lower storage stability. Vitamin C release was fastest from PEC and GEL and slowest from HA; STA and CHI showed marked pH‑dependent dissolution. Sensory results mirrored instrumental trends: PEC was most preferred for rapid intraoral disintegration, whereas CHI was least favored. Overall, hydrocolloid selection governed water management, disintegration, and release profiles, directly linking material design with consumer‑relevant performance and offering guidance for polymer choice in functional‑food ODFs.
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Nature Communications
·
2025
·
IF 15.7
Yinglan Yu,Yongfeng Xu,Zehui Yu,Xinrui Liu,Jiayue Guo,Min Xiang,Junmeng Chen,Riyanto Teguh Widodo,Lei Luo
Oral antibiotics are a mainstay for treating bacterial infections, but unabsorbed portions can reach the caecum and colon, leading to gut dysbiosis. Herein, we engineer a biohybrid delivery system through the integration of milk extracellular vesicles with liposomes. The hybrid vesicles employ targeting mechanisms via neonatal Fc receptor and peptide transporter 1, facilitating antibiotic transport across the proximal small intestine. These vesicles exhibit superior drug encapsulation efficiency, stable release behavior, efficient mucus traversal, higher endocytosis, increased basolateral exocytosis, and improved oral absorption, achieving a 3.24-fold increase in oral bioavailability compared to free antibiotics. In lung bacterial infections and bacteremia models, hybrid vesicle-encapsulated cefdinir outperforms free antibiotics in eliminating infections. Notably, this approach also mitigates adverse effects on the intestinal microbiota, safeguarding the animals from dysbiosis-associated metabolic syndromes and opportunistic pathogen infections. This innovative hybrid vesicle system holds promise for the oral delivery of other drugs that suffer from limited absorption or cause gut dysbiosis. In this work, authors present a biohybrid delivery system aimed at overcoming low oral bioavailability and antibiotic-induced dysbiosis by enabling efficient antibiotic transport in the proximal small intestine.
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Clinical Epigenetics
·
2025
·Vol. 18
·期 1
·12
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IF 4.4
Yu Chao,Yao Liyuan,Du Xinyu,Yu Jianjun,Wang Yanjin,Hou Xiying,Shen Fengchen,Liu Na,Zhuang Shougang
Background Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3), has been implicated in promoting renal fibrogenesis. Nevertheless, its precise role and underlying mechanisms remain incompletely defined. Methods To investigate the role of EZH2 in partial epithelial-mesenchymal transition (pEMT) and renal fibrosis, we utilized a mouse model with renal tubular cell-specific EZH2 deletion and administered gambogic acid (GA), a selective EZH2 degrader, following unilateral ureteral obstruction (UUO). In vitro, mouse renal epithelial cells were stimulated with TGF-β1 and treated with either EZH2-specific siRNA or GA to assess the effects on EMT and Notch1/3 signaling. In addition, chromatin immunoprecipitation (ChIP) assays were conducted to evaluate the binding of EZH2 and H3K27me3 to the promoters of Notch1 and Notch3. Results Compared with wild-type controls, mice with tubular cell-specific EZH2 deletion exhibited significantly reduced renal fibrosis, characterized by decreased expression of fibronectin, collagen III, vimentin, and Snail, while preserving E-cadherin levels in injured kidneys. Pharmacological degradation of EZH2 with GA produced comparable antifibrotic effects. UUO injury markedly upregulated Notch1, Notch3, the Notch intracellular domain, Hes1, Hey2, and Jagged-1; these increases were significantly suppressed by either EZH2 deletion or GA treatment. Similarly, in vitro, GA or EZH2-specific siRNA inhibited the expression of Notch signaling molecules in TGF-β1–treated renal epithelial cells. Chromatin immunoprecipitation analyses revealed direct binding of EZH2 and H3K27me3 to the Notch1 and Notch3 promoters. UUO injury enhanced EZH2 binding while reducing H3K27me3 enrichment at these sites, effects reversed by GA treatment. Conclusions These findings demonstrate that epithelial EZH2 contributes to pEMT in renal tubular cells and promotes renal fibrosis, at least in part through activation of Notch signaling. Targeting EZH2 may hold potential as a therapeutic approach for chronic kidney disease.
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