ChemElectroChem
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2018
·Vol. 5
·期 13
·1708-1716
·
IF 4.446
Siyu Zhong,Hang Zhang,Jiecai Fu,Huimin Shi,Lei Wang,Wei Zeng,Quanhui Liu,Guanhua Zhang,Huigao Duan
Graphical Boosting the network : A 3D porous electrode as anode in lithium-ion batteries is formed, consisting of ZnO-CoO nanoparticles dispersed in a carbon network. The electrode exhibits high specific capacity, superior rate capability, and enhanced cycling stability. The improved electrochemical performance is attributed to the synergistic effect between the active bimetallic oxide and the in-situ coating of the carbon matrix. For applications in lithium-ion batteries, carbon based materials possess high conductivity, whereas transition metal oxides usually show high theoretical lithium ion storage capabilities. Therefore, engineering transition metal oxides into three-dimensional (3D) carbon networks as anodes is expected to achieve long cycling life and excellent rate performance. Here, we report a facile and environmental friendly method for the in-situ synthesis of 3D carbon coated bimetallic oxides with porous network structure. The carbon matrix originates from citric acid, which can be used as food additive. Benefiting from the synergistic effects between ultrafine metal oxides and the conductive carbon layers, the as-synthesized ZnO-CoO nanoparticles dispersed in the porous carbon network (ZnO-CoO@C) exhibit faster lithium diffusion kinetics and significantly improved specific capacity at various current densities and extended cycling life (503 mAh g −1 after 700 cycles at 2000 mA g −1 ). Full-cell assemblies using ZnO-CoO@C as anode and the commercially available material NCM523 as cathode, display a high charging capacity of 94 mAh g −1 after 100 cycles at 100 mA g −1 . The simple and cost-effective synthesis strategy could be motivating for the large-scale manufacture of other in-situ carbon coated bimetallic oxides electrodes for promising energy storage devices.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Zhenbao Zhu,Cui Zhao,Jianhua Yi,Ning Liu,Yuangang Cao,Eric A. Decker,David Julian McClements
The impact of interfacial composition on lipid and protein co-oxidation in oil-in-water emulsions containing a mixture of proteins and surfactants was investigated. The emulsions consisted of 5% v/v walnut oil, 0.5% w/v whey protein isolate (WPI), and 0 to 0.4% w/v Tween 20 (pH 3 and pH 7). The protein surface load, magnitude of the ξ-potential, and mean particle diameter of the emulsions decreased as the Tween 20 concentration was increased, indicating the whey proteins were displaced by this nonionic surfactant. The whey proteins were displaced from the lipid droplet surfaces more readily at pH 3 than at pH 7, which may have been due to differences in the conformation or interactions of the proteins at the droplet surfaces at different pH values. Emulsions stabilized by whey proteins alone had relatively low lipid oxidation rates when incubated in the dark at 45 °C for up to 8 days, as determined by measuring lipid hydroperoxides and 2-thiobarbituric acid-reactive substances (TBARS). Conversely, the whey proteins themselves were rapidly oxidized, as shown by carbonyl formation, intrinsic fluorescence, sulfhydryl group loss, and electrophoresis measurements. Displacement of whey proteins from the interface by Tween 20 reduced protein oxidation but promoted lipid oxidation. These results indicated that the adsorbed proteins were more prone to oxidation than the nonadsorbed proteins, and therefore, they could act as better antioxidants. Protein oxidation was faster, while lipid oxidation was slower at pH 3 than at pH 7, which was attributed to a higher antioxidant activity of whey proteins under acidic conditions. These results highlight the importance of interfacial composition and solution pH on the oxidative stability of emulsions containing mixed emulsifiers.
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ANDROLOGIA
·
2018
·Vol. 51
·期 1
·e13160
·
IF 1.588
Guotao Chen,Jianhuai Chen,Baibing Yang,Wen Yu,Yun Chen,Yutian Dai
Nonorganic erectile dysfunction is a problem with unknown central mechanisms. Changes in brain activity in the amygdala have been observed in human patients. This study aimed to investigate the dopamine system in the basolateral amygdala of male rats with nonorganic erectile dysfunction. We applied chronic mild stress to induce nonorganic erectile dysfunction. After exposure to chronic mild stress, the sucrose consumption test, sexual behaviour test and apomorphine test were used to select depression-like rats with erectile dysfunction as nonorganic erectile dysfunction model rats. The sexual behaviour of these rats after central infusion of a dopamine D1/D2 receptor agonist/antagonist was observed. The expression levels of dopamine D1/D2 receptors and tyrosine hydroxylase in the basolateral amygdala were also measured. The result of the sucrose consumption test, sexual behaviour test and apomorphine test indicated a successful nonorganic erectile dysfunction model. Central infusion of a dopamine D2 receptor agonist increased intromission ratio in model rats. Lower expression levels of tyrosine hydroxylase and the dopamine D2 receptor in the basolateral amygdala were observed in rats with nonorganic erectile dysfunction. These results suggest that impairment of the dopamine D2 receptor pathway in the basolateral amygdala may contribute to the development of nonorganic erectile dysfunction.
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BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Lin Liu,Hua Zhang,Zhenxin Wang,Daqian Song
In the present work, peptide-functionalized upconversion@silica nanoparticle (termed as UCNP@SiO 2 @Cy5-pep)-based fluorescence resonance energy transfer (FRET) sensing platform has been fabricated for the detection of caspase-9 activity in vitro and in vivo. A Cy5 labeled peptide containing specific motif LEHD for caspase-9 cleavage was designed and conjugated with UCNP@SiO 2 through covalent attachment . The red upconversion luminescence (UCL) emission of UCNP@SiO 2 can be quenched by Cy5 while the green UCL emission of UCNP@SiO 2 remains undisturbed. After the cleavage of LEHD by caspase-9, the Cy5 departed from UCNP@SiO 2 surface, resulting in recovery of red UCL emission of UCNP@SiO 2 . The UCNP@SiO 2 @Cy5-pep has been successfully used to monitoring the changes of caspase-9 activity levels in apoptotic cancerous cells (MG-63 and SW480) by cisplatin-induction. Under same experimental conditions, it is found that the intracellular caspase-9 activity level of cisplatin-treated MG-63 cells is higher than that of cisplatin-treated SW480. This result is consistent with that of commercial caspase-9 activity kits. The UCL signal intensity ratio of red emission to green emission of UCNP (termed as R/G) is linearly dependent on the amount of MG-63 cells within the range of 5 × 10 3 to 1 × 10 6 cells (i.e., 0.5–100 U mL −1 caspase-9) with a limit of detection (LOD) of 675 cells (i.e., 0.068 U mL −1 caspase-9). Furthermore, the practicability of UCNP@SiO 2 @Cy5-pep is demonstrated by detection of caspase-9 activities in tumor tissues in vivo, and satisfactory results are obtained.
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Science China-Chemistry
·
2018
·Vol. 61
·期 12
·1624-1629
·
IF 4.448
Ma Qinqin,Wang Jie,Zheng Wei,Wang Qian,Li Zhiheng,Cong Hengjiang,Liu Huijun,Chen Xueyuan,Yuan Quan
Phosphor materials have been rapidly developed in the past decades. Developing phosphors with desired properties including strong luminescence intensity and long lifetime has attracted widespread attention. Herein, we show that hetero-valence ion doping can serve as a potent strategy to manipulate luminescence in persistent phosphors by controlling disorder in the host lattice. Specifically, spinel phosphor Zn(Ga 1− x Zn x )(Ga 1− x Ge x )O 4 :Cr is developed by doping ZnGa 2 O 4 :Cr with tetravalent Ge 4+ . Compared to the original ZnGa 2 O 4 :Cr, the doped Zn(Ga 1− x Zn x )(Ga 1− x Ge x )O 4 :Cr possesses significantly enhanced persistent luminescence intensity and prolonged decay time. Rietveld refinements show that Ge 4+ enters into octahedral sites to substitute Ga 3+ , which leads to the co-substitution of Ga 3+ by Zn 2+ for charge compensation. The hetero-valence substitution of Ga 3+ by Ge 4+ and Zn 2+ enriches the charged defects in Zn(Ga 1− x Zn x )(Ga 1− x Ge x )O 4 :Cr, making it possible to trap large amounts of charge carriers within the defects during excitation. Electron paramagnetic resonance measurement further confirms that the amount of Cr 3+ neighboring charged defects increases with Ge 4+ doping. Thus charge carriers released from defects can readily combine with the neighboring Cr 3+ to produce bright persistent luminescence after excitation ceases. The hetero-valence ion doping strategy can further be employed to develop many other phosphors and contributes to lighting, photocatalysis and bioimaging.
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BIOMEDICINE & PHARMACOTHERAPY
·
2018
·
IF 3.457
YingHui Zhang,Bing Wang,Feng Guo,ZhiZhen Li,GuiJun Qin
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes. Hesperetin , a natural flavanone glycoside compound in citrus fruits, has been demonstrated to exert hypoglycemic effects and protect kidney in experimental diabetic animals. The current study was aimed to investigate the mechanisms underlying the hypoglycemic effects of hesperetin in high-fat/streptozocin (STZ)–induced diabetic nephropathy. The results showed that mice in whom hesperetin was administered for 4 weeks attenuated the increased fasting blood glucose and impaired glucose tolerance ability that was observed in high-fat/STZ mice. In addition, we found that hesperetin ameliorated the abnormalities of biochemical parameters in serum, liver, and kidney of mice with diabetic nephropathy. Hesperetin also rescued the irregular distortions in glomerular basement membrane and expanded mesangial regions. Moreover, hesperetin repaired the function of podocyte by increasing renal nephrin expression and decreasing renal alpha-smooth muscle actin expression. Furthermore, hesperetin inhibited the expression of transforming growth factor-β1 (TGF-β1) and its downstream effectors integrin-linked kinase (ILK) and Akt. In conclusion, our study implies that hesperetin produced protective effects in diabetic nephropathy possibly by suppressing TGF-β1-ILK-Akt signaling.
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Translational Cancer Research
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2019
·
IF 1.07
Heqi Bu,Dianlei Liu,Junhui Cui,Ke Cai,Feng Shen
Background Oridonin has been demonstrated to have anticancer effect on all kinds of cancer cells and it has shown anti-tumor activity in some tumors partially via the inactivation of Wnt/β-catenin signaling pathway. The study investigated the anticancer effect of oridonin on colon carcinoma cell line COLO205 and explored underlying mechanism. Methods Cell Counting Kit-8 (CCK-8) assay was performed to assess cell viability. Flow cytometry was performed to analyze the apoptosis. The key target genes and proteins involved in Wnt/β-catenin pathway were detected by quantitative polymerase chain reaction (qPCR) and Western blotting. The xenograft tumor model of colon cancer COLO205 cell was introduced to detect anti-tumor effects in vivo . Transferase-mediated dUTP nick end labeling (TUNEL) assay was adopted to test the apoptotic cells in the tumor tissues. Results Oridonin inhibited the proliferation of colon cancer COLO205 cells in a dose-dependent and time-dependent manner. Oridonin induced apoptosis by increasing the cleavage of caspases in vitro . Furthermore, the expression levels of β-catenin and its downstream targets, including c-myc, cyclinD1 and survivin were significantly reduced. Nevertheless the knockdown of β-catenin by specific small interfering RNA (siRNA) could augment the anti-proliferative and pro-apoptotic effects by oridonin in COLO205 cells. Meanwhile, oridonin also increased protein expression level of glycogen synthase kinase 3β (GSK3β) and decreased the phosphorylation level of GSK3β. In vivo , oridonin treatment significantly suppressed tumor growth of COLO205 cell xenografts, and which was accompanied by the restrain of Wnt/β-catenin pathway. Conclusions Our present study demonstrated that the growth inhibition and apoptosis induction in colon cancer COLO205 cells by oridonin could be partially mediated through discontinuing Wnt/β-catenin signaling pathway.
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Scientific Reports
·
2017
·Vol. 7
·期 1
·1-11
·
IF 4.259
Huang Haiying,Tao Xuanyu,Jiang Yiming,Khan Aman,Wu Qi,Yu Xuan,Wu Dan,Chen Yong,Ling Zhenmin,Liu Pu,Li Xiangkai
Soil contamination by PAH and heavy metals is a growing problem. Here, we showed that a new isolate, Pseudomonas brassicacearum strain LZ-4, can simultaneously degrade 98% of 6 mM naphthalene and reduce 92.4% of 500 μM hexavalent chromium [Cr (VI)] within 68 h. A draft genome sequence of strain LZ-4 (6,219,082 bp) revealed all the genes in the naphthalene catabolic pathway and some known Cr (VI) reductases. Interestingly, genes encoding naphthalene pathway components were upregulated in the presence of Cr (VI), and Cr (VI) reduction was elevated in the presence of naphthalene. We cloned and expressed these naphthalene catabolic genes and tested for Cr (VI) reduction, and found that NahG reduced 79% of 100 μM Cr (VI) in 5 minutes. Additionally, an nahG deletion mutant lost 52% of its Cr (VI) reduction ability compared to that of the wild-type strain. As nahG encodes a salicylate hydroxylase with flavin adenine dinucleotide (FAD) as a cofactor for electron transfer, Cr (VI) could obtain electrons from NADH through NahG-associated FAD. To the best of our knowledge, this is the first report of a protein involved in a PAH-degradation pathway that can reduce heavy metals, which provides new insights into heavy metal-PAH contamination remediation.
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Agronomy-Basel
·
2024
·Vol. 14
·期 8
·1697
·
IF 3.3
Jing Xia,Lili Nan,Kun Wang,Yuheng Yao
Medicago sativais a high-quality legume forage that is widely cultivated around the world. However, low phosphorus (LP) stress is one of the main limiting factors for its yield and quality. Currently, it is unclear how various alfalfa root types respond to LP stress. Thus, the creeping-rootedM. varia‘Gannong No. 4’ (or GN), tap-rootedM. sativa‘Longdong’ (or LD), and rhizomatous-rootedM. sativa‘Qingshui’ (or QS) were selected to detect changes in growth, metabolites, phytohormones, and organic acids after 34 days of LP stress treatment (0.01 mmol·L−1KH2PO4). We observed LP stress significantly inhibited plant growth, and 123, 73, and 42 considerably upregulated differential metabolites were categorized into 33, 26, and 20 metabolic pathways in GN, LD, and QS under LP stress, respectively. Amino acids, plant growth regulators, and organic acids are the main metabolites. After 34 d of LP treatment, the plant height, total surface area, leaf length, ground biomass, leaf width, total volume, leaf area, and ZT content of different root types of alfalfa significantly decreased, while the contents of malic acid, citric acid, oxalic acid, IAA, ABA, and GA3significantly increased. The plant height, leaf length, leaf width, leaf area, total surface area, total volume, ground biomass, root biomass, the number of different metabolites, and the contents of malic, citric, and oxalic acid, and IAA of GN were significantly higher than those of QS and LD under LP stress. From this point of view, GN was more tolerant than LD and QS under the LP condition.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Panchan Dansawad,Yanxiang Li,Lixia Cao,Haigang Gao,Chaoyong Yang,Enming Huang,Siming You,Wangliang Li
A nanofibrous membrane made of unmodified recycled polyethylene terephthalate (rPET) was fabricated by electrospinning using plastic water bottle as raw materials. Using rPET polymer to fabricate membranes may help limit the discharge of plastic bottle waste into the environment and can treat oily wastewater simultaneously, especially emulsions. The variation in the concentration of rPET polymer and the properties of electrospun nanofibers , such as surface morphology and fiber diameter , had a significant impact on both the efficiency of oil droplet capturing and the surface wettability of the membrane. Water-in-oil emulsions and oil-in-water emulsions were separated using the nanofibrous membranes of different concentrations of rPET polymer, and the separation efficiencies at different concentrations of oil, and oil types were measured. The rPET nanofibrous membrane exhibited a water contact angle of 140.1° and was superoleophilic in air and underwater. The membranes exhibited excellent separation performances: >98% separation efficiency and a flux of more than 6500 L m -2 h -1 for water in hexadecane and octane emulsions; >95 % efficiency and a flux of 1509.70 L m -2 h -1 after three separation cycles of water-in-oil emulsions. For oil-in-water emulsions, the separation efficiencies were higher than 95 %, and flux was more than 3525.22 L m -2 h -1 for hexadecane octane and heptane in water emulsions, with an efficiency of >87.9 % and flux of 4186.20 L m -2 h -1 after three separation cycles. Moreover, the as-prepared membrane exhibited high performance of oil-water separation in harsh conditions, including strong acidic, strong basic, and strong salt solutions, with separation efficiencies of more than 98 % and flux of more than 12,700 L m -2 h -1 . However, as water accumulated on the membrane surface , absorption and separation efficiency and flux were lowered significantly. This suggests the need to enhance the efficiency of the membrane and reduce the chance of water accumulation on the membrane surface.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6
Zheren Tong,Xiaolu Jie,Ziwei Chen,Mingtao Deng,Xin Li,Zhiwen Zhang,Faxiang Pu,Zhangfu Xie,Zijin Xu,Ping Wang
Crocetin (CCT), a natural bioactive compound extracted and purified from the traditional Chinese medicinal herb saffron, has been shown to play a role in neurodegenerative diseases , particularly depression. However, due to challenges with solubility, targeting, and bioavailability, formulation development and clinical use of CCT are severely limited. In this study, we used the emulsification-reverse volatilization method to prepare CCT-loaded nanoliposomes (CN). We further developed a borneol (Bor) and lactoferrin (Lf) dual-modified CCT-loaded nanoliposome (BLCN) for brain-targeted delivery of CCT. The results of transmission electron microscope (TEM) and particle size analysis indicated that the size of BLCN (∼140 nm) was suitable for transcellular transport across olfactory axons (∼200 nm), potentially paving a direct path to the brain. Studies on lipid solubility, micropolarity, and hydrophobicity showed that BLCN had a relatively high Lf grafting rate (81.11 ± 1.33 %) and CCT entrapment efficiency (83.60 ± 1.04 %) compared to other liposomes , likely due to Bor improving the lipid solubility of Lf, and the combination promoting the orderly arrangement of liposome membrane molecules. Microplate reader and fluorescence microscopy analysis showed that BLCN efficiently promoted the endocytosis of fluorescent coumarin 6 into HT22 cells with a maximal fluorescence intensity of (13.48 ± 0.80 %), which was significantly higher than that of CCT (5.73 ± 1.17 %) and CN (12.13 ± 1.01 %). BLCN also exhibited sustained function, remaining effective for more than 12 h after reaching a peak at 1 h in cells, while CN showed a significant decrease after 4 h. The uptake mechanisms of BLCN in HT22 cells mainly involve energy-dependent, caveolae-mediated, and microtubule-mediated endocytosis, as well as micropinocytosis. Furthermore, BLCN displayed a significant neuroprotective effect on HT22 cells in glutamate-, corticosterone-, and H 2 O 2 -induced models. Tissue fluorescence image analysis of mice showed that BLCN exhibited substantial retention of fluorescent DiR in the brain after nasal administration for 12 h. These findings suggest that CCT has the potential for cellular uptake, neuroprotection , and targeted delivery to the brain following intranasal administration when encapsulated in Bor and Lf dual-modified nanoliposomes.
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高影响因子
CARBON
·
2025
·
IF 11.6
Lin Xie,Ruilin Liu,Xiaomeng Jiang,Cui Ni,Baolei Wang,Chuanxin Hou,Di Lan,Wei Du,Xiubo Xie
In order to obtain multiple interfaces of Co/CoO by tuning the oxidation process and simultaneously clarify the interface migration, Co particles loaded on mangosteen shell-derived carbon (MSC) were prepared, and then oxidized under a mixed atmosphere of Ar/O 2 and 300 °C with different oxidation time. Due to the existence of MSC, the Co can completely oxidized in short time of 60 min and low O 2 concentration of 5 %. The oxidation process is: Co→CoO→Co 3 O 4 . A lot of defects in-situ formed in the oxidation process can be clearly detectable. Co/MSC composites oxidized at 300 °C for 10 min exhibits considerable minimum reflection loss of −37.86 dB and an effective absorption bandwidth of 5.28 GHz among the composites with different oxidation times. The Co/CoO, CoO/C, Co/C heterogeneous interfaces are conducive to the depletion of electromagnetic waves through interfacial polarization. The in-situ formed defects are positive for enhancing the dipole prolarization, and the natural resonance is also enhanced due to the presence of Co and its oxides. The positive effects of carbon additive in the oxidation of Co on the in-situ defects formation and multiple interface construction provide a new perspective for designing high performance microwave absorption materials.
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