FASEB JOURNAL
·
2026
·Vol. 40
·期 3
·e71499
·
IF 4.2
Liwen Xu,Fei Zheng,Dandan Wang,Qing Yang
N-terminal acetyltransferases are emerging as potential therapeutic targets in cancer. N-alpha-acetyltransferase 30 (NAA30), which serves as the catalytic subunit of the NATC complex. However, the role of NAA30 in ovarian cancer remains unknown. In this study, we found that NAA30 expression was abnormally upregulated in ovarian cancer tissues compared to normal tissues. Functionally, NAA30 promoted cell proliferation, migration, and invasion in ovarian cancer cells. Moreover, in vivo experiments revealed that NAA30 enhanced tumor growth and intraperitoneal metastasis in mouse models. We further explored the regulatory mechanisms underlying NAA30 upregulation. Dual-luciferase assays demonstrated that the transcription factor nuclear receptor subfamily 2 group C member 2 (NR2C2) significantly enhanced the transcriptional activity of the NAA30 promoter. Besides, NR2C2 increased the migratory, invasive, and proliferative capabilities of ovarian cancer cells. Importantly, NAA30 knockdown reversed the pro-tumorigenic effects of NR2C2 overexpression on the malignant phenotype. To identify the downstream targets of NAA30, we employed IP-LC/MS and N-terminal acetylation modification omics. Actin-Related Protein 2/3 Complex Subunit 1B (ARPC1B) was identified as a direct target of NAA30. It was demonstrated that NAA30 protein binds to ARPC1B protein and that NAA30 knockdown enhanced the polyubiquitination of ARPC1B and promotes its degradation. Crucially, the re-expression of ARPC1B in NAA30-silenced cells effectively restored these malignant phenotypes. These findings highlight the critical role of the NR2C2-NAA30-ARPC1B axis in ovarian cancer progression and provide more foundation for the development of more effective treatment strategies for patients with ovarian cancer. Graphical In ovarian cancer, transcription factor NR2C2 is highly expressed and enhances the transcription of NAA30. This subsequently suppresses the ubiquitination of ARPC1B, leading to its protein stabilization, which ultimately promotes malignant tumor behaviors and disease progression.
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DOI
PubMed
高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Xinyu Cui,Peiqin Hong,Yang Jiao,Peng Hu,Haibo Fan,Feng Teng
Heterogeneous atomic doping is the mainstream way to enhance the electrochemical performance of porous carbon electrode materials. Herein, a three-dimensional honeycomb-like porous carbon material was synthesized by directly one-step carbonization-activation polyvinyl alcohol hydrogel method. In this study, a N, S co-doped porous carbon material was prepared by introducing thiourea during the hydrogel formation process. The as-synthesized product possesses a large specific surface area and a well-developed porous structure. Notably, the obtained N, S co-doped porous carbon delivers an excellent specific capacitance of 260.5 F g −1 at a current density of 1 A g −1 in a 6 M KOH electrolyte, along with outstanding cycling stability. These values are much higher than those of undoped porous carbon, single N-doped porous carbon, and single S-doped porous carbon. After 10,000 cycles, the material's specific capacitance retention remains stable, with a Coulombic efficiency approaching 100%. This work presents a facile and effective pathway for the electrode rational design of next-generation energy storage devices.
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高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2026
·
IF 2.4
Zishan Zhou,Hongquan Tao,Haocheng Yang,Ao Duan,Jiahui Yu,Yixin Chen,Yongyan Zhu,Quanhong Zhu
Favorable biocompatibility is essential to biomaterials, and natural amino acids are recognized as the promising building block of polymers due to their non-toxicity and tunable side chains. We prepared polymeric nanoparticles (NPs) using N-acryloyl-L-tryptophan monomer by precipitation polymerization, and modified with polyethylene glycol and folate (PEG-FA) to improve the solubility and target folate-receptors (FR) overexpressed tumor tissues. Serving as drug carriers for vinblastine (VBL), NPs-PEG-FA with about 212.4 nm had the drug loading of VBL of 6.65 ± 0.41% after co-incubating for 1 h and showed sustained-release in pH 7.4 PBS, in which 99.87 ± 1.00% of VBL was released from NPs-PEG-FA during 72 h. Furthermore, NPs-PEG-FA was more efficiently taken up by FR positive Hela cells compared with NPs-PEG, which signified folate could enhance the internalization of NPs-PEG-FA into FR over-expressed cells. And NPs-PEG-FA began to enter Hela cells in large quantities from 3 h onwards, meanwhile the released drug increased more quickly in the first 3 h, which indicated most of the drugs would be released after entering tumor cells. More importantly, NPs-PEG-FA had good biocompatibility to L929 mouse fibroblast cells and exhibited hemocompatibility via the assays of hemolysis, antithrombogenicity, coagulation activation and platelet activation. NPs-PEG-FA could serve as drug carriers for delivering drugs into FR positive tumor cells.
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高影响因子
JOURNAL OF CATALYSIS
·
2026
·
IF 6
Zerui Su,Yang Li,Jianbin Huang,Jian Zhang
Hydrogen energy is regarded as an ideal energy carrier due to its advantages such as high energy density, environmental friendliness, and wide availability. The storage and release of hydrogen using liquid organic hydrogen carriers (LOHCs) such as N-ethylcarbazole (NECZ) offer distinct advantages for safe hydrogen transport and storage. Developing efficient catalysts for this reversible process remains a critical challenge. At present, the high cost of noble metal catalysts hinders their widespread application, and most of the non-noble metal catalysts are not efficient in reversible hydrogenation storage of NECZ. In this study, a silica supported non-noble Ni was prepared by the wet-kneading method, which successfully achieved the reversible hydrogen storage of NECZ. The catalyst exhibited high activity and moderate stability, achieving hydrogen storage of 5.77 wt% within 6 h under 6 MPa of H 2 at 150 °C, and hydrogen release of 5.77 wt% within 1.5 h at 200 °C during 5 cycles. XPS studies identified Ni 0 as the main active site for hydrogenation-dehydrogenation cycles. IR and kinetic studies further revealed that same Ni 0 sites are poisoned by the intermediate 4H-NECZ. This work might pave the way for designing high-performance non-noble catalysts for reversible chemical hydrogen storage.
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高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Zengjin Fu,Yan Hao,Tingrui Lin,Huiling Ma,Huazheng Sai,Hui Yang
A novel adsorbent (PHPM) was synthesized through the functionalization of N -(2-Hydroxyethyl) acrylamide (HEAA) with phytic acid (PA) and applied for the adsorption of La(III) and Ce(III) ions. The material was characterized by means of FTIR, TGA, SEM, and XPS. The present study systematically investigated the effects of contact time, adsorbent dosage, initial La(III) or Ce(III) concentration, and pH value on the adsorption capacity. The maximum theoretical adsorption capacities of PHPM for La(III) and Ce(III) were determined to be 198.0 and 186.2 mg·g −1 , respectively. The adsorption process followed the pseudo-second-order kinetic model and the Langmuir isotherm model, as further confirmed by nonlinear fitting with low RMSE and χ 2 values. Thermodynamic analysis revealed negative Δ G values, positive Δ H and Δ S values, indicating a spontaneous, endothermic, and entropy-driven process. Furthermore, PHPM demonstrated high adsorption efficiency toward La(III) and Ce(III), even in the presence of competing ions. A preliminary cost analysis indicated that the preparation of PHPM was economically feasible with low cost. The adsorbent maintained approximately 50% of its initial adsorption capacity after ten consecutive adsorption-desorption cycles. The findings demonstrate that PHPM was a promising adsorbent for the recovery of La(III) and Ce(III) from aqueous environments.
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DOI
高影响因子
Chem Catalysis
·
2026
·
IF 10.7
Haiwei Su,William Orbell,Lijuan Sun,Hongwen Zhang,Haibo Yin,Zhen Chen,Qinqin Liu,Peng Zhou,Hua Tang,Junhua Li
Photocatalytic amine oxidation coupled with hydrogen evolution offers a sustainable route to green hydrogen and value-added chemicals, yet efficient N–H bond activation remains challenging. Herein, we construct atomic Ag–N frustrated Lewis pairs (FLPs) composed of low-valence Ag single atoms as Lewis acids and adjacent electron-rich N atoms as Lewis bases by anchoring high-density Ag single atoms onto N-deficient g-C 3 N 4 nanosheets to form an Ag–N 1 C 2 structure. These atomic Ag–N FLP sites enable efficient adsorption and selective N–H bond cleavage through synergistic coordination of Ag with the amine N atom and neighboring N sites with H. Meanwhile, Ag single atoms serve as effective hole-transfer bridges, enhancing surface hole accumulation and accelerating oxidation kinetics. The resulting photocatalyst exhibits a benzylamine oxidation rate of 0.85 mmol g cat −1 h −1 , converts benzylamine to N -benzylidenebenzylamine with >99% selectivity, and achieves a hydrogen evolution rate of 1.86 mmol g cat −1 h −1 .
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高影响因子
MOLECULES
·
2026
·Vol. 31
·期 11
·1908
·
IF 5.1
Wei Cao,Lifang Chen,Tingting Wang,Ke Wang,Zhen Song,Zhiwen Qi
In order to address corrosion and pollution problems of liquid acids and limitations of traditional solid acids, sulfated MOF-808-SO4catalysts were developed by creating unsaturated sites in MOF-808 for sulfate grafting with ligand defect engineering. Characterization verified framework integrity, successful sulfate coordination, and maintenance of high surface areas and tunable porosity. Temperature-programmed desorption of ammonia (NH3-TPD) establishes a clear consistent trend between defect density and the concentration as well as the strength of acid sites, indicating that a higher degree of ligand deficiency promotes the formation of more abundant and stronger acid centers. For esterification of acetic acid with n-butanol, the catalyst prepared by replacing 40 mol% of BTC with BDC achieved ≥99% conversion of acetic acid under mild conditions of 2.0 wt% catalyst loading and 1:2 alcohol/acid molar ratio at 120 °C for 6 h, outperforming conventional solid acids. This performance stems from high-density strong Brønsted acid sites strongly coordinated at defects and an open pore structure facilitating diffusion. The catalyst was easily recovered by ethanol washing and maintained stable activity over five cycles without loss of catalytic capability. This work suggests defect engineering as an effective strategy for tuning acidity and catalytic performance in MOF-based solid acids for green esterification.
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DOI
PubMed
高影响因子
Materials
·
2026
·Vol. 19
·期 11
·2286
·
IF 3.7
Yi Zhou,Yi Zhang,Zhanhong Zhao,Yansen Qu,Jiajun Wu,Xueqin Ma,Xinghua Chang
Silicon-based anodes are considered promising alternatives to graphite anodes owing to their high theoretical lithium-storage capacity and abundant reserves. However, silicon nanoparticle anodes are severely limited by large volume expansion, unstable interfacial chemistry, and poor electrical connectivity during repeated lithiation/delithiation. Herein, we develop a yolk–shell N-doped carbon network (NCN) strategy to construct Si@void@NCN composites. The optimized Si@void@NCN-1 achieves a balanced architecture between void buffering and carbon network integrity, delivering a high initial discharge capacity of 1245.5 mAh g−1and an initial charge capacity of 735.8 mAh g−1. It also demonstrates stable long-term cycling performance, retaining a reversible capacity of 402.5 mAh g−1after 500 cycles at 0.5 A g−1with a capacity retention of 68.66%, and shows improved rate reversibility and electrode structural stability, with an electrode thickness increase of only 80.4% after rate cycling, much lower than that of densely carbon-coated Si@C. Kinetic analysis, post-cycling structural characterization, and in situ EIS further reveal that the yolk–shell void-buffering structure and the N-doped three-dimensional conductive network act synergistically to mitigate Si volume expansion, enhance structural stability, and facilitate electron/ion transport. This study emphasizes the importance of integrating buffering structures with Si/C composites, providing guidance for the rational design of advanced silicon-based electrode materials.
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DOI
PubMed
高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Yangyang Ren,Zehao Zang,Hua Ning,Guichao Zhang,Lanlan Li,Xiaojing Yang,Zunming Lu,Xinghua Zhang,Xiaofei Yu
Highly graphitic carbon-supported Pt particles (Pt/Co–N–C) was developed. • Regulating the electronic structure of Pt through the strong metal-support interaction. • Intrinsic activity was increased by optimizing O 2 adsorption and lowering energy barrier. • High mass activity and excellent stability of Pt/Co–N–C were achieved. Developing durable supported Pt-based materials is essential for advancing the oxygen reduction reaction in fuel cells, as harsh electrocatalytic conditions often trigger corrosion of carbon supports. The support materials’ physical and chemical properties play a crucial role in the overall performance of Pt-based catalysts. Herein, a highly stable electrocatalyst (Pt/Co–N–C) consisting of small Pt particles coupled tightly with highly graphitized Co–N–C substrate for efficient catalysis was proposed. Pt/Co–N–C exhibited a remarkable mass activity in acidic media, 6.4 times higher than that of commercial Pt/C. Notably, Pt/Co–N–C displayed exceptional stability, with only a 3 mV decrease in half-wave potential and retaining 95.8% mass activity even after 50,000 potential cycles during the accelerated durability tests. Experimental and theoretical analysis highlighted the enhanced support-catalyst and electronic effects between Pt and Co–N–C matrix, thereby enhancing the mass transfer and preventing the structural degradation of the electrocatalyst. This work underscored the possibility of simultaneously modifying Pt active sites and carbon support as effective electrode catalysts in fuel cells. Download: Download high-res image (307KB) Download: Download full-size image
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DOI
高影响因子
Functional Materials Letters
·
2019
·
IF 1.388
Lin Zhao,Yanzhao Xie,Qiuyu Lin,Rongze Zheng,Yong Diao
A series of composite catalysts of C, N and P co-doped TiO 2 were prepared by sol-gel method, using a biomass (soluble starch) dopant. The samples were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV-Vis diffuse reflectance spectroscopy (DRS), fourier transform infrared (FTIR) spectroscopy. The results show that TiO 2 is co-doped with C, N and P by one step. The resulting composite exhibited higher specific surface area, wider visible-light absorption band with respect to the pure TiO 2 . The sample calcined at 400 ∘ C for 2 h with a doping amount of 6 g soluble starch showed the best electrochemical performance. The C, N and P co-doped TiO 2 was also used for the degradation of methylene blue (MB) and degradation ratio was up to 98% in 80 min under visible light irradiation.
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高影响因子
ACS Nano
·
2017
·
IF 13.942
Jin Jia,Tanli Xiong,Lili Zhao,Fulei Wang,Hong Liu,Renzong Hu,Jian Zhou,Weijia Zhou,Shaowei Chen
Probing competent electrocatalysts for hydrogen evolution reaction (HER) of water splitting is one of the most hopeful approaches to confront the energy and environmental crisis. Herein, we highlight ultrathin N-doped Mo2C nanosheets (N-Mo2C NSs) in the role of greatly efficient platinum-free-based electrocatalysts for the HER. The transformation of crystal phase and structure between MoO2 nanosheets with a thickness of ∼1.1 nm and N-Mo2C NSs with a thickness of ∼1.0 nm is studied in detail. Structural analyses make clear that the surfaces of the N-Mo2C NSs are absolutely encompassed by apical Mo atoms, hence affording an ideal catalyst prototype to expose the role of Mo atoms for the duration of HER catalysis. Theoretical calculations demonstrate that the nanosheet structure, N doping, and particular crystalline phase of Mo2C produce more exposed Mo active sites, including Mo atoms on the C plane and doped N atoms. Through detailed electrochemical investigations, N-Mo2C NSs possess HER activity with an onset potential of −48.3 mV vs RHE, Tafel slope of 44.5 mV dec–1, and overpotential of 99 mV vs RHE at the cathodic current density of 10 mA cm–2 with excellent long-term stability. Lastly, the calcination temperature and dicyandiamide amount can obviously affect the phase transformation and surface structure of molybdenum carbide, resulting in an adjustable HER activity. This synthesis mechanism will facilitate the understanding and optimization of Mo-based electrocatalysts in the energy conversion field.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Junhao Huang,Jiacheng Li,Yuhong Feng,Ke Li,Huiqiong Yan,Pengbo Gao,Ting Xiao,Chunxiu Wang
In this study, the aggregation of N-octyl-β- d -glucopyranoside (OGP) and cholesteryl grafted sodium alginate derivative (CSAD) in solutions was investigated by surface tension method, fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy. Results showed that cholesteryl of CSAD and OGP were adsorbed competitively to the gas–solution interface. Four different conformations of complexes were found with the increasing of OGP concentration (C). When C < critical aggregation concentration (CAC), the OGP stimulates CSAD association. When CAC < C < critical micelle concentration (CMC), the OGP was stimulated by hydrophobic interaction, then it compounded CSAD to form polymer–surfactant complexes and some pearl-chain structure complexes. When CMC < C < adsorbed saturation concentration (C 2 ), the quantity of pearl-chain structure complexes increases, they interact to form core–shell structure complexes, and several core–shell structure complexes formed short string-structures by association of CSAD molecule. When C > C 2 , adsorption amount of OGP to CSAD reached saturation, OGP molecules formed small single OGP micelles , while the string-structures were dissolved because the cholesteryl among the micelles were replaced by the single OGP micelles.
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高影响因子
危险品化学品经营许可证（带存储）