CARBOHYDRATE POLYMERS
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2018
·
IF 5.158
Yan Zhang,Xinyi Tan,Tianyang Ren,Chao Jia,Zaixing Yang,Hong Sun
A ternary core/shell based nanoparticulate complex was designed for the sequential and site-specific drug delivery. First, bovine serum albumin nanoparticles (BSA NPs) were served as the core for loading gambogic acid (GA). Subsequently, the BSA NPs were adsorbed by polyethylenimine and then shielded with carboxymethyl chitosan-folate (CMCS-FA) as the outer shell for encapsulating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), forming the GA/TRAIL co-delivery BSA (GTB) NPs. In normal tissues, the GTB NPs were negatively charged; in acidic tumor tissues, the shielding CMCS-FA was detached, allowing the release of TRAIL, which binds to the cell death receptor on the plasma membrane. The resulting positively charged complex promoted cellular internalization and escaped from lysosomes, producing a rapid release of GA, which exerted the combined tumor therapy by regulating both intrinsic and extrinsic apoptotic pathways. In vitro and in vivo studies confirmed that GTB NPs could enhance antitumor efficacy and reduce adverse effects.
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES
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2018
·
IF 1.845
Yongli Jiang,Chenjun Zhuang,Yu Zhong,Yanyun Zhao,Yun Deng,Haiyan Gao,Hangjun Chen,Honglei Mu
The composite bilayer film based on polyvinyl alcohol, sodium alginate, and chitosan were developed in this study, and the effects of the related coating on internal-quality changes of salted duck eggs (SDEs) during storage were determined. The results showed that the overall properties of the bilayer film were better than those of monolayer films, including storage stability. Coatings could significantly (p < 0.05) reduce quality deterioration of SDEs such as water loss, oil exudation, and gritty. The bilayer coating was more effective in inhibiting the increase of egg yolk pH and total bacterial counts than monolayer coatings. After storage for 60 days, water content of bilayer coated SEDs was 19.7% higher than that of the control SDEs, oil exudation was 38% higher, and gritty texture was 27.9% higher. Moreover, bilayer coating could prolong the shelf life of SDEs to more than 60 days at 25°C and 50% relative humidity according to the results of total bacterial count experiment, while the shelf life of control SDEs was less than 45 days. This study indicated the potential application of bilayer composite coating for preservation of SDEs.
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CARBOHYDRATE POLYMERS
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2017
·
IF 4.811
Beibei Wang,Xiaodeng Yang,Congde Qiao,Yan Li,Tianduo Li,Chunlin Xu
The effects of N -(2-hydroxyl)-propyl-3-trimethylammonium chitosan chloride (HTCC) on the physicochemical properties of sodium carboxymethyl cellulose (CMC)-based films were investigated. The prepared HTCC/CMC film-forming solutions (FFSs) with varying mass ratios exhibited shear-thinning behavior and typical pseudo-plasticity. The highest apparent viscosity and lowest crossover frequency was obtained for the HTCC/CMC FFS with a mass ratio of 10%, due to the formation of the strongest intermolecular interactions, which also led to the best mechanical properties. Furthermore, the effects of temperature and degree of substitution of HTCC on the composite film properties were also investigated. Structural property assessment by FTIR, SEM, and DSC showed a clear interaction between HTCC and CMC, leading to the formation of a new composite material with enhanced physicochemical properties. The data demonstrate the importance of HTCC in CMC-based films for food and drug packaging.
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JOURNAL OF NANOPARTICLE RESEARCH
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2017
·Vol. 19
·期 10
·1-12
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IF 2.02
Tian Fei,Niu Libo,Chen Bo,Gao Xuejia,Lan Xingwang,Huo Li,Bai Guoyi
A novel magnetic core-shell nanocomposite Fe 3 O 4 @Chitosan@ZnO was successfully prepared by in situ chemical precipitation method. It has a clear core-shell structure with magnetic Fe 3 O 4 (about 160 nm in diameter) as core, chitosan as the inner shell, and ZnO as the outer shell, as demonstrated by the transmission electron microscopy and the related elemental mapping. Moreover, this nanocomposite has high magnetization (43.6 emu g −1 ) so that it can be easily separated from the reaction mixture within 4 s by an external magnetic field. The introduction of the natural chitosan shell, instead of the conventional SiO 2 shell, and its combination with the active ZnO ensures this novel nanocomposite green character and good catalytic performance in the synthesis of 2-benzimidazoles with moderate to excellent isolated yields at room temperature. Notably, it can be recycled seven times without appreciable loss of its initial catalytic activity, demonstrating its good stability and making it an attractive candidate for the green synthesis of 2-benzimidazoles.
A novel magnetic core-shell nanocomposite exhibited high activity and good stability in the green synthesis of 2-benzimidazoles under mild reaction conditions.
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RSC Advances
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2017
·Vol. 7
·期 66
·41838-41846
·
IF 3.108
Yanqing Du,Yujiang Li,Tao Wu
Oil/water separation has become a worldwide challenge due to large volumes of industrial oily wastewater and frequent oil spill accidents, which constitute an enormous threat to human and biological safety. Herein, a superhydrophilic and underwater superoleophobic composite membrane was fabricated using the vacuum-assisted filtration technique of assembly of chitosan (CS) and titanium dioxide (TiO2) on a cellulose acetate membrane for emulsified oil separation. The hydrophilic chitosan–TiO2 (CST) composite and nanoscale hierarchical structure are beneficial for forming a water layer that can repel the infiltration of oil droplets into the membrane. The modified membrane demonstrated an excellent flux up to 6002.5 L m−2 h−1 for hexadecane-in-water emulsion, which is one order of magnitude higher than traditional filtration membranes. Furthermore, the separation efficiency for all of the emulsified oils is above 97%, indicating superior oil/water separation performance. Most importantly, the modified membrane can maintain underwater superoleophobicity even in corrosive aqueous media, including strongly acidic, strongly alkaline, and highly saline solutions. It is expected that the chitosan–TiO2 composite membrane can be potentially useful in treating oily wastewater from industry and daily life.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
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IF 2.323
Huan Wang,Ping Zhang,Jing Liu
A novel triethylene tetramine-functionalized magnetic graphene oxide chitosan composite material (TETA-MGO/CS) with a high adsorption capacity for the phosphate was prepared by chemical coprecipitation and subsequently modified by triethylene tetramine. TETA-MGO/CS was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry, X-ray diffraction, thermogravimetry, and Brunauer–Emmett–Teller analyses. The adsorption experiments of phosphate on TETA-MGO/CS were compared with MGO, MGO/CS, and TETA-MGO. Effects of pH, initial concentration of phosphate, adsorption time, and adsorption temperature were studied. The results indicated that the adsorption capacity of the four adsorbents were highly pH dependent and reached optimum at pH 3.0. Adsorption processes reached the equilibrium within 50 min. The adsorption data of the four adsorbents were well-fitted with the Langmuir isotherm. The maximum adsorption capacities of MGO, MGO/CS, TETA-MGO, and TETA-MGO/CS at 298 K calculated from Langmuir isotherm were 300.13, 314.83, 339.65, and 353.36 mg·g–1, respectively. This result is ascribed to an increase of amino after MGO functionalized by TETA and CS. The adsorption mechanism of phosphate on TETA-MGO/CS could be mainly related with electrostatic interaction. Moreover, phosphate ions adsorbed onto TETA-MGO/CS could be desorbed and can be reused three times. It indicated that TETA-MGO/CS can be used as a efficient and renewable adsorbent.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Xuerong Luo,Wenting Shi,Imran Mahmood Khan,Lin Yue,Zhouping Wang
As an essential oil component, farnesol (Far) possesses biological activity. Nevertheless, its high hydrophobicity and volatility pose significant limitations to its practical application. Hydroxypropyl chitosan (HPCS) is a modified chitosan characterized by excellent solubility and a wealth of reactive groups. In this study, we used HPCS as the primary matrix to improve the stability and solubility of Far through chemical modification and physical loading. Subsequently, we comparatively analyzed the thermal stability, antioxidant activity and antibacterial activity of the two products. The derivatives (HPCS-Far-1–3) and nanoparticles (HPCS NPs, HPCS-Far NPs) were fabricated by bromide-mediated nucleophilic substitution and ionic gelation methods, respectively. The comparative analysis of these two derivatives presented potent antibacterial and antioxidant properties along with better solubility and thermal stability. This study is the first to compare the complex properties between chemical modification and physical loading, which offers valuable insight for the application of Far in different scenarios.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Mingfang Sun,Jun Wang,Jun Kang,Yaxin Zhao,Huafeng Tian,Yujuan Jin,Rakesh Kumar,Junfeng Wang
This study utilizes electrospinning to develop bio-based fibrous films composed of zein and polylactic acid (PLA), with chitosan added in varying concentrations. The resulting films exhibit remarkable filtration efficiency, capturing over 95 % of airborne pollutants, while maintaining a low pressure drop of less than 4 mbar. A key innovation in this work is the integration of chitosan. Chitosan, a naturally derived polysaccharide, significantly increases the conductivity and viscosity of the spinning solution, enhancing interactions among PLA, chitosan, and protein molecules. This leads to a robust network structure with improved hydrophobicity and a bimodal structure, both essential for maintaining high filtration efficiency without reducing breathability. The addition of chitosan effectively addresses the common issue of high pressure drop in PLA/zein composite films, improving the product's efficiency and practicality for air filtration applications. Furthermore, the inherent mechanical strength and ductility of chitosan contribute to the fibrous films' overall durability and functionality. These properties make chitosan-modified zein/PLA fibers highly suitable for air pollution control, especially in personal protective equipment. This research underscores the potential of chitosan-enhanced bio-based materials as sustainable and effective solutions for advanced air filtration technologies.
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CATALYSIS COMMUNICATIONS
·
2012
·
IF 2.986
Jinjin Zang,Shaoyi Jia,Yong Liu,Songhai Wu,Yinbao Zhang
In this paper, polyvinyl alcohol (PVA) was modified with 3-aminopropyl triethoxysilane (APTES) and formed chemically crosslinked beads with chitosan. FTIR and SEM were used to characterize the support and immobilized catalase. Compared with control group, the activity of modified group increased about 1400 U/g support . The optimal temperature and optimal pH of immobilized catalase were 45 °C and pH 7.0. The thermal stability of catalase also enhanced after immobilization. Moreover, the immobilized catalase retained more than 90% of its original activity after using it for 9 times.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Chengyu Ji,Nan Shi,Yingjie Li,Daihuo Liu,Qingcong Wei,Guanglei Ma,Xiaofang Shi,Zhiguo Hu
Hydrogels are currently under extensive research as flexible quasi-solid electrolytes for zinc-ion batteries. However, the non-degradability and non-recyclability of hydrogel electrolytes pose significant issues, leading to resource wastage and plastic pollution. Moreover, the increasing needs of hydrogel electrolyte with various shapes to meet individual requirements of next-generation flexible battery raise significant challenges. In this study, we introduce the Hofmeister effect and multiple non-covalent interactions to fabricate an eco-friendly and recyclable multifunctional hydrogel electrolyte using biomass natural polymers. This is achieved by simply soaking primary hydrogel networks of carboxymethyl chitosan (CMCS) and gelatin in zinc sulfate (ZnSO4) aqueous solutions, abbreviated as GCZ-x. The GCZ-x hydrogels exhibit both stiffness and toughness due to the formation of crystalline domains and ionic crosslinks. The dynamic physical interactions and temperature and pH responsiveness of the GCZ-x hydrogels enable them excellent processability and recyclability. The zinc-ion battery with GCZ-x hydrogel as electrolyte exhibits high specific capacity and superior cyclic performance (2200 h at 0.1 A g −1 ) without the formation of zinc dendrites. The GCZ-x electrolyte is sustainable with high recycling rate (above 80 %). It is envisaged that the GCZ-x hydrogel electrolyte will initiate new prosperity of green zinc-ion batteries in energy-efficient and environmentally sustainable ways.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaobi Fang,Xiaojing Chen,Wei Dong,Fan Ye
In the management of diabetic oral ulcers, current treatments frequently fall short due to complications from bacterial contamination, oxidative damage, and impaired angiogenesis. These shortcomings highlight the pressing need for more efficacious interventions that not only circumvent these issues but also expedite healing processes. To bridge this gap, we have introduced a novel hydrogel patch, POQ2 [a poly(tannic acid) particle-incorporated oxidized β-glucan/quaternized chitosan hydrogel]. POQ2 demonstrated significant improvements in healing outcomes by enhancing bacterial clearance (up to 99.7 % against Escherichia coli and 99.2 % against Staphylococcus aureus ), reducing oxidative stress through efficient ROS scavenging (70.2 % reduction in DPPH radicals), and promoting angiogenesis. In vivo experiments on diabetic rat models showed accelerated wound closure and reduced IL-6 inflammatory markers, with nearly complete ulcer healing within seven days. The introduction of POQ2 into clinical protocols represents a substantial advancement in the management of diabetic oral ulcers, promising not only improved patient outcomes but also a shift in the standard of care in this challenging clinical area. This innovation not only fills a significant gap in diabetic wound care but also sets a new benchmark for the development of future treatments, potentially influencing broader therapeutic strategies for managing complex diabetic wounds.
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International Journal of Nanomedicine
·
2024
·
IF 6.6
Qi Wang,Jiaxin Dong,Mengxian Du,Xinna Liu,Shiqi Zhang,Di Zhang,Wanyun Qin,Xikun Xu,Xianghui Li,Ruidong Su,Leyi Qiu,Baoqiang Li,Huiping Yuan
Introduction: Glaucoma is a prevalent cause of irreversible vision impairment, characterized by progressive retinal ganglion cells (RGCs) loss, with no currently available effective treatment. Rapamycin (RAPA), an autophagy inducer, has been reported to treat glaucoma in rodent models by promoting RGC survival, but its limited water solubility, systemic toxicity, and pre-treatment requirements hinder its potential clinical applications.Methods: Chitosan (CS)-RAPA carbon dot (CRCD) was synthesized via hydrothermal carbonization of CS and RAPA and characterized by transmission electron microscopy, Fourier transform infrared spectra, and proton nuclear magnetic resonance. In vitro assays on human umbilical cord vein endothelial and rat retinal cell line examined its biocompatibility and anti-oxidative capabilities, while lipopolysaccharide-stimulated murine microglia (BV2) assays measured its effects on microglial polarization. In vivo, using a mouse retinal ischemia/reperfusion (I/R) model by acute intraocular pressure elevation, the effects of CRCD on visual function, RGC apoptosis, oxidative stress, and M2 microglial polarization were examined.Results: CRCD exhibited good water solubility and anti-oxidative capabilities, in the form of free radical scavenging. In vitro, CRCD was bio-compatible and lowered oxidative stress, which was also found in vivo in the retinal I/R model. Additionally, both in vitro with lipopolysaccharide-stimulated BV2 cells and in vivo with the I/R model, CRCD was able to promote M2 microglial polarization by activating autophagy, which, in turn, down-regulated pro-inflammatory cytokines, such as IL-1β and TNF-α, as well as up-regulated anti-inflammatory cytokines, such as IL-4 and TGF-β. All these anti-oxidative and anti-inflammatory effects ultimately aided in preserving RGCs, and subsequently, improved visual function.Discussion: CRCD could serve as a potential novel treatment strategy for glaucoma, via incorporating RAPA into CDs, in turn not only mitigating its toxic side effects but also enhancing its therapeutic efficacy.
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