查找使用阿拉丁产品的科研文献

Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery

Liu Cui,Xi Wang,Zhaoyun Liu,Ziqi Li,Ziwei Bai,Kui Lin,Jian Yang,Yuanlu Cui,Fei Tian

Stimulus-responsive nanomaterials have become a hot spot in controllable drug delivery systems researches owing to their spatiotemporal controllable properties based on the differences between tumor microenvironment and normal tissue. Herein, iron (III) carboxylate metal-organic framework nanoparticles coated with glycyrrhetinic acid-chitosan conjugate (MIL-101/GA-CS) were successfully fabricated and acted as the pH-responsive and target-selective system to deliver doxorubicin (DOX) for hepatocellular carcinoma (HCC) therapy. The prepared nanocarrier possess the advantages of uniform size, comparable drug loading efficiency (28.89%), and superior pH-dependent controlled drug release (DOX release of 2.74% and 89.18% within 72 h at pH 7.4 and 5.5, respectively). In vitro cytotoxicity assays showed that the drug-loaded nanocarriers exhibited excellent inhibitory effects on HepG2 cells due to the sustained release of DOX, while the nanocarriers showed no significant toxicity. Furthermore, cell uptake experiments demonstrated that MIL-101-DOX/GA-CS could target HepG2 cells based on receptor-dependent internalization of glycyrrhetinic acid receptors mediated. In vitro 3D hepatoma cell microspheres experiments showed that MIL-101-DOX/GA-CS had excellent penetration and tumor killing ability. Therefore, MIL-101-DOX/GA-CS nanoparticles have a prospective application in cancer therapy as a pH-responsive controlled drug delivery system.

Mussel-inspired self-healing hydrogel based on gelatin and oxidized tannic acid for pH-responsive controlled drug release

Yangyan Tang,Ximeng Sun,Jiangchuan Ma,Qishe Yan

A series of mussel-inspired pH-responsive self-healing hydrogels based on gelatin crosslinked by oxidized tannic acid (GLT-OTAs) were prepared and used as controlled drug delivery systems (CDDS). An antiphlogistic drug, indomethacin (IDMC) was used as model drug to be immobilized into the hydrogels. The obtained hydrogel samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). Mechanical stability, biocompatibility and self-healing property of the hydrogels were estimated, respectively. Swelling and drug release behaviors of these hydrogels were measured in phosphate buffered saline (PBS) with pH 7.4 (simulated intestinal fluid) and HCl solution with pH 1.2 (simulated gastric fluid) at 37 °C. Effect of the OTA content on the structures and characteristics of all samples was discussed. FTIR spectra revealed the covalent cross-linking between gelatin and OTA induced by Michael addition and Schiff base reaction. Both XRD and FTIR all showed the drug (IDMC) was loaded successfully and existed steadily. GLT-OTA hydrogels had satisfactory biocompatibility, superior self-healing. Results also illustrated that the mechanical strength, internal structure, the swelling and drug release behaviors of the GLT-OTAs hydrogel were greatly affected by the OTA content. With increasing the OTA content, the mechanical stability of GLT-OTAs hydrogel became better and better, and their internal structure became more and more compact. The swelling degree (SD) and cumulative drug release of all hydrogel samples tended to decrease with increasing OTA content and both had obvious pH responsiveness. For each hydrogel sample, the cumulative drug release in PBS at pH 7.4 was greater than that in HCl solution at pH 1.2. These results indicated that the obtained GLT-OTAs hydrogel had promising potential to be used as effective pH-responsive and self-healing drug delivery materials.

Enhanced electrochemical performance of ammonium vanadate (NH4V4O10) cathode for rechargeable aqueous zinc-ion batteries by altering pH regulators

Chao Lu,Zhi Yang,Yi Ding,Yujie Wang,Xiaolian Wang,Tao Li,Qiuyang Tan

Ammonium vanadate (NH 4 V 4 O 10 : NVO) as cathode for rechargeable aqueous zinc-ion batteries (AZIBs) have drawn extensive concern due to its high specific capacity and long cycle life. The controllable synthesis of high-performance NH 4 V 4 O 10 is greatly desirable for the development of AZIBs but still remains a significant challenge. In this work, sulfuric acid, hydrochloric acid, and nitric acid were used as pH regulators to prepare NVO via a simple one-step hydrothermal route. The resulting NVO product (NVO-1) based on sulfuric acid pH regulator has the optimal overall performance for its favorable structure stability originated from the high crystallinity and wonderful 3D cross-linked nanowire morphology, contributing to fast electron transfer in the (de)intercalation process of Zn 2+ . Consequently, NVO-1 electrode exhibits excellent rate capability and cyclic stability, delivering high reversible capacities of 418.9 and 257.1 mAh g −1 at current densities of 0.1 and 2 A g −1 , respectively, and demonstrating a discharge capacity of 105.7 mAh g −1 as well as superior long-term durability with an ultra-high capacity retention of 119.7 % at a large current density of 5 A g −1 after 2000 cycles. Investigation on the electrochemical kinetics reveals that surface capacitive behavior plays a significant role in the highly reversible Zn 2+ storage in NVO electrode.

Preparation and characterization of pH and thermally responsive perfluoropolyether acrylate copolymer micelles and investigation its drug-loading properties

Dezhong Xu,Ao Li,Weijie Lin,Qiuxia Zou,Shuai Wu,Ajoy Kanti Mondal,Wangchuan Xiao,Fang Huang

In this study, pH and thermally responsive P(PFPHM 9 - b -DMAEMA- b -PEGMEA 480 ) was prepared by atom transfer radical polymerization (ATRP) using perfluoropolyether hydroxyethyl methacrylate (PFPHM) as hydrophobic core, 2-(Dimethylamino) ethyl methacrylate as pH and thermal response function segment, and poly (ethylene glycol) methyl ether acrylate 480 as hydrophilic shell, respectively. The chemical structure, critical micelle concentration (CMC), lower critical solution temperature (LCST), biological toxicity, stability of micelles, drug-loading performance and cumulative drug release rate of prepared P(PFPHM 9 - b -DMAEMA- b -PEGMEA 480 ) were analyzed by 19 F NMR, 1 H NMR, FTIR, DLS, UV–Vis, laser confocal microscopy and fluorescence spectrophotometer. The results show that P(PFPHM 9 - b -DMAEMA- b -PEGMEA 480 ) exhibites a CMC of 7.5 g/L, LCST of 37.6°C and excellent micelle stability. Moreover, the analysis of drug-loading indicates that the polymer displayed drug loading efficiency (DL) is 21.3% and the encapsulation efficiency (EE) is 90.0%. Its cumulative drug release rates at pH = 6.5 (42°C) is almost double of those at pH = 7.4 (42°C), pH = 6.5 (37°C) and pH = 7.4 (37°C). These results suggeste that the P(PFPHM 9 - b -DMAEMA- b -PEGMEA 480 ) at pH ranging from 6.5 to 7.4 and temperature ranging from 37 to 42°C are pH and temperature sensitive. It has great potential application as a drug loading for DOX.

Simultaneous Detection of Temperature, Strain, Refractive Index, and pH Based on a Phase-Shifted Long-Period Fiber Grating

Ting Liu,Yaowei Li,Xinyi Dai,Wenbo Gan,Xunsi Wang,Shixun Dai,Baoan Song,Tiefeng Xu,Peiqing Zhang

Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su,Liya Xie,Zhenqing Hou

Nanomedicine hybrid and catechol functionalized chitosan as pH-responsive multi-function hydrogel to efficiently promote infection wound healing

Pingping Sun,Jingmiao Jiao,Xiaoyu Wang,Long Chen,Zhiyong Chen,Kun Zhang,Kai Qu,Xian Qin,Zailiang Yang,Julia Li Zhong,Wei Wu

The complicated wound repair process caused by microbial infection is still a clinical problem due to antibiotic resistance. Therefore it is necessary to employ the incorporating bioactive molecules in the dressing to solve this problem. Herein, a multifunctional nanocomposite hydrogel (CS-HCA-Icps) with the pathological pH-responsive drug release has been developed to promote the infection-impaired wound healing. CS-HCA-Icps nanocomposite hydrogel composed of catechol-grafted chitosan (CS-HCA) and a curcumin-Fe 3+ coordination nanoparticles (Icps, Cur-Fe 3+ ) exhibits the favorable activities in free radical scavenging, anti-bacterial and anti-inflammatory. The favorable biocompatibility is also demonstrated both in vitro and in vivo experiments. These demonstrate the promoting efficacy of hydrogel in wound healing. In this study, Chitosan (CS) shows excellent biocompatibility and antibacterial properties for tissue repair. After functional modification with HCA, the catechol groups are beneficial to improve antioxidant capacity for wound repair, Moreover, Icps nanomedicine are able to enhance the loaded Cur release in response to the pathological acidic microenvironment at the inflammatory stage of wounds. Thus, the pathological pH-responsive hydrogel integrating anti-bacterial, antioxidant, and anti-inflammatory functions may represent a promising strategy for safe and efficient wound healing, in particular for potential clinical use.

Fluorescent filter paper with pH-responsive carbon dots for the on-site detection of biogenic amines in food

Jianfeng Yan,Quanbin Fu,Shikai Zhang,Xianbao Shi,Yuanhong Zhang,Juying Hou,Junling Duan,Shiyun Ai

As a kind of organic basic compound containing nitrogen, biogenic amine is released from food spoilage and considered as an indicator for monitoring food freshness. Herein, an excellent dual-emission ratiometric fluorescent sensor for eight kinds of biogenic amines was established via the facile mixing of pH-responsive carbon dots and Rhodamine B. The developed sensor shows a rapid response (10 s), low limit of detection (0.733–3.943 μM) and a wide linear range (0–150 μM). More importantly, a portable fluorescent filter paper was prepared by simple dispersing the filter paper in a solution mixture of carbon dots and Rhodamine B. The obtained fluorescent filter paper based sensor showed an obvious color change in the presence of biogenic amine vapor derived from shrimp and mushroom. The results revealed that this sensor could realize the on-site and visual detection of biogenic amines in real food samples, making it suitable for potential application in food safety monitoring.

Well-Defined Shell-Sheddable Core-Crosslinked Micelles with pH and Oxidation Dual-Response for On-Demand Drug Delivery

Xinfeng Cheng,Qiyang Li,Xiaomeng Sun,Yuxin Ma,Huanping Xie,Weiguang Kong,Xianchao Du,Zhenghui Zhang,Dongfang Qiu,Yong Jin

Micellar-nanocarrier-based drug delivery systems possessing characteristics such as an excellent circulation stability, inhibited premature release and on-demand site-specific release are urgently needed for enhanced therapeutic efficacy. Therefore, a novel kind of shell-sheddable core-crosslinked polymeric micelles with pH and oxidation dual-triggered on-demand drug release behavior was facilely constructed. The multifunctional micelles were self-assembled from a carefully designed amphiphilic triblock PEGylated polyurethane (PEG-acetal-PUBr-acetal-PEG) employing an acid-labile acetal linker at the hydrophilic–hydrophobic interface and pendant reactive bromo-containing polyurethane (PU) as the hydrophobic block, followed by a post-crosslinking via oxidation-cleavable diselenide linkages. These well-defined micelles exhibited an enhanced structural stability against dilution, achieved through the incorporation of diselenide crosslinkers. As expected, they were found to possess dual pH- and oxidation-responsive dissociation behaviors when exposure to acid pH (~5.0) and 50 mM H2O2conditions, as evidenced using dynamic light-scattering (DLS) and atomic force microscopy (AFM) analyses. An in vitro drug release investigation showed that the drug indomethacin (IND) could be efficiently encapsulated in the micelles, which demonstrated an inhibited premature release compared to the non-crosslinked ones. It is noteworthy that the resulting micelles could efficiently release entrapped drugs at a fast rate in response to either pH or oxidation stimuli. Moreover, the release could be significantly accelerated in the presence of both acid pH and oxidation conditions, relative to a single stimulus, owing to the synergetic degradation of micelles through pH-induced dePEGylation and oxidation-triggered decrosslinking processes. The proposed shell-sheddable core-crosslinked micelles with a pH and oxidation dual-response could be potential candidates as drug carriers for on-demand drug delivery.Keywords:shell-sheddable;core-crosslinking;pH-responsive;oxidation-responsive;drug delivery

Preparation and application of high-brightness red carbon quantum dots for pH and oxidized L-glutathione dual response

Yuwei Du,Lei Cao,Xinlu Li,Tongtong Zhu,Ruhong Yan,Wen-Fei Dong,Li Li

Carbon dots (CDs) with red fluorescence emission are highly desirable for use in bioimaging and trace- substance detection, with potential applications in biotherapy, photothermal therapy, and tumor visualization. Most CDs emit green or blue fluorescence, thus limiting their applicability. We report a novel fluorescent detection platform based on high-brightness red fluorescence emission carbon dots (R-CDs) co-doped with nitrogen and bromine, which exhibit pH and oxidized L-glutathione (GSSG) dual-responsive characteristics. The absolute quantum yield of the R-CDs was as high as 11.93%. We discovered that the R-CDs were able to detect acidic pH in live cells and zebrafish owing to protonation and deprotonation. In addition, GSSG was detected in vitro over a broad linear range (8–200 μM) using the R-CDs with excitation-independent emission. Furthermore, cell imaging and bioimaging experiments demonstrated that the R-CDs were highly cytocompatible and could be used as fluorescent probes to target lysosomes and nucleolus. These studies highlight the promising prospects of R-CDs as biosensing tools for bioimaging and trace-substance detection applications.

Anisotropic Bi-Layer Hydrogel Actuator with pH-Responsive Color-Changing and Photothermal-Responsive Shape-Changing Bi-Functional Synergy

Chao Ma,Shuyi Peng,Lian Chen,Xingyu Cao,Ye Sun,Lin Chen,Lang Yang,Chunming Ma,Qijie Liu,Zhenzhong Liu,Shaohua Jiang

Stimuli-responsive color-changing and shape-changing hydrogels are promising intelligent materials for visual detections and bio-inspired actuations, respectively. However, it is still an early stage to integrate the color-changing performance and shape-changing performance together to provide bi-functional synergistic biomimetic devices, which are difficult to design but will greatly expand further applications of intelligent hydrogels. Herein, we present an anisotropic bi-layer hydrogel by combining a pH-responsive rhodamine-B (RhB)-functionalized fluorescent hydrogel layer and a photothermal-responsive shape-changing melanin-added poly (N-isopropylacrylamide) (PNIPAM) hydrogel layer with fluorescent color-changing and shape-changing bi-functional synergy. This bi-layer hydrogel can obtain fast and complex actuations under irradiation with 808 nm near-infrared (NIR) light due to both the melanin-composited PNIPAM hydrogel with high efficiency of photothermal conversion and the anisotropic structure of this bi-hydrogel. Furthermore, the RhB-functionalized fluorescent hydrogel layer can provide rapid pH-responsive fluorescent color change, which can be integrated with NIR-responsive shape change to achieve bi-functional synergy. As a result, this bi-layer hydrogel can be designed using various biomimetic devices, which can show the actuating process in the dark for real-time tracking and even mimetic starfish to synchronously change both the color and shape. This work provides a new bi-layer hydrogel biomimetic actuator with color-changing and shape-changing bi-functional synergy, which will inspire new strategies for other intelligent composite materials and high-level biomimetic devices.

pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity

Jie Zhang,Liwen Wei,Xiaocao Ma,Jingguo Wang,Siping Liang,Kang Chen,Minhao Wu,Li Niu,Yuanqing Zhang

Metabolic dysregulation contributes not only to cancer development but also to a tumor immune microenvironment (TIME), which poses great challenges to chemo- and immunotherapy. Targeting metabolic reprogramming has recently emerged as a promising strategy for cancer treatment, but the lethality against solid tumors appears to be fairly restricted, partially due to the poor solubility of small molecule drugs. Herein, we construct a versatile biomimetic nanoplatform (referred to as HM-BPT) employing pH-sensitive tumor-tropism hybrid membrane-coated Manganese oxide (MnO 2 ) nanoparticles for the delivery of BPTES, a glutamine metabolism inhibitor. Basically, hybrid membranes consisting of mesenchymal stem cell membranes (MSCm) and pH-sensitive liposomes (pSL) enable the biomimetic nanoplatform to target TME and escape from endo/lysosomes after endocytosis . The results reveal that HM-BPT treatment leads to remarkable tumor inhibition, cytotoxic T lymphocyte (CTL) infiltration , as well as M1 phenotype repolarization and stimulator of IFN genes (STING) pathway activation in macrophages in a 4T1 xenograft model. Furthermore, glutathione (GSH) depletion and oxygen (O 2 ) supply synergistically ameliorate the immunosuppressive status of the TME, boosting potent antitumor immune responses. Overall, our study explores an integrated therapeutic platform for TME reprogramming and immune activation, offering tremendous promise for cancer combination therapy. Statement of significance Metabolic abnormalities and the tumor immune microenvironment (TIME) lead to hyporesponsiveness to conventional therapies, ultimately resulting in refractory malignancies. In the current work, a biomimetic nanoplatform (HM-BPT) was developed for TME metabolic reprogramming in favor of immunotherapy. Particularly, hybrid membrane camouflage endowed the nanoplatform with TME targeting, endo/lysosomal escape, and sensitive release properties. The impact of hybrid membrane fusion ratio on cellular uptake and cell viability was explored, yielding beneficial references for the future development of bioactive nanomaterials . Intravenous administration of HM-BPT substantially relieved tumor burden and restored innate and acquired immune activation in 4T1 xenograft models. In conclusion, the created HM-BPT system has the potential to be a promising nanoplatform for combining cancer therapies.