International Journal of Pharmaceutics-X
·
2025
·
IF 6.4
Yanan Liu,Guixue Chen,Maojian Li,Man Li,Daoxuan Xie,Zheng Luo
Patients with amyotrophic lateral sclerosis (ALS) often experience difficulty swallowing, making oral administration unsuitable for effective treatment. A transdermal drug delivery system (TDDS) offers a long-acting, non-invasive alternative for ALS therapy. In this study, a riluzole transdermal patch capable of sustained release over 72 h was developed. In vitro skin permeation and pharmacokinetic experiments were conducted to evaluate the impact of various factors—including drug loading, type and concentration of chemical penetration enhancers (CPEs), and type of pressure-sensitive adhesive—on riluzole absorption through the skin. The optimized patch formulation contained 17 % ( w /w) riluzole and 10 % (w/w) polyglyceryl-3 dioleate (PGD), with an adhesive layer thickness of 111 μm. The final prescription penetration rate of riluzole was found to be 2.96 μg/(h·cm 2 ). Optimized formulation displayed enhanced stability and prolonged pharmacokinetic performance ( C max = 74.34 ± 13.62 ng/mL, MRT 0- t = 34.91 ± 11.31 h). No significant skin irritation was observed. The role of PGD in the in vitro release and in vivo transdermal absorption of riluzole was thoroughly investigated. The results revealed that PGD not only reduced the interaction between riluzole and the pressure-sensitive adhesive, enhancing drug release but also increased the fluidity of skin lipids, leading to improved transdermal absorption. This study provides a comprehensive molecular-level understanding of PGD's effect on riluzole permeation, offering valuable insights for the rational selection of CPEs in the development of riluzole TDDS.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Guoqiang Zhao,Wenjing Chen,Rongrong Zhang,Rui Zhang,Bo Jiang,Ruyan Hou,Xing Huang
Cypermethrin, a common pyrethroid insecticide, raises significant ecological concerns due to its widespread use. In this study, a highly efficient cypermethrin-degrading strain, Rhodococcus sp. H-3, was isolated. The strain was capable of degrading 30 mg/L cypermethrin at the rate of 83.48 % within 7 days and it could hydrolyze cypermethrin into 3-phenoxybenzoic acid (3-PBA) and permethric acid (DCVA). A novel cypermethrin degradation gene, cymE1 , was identified in strain H-3 through genome analysis, and its highest level of amino acid sequence similarity observed was 33.50 % in the Swiss-Prot database. The functional strain, SCK6-E, which could secrete CymE1, was successfully constructed by using double-exchange strategies. Strain SCK6-E could be applied for the removal of cypermethrin residues from tea plant leaves with a removal rate of 57.83 % within 2 h. Furthermore, strain H-3 demonstrated the capability to remediate cypermethrin-contaminated soil, exhibiting a degradation rate of 65.80 % over 10 days. The results of the 16S rRNA high-throughput sequencing indicated that strain H-3 was conducive to the restoration of the diversity and richness of the bacterial community in the soil. This study provides novel strain and gene resources for researching the degradation mechanism of pyrethroids, and offers valuable insights for developing effective pesticide residue remediation strategies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2022
·Vol. 35
·期 8
·2209002
·
IF 32.086
Jibin Zhang,Tiankai Zhang,Zhuangzhuang Ma,Fanglong Yuan,Xin Zhou,Heyong Wang,Zhe Liu,Jian Qing,Hongting Chen,Xinjian Li,Shijian Su,Jianing Xie,Zhifeng Shi,Lintao Hou,Chongxin Shan
Pure-red perovskite LEDs (PeLEDs) based on CsPb(Br/I) 3 nanocrystals (NCs) usually suffer from a compromise in emission efficiency and spectral stability on account of the surface halide vacancies-induced nonradiative recombination loss, halide phase segregation, and self-doping effect. Herein, a “halide-equivalent” anion of benzenesulfonate (BS – ) is introduced into CsPb(Br/I) 3 NCs as multifunctional additive to simultaneously address the above challenging issues. Joint experiment-theory characterizations reveal that the BS – can not only passivate the uncoordinated Pb 2+ -related defects at the surface of NCs, but also increase the formation energy of halide vacancies. Moreover, because of the strong electron-withdrawing property of sulfonate group, electrons are expected to transfer from the CsPb(Br/I) 3 NC to BS – for reducing the self-doping effect and altering the n-type behavior of CsPb(Br/I) 3 NCs to near ambipolarity. Eventually, synergistic boost in device performance is achieved for pure-red PeLEDs with CIE coordinates of (0.70, 0.30) and a champion external quantum efficiency of 23.5%, which is one of the best value among the ever-reported red PeLEDs approaching to the Rec. 2020 red primary color. Moreover, the BS – -modified PeLED exhibits negligible wavelength shift under different operating voltages. This strategy paves an efficient way for improving the efficiency and stability of pure-red PeLEDs.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 25
·13308-13316
·
IF 7.443
Bin Yang,Lei Yu,Huijun Yan,Yanbo Sun,Qi Liu,Jingyuan Liu,Dalei Song,Songxia Hu,Yi Yuan,Lianhe Liu,Jun Wang
Pseudocapacitor electrode materials, such as transition metal oxides/sulfides, have been extensively investigated and shown to have fast energy storage properties, but their low rate performance and poor cycle stability are serious problems in practical applications. We present here a design for the architecture of these electrode materials with the aim of improving the rate performance and cycle stability of pseudocapacitors by using an interface ion-exchange method. Precursor materials obtained by a hydrothermal reaction were soaked in aqueous NaHS solution to synthesize the urchin-like core–shell structure of NiCo2(CO3)1.5(OH)3@NiCo2S4. Such core–shell nanostructure electrode materials can make full use of both components with synergistic effects. Excellent results were obtained with a capacitance of 956.4 F g−1 at a current density of 4 A g−1 in the three-electrode system and an actual energy density of 32.3 W h kg−1 and power density of 1835 W kg−1 in the asymmetrical supercapacitor.
✓ 已验证
DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2019
·
IF 1.873
Zhihua Chai,Lixiao Ma,Ruiting Meng,Shan Liu,Yanxia Wang
Gold nanoparticles (AuNPs) were prepared by a solvothermal method using sodium alginate (SA) as both, the reductant and stabilizer . The formation of SA-AuNPs was confirmed by UV–Vis spectroscopy, transmission electron microscopy , X-ray diffractometry, and X-ray photoelectron spectroscopy . SA-AuNPs were functionalized with fluorescent 3-(dansylamino)phenylboronic acid (DAPB) moieties, through interactions between boronic acids and diol groups. The fluorescence resonance energy transfer from DAPB to AuNPs quenched the fluorescence of DAPB. In the presence of glucose, the competitive binding of DAPB with glucose resulted in the release of assembled DAPB from the surface of SA-AuNPs, resulting in the increase in fluorescence intensity . Furthermore, catalytic reduction of 4-nitrophenol was monitored via spectrophotometry using DAPB functionalized SA-AuNPs probes as catalyst. Compared to SA-AuNPs, the nanoprobes exhibited higher catalytic rates.
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Hongrui Jia,Weitong Zhu,Shuai Yang,Fei Li,Linghang Wang
<001> oriented x Bi(Mg 1/2 Ti 1/2 )O 3 -(0.7- x )Pb(Mg 1/3 Nb 2/3 )O 3 -0.3PbTiO 3 (BMT-PMN-PT) textured ceramics are successfully fabricated by the template grain growth method using BaTiO 3 platelets as template. BMT-PMN-PT textured ceramics with different BMT contents are studied in terms of crystal structure, microstructures, dielectric and ferroelectric properties, and electric field induced strain. The as-fabricated BMT-PMN-PT textured ceramics were found to have a strong orientation along <001> direction. The frequency dispersion of dielectric constant of BMT-PMN-PT textured ceramics increases gradually and its relaxability becomes stronger with increasing BMT content. A large electric-field induced strain (0.42 % at 4 kV/mm) is obtained in 0.25BMT-0.45PMN-0.3PT textured ceramics with Lotgering factor 0.94, which is about 83 % enhancement than that of the randomly oriented ceramics (0.23 % at 4 kV/mm). The strain of 0.25BMT-0.45PMN-0.3PT textured ceramics have a relatively high thermal stability, with a slight decrease from 0.42 % to 0.28 % in the temperature range of 20−100 °C. Our research suggests that 0.25BMT-0.45PMN-0.3PT textured ceramics have a greatly potential for actuator devices applications owing to its advantages of large electric field induced strain response.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 24
·28077-28087
·
IF 2.478
Zhao Jiaqi,Hu Chen,Lu Jingyao,Sun Ruyi,Wang Zhen,Yin Yanzhen,Liu Wenlong,Gu Chengcheng,Li Zichao,Zhong Degao,Teng Bing
A series of single-phase white-emitting phosphors Ba 3 Bi(PO 4 ) 3 (BBP):8 at.% Dy, x at.% Eu were successfully synthesized through high temperature solid-phase method. The luminescence properties of BBP:8 at.% Dy, x at.% Eu were systematically investigated. Experimental results indicate the doping of Eu 3+ ions can effectively compensate the red light component in the emission spectrum and tune the correlated color temperature of BBP:8 at.% Dy, x at.% Eu from cool white light (5097 K) to warm white light (3661 K). Moreover, BBP:8 at.% Dy 3+ , 0.8 at.% Eu 3+ phosphor exhibits excellent thermal stability and the fluorescence intensity at 150 °C can still maintain 76% of that at 25 °C, while the activation energy is determined to be ~ 0.23 eV. In addition, the quantum efficiency of BBP:8 at.% Dy 3+ , 0.8 at.% Eu 3+ phosphor were measured to be 61%. These results suggest that BBP:8 at.% Dy 3+ , 0.8 at.% Eu 3+ can be a NUV-pumped single-phase white phosphors with excellent comprehensive performances.
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 14
·2000144
·
IF 2.335
Guangfa Shi,Xiaomin Cai,Wenqiang Wang,Gengchao Wang
Polymeric positive temperature coefficient (PTC) materials can be used to install “brake” technology for the thermal runaway of lithium-ion batteries. However, it still has poor cycle stability and obvious negative temperature coefficient (NTC) effect, which reduces the reliability of the material. In order to solve these problems, conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) modified multilayer graphene (MLG) conductive additive (PEDOT-MLG) is introduced into middle density polyethylene/carbon black (MDPE/CB) system. Compared with the conventional modification, the PEDOT modified MLG shows high conductivity and excellent thermal stability. In addition, the introduction of PEDOT-MLG into MDPE/CB can further reduce the room temperature resistivity due to the good compatibility between the modified graphene and the matrix, thus improving the PTC intensity to 7.1. What is more, MLG limits the re-aggregation of CB particles when the temperature further rises, which effectively weakens the NTC effect.
研究领域:
高分子材料科学
·
功能材料
·
能源材料
·
纳米复合材料
·
电学性能
·
锂离子电池安全
✓ 已验证
DOI
高影响因子
Bioengineered
·
2022
·
IF 6.832
Meng-Hui Zhang,Jun Liu
Liver hepatocellular carcinoma (LIHC) is the most common type, comprising 75–85% of all liver malignancies. We investigated the roles of cleavage stimulation factor 2 (CSTF2) in LIHC and explored the underlying mechanisms. CSTF2 expression and its association with LIHC patient survival probability were analyzed with The Cancer Genome Atlas. CSTF2 expression in LIHC cells was assessed using western blot and quantitative real-time PCR. Alterations in CSTF2 expression were induced by cell transfection. Cell colony formation, apoptosis, proliferation, invasion, and migration were assessed using colony formation, flow cytometry, 5-ethynyl-2ʹ-deoxyuridine, and transwell assays. Pathway enrichment analysis was performed using gene set enrichment analysis (GSEA). The expression of apoptosis-, metastasis-, and pathway-associated factors was determined via western blot. The pathway rescue assay was further performed using 740Y-P or Wortmannin. CSTF2 upregulation was observed in LIHC tissues and cells. Patients with high CSTF2 expression had a lower probability of overall survival. CSTF2 overexpression enhanced colony formation, proliferation, invasion and migration, while repressing apoptosis in LIHC cells. GSEA revealed that CSTF2 was mainly enriched in the phosphatidylinositol 3′-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. Western blot analysis proved that CSTF2 overexpression activated this pathway. CSTF2 knockdown yielded the opposite effects. 740Y-P, a PI3K activator, reversed the CSTF2 knockdown-triggered effects on cell proliferation, apoptosis, invasion, and migration. Moreover, Wortmannin, a PI3K inhibitor, also reversed the CSTF2 overexpression-induced effects on cell proliferation, apoptosis, invasion, and migration. These results indicated that CSTF2 overexpression might exacerbate the malignant phenotypes of LIHC cells via activation of PI3K/AKT/mTOR pathway.
✓ 已验证
DOI
PubMed
高影响因子
Laser & Photonics Reviews
·
2026
·
IF 9.7
Dawei Wen,Haoyuan Weng,Bin Xiao,Pan Wang,Ruijing Fu,Zhiwei Ma,Qingguang Zeng,Guanjun Xiao
Luminescence pressure sensors, valued for their remote sensing capability and high resolution, have been developed recently. However, most current sensors rely on a linear relationship between an optical property and pressure. We propose a nonlinear machine learning (ML) method to model the luminescence intensity ratio (LIR) as a function of pressure. The versatility and performance of this method are demonstrated using (Y,Gd)(Al,Ga) 3 (BO 3 ) 4 :Cr 3+ phosphors as luminescent pressure sensors. The relative sensitivities of the 2 E → 4 A 2 / 4 T 2 → 4 A 2 LIRs in (Y,Gd)(Al,Ga) 3 (BO 3 ) 4 :Cr 3+ range from 1.58%/GPa to 25.27%/GPa. The ML fitting demonstrates a superior performance compared to linear fitting, with lower mean absolute errors (0.0355–0.1499 GPa vs. 0.1209–0.6955 GPa) and higher R 2 values (99.70–99.98% vs. 93.69–99.79%). The ML fitting method is more suitable for modeling the nonlinear relationships between LIR and pressure than traditional linear fitting. The nonlinear ML fitting approach offers a powerful new way to model the relationships between luminescence features and various physical parameters.
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2026
·
IF 3.5
Shichun Weng,Jinyao Hu,Wei Feng,Xiaoqiao Zhao,Zichao Guo,Liping Chen,Wanghua Chen,Xuedong Gong
3,4-Bis(4-nitrofurazan-3-yl)furoxan (DNTF) is a high-performance hydrogen-free explosive, its conventional route exhibits that the reaction mechanisms remain ambiguous, high thermal risk and the yield is relatively low. This work clarifies the oxidation/sulfonation mechanism, identifies the cause of oxidant loss, and develops an efficient and safe synthesis. First, the key intermediate 3-(4-aminofurazan-3-yl)-4-(nitrofurazan-3-yl)furoxan (ANTF) and the by-product 3-(4-aminofurazan-3-yl)-4-(amino sulfonic acid furazan-3-yl)furoxan (SNFF) were detected by HPLC-MS technique, it was also discovered and verified that SNFF can catalyze the decomposition of Caro’s acid, causing oxidant collapse by catalytically cleaving the O–O bond of peroxymonosulfuric acid, releasing O2. Besides, density functional theory (DFT) calculation results show that oxidation reaction initiates at the amino group distal to the furoxan oxygen, with the second nitro conversion as the highest-energy step. Furthermore, it is proposed that a sulfonation reaction occurs between 3,4-bis(4-aminofurazan-3-yl)furoxan (DATF) and sulfur trioxide, followed by oxidation to generate SNFF. Notably, reaction calorimetry results showed that the oxidation process still carries a significant risk of a thermal runaway, where both excessively quick and slow feeding rates influence the yield of the oxidation process and enhanced reaction temperature and concentration of Caro’s acid indeed increase the oxidation capacity while suppressing sulfonation side reaction. By considering the balance of thermal risk and optimal process parameters, the DNTF yield could reach 75% with >99% purity.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Weijie Wang,Xiufan Wu,Fan Cao,La Li,Xuqin Guo,Hongyang Zhao,Mengru Li,Hongrui Liu,Ying Chen
Lung cancer represents a major global health challenge, and the development of new therapeutic agents remains a serious task. This study designed and synthesized 27 novel coumarin-furoxan hybrids. Among them, compound 6o exhibited potent nanomolar-level antiproliferative activity against six nonsmall cell lung cancer (NSCLC) cell lines, including both wild-type and drug-resistant models. Mechanistic investigations revealed that 6o downregulates the expression of ferroptosis-related factors SLC7A11 and GPX4, thereby disrupting redox homeostasis, depleting glutathione, and accumulating lipid peroxides, which collectively trigger ferroptosis. Furthermore, 6o elevated mitochondrial nitric oxide (NO) and reactive oxygen species (ROS) levels, exacerbating cellular damage. 6o also displayed low hERG channel toxicity, favorable in vivo safety, and acceptable solubility. In summary, 6o demonstrates high efficacy against both wild-type and drug-resistant NSCLC cells via a ferroptosis-mediated mechanism, along with a promising safety profile, supporting its potential as a candidate for further development.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）