Journal of Neuroinflammation
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2025
·Vol. 22
·期 1
·268
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IF 10.1
Li Shumei,Wang Lei,Luo Qiqi,Fan Maiying,Xu Yixiao,Liu Xiehong,Zhang Yiyuan,Zou Lianhong
IntroductionCardiac arrest (CA) is a life-threatening emergency with a global one-year survival rate of 2%-10%. Brain injury significantly impacts CA outcomes, and neuroinflammation is a key mediator of cerebral damage. Interleukin-17 (IL-17) has been implicated in multiple inflammatory disorders, yet its contribution to CA-induced cerebral damage remains undefined.ObjectiveTo elucidate the role of the IL-17 axis in CA-triggered neuroinflammation and to determine whether IL-17 blockade can attenuate hippocampal injury and improve neurologic recovery.Methods Asphyxial CA was induced in adult Sprague-Dawley rats followed by cardiopulmonary resuscitation. Blood–brain barrier (BBB) integrity, Th17 infiltration, astrocyte polarization, and downstream signaling were assessed by flow cytometry, RNA-seq, qRT-PCR, ELISA, immunofluorescence, and western blotting. IL-17 A or IL-17RA was neutralized in vivo with specific antibodies, and human SVGP12 astrocytes were employed for mechanistic validation.Results CA promotes Th17 cell differentiation and enhances blood-brain barrier (BBB) permeability, facilitating the infiltration of Th17 cells and their secreted IL-17 A/F into the hippocampus. IL-17 A/F specifically binds to IL-17RA/RC on astrocytes, activating NF-κB, and MAPK pathways, which drive A1 polarization of astrocytes and exacerbate neuroinflammation. IL-17 A neutralization reverses A1 polarization of astrocytes, reduces neuronal apoptosis, improves 24-hour neurologic deficit scores, and enhances survival in CA rats. In vitro, IL-17 A induced A1 polarization and inflammatory cytokine release in astrocytes, effects abolished by IL-17RA blockade.Conclusion Our study elucidates the mechanisms underlying CA-induced neuroinflammation and identifies the IL-17 A pathway as a potential therapeutic target for mitigating neurological injury following cardiac arrest.
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Nature Communications
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2025
·Vol. 16
·期 1
·10319
·
IF 15.7
Yuan Bo-Jun,Xu Si-Min,Liu Xiang,Li An-Zhen,Wang Xi,Shi Qiujin,Li Ruo-Pu,Zhang Chunyu,Zhao Xikang,Zheng Jinyu,Li Bi-Jie,Duan Haohong
Electrically-powered synthesis provides a sustainable approach for propylene oxidation to propylene oxide and propylene glycol in aqueous medium using water as the oxygen source, which can substitute conventional energy-intensive process that relies on hazardous oxidants. However, current electrosynthesis is suffering from expensive catalysts, low current density and Faradaic efficiency. Herein, guided by accidental finding of Ag + showing activity for propylene electrooxidation to propylene glycol and following mechanistic understanding, we report 1,2,3-triazole-chelated Ag catalyst with improved current density (15.8 mA/cm 2 ) and Faradaic efficiency (62.5%), comparable with heterogeneous Pt and Pd catalysts using 30-fold less expensive metal. We experimentally and theoretically demonstrate that triazole coordination modulates the oxidative ability of the in-situ formed Ag-oxo species, suppressing overoxidation and oxygen evolution. Furthermore, by employing a high-pressure electrolyzer, we strengthen propylene mass transfer and attain an enhanced current density of 61.1 mA/cm 2 with Faradaic efficiency of 73.4%. By circulating electro-deposition/dissolution of Ag, the catalyst shows reusability in 10 cycles. This work demonstrates the potential of using cost-effective homogeneous catalyst for propylene electrooxidation.
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Nature Communications
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2025
·
IF 15.7
Li Hangren,Tu Jie,Du Siyuan,Xi Guoqiang,Liu Chen,Fang Yue-Wen,Xu Shuai,Zhang Jia-Han,Sun Enqi,Ouyang Shunli,Liu Xudong,Shi Longyuan,Liu Xiuqiao,Zheng Dongxing,Guo Lei,Zhang Xixiang,Jin Kuijuan,Tian Jianjun,Zhang Linxing,Xing Xianran
Developing an efficient and non-destructive stripping method suitable for most fragile freestanding films is essential for developing industrial semiconductor integration and flexible devices. Here, we propose a rapid stripping process of directional electrodynamic decomposition based on the conductive LaNiO 3 sacrificial layer, which can effectively overcome the surface tension during solution penetration. Notably, the release rate of oxide films can be increased to 600 mm 2 /min, which is two orders of magnitude more than that of traditional soaking method, ascribed to the improvement of the adsorption energy and electron transfer by the electric field. The electrodynamic stripping efficiency is not limited by thickness and area size of sacrificial layers and enables non-destructive and scalable fabrication of freestanding films. The crack-free 3-inch freestanding PbZrO 3 epitaxial membrane represents the largest ferroelectric-based membrane achieved to date, which enables its direct integration into flexible piezoelectric sensor array. Intriguingly, a record-breaking 12-inch polycrystalline membrane has been developed to address the requirements of industrial-scale semiconductor manufacturing. The strain-relaxed PbZrO 3 membranes exhibit the hysteresis loop of the antiferroelectric transition to ferroelectric. This electrodynamic approach with conductive sacrificial layer will greatly improve the stripping efficiency of high-quality functional freestanding membranes, thereby promoting their application in wafer-level electronic devices.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10338
·
IF 15.7
Wang Tao,Yang Guo,Cui Mingjin,Xia Huitang,Jiang Chenlu,Xia Yuheng,Chen Ke,Yang Menghao,Bae Jiwoong,Gu Cheng,Ding Yu
Self-charging batteries, which integrate energy conversion and storage within a single system, represent a promising technology for building a reliable and intelligent energy network. However, the charging rate of conventional self-charging energy systems that use solid-state electrodes is limited by slow solid-gas reaction processes at the electrode-air interface. A complete charging procedure typically requires several hours. Here we show a self-charging organic redox flow battery to address the limitations of solid-state reaction kinetics. A high charging rate is achieved, with 94% of the total capacity reached within 8 minutes, owing to the rapid kinetics of liquid-phase redox reactions. Using manganese oxide-based catalysts to reduce side reactions, the flow battery exhibits nearly 99.98% capacity retention over 1,600 cycles. Even in a harsh environment of -10 °C, the battery can run more than 2,500 cycles at a current density of 20 mA cm -2 . The redox chemistry underlying the self-charging mechanism is investigated through computational modeling and in situ characterization, revealing that fast outer-sphere electron transfer during the enolization reaction contributes significantly to the reaction kinetics. In the proof-of-concept demonstration, we further extend the system from zinc to magnesium and aluminum as the negative electrodes, demonstrating a potential pathway for constructing sustainable energy systems.
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Nature Communications
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2025
·Vol. 16
·期 1
·10186
·
IF 15.7
Tian Kaige,Chen Sai,Sun Guodong,Sun Jiachen,Wang Xianhui,Cai Jianhua,Wang Zhiyuan,Fu Donglong,Zhao Zhi-Jian,Pei Chunlei,Gong Jinlong
The integration of CO 2 into the dehydrogenation of propane (PDH) holds significant promise for both propylene production and greenhouse gas utilization. However, a pivotal challenge lies in mitigating the undesirable dry reforming of propane (DRP), which diminishes propylene selectivity compared to direct PDH processes. Herein, we describe a coupled process that integrates PDH with reverse water gas shift (RWGS) using a tandem catalytic system. The PtSn/Al 2 O 3 analogue performs the dehydrogenation reaction, while an adjacent defective CeO x /Al 2 O 3 at nanoscale acts as the hydrogenation sites for CO 2 . Catalysis and kinetic studies demonstrate the in-situ removal of hydrogen from PtSn/Al 2 O 3 to adjacent CeO x /Al 2 O 3 , facilitated by CO 2 , shifts the quasi-equilibrium of PDH towards propylene production, while suppressing the competitive DRP side reaction. This hydrogen spillover-mediated coupling mechanism enables superior propylene selectivity of ~98.8%, along with high CO 2 (~43.9%) and propane conversion (~44.2%) at 550 °C, outperforming direct PDH (~40.6%). Analysis of CO 2 footprint indicates the PDH-RWGS tandem process has the potential for carbon utilization to mitigate detrimental CO 2 emissions.
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Scientific Reports
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2025
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IF 3.9
Song Lingyong,Li Weize,Hu Zhizhong,Lv Yangbo,Liu Jincang,Cheng Feng,Xu Chunping
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of novel antimicrobial strategies. This study developed and optimized thymol-loaded nanoemulsions (TNE) as a standardized, reproducible alternative to variable essential oil formulations using central composite design. The optimal formulation comprised 4.6% oil phase, 18.5% surfactant, and 2.5:1 surfactant-to-cosurfactant ratio, yielding nanoemulsions with particle size of 25.51 ± 0.15 nm, polydispersity index (PDI) of 0.114 ± 0.008, and zeta potential of − 2.73 ± 0.12 mV. TNE demonstrated consistent antimicrobial activity with MIC values of 15 mg/mL against MRSA and other bacterial strains. Comprehensive mechanistic studies using five complementary assays revealed that TNE exerts antimicrobial effects through multiple membrane-targeting pathways, including membrane permeabilization, depolarization, hydrophobicity alteration, and rigidity modulation. The multi-target mechanism suggests reduced likelihood of resistance development compared to conventional single-target antibiotics. These findings demonstrate that systematically optimized thymol nanoemulsions represent a promising standardized platform for combating multidrug-resistant infections, offering enhanced stability, controlled release characteristics, and reduced resistance potential.
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IONICS
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2025
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IF 2.6
Ding Zhengyu,You Maoyu,Xin Binjie,Newton Amin
Supercapacitors require electrode materials that integrate high specific capacitance, and efficient ionic transport. Herein, a novel MXene/short carbon nanofiber@polyaniline (MSCPM) hybrid membrane was synthesized via chemical oxidative polymerization and vacuum-assisted filtration. By optimizing the mass ratio of MXene to short carbon nanofiber@polyaniline (SCNF@PANI), a three-dimensional hierarchical architecture was achieved, where MXene nanosheets interlocked with PANI-coated CNFs to form covalent interface bonds. This design leverages the metallic conductivity of MXenes for rapid electron transport, CNFs’ mechanical rigidity of CNFs to maintain structural integrity, and PANI’s pseudo-capacitance of PANI for enhanced energy storage. The hybrid membrane exhibited exceptional electrochemical performance, achieving a specific capacitance of 601.8 F g − 1 at 5 mV s − 1 , surpassing most reported MXene-based materials. Notably, the composite retained 81.5% of its capacitance after 10,000 cycles, demonstrating remarkable cycling stability. The synergistic integration of hydrophilic MXenes, porous CNFs, and polar PANI functionalities ensures efficient electrolyte infiltration and ion diffusion. Simultaneously, the covalent interface bonds enhance the charge transfer efficiency and structural integrity. This work establishes a scalable strategy for high-performance supercapacitor electrodes, advancing the integration of MXenes with carbon nanomaterials and conductive polymers. These design principles provide new insights into interfacial engineering for multifunctional energy storage applications, particularly in high-temperature devices.
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MICROCHIMICA ACTA
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2025
·Vol. 192
·期 12
·820
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IF 5.3
Quang Phan Quang Huy,Khoa Huynh Anh,Nguyen Hoang Cao,Trung Nguyen Tran Nhat,Minh Dang Thanh Cong,Nhung Tran Nguyen Cam,Khoa Tran Dang,Nghia Nguyen Ngoc,Ha Huynh Ky Phuong,Hieu Nguyen Huu
To enable rapid, on-site monitoring of amoxicillin and ensure controlled administration, we have developed a paper-based analytical device (PAD) incorporating a molecularly imprinted polymer (MIP) anchored on graphitic carbon nitride (g-C₃N₄) nanosheets. The MIP@g-C₃N₄ composite was synthesized via in situ polymerization of 3-aminopropyl triethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) around amoxicillin templates on g-C₃N₄, yielding highly specific binding cavities upon template removal. The g-C₃N₄ nanozyme’s intrinsic peroxidase-like activity catalyzes the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to its blue oxidized form (oxTMB) in the presence of hydrogen peroxide. In the absence of amoxicillin, a vivid blue signal develops, whereas competitive binding of amoxicillin at the MIP sites inhibits nanozyme activity, causing a proportional decrease in color intensity. Analytical characterization demonstrated a linear response over 0–100 µM amoxicillin, with a limit of detection (LOD) of 0.97 µM. The integration with the PAD format permits semi-quantitative visual readout and quantitative determination via a portable smartphone, all within minutes and without the need for complex instrumentation. When applied to spiked milk and tap water, the MIP@g-C₃N₄ sensor achieved recoveries of 92–105% with negligible interference from structurally related antibiotics. The marriage of MIP selectivity, g-C₃N₄ nanozyme catalysis, and low-cost PAD architecture delivers a user-friendly, field-deployable platform for rapid amoxicillin screening, promising significant potential to bolster antibiotic stewardship and mitigate overdose-related health risks across clinical, environmental, and food-safety applications. Graphical
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CELLULOSE
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2025
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IF 4.8
Li Min,Shi Xuehui,Tao Furong,Ji Hairui,Ji Xingxiang,Tian Zhongjian,Chen Jiachuan
The flammability of most decorative paper poses a potential fire hazard to buildings. In this study, softwood fibers were modified with phytic acid and urea to obtain phytic acid esterified cellulose (PAEC) with good flame-retardant properties. Due to the introduction of phosphorus and nitrogen elements in PAEC, the heat release rate (HRR) and total heat release (THR) decreased from 170.9 W/g and 7.6 kJ/g to 104.3 W/g and 4.9 kJ/g, respectively, when compared with raw fibers. Subsequently, PAEC was composited with talc powder, carboxylated nanofibers, and calcium ions to prepare flame retardant paper. The results indicated that the HRR of the 170.9 W/g of the paper was decreased to 47.0 W/g. The network structure formed by the cross-linking between carboxyl groups in nanofibers and Ca 2⁺ enhanced the paper’s mechanical properties. The strength reached 12.18 MPa, which was 1.4 times as high as that of raw paper. Therefore, the prepared flame-retardant paper is expected to provide a candidate for the preparation of decorative paper. Graphical abstract
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Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1349
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IF 7.5
Zhu Ganggui,Li Qiaxuan,Yao Qifeng,Zhao Jin,Ding Shuo,Mai Shixiong,Yue Bingqin,Chen Jingyu,Huang Man
Background Lung ischemia-reperfusion injury (LIRI) is associated with a variety of postoperative complications and affects patient prognosis. β-Nicotinamide mononucleotide (NMN) has attracted much attention due to its potential role in cellular energy metabolism and antioxidant properties. Exploring the mitigating role of NMN in ischemia-reperfusion injury after lung transplantation is crucial for improving lung transplantation success and patient quality of life. Methods A LIRI model was established using the mouse left lung portal clamp method, and the cold ischemia-reperfusion (CI/R) model with BEAS-2B cells in vitro was used to simulate the lung transplantation environment. The protective effect of NMN against lung ischemia-reperfusion injury was analyzed by histopathology, ELISA, immunofluorescence, Western blot and RT-PCR. Combined multi-omics profiling were used to study the mechanisms by which NMN attenuated lung ischemia-reperfusion injury. Results NMN significantly attenuated ischemia-reperfusion-induced structural abnormalities, pulmonary edema, inflammatory infiltration and oxidative stress injury in mouse lung tissue. Similarly, NMN attenuated CI/R-induced oxidative stress and inflammatory responses in BEAS-2B cells. Based on multi-omics analysis, we found that NMN ameliorated the apoptosis after ischemia/reperfusion through down-regulation of cleaved Caspase 3, BAX and up-regulation of BCL-2. Moreover, NMN also affected mitochondrial metabolic processes, including promoting mitochondrial oxidative phosphorylation, increasing ATP synthesis, enhancing mitochondrial complex activity, decreasing ROS generation, slowing down the decrease of mitochondrial membrane potential, and inhibiting the opening of the mitochondrial membrane permeability transition pore. Mechanistically, we found that NMN attenuates inflammation and oxidative damage through activation of the SIRT1 and NF-κB signaling pathways, and that SIRT1-specific inhibition of EX527 reversed these protective effects of NMN against inflammation and oxidative damage in vivo and in vitro. Conclusion NMN has a protective effect on inflammation and oxidative damage induced by ischemia-reperfusion injury after lung transplantation, and the SIRT1/NF-κB pathway may be involved in one of the mechanisms of the protective effect.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2025
·Vol. 40
·期 6
·1782-1789
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IF 1.1
Cai Yao,Wu Hongmei
This article provided a preparation protocol for poly(lactic acid) (PLA)/modified epoxidized soybean oil (ECP)/nano-magnesium oxide(n-MgO) ternary composites and studied their mechanical and antibacterial properties. By means of an organic synthesis technique, epoxidized soybean oil (ESO) is chemically grafted to PLA to synthesize ESO chemically plastically modified PLA, abbreviated ECP. To fabricate PLA/ECP/n-MgO composite materials, ECP acts as a plasticizer and a compatibilizer simultaneously, and n-MgO acts as an enhancer. Then scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, universal tester, and antibacterial research were exploited to characterize the morphology, thermal resistance, mechanical properties, and antibacterial performance of PLA/ECP/n-MgO composites. The experimental results show that ECP acts as a plasticizer by causing heterogeneous nucleation, which increases PLA’s crystallinity. Evenly distributed n-MgO can greatly improve PLA’s antibacterial qualities. Furthermore, ECP and n-MgO work together to improve the positive aspects of PLA/ECP/n-MgO composites, with PLA/ECP/n-MgO 100/1/0.5 composites having the best overall properties. While improving the mechanical performance and toughness of PLA, this work offers a prospective approach and foundational database for the creation of multifunctional biodegradable composites.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10551
·
IF 15.7
Meng Qingcai,Li Chengxi,Cai Yuping,Chen Ying,Chen Xiaoqing,Wang Xin,Zhang Biling,Zhang Yue,Liu Feng,Chen Meixin
Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying bidirectional transport of itaconate across membranes and its effects on intracellular bacterial replication are less known. Here, we identify MCT1 and MCT4 as bidirectional transporters of itaconate. In addition to modulating itaconate concentration as transporters at the plasma membrane, MCT1 and MCT4 function as itaconate transporters at Salmonella -containing vacuole (SCV). Upon Salmonella infection, MCT1 and MCT4 transport itaconate into SCV facilitated by RAB32. Itaconate is also secreted out of cells through MCT1 and MCT4 as the infection persists. The suppression of MCT1 and MCT4-dependent itaconate secretion increases the overall concentration of itaconate and the proportion of itaconate-targeted Salmonella intracellularly, consequently inhibiting Salmonella replication. Our study thus offers valuable insights into itaconate transport during bacterial infection and provides proof of principle for the development of itaconate-dependent therapeutic strategies.
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