JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
·
IF 2.323
Hui Zhang,Zengkun Liu,Xiping Huang,Qi Zhang
The solubility data of sodium l-ascorbate in water, methanol, ethanol, acetone, chloroform, ethyl acetate, isopropyl alcohol, isobutyl alcohol, n-hexane, water–methanol mixture and water–ethanol mixture have been determined in the temperatures range of 278.15–323.15 K by a static analytic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation, CNIBS/R-K model, and Jouyban–Acree model. On the basis of the solubility data, a novel model-free design approach (semisupersaturation control, SSSC) for combined cooling and antisolvent crystallization (CCAC) processes has been proposed and evaluated for sodium l-ascorbate in a methanol–water mixture. This approach can be easily implemented without complicated online monitors. Sodium l-ascorbate crystals with large and uniform morphology were obtained using the CCAC process, which was designed by the SSSC approach.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Yiyuan Duan,Zhongwei Liu,Qingqing Zhang,Jinqing Hu,Songyan Zheng,Xuejin Mao,Yuanxing Wang
We adopted HS-SPME-GC–MS and UPLC-Q-TOF/MS in our study to analyze changes in volatile components (VOCs) and non-VOCs during the growth of Citrus maxima cv. Jinggang honey pomelo. In total, 75 VOCs and 65 non-VOCs were identified. Terpenes were the most important components of the VOCs, D-limonene and germacrene D were the most representative. The contents of organic acids, flavonoids, coumarins, and amino acids gradually decreased throughout the growth process, while delayed bitter compounds (limonin and nomilin) continued accumulating. According to variable importance in the projection >1 and p < 0.05, 25 non-volatile differential metabolites were selected. KEGG pathway analysis indicated that phenylpropanoid biosynthesis was the main pathway around which a sophisticated metabolic network was formed. The flavor of Jinggang honey pomelo evolved with changes in its components, ultimately presenting flavor characteristics of citrus and green aromas, balanced sweet and sour flavors, and a hint of bitterness in the aftertaste.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Jian Hu,Xueyan Yun,Yan Zheng,Tao Sun,Lijun Song,Pengju Pan,Tungalag Dong
High costs and low performance have constrained the application of bio-based materials in food packaging. Herein, a series of ultra-thin poly(L-lactic acid-iconic acid N-diol) (P(LA-NI)) copolymer films were developed using a “one-step” polycondensation process with integrated toughness, barrier properties, gas selectivity, and quality control features. The massive branched structure and gg conformers in P(LA-NI) act as “internal chain expansion” and “internal plasticization”. Meanwhile, P(LA-NI) contains numerous polar groups and unique nanoscale microphase structures to realize excellent CO 2 , O 2 barrier, CO 2 /O 2 selectivity, anti-fogging, and UV shielding functions. The atmosphere within the package spontaneously achieves the desirable low O 2 and high CO 2 levels when packaging button mushrooms with high respiratory metabolism. Eventually, the shelf life of button mushrooms reached 24 days, >3-fold extended. This PLLA-based film meets “dual carbon” and “food safety” goals and has vast potential for fresh food preservation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Haoxin Li,Yanxi Wang,Wan Aida Wan Mustapha,Xiaoping Zhang,Fankui Zeng,Jia Liu
A fish scale (FS) gelatin-fatty acid conjugate (GFC) with alkyl chain lengths of 8–18 was constructed to increase the aqueous solubility of curcumin. The effect of alkyl chain length on the interaction between GFC and curcumin was characterized by dynamic light scattering (DLS), X -ray photoelectron spectroscopy (XPS), fluorescence spectroscopy (FS), and isothermal titration calorimetry (ITC). The surface hydrophobicity (from 4987 ± 223.79 to 9982 ± 262.78) and curcumin loading capacity (from 8.20 ± 0.54 to 31.18 ± 1.41 μg/mg) of the GFC exhibited significant enhancements through increasing alkyl chain lengths from 8 to 18. This was accompanied by a reduction in particle size (from 661.5 ± 28.9 to 329.7 ± 6.6 nm) and ζ -potential (from −2.7 ± 0.92 to −26.8 ± 0.27). FS and ITC confirmed that GOC shared an optimal binding constant ( K a , 2.40 × 10 8 L·mol −1 and 3.47 × 10 5 M −1 ) and binding site ( n , 1.45 and 2.276) with curcumin among GFCs. Increasing GFC's alkyl chain length also boosted the stability of entrapped curcumin against the thermal environment and ultraviolet radiation. These results could be beneficial for gelatin-based nanocarrier development and application.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Zihao Zhang,Lu Mu,Jinlong Li,Haixin Zhao,Hong-Man Hou,Gong-liang Zhang,Hongshun Hao,Jingran Bi
In order to address the issue of food contamination by microorganisms and effectively harness the antibacterial properties of nisin, we attempted to incorporate nisin into natural polymer films while addressing its inherent instability. An antibacterial food packaging film based on carboxymethyl chitosan (CCS) binding with L-cysteine (CYS) and oxidized konjac glucomannan (OKG) was developed through both Schiff base reaction and addition reaction of thiol aldehyde. To analyze the effect of addition reaction of thiol aldehyde on the CCS-CYS/OKG films' physicochemical properties, the CCS-CYS was prepared with different CYS combination rates, which were further used to fabricate composite films. It is found that the incorporation of CYS improved the mechanical properties of CCS-CYS/OKG films and facilitated the formation of a denser network structure. The incorporation of CYS also enhanced the film's ultraviolet barrier property, swelling behaviors, as well as loading and release capacity of nisin. As the CYS binding rate of 22.76 %, the CCS-CYS(2)/OKG film exhibited an efficient loading capacity for nisin at 91.53 % with a sustained release over 240 min. Kinetic model analysis revealed that nisin was released through non-Fickian diffusion, mainly driven by gradient concentration and osmotic pressure. Furthermore, the CCS-CYS(2)/OKG-nisin film also displayed significant antibacterial activity against Staphylococcus aureus with an inhibition zone diameter of 22.63 mm at 10 h, thereby, that was also successfully employed for salmon preservation.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 5
·2118
·
IF 4.9
Xiyue Wang,Miaoyunhuan Wang,Yuqing Dong,Shuqing Yu,Shanshan Zhang,Pinghua Sun,Lu Wang,Jibin Liu,Houwen Lin,Xinhui Pan,Xiaobin Li
Chenopodium albumL., as a folkloric herb, is traditionally used to treat poisonous insect bites, vitiligo, and other ailments. However, its impact on thrombosis remains unknown. In this study, we discovered that the ethanol extract ofC. albumexhibited a remarkable antithrombotic effect using a zebrafish thrombosis model for the first time. Activity evaluation showed that fraction CA-C could improve thrombus aggregation in the caudal vein, increase blood return in the heart, and alleviate the slowing of blood flow compared with those in the model group. Then, analysis by ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass (UPLC-Q-TOF-MS) identified 58 constituents of CA-C, with most of them belonging to flavonoids, alkaloids, and steroidal saponin components. Moreover, using a comprehensive strategy of network pharmacological analysis, transcriptomic assay, and RT-qPCR validation, we found that CA-C could mediate the TLR’s signaling pathway and its downstream MAPKs and PI3K/AKT signaling pathways to exert an antithrombotic effect. This study broadens the clinical application of plantC. albumand provides new insight into the chemical profile, pharmacodynamics, and potential mechanisms of CA-C as candidate agents for treating thrombosis.
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CHROMATOGRAPHIA
·
2012
·Vol. 75
·期 5
·289-296
·
IF 1.195
Zhang Yulin,Huang Liang,Chen Qinhua,Chen Zilin
A silica monolithic column chemically modified with l -pipecolic acid as chiral stationary phase has been developed for chiral separation of dansyl amino acids by capillary electrochromatography–mass spectrometry (CEC–MS). The monolithic column was prepared by a sol–gel process and subsequent chemical modification by l -pipecolic acid as chiral selector with 3-glycidoxypropyltrimethoxysilane as spacer. Interestingly, it was found that the l -pipecolic acid-modified monolithic column can hold copper(II) ions tightly after loading Cu(II) ions during column preparation and conditioning and allows CEC separation to be conducted based on chiral ligand exchange with MS detection by a mobile phase without copper ions. It has been demonstrated that the chiral monolithic column operates well for enantioseparation of several dansyl amino acids by CEC–MS.
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NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 23
·14486-14497
·
IF 3.269
Yuxian Wang,Ling Jiang,Ce Wei,Hongman Zhang
Fatty acids, composed of an amphiphilic carbon chain and a carboxyl group, are a simple class of anion surfactants when they are protonated in the presence of an alkali. They can form ion-pairing amphiphile molecules and self-assemble into different nanostructures, which can be widely applied. However, the phase transition of these nanostructures can be easily triggered by external conditions, such as pH, temperature, the addition of salts and so on. In this work, medium-chain fatty acids (MCFAs) containing 8–12 carbons were chosen as the objects for self-assembly with organic amino counter-ions, L-arginine. We investigated the effects of chain length, pH, temperature and solvent on the phase transition based on diagrams, which could be determined by freeze fracture transmission electron microscopy (FF-TEM) and polarizing microscopy observations (PMO) combined with rheological properties. The results showed that rich phase behavior was observed in the octanoic acid (C8:0) system. However, it was insensitive to changes in pH because of the lower hydrophobicity. In contrast, for decanoic acid (C10:0) and lauric acid (C12:0) systems, phase transition from the L1 phase (micelles) to the Lα phase (vesicles) was observed and they showed stimulus-response to the change of pH. At the same time, lauric acid was sensitive to temperature, which was ascribed to the higher Krafft point. Besides, when the solvent was replaced by glycerin, phase transitions occurred from vesicles to micelles in these three systems. We hope that this phase transition observed in the MCFA system will provide a good insight into drug delivery, material science, and other related areas.
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ADVANCED ENGINEERING MATERIALS
·
2025
·
IF 3.3
Beibei Zhou,Yulong Zou,Hongyang You,Bing Zhang,Xili Lu
The integration of water-induced shape memory polymers into 4D printing provides novel opportunities to create innovative intelligent medical devices. Herein, poly(L-lactic) acid (PLLA)/silk fibroin (SF) scaffolds with water-induced shape memory capabilities and enhanced mechanical properties are developed using direct-write 4D printing technology. By analyzing the influence of the content of SF on the rheological properties, apparent viscosity and volatile properties of the ink, and the direct writing process of PLLA/SF scaffolds is systematically investigated. Results reveal that the PLLA/SF-30 wt% scaffold with a 50% filling ratio achieves the optimal mechanical properties, a compressive strength of 12.27 MPa, and a compressive modulus of 2.01 MPa, which is 1.42 and 2.83 times that of pure PLLA scaffolds, respectively. Furthermore, the PLLA/SF-30 wt% scaffold exhibits good shape memory behavior in water at 40 °C, with a shape fixation ratio ( R f ) of 94.6% and a shape recovery ratio ( R r ) of 67.0%. A 4D-printed grabber made from PLLA/SF-30 wt% can successfully grasp objects weighing 10 times its own weight. These results provide important insights into the potential applications in healthcare, enhancing their promise for personalized medical devices.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2024
·
IF 2.8
Zixin Lin,Guanghui Wang,Zhongkui Zhou,Nansheng Deng,Xuewen Zhang
BACKGROUND Soil in uranium mining areas is contaminated by uranium and associated heavy metals, posing a significant threat to human health and ecological security. Chelating agent assisted phytoremediation is a cost-effective and ecologically friendly remediation approach for uranium and associated heavy metals contaminated soil. In this work, a novel slow-release composite chelating agent (SR CMC-g-CMCD -EDTA/AC) was fabricated using carboxymethyl chitosan-graft-carboxymethyl-β-cyclodextrin (CMC-g-CMCD) as a slow-release carrier and EDTA/ammonium citrate (AC) as a composite chelating agent through the spray drying method, which was used for phytoremediation of soil co-contaminated with uranium and chromium. RESULTS CMC-g-CMCD exhibited superior slow-release performance for both EDTA and AC in comparison with CMC and CMCD. When applied to soil contaminated with uranium (U) and chromium (Cr), SR CMC-g-CMCD -EDTA/AC effectively regulated the release of U and Cr. Sunflowers ( Helianthus annuus L.) grown in treated soil showed a significant increase in U and Cr uptake by 70.55% and 35.55%, respectively, and reduced leaching losses by 34.88% and 37.42%. CONCLUSION SR CMC-g-CMCD -EDTA/AC not only assists in the phytoremediation of soil co-contaminated with U and Cr but also reduces the risk of leaching into groundwater during the soil phytoremediation process. SR CMC-g-CMCD -EDTA/AC-assisted phytoremediation technology was an effective and environmentally friendly remediation means for the removal of U and heavy metals from contaminated soils in uranium mining areas. © 2024 Society of Chemical Industry (SCI).
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MOLECULES
·
2024
·Vol. 29
·期 7
·1563
·
IF 4.2
Tao Yu,Long Yang,Xianchao Shang,Shiquan Bian
Deep eutectic solvents (DESs) are novel solvents with physicochemical properties similar to those of ionic liquids, and they have attracted extensive attention for the extraction of bioactive compounds from different plant materials in the context of green chemistry and sustainable development. In this study, seven DESs with different polarities were explored as green extraction solvents for cembratrien-diols (CBT-diols) from waste tobacco flowers. The best solvent, DES-3 (choline chloride: lactic acid (1:3)), which outperformed conventional solvents (methanol, ethanol, and ethyl acetate), was selected and further optimized for microwave-assisted DES extraction using the response surface methodology. The maximum yield of CBT-diols (6.23 ± 0.15 mg/g) was achieved using a microwave power of 425 W, microwave time of 32 min, solid/liquid ratio of 20 mg/mL, and microwave temperature of 40 °C. Additionally, the isolated CBT-diols exhibited strong antimicrobial activity againstSalmonella,Staphylococcus aureus,Escherichia coli,Bacillus subtilis, andPseudomonas aeruginosaand antitumor activity in the human liver cancer HepG2 and SMMC-7721 cell lines. This study highlights the feasibility of recovering CBT-diols from tobacco flower waste using DESs and provides opportunities for potential waste management using green technologies.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2024
·
IF 2.8
Xijin Yang,Ying Li,Qiju Shao,Zhirong Li,Zeli Chun,Yan Wang,Yaping Zhou,Rongxiang Chen
Persicaria chinensis (L.) H. Gross ( P. chinensis ), also known as “Huotanmu” in Chinese, is a traditional ethnic herbal medicine and a functional food ingredient. In this study, liquid chromatography − electrochemical detection (LC-ECD) screening, liquid chromatography − tandem mass spectrometry (LC-MS/MS) identification, and multivariate statistical analysis were combined to clarify the antioxidant components in P. chinensis . The samples were extracted using 80 % aqueous methanol under ultrasound-assisted extraction and their in vitro antioxidant activities were evaluated. The fingerprint of P. chinensis was established using LC-ECD, while the identification of major chemical components was performed using LC-MS/MS through comparison of ion fragments. Subsequently, grey correlation analysis and partial least squares regression analysis were used to investigate the association of different compounds with antioxidant activity. P. chinensis from different sources showed excellent DPPH radical scavenging capacity, ABTS radical scavenging capacity, and ferric reducing antioxidant power. A total of 25 common peaks were obtained and identified in the LC-ECD fingerprint of P. chinensis , which were primarily comprised of tannins and flavonoids. The similarity between samples of different batches was ≥ 0.767, indicating relatively consistent quality. The comprehensive analysis results of grey relational analysis and partial least squares regression analysis indicated that tannins such as di-galloyl-HHDP-hexoside and davidiin were the major contributors to the antioxidant activity of P. chinensis . Therefore, LC-ECD can rapidly screen the potential phenolic antioxidants of P. chinensis , providing a basis for its product development, resource utilization, and quality control.
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