INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yanfei Zhu,Junhong Ling,Xinyi Xu,Xiao-kun Ouyang,Nan Wang
The high expression of reduced glutathione (GSH) and low pH in tumor sites have encouraged new ideas for targeted drug release. The tumor microenvironment is a crucial target for studying the anti-tumor efficiency of photothermal therapy because the microenvironment plays a key role in cancer progression, local resistance, immune escaping, and metastasis. Herein, active mesoporous polydopamine nanoparticles loaded with doxorubicin and functionalized with N,N′ -bis(acryloyl)cystamine (BAC) and cross-linked carboxymethyl chitosan (CMC) were used to induce simultaneous redox- and pH-sensitive activity to achieve photothermal enhanced synergistic chemotherapy. The inherent disulfide bonds of BAC were able to deplete glutathione, thus increasing the oxidative stress in tumor cells and enhancing the release of doxorubicin. Additionally, the imine bonds between CMC and BAC were stimulated and decomposed in the acidic tumor microenvironment, improving the efficiency of light conversion through exposure to polydopamine. Moreover, in vitro and in vivo investigations demonstrated that this nanocomposite exhibited improved selective doxorubicin release in conditions mimicking the tumor microenvironment and low toxicity towards non-cancerous tissues, suggesting there is high potential for the clinical translation of this synergistic chemo-photothermal therapeutic agent.
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EUROPEAN POLYMER JOURNAL
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2023
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IF 6
Lu Wang,Xin Gang,Yu Xiao,Yi Ren,Jianhong Wang,Baolong Niu,Wenfeng Li
In this study, CMCS-CuO nanoparticles were added to the SA matrix by blending method to prepare SA/CMCS-CuO composite microspheres. The chemical structure and morphology of the composite beads were characterized. The results showed that there was a certain molecular interaction between CMCS-CuO NPs and SA matrix. The swelling experiment showed that with the increase of the mass of CMCS-CuO NPs, the maximum swelling ratio of gel microspheres decreased from 49.83% to 38.2%, and the time to reach the maximum swelling ratio also increased from 8 h to 11 h. Cytotoxicity test, hemolysis test, and cell migration test showed that the composite microspheres had good biocompatibility. Curcumin was added to the composite bead matrix by the blending method, and curcumin-loaded SA/CMCS-CuO composite beads were prepared by the crosslinking method. In vitro release experiments showed that SA/CMCS-CuO composite microspheres had good pH sensitivity, and the addition of CMCS-CuO NPs prolonged the in vitro release time of cur. It has certain application potential in the field of drug release.
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Scientific Reports
·
2022
·Vol. 12
·期 1
·1-13
·
IF 4.996
Luo Meng,Lin Juntao,Zhou Xinhua,Pu Xia
This study provides a promising controlled release form of nuclear polyhedrosis virus (NPV) for targeted control of lepidopteran pests. However, the application of NPV is limited due to its sensitivity to UV inactivation. This study investigated the anti-UV properties of microcapsules of SeMNPV occlusion bodies (OBs) encapsulated by calcium alginate (CA), and also the influence of the modification of CA by chitosan (CS), whey protein (WP), and polydopamine (PDA). These capsules were used to deliver, in a controlled release manner virions under alkaline pH conditions. Characterization of the structure, morphology, particle size, encapsulation efficiency, contact angle, insecticidal activity, UV resistance and in vitro release of the microcapsules was conducted. The modified microcapsules had better sphericity, and were devoid of SeMNPV OBs on the surface. The encapsulation rate was 84.76 ± 0.59%. PDA@CA-NPV had the highest wettability and the contact angle was 74.51 ± 0.53°. The 50% lethal concentration values (LC 50 ) of CA-NPV, CS@CA-NPV, WP@CA-NPV and PDA@CA-NPV were 11.5, 10.7, 10.5 and 1.2 times that of SeMNPV OBs alone. The modified microcapsules all improved the anti-UV performance of the virus, and PDA@CA-NPV was the most UV-resistant. Using qPCR, it was observed that under alkaline conditions, a large number of virions were released from PDA@CA-NPV, CA-NPV and SeMNPV OBs. Microencapsulated virus under alkaline conditions did not change the release pattern of virions.
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JOURNAL OF LUMINESCENCE
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2023
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IF 3.6
Jian Wu,Xianju Zhou,Duo Zhang,Li Li,Sha Jiang,Guotao Xiang,Yongjie Wang,Xiao Tang,Jingfang Li,Zhongmin Cao
The development of advanced anti-counterfeiting strategies and materials based on rare earth luminescent materials has shown great applications in preventing serious counterfeiting forgery techniques. In this work, a series of lanthanide organic complexes [Ln 3 (PDC) 3 Bipy(H 2 O) 3 ]·2H 2 O(Ln = Eu, Tb, Eu x Tb 1-x , H 2 PDC: pyridine-3,5-dicarboxylicacid, H 2 Bipy: 2,2-bipyridine), were synthesized via hydrothermal method . The results of Fourier transform infrared spectra(FTIR), thermos-gravimetric analysis(TGA) and powder X-ray diffraction(XRD), illustrate that the complexes share similar structures. The complexes exhibit strong emission even with the presence of water molecules coordinated in the structure. By adjusting the Eu/Tb molar ratio of the complexes, tunable emission color from green, yellow to red was achieved. Furthermore, both the luminescence color and the intensity exhibit obvious changes when the pH of the solution (glycerol: H 2 O = 1:1 V/V) is varied from neutral to acid or to basicity . In addition, Eu 3+ and Tb 3+ metal ions in the binuclear complexes respond differently to pH alteration, therefore the emission color and intensity of the binuclear complexes are tuned with pH. Based on the special pH response of the complexes, we demonstrated the potential utility of the samples for security anti-counterfeiting and information multiple encryption.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2023
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IF 6
Yan Zhu,Yuanyuan Yao,Jinfeng Xi,Caiguo Tang,Lifang Wu
Fusarium graminearum ( F. graminearum ) is a vital pathogen of Fusarium head blight (FHB). Hydrogen sulfide (H 2 S), which can be induced by stress in plants as a fungal inhibitor, affects the germination of spores through the detection of environmental factors such as temperature and pH. Based on mathematical models, F. graminearum was treated with different temperatures, pH, and H 2 S concentration to investigate spore germination events. This paper considered the synergistic effects of temperature and pH on spores in order to determine the optimal germination environment. Under these circumstances, the inhibition of spore germination with different concentrations of H 2 S was quantified. The results suggested that the germination time negatively correlates with the germinating rate. An increase in temperature altered the weak alkali preference of F. graminearum spores. At 28 °C, spores were more sensitive to the changes in pH. H 2 S gas could delay the germinating process significantly, however the required H 2 S concentration varied with environmental changes. This paper provides a perspective on the synergistic effect of temperature and pH on spore germination and contributes to determining the concentration of H 2 S as a management of FHB.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 8
·2262-2271
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IF 4
Pengzuo Chen,Kaixun Li,Yutong Ye,Doufeng Wu,Yun Tong
Developing high-performance and low-cost self-supporting electrodes as pH-universal electrocatalysts for the hydrogen-evolution reaction (HER) and realizing high-quality hydrogen production at a high current density are highly desirable, but are hugely challenging. We created a self-supporting electrode with a coupled hierarchical heterostructure by simple electrodeposition followed by sulfurization. It comprised oxygen-deficient molybdenum oxide (MoO3−x) and cobalt phosphide (CoP) on nickel foam (NF), which represented a highly active pH-universal electrocatalyst for the HER at a high current density. Benefiting from a plethora of catalytic active sites, improved interfacial charge transfer, and strong electronic interaction, this type of MoO3−x@CoP/NF electrode delivered a superior catalytic performance. Overpotentials of only 100 mV, 135 mV, and 400 mV were needed to realize a high current density of 1 A cm−2 in alkaline, acid and neutral media, respectively, which were superior to those of most other well-developed materials based on non-noble metals. Our experimental work demonstrates the synergistic advantages of a MoO3−x@CoP heterostructure for improving the intrinsic catalytic performance but also paves a new path for the rational design of advanced electrodes for hydrogen generation in a wide range of pH conditions.
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Materials Today Communications
·
2023
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IF 3.8
Yushu Han,Rui Bao,Jianhong Yi,Hongdong Li,Liang Liu,Shuyu Huang,Zhaojie Li,Wenfu Zhang,Deqi Min
Carbonized polymer dots (CPDs) have drawn a lot of attention in the past ten years because of their excellent selectivity and sensitivity. In this study, tungsten was doped into CPDs (W-CPDs) using a simple hydrothermal technique for the first time. With an excitation/emission maximum of 365/455 nm and excitation-independent emission, W-CPDs exhibit blue fluorescence and have an average particle diameter of 2.33 nm. Because of the dynamic quenching between Fe (III) and W-CPDs, there is a good linear relationship between the Fe (III) concentration and the limit of detection (LOD) of 0.012 μM for W-CPD fluorescence intensity. The intensity of the W-CPDs fluorescence is also found to be linearly correlated with pH values between 5.0 and 10.0. This technique enables quick detection of Fe (III) in drinking water and is expected to lower the risk of Fe (III) ingestion by humans. In addition, the creation of fluorescent flexible devices and information encryption are fascinating applications for W-CPDs.
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OPTICAL MATERIALS
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2022
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IF 3.754
Xiangqiong He,Bing Yu,Xiulan Zhang,Hailin Cong
By changing the amount of acrylic acid, different monodisperse poly(styrene-co-methyl methacrylate-co-3-sulfopropyl methacrylate potassium salt-co-acrylic acid) (P(St-MMA-SPMAP-AA)) microspheres are synthesized by soap-free emulsion polymerization . Two-dimensional or three-dimensional PSMSSA colloidal crystals are successfully prepared by the gas-liquid interface assembly method. A noticeable shift of the bandgap of the PSMSSA colloidal crystals is observed at different pH, after the addition of diluted HCl aqueous, a structure color of amaranth is found for the PSMSSA colloidal crystals, and a structure color of blue-green is formed under neutral conditions. By using PSMSSA colloidal crystals on the liquid interface , the colloidal voids are filled with liquid, and its optical and pH-responsive properties can be directly measured without re-transfer, realizing the simple and efficient preparation of pH-responsive colloidal crystals sensors. Compared with the traditional pH sensor, the gas-liquid interface self-assembled colloidal crystals sensor is not only economical and economical, but also a reversible sensor visible to the naked eye.
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Energy & Environmental Materials
·
2023
·
IF 15
Shuairu Zhu,Xue Wang,Jiabo Le,Na An,Jianming Li,Deyu Liu,Yongbo Kuang
Developing stable and efficient nonprecious-metal-based oxygen evolution catalysts in the neutral electrolyte is a challenging but essential goal for various electrochemical systems. Particularly, cobalt-based spinels have drawn a considerable amount of attention but most of them operate in alkali solutions. However, the frequently studied Co–Fe spinel system never exhibits appreciable stability in nonbasic conditions, not to mention attract further investigation on its key structural motif and transition states for activity loss. Herein, we report exceptional stable Co–Fe spinel oxygen evolution catalysts (~30% Fe is optimal) in a neutral electrolyte, owing to its unique metal ion arrangements in the crystal lattice. The introduced iron content enters both the octahedral and tetrahedral sites of the spinel as Fe 2+ and Fe 3+ (with Co ions having mixed distribution as well). Combining density functional theory calculations, we find that the introduction of Fe to Co 3 O 4 lowers the covalency of metal-oxygen bonds and can help suppress the oxidation of Co 2+/3+ and O 2− . It implies that the Co–Fe spinel will have minor surface reconstruction and less lattice oxygen loss during the oxygen evolution reaction process in comparison with Co 3 O 4 and hence show much better stability. These findings suggest that there is still much chance for the spinel structures, especially using reasonable sublattices engineering via multimetal doping to develop advanced oxygen evolution catalysts.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Hai Liu,Guoying Tan,Mengxuan Li,Zhuang Zhang,Marshet Getaye Sendeku,Yaping Li,Yun Kuang,Xiaoming Sun
Hydrogen evolution reaction is an important half-cell reaction in electrocatalytic water splitting process, which is an efficient way to store renewable energy into hydrogen fuel. However, grid scale water splitting always require high current densities up to amperes per square centimeter, which results change in local pH on the electrode surface, leading to instability risk of cathodic catalyst. Herein, a single atomic Ru doped WO 3 catalyst was fabricated, which exhibit excellent hydrogen evolution reaction (HER) activity with only 28.0, 17.6, and 83.0 mV in acidic, alkaline, and neutral media respectively as well as robust stability for 100 h at ampere-level current density is reported. Synchrotron radiation and density functional theory (DFT) calculations revealed that the defective oxygen and strong electron transfer from W sites to Ru not only achieved moderate H adsorption but also protected Ru sites from agglomeration, leading to superior HER activity and stability at industrial current density.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
·
IF 5.062
Mengfei Li,Hongyu Chen,Dingchuan Peng,Xuehan Lu,Jianping Kong,Shujun Luo,Shiqi Li,Chunlu Tan,Ying Wang
A biodegradable drug delivery system with pH-sensitive property holds vast promise for the improvement of gemcitabine (GEM) in pancreatic cancer cells. Here, a cationic pH-sensitive liposome containing GEM with FU coating (pPSL-FU-GEM, DOTAP: CHEMS : Chol: DSPE-mPEG2000) was designed to improve the bioavailability and efficacy of GEM. After entering the acidic environment of cells, pPSL-FU-GEM could release gemcitabine through an endocytic escape mechanism, preventing it from being degraded by enzymes. The negatively charged fucoidan (FU), which was separated and purified by anion exchange column purification, could target to pancreatic cancer cells and shed, resulting in liposomes uptake by cells. Release studies and intracellular trafficking studies showed that pPSL-FU-GEM released more drug than non-pH-sensitive liposomes in vitro . Meanwhile, pPSL-FU-GEM also showed better anti-proliferative activity than free gemcitabine in pancreatic cancer cells. Overall, we demonstrated the potential of FU-coating pH-sensitive liposomes containing gemcitabine and the drug delivery function in pancreatic cancer cells.
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Journal of Physical Chemistry C
·
2023
·
IF 3.7
Chunyu Yu,Xue Li,Xin Qiao,Zhiwei Zhang,Danyang Zhang,Hua Liu,Xue-Li Hao,Zhongzhi Wang,Hongpeng You,Liang Zhou
Fluorescent carbon quantum dots (r-CDs) were synthesized safely and readily by stirring at room temperature with a yield of 76.5%. The synthesized r-CDs exhibit bright green emission with an absolute quantum yield of 12.0% under the excitation of ultraviolet light. Within the pH range of 3–12, the r-CDs exhibit excellent fluorescence stability. Interestingly, the fluorescence intensity of r-CDs faded promptly when the pH value diminished to 2 and then regained when the pH value returned to 3. This means that r-CDs can be used as “on–off–on” fluorescent probes for pH sensing. The mechanism of this sensitive pH response behavior was discussed in detail, and a possible mechanism of protonation–deprotonation–protonation processes was proposed. In addition, we have proposed a green preparation route for eco-friendly filter paper using anticounterfeiting. Interestingly, the presence of Fe2+ significantly quenched the fluorescence of r-CDs. Experimental results demonstrated the r-CDs can also be used to detect the content of Fe2+ in water, and the detection limit was 8.82 μM/L.
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