JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
·
2014
·
IF 3.679
Sheng-Jie Chen,Yong-Qi Li,Yong-Yong Wang,Xiao-Li Zhao,Ye Liu
The ionic hybrid P,N-ligands of 1 and 2 have been synthesized as one type of unconventional tertiary phosphines with the advantages of both the π-accepting ligands and the hemilabile ligands. The corresponding ionic Rh(I)-complexes of 1A and 2A proved to be more efficient catalysts for hydroformylation of 1-octene over isomerization than the traditional Rh I (acac)(CO)(PPh 3 ), due to the π-backdonation interaction in Rh → P linkage and the hemilabile ligation of N,P-coordinating sites to Rh-center. The in situ high-pressure FT-IR analysis indicated that: (1) the formation and lifetime of the active Rh H species (2047 cm −1 ) derived from 1A are facilitated by the presence of ligand 1 ; (2) the formation of the active Rh H species is depressed without the aid of the P,N-hemilabile ligation; and (3) the active Rh H species derived from Rh I (acac)(CO)(PPh 3 ) is unstable and susceptible to the formation of the inactive carbonyl-bridged Rh-dimer.
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JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 18
·12837-12849
·
IF 2.993
Han Zongzhuang,Shen Yu,Wang Fumin,Zhang Xubin
Hierarchical titanium silicalite-1 (TS-1) without generated anatase TiO 2 species was synthesized in the presence of polyquaternium-7 (M550) by one-step hydrothermal crystallization method and characterized by field-emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray fluorescence (XRF), Fourier transform infrared spectra, ultraviolet visible spectra, Raman spectroscopy and N 2 adsorption–desorption measurements. The experimental results show that highly porous TS-1 crystals, with pores of ca. 2.6–4.9 nm diameter, are obtained under hydrothermal conditions by using polyquaternium-7 as the mesopore-directing agent. The polyquaternium-7 has a great influence on both the textural properties and the coordination of Ti species in the framework of TS-1. The catalytic properties and recyclability of the prepared mesoporous TS-1 for hydroxylation of phenol with H 2 O 2 have been evaluated, and their activity has been compared with those of TS-1 with only micropores. The great catalytic activity, selectivity and stability of the hierarchical TS-1 as well as the cheap price and environmental-friendly nature of the used mesopore-directing agent allow to consider this hierarchical TS-1 as a promising catalyst for industry application.
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Agronomy-Basel
·
2022
·Vol. 13
·期 1
·46
·
IF 3.949
Han Yan,Rui Wang,Ning Ji,Jiangkuo Li,Chao Ma,Jiqing Lei,Liangjie Ba,Guangzhong Wen,Xiaobo Long
In order to study a short-term and efficient technology by 1-methylcyclopropene (1-MCP) in blueberry, the fruit was treated with 0, 0.5, 1 and 3 μL/L 1-MCP for 2 h then stored at 25 ± 1 °C with 40–50% relative humidity (RH) for 9 d. The weight loss, decay incidence, respiration rate, firmness, soluble solid content (SSC), titratable acid (TA), Brix-acid ratio (BAR), sensory evaluation, content of cell wall polysaccharide, activities of cell wall composition-related enzymes and energy metabolism in blueberry were determined during shelf life. The results showed that the weight loss, decay incidence and respiration rate were reduced by 3 μL/L 1-MCP treatment. Compared to other groups, the firmness, the content of TA and anthocyanins were maintained in 3 μL/L 1-MCP-treated blueberry. In contrast, the SSC and BAR were lower compared to those untreated. However, the sensory evaluation of “taste” and “aroma” value showed no differences in all fruits. The content of protopectin, cellulose and hemicellulose was higher in 1-MCP-treated blueberry, accompanied by a decrease in polygalacturonase (PG) and pectin methyl esterase (PME) activity. The content of water-soluble pectin (WSP) was lower in 1-MCP-treated blueberry than untreated ones. The activity of phenylalanine ammonia lyase (PAL), peroxidase (POD), cinnamyl alcohol dehydrogenase (CAD) and 4-coumarate-CoA ligase (4CL) was higher in 1-MCP-treated blueberry than the untreated, which induced more serious lignification. The results of energy metabolism also showed that the 1-MCP treatment could ensure sufficient intracellular energy supply. The 3 μL/L 1-MCP treatment could maintain the shelf quality and retard decomposition of cell wall polysaccharide by ensuring sufficient intracellular energy supply and inhibiting cell wall-degrading enzymes activity. Taken together, this study highlighted an efficient and short-term 1-MCP treatment technique.Keywords:blueberry;1-MCP;cell wall polysaccharide;shelf life;karst fruit
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PLANT PHYSIOLOGY AND BIOCHEMISTRY
·
2023
·
IF 6.5
Qingwei Jia,Yuqing Yin,Shuting Gai,Lu Tian,Zhihao Zhu,Lei Qin,Yong Wang
Cryptochromes (CRYs), as blue-light photoreceptors, play a crucial role in regulating flowering time and hypocotyl and cotyledon development. Their physiological functions have been extensively studied in various plant species. However, research on onions remains limited. In this study, we identified AcCRY1 and conducted preliminary investigations into its function. Our results demonstrate that AcCRY1 possesses a conserved domain typical of cryptochromes with high homology to those found in monocots. Furthermore, we examined the expression level of AcCRY1 in onion. The green tissues is significantly higher compared to non-green tissues, and it exhibits a significant response to blue-light induction. AcCRY1 demonstrates cytoplasmic localization under blue-light conditions, while it localizes in the nucleus during darkness, indicating a strong dependence on blue-light for its subcellular distribution. In comparison to cry1 , overexpression of AcCRY1 leads to a significant shorten in seedling hypocotyl length, notable expansion of cotyledons, and acceleration of flowering time. The yeast two-hybrid experiment demonstrated the in vitro interaction between AcCRY1, AcCOP1, and AcSPA1. Additionally, BIFC analysis confirmed their interaction in Onion epidermis. Notably, under blue-light conditions, a significantly enhanced binding activity was observed compared to dark conditions. These findings establish a functional foundation for the regulatory role of AcCRY1 in important physiological processes of onion and provide initial insights into the underlying molecular mechanisms.
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PubMed
高影响因子
Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 6
·772-783
·
IF 4.5
Gao Xiu,Luo Beining,Hong Yanping,He Peihang,Zhang Zedong,Wu Guoqiang
Development of a titanium silicalite-1 (TS-1) catalyst with good crystallinity and a four-coordinate Ti framework is critical for efficient catalytic oxidation reaction under mild conditions. Herein, a size-controlled TS-1 zeolite (TS-1#0.1ACh (acetylcholine)) was synthesized via steam-assisted crystallization by introducing acetylcholine as a crystal growth modifier in the preparation process, and TS-1#0.1ACh was also employed in epoxidations of different substrates containing C=C double bonds. The crystalline sizes of the as-synthesized TS-1#0.1ACh catalysts were controlled with the acetylcholine content, and characterization results showed that the particle sizes of highly crystalline TS-1#0.1ACh zeolite reached 3.0 µm with a good Ti framework. Throughout the synthetic process, the growth rate of the crystals was accelerated by electrostatic interactions between the connected hydroxyl groups of the acetylcholine modifier and the negatively charged skeleton of the pre-zeolites. Furthermore, the TS-1#0.1ACh catalyst demonstrated maximum catalytic activity, good selectivity and high stability during epoxidation of allyl chloride. Importantly, the TS-1#0.1ACh catalyst was also highly versatile and effective with different unsaturated substrates. These findings may provide novel, easily separable and large TS-1 catalysts for efficient and clean industrial epoxidations of C=C double bonds.
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3 Biotech
·
2019
·Vol. 9
·期 7
·1-9
·
IF 1.786
Yan Hong De,Guo Bing Han,Wang Zhao,Qian Jun Qing
The lipase from Aspergillus oryzae was modified with a surfactant and then observed to exhibit high catalytic efficiency and enantioselectivity for the kinetic resolution of ( RS )-1-phenylethanol. The influential factors of the modified-lipase preparation were investigated, including the surfactant source, the organic cosolvent, and the buffer pH. The optimum modification conditions were found with a surfactant of polyoxyethylene sorbitan monopalmitate, an organic cosolvent of tetrahydrofuran and a phosphate buffer of pH 7.0. In the transesterification of ( RS )-1-phenylethanol with vinyl acetate, the surfactant-modified lipase showed excellent enantioselectivity for the R -isomer ( E > 200), giving an enantiomeric excess of higher than 99% for ( R )-1-phenylethyl acetate at 46.8% conversion with the reaction time of 2 h at 30 °C. The enzymatic activity had barely altered after 30 days even at 50 °C when it was saved in a powdered state. The results indicated that the modification strategy was useful and highly efficient, and that modified A. oryzae lipase was a promising biocatalyst in the kinetic resolution of ( RS )-1-phenylethanol.
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Journal of Physical Chemistry C
·
2020
·
IF 4.189
Yeming Xian,Yongli Zhang,Naveed Ur Rahman,Hang Yin,Yi Long,Peng Liu,Wenzhe Li,Jiandong Fan
Owing to the high toxicity of Pb-based hybrid perovskites, a hypotoxic element, e.g., Sn, was employed to partially or completely replace Pb with the aim of gaining environmentally friendly lead-free photoelectronic device. Herein, for the first time we hydrothermally grow a series of all-inorganic CsSnxPb1–xBr3 (0 ≤ x ≤ 1) perovskite single crystals and carefully study their crystallographic structure and electronic structure that are subject to the varied x value. The phase transition and narrowed band gap from CsPbBr3 to CsSnBr3 are observed, which is similar to the evolution of MASnxPb1–xBr3 perovskites while varying the ratio of Sn/Pb. Likewise, the incremental concentration of Sn atoms in the lattice tend to cause the energy level splitting that likely derives from the orbital overlapping between Sn and/or Pb atoms, which thereby gives rise to the narrowed band gap. Equally important is that the incorporation of Sn atoms is demonstrated to be capable of tightening the electron orbital coupling between Sn and/or Pb atoms, which thereafter enables advantageous balancing of the orbital overlap in the crystal structure with balanced and highly ordered arrangement of [SnBr6]4– and/or [PbBr6]4– octahedra and thus allows us to improve carrier transport and to benefit the real ecofriendly application of photoelectronic devices.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 52
·期 18
·11109-11119
·
IF 2.599
Zhu Hong,Li Rui,Wang Fanghui,Chen Nanjun,Li Ziming,Wang Zhiqian
To improve the conductivity of anion exchange membranes without reducing the mechanical properties, a series of poly ionic liquids (PILs) with precursors of 1,3,5-tris(1-imidazolyl)benzene (TIB) containing tri-conduct groups were synthesized and incorporated into quaternized poly (2,6-dimethyl phenylene oxide) (QPPO) membranes. The new poly ionic liquids we designed contain ternary conduct groups in one monomer which are advantageous to form ionic channels and thus dramatically increase the conductivity of membranes. Various alkyl chains were introduced into TIB during polymerization to tune the distance between two tri-conduct groups. The resulting PILs/QPPO composite membranes showed good thermal stability, appropriate mechanical properties, enhanced conductivity and fuel cell performance. When the numbers of –CH 2 – between two tri-conduct groups reached 12, the composite membrane showed the highest conductivity and fuel cell performance (55.5 mS/cm at 80 °C and 168.9 mW/cm 2 ). The composite membranes we prepared show potential application in anion exchange membrane fuel cells (AEMFCs).
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PHARMACEUTICAL BIOLOGY
·
2025
·
IF 4.8
Yong-xiang Huang,Jin-ru Zhang,Shi-hua Fu,Zhe Liu,Hui-jun Zhong,Qing-yang Zhong,Yin-di Luo,Ying-jie Hu,Hai-peng Zhu,Bin Wen,Song Chen
Context Macrophages play a critical role in the pathogenesis of ulcerative colitis (UC). Indirubin (IDR), a natural ligand of the aryl hydrocarbon receptor (AhR), has been shown to ameliorate DSS-induced colitis in our previous study (Liu Z et al.).Objective To investigate whether IDR exerts its protective effects by regulating M1/M2 polarization and inhibiting ferroptosis in macrophages.Materials and Methods Immunohistochemistry staining targeting CD206 and F4/80 was performed to evaluate the effect of IDR on the polarization of M1/M2 macrophages in colitis. Subsequently, the effects of IDR on the M1- or M2-polarization of THP-1-derived macrophages were investigated. Furthermore, the effects of IDR on ferroptosis in the colon tissue of mice and on RSL3-induced ferroptosis in THP-1-derived macrophages were assessed. The results were verified in mouse peritoneal macrophages.Results In addition to reducing the infiltrated macrophages, IDR treatment preserved CD206+ macrophages in DSS-induced colitis. Using cultured THP-1 cells, we demonstrated that IDR inhibited M1 polarization and prompted M2 polarization. Furthermore, we showed that IDR treatment decreased levels of 4-HNE while increasing GPX4 and NRF2 in DSS-induced colitis and THP-1 cells. IDR treatments also reduced cellular reactive oxygen species (ROS) and iron content, and mitigated RSL3-induced ferroptosis in THP-1-derived macrophages. Similarly, IDR augmented M2-polarization and alleviated ferroptosis in peritoneal macrophages.Discussion and Conclusion IDR skews the polarization of macrophages from M1 to M2. Furthermore, it inhibits ferroptosis in both mice and THP-1-derived macrophages. These mechanisms may contribute to the therapeutic effects of IDR in the treatment of UC.
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产品关联
DOI
PubMed
高影响因子
Cell and Bioscience
·
2025
·Vol. 15
·期 1
·159
·
IF 6.2
Sun Weikang,Zhang Mengyu,Wang Ruilin,Yang Jie,Rasool Ameena Tur,Luo Renjie,Liu Xiangdong,Cao Peng,Li Erguang
Background The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in virus infection is undefined. Results We show that genetic ablation of PTBP1 renders cell resistant to herpes simplex virus 1 (HSV-1) infection. HSV-1 utilizes 3-O-sulfated heparan sulfate proteoglycans (HSPGs) for attachment and for infection of epithelial cells. We found that knockout of PTBP1 expression resulted in loss of HS3ST3A1 and HS3ST3B1, heparan sulfate glucosaminyl 3-O-sulfotransferase genes for 3-O-sulfation of the heparan sulfate (HS) chains of HSPGs. Each of the HS3ST3A1/HS3ST3B1 genes is composed of 2 exons separated by an extraordinarily long intron whose removal requires PTBP1-associated looping. We found that PTBP1 interacted with the intronic region of HS3ST3A1/HS3ST3B1 pre-mRNAs and modulated their processing to mRNA. The essential role of PTBP1 in functional HS3ST3A1 expression and in HSV-1 infection was demonstrated by ectopic re-expression in the knockout (ko) cells. In addition, we showed that targeting PTBP1 expression by microRNA mimics reduced disease symptoms in a mouse herpetic stromal keratitis (HSK) model. Conclusions The results demonstrate that PTBP1 mediates HSV-1 infection of epithelial cells through splicing regulation of HS3ST3A1/HS3ST3B1. These studies provide a new area for novel therapeutic strategies through splicing regulation. Graphical abstract By Sun et al. RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression.
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高影响因子
Food Bioscience
·
2026
·
IF 6.2
Qi Wu,Xiang Ruan,Meng qi Li,Xu Yang,Jing Ren
Food allergy represents a group of disorders driven by abnormal immune responses, with a prevalence that has been rising steadily in recent years. Research indicates that human milk oligosaccharides and gut probiotics play an essential role in early-life immune regulation and the establishment of allergic tolerance. This study preliminarily explored the alleviating effects of a combined intervention with HMOs and Lc. paracasei 1 in OVA-induced food-allergic mice. The results demonstrated that the combined intervention markedly relieved allergic symptoms, reduced symptom scores, lowered serum IgE levels, rebalanced Th1/Th2 cytokines, and enhanced intestinal barrier integrity. 16S rRNA sequencing revealed that the HMOs and Lc. paracasei 1 combination significantly increased gut microbiota α-diversity and promoted the enrichment of beneficial bacteria, including Lactobacillus and Bifidobacterium . Concurrently, levels of key microbial metabolite, particularly short-chain fatty acids, rose substantially. Further untargeted Metabolomics analysis identified significant alterations in multiple differential metabolites across treatment groups, such as indole-3-acetic acid, indole-3-propionic acid, tryptophan, taurocholic acid, deoxycholic acid, and arachidonic acid. KEGG pathway enrichment analysis showed these metabolites were primarily involved in tryptophan metabolism, fatty acid metabolism, bile acid metabolism, and amino acid biosynthesis. Microbiome-metabolite correlation analysis further indicated that the abundances of Lactobacillus and Bifidobacterium were strongly positively correlated with indole metabolites and SCFAs. These findings suggest that the combined intervention of HMOs and Lc. paracasei 1 may alleviate food allergy symptoms by modulating gut microbiota composition and the metabolic profile, thereby influencing the body’s immune response.
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RSC Advances
·
2019
·Vol. 9
·期 46
·26729-26733
·
IF 3.049
Ya Zhu,Jialing Han,Qian Zhang,Zhou Zhao,Jin Wang,Xiaowei Xu,Haiping Hao,Jun Zhang
Human NAD(P)H:quinone oxidoreductase (hNQO1) can be used as a biomarker for the early diagnosis of cancer. In this article, a novel fluorescent probe 1 for detecting hNQO1 was designed and synthesized by using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) derivative (TCF-OH) as a fluorophore and quinone propionic acid (QPA) as a recognition group. The probe, which has high selectivity for hNQO1 and a Stokes shift of about 117 nm, shows a linear relationship with hNQO1 concentrations in the range of 0.25–3 μg ml−1 with the color changes from yellow to red and was successfully applied to intracellular hNQO1 imaging.
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