NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Yiting Geng,Yiwei Wang,Qingyu Meng,Ningbo Huang,Shan Huang,Xiaojun Chen
Conventional antimicrobial strategies relying on multiple antibiotics are becoming increasingly ineffective against drug-resistant strains, highlighting the urgent need for non-antibiotic-dependent therapeutic approaches. In this context, nanotechnology-based multifunctional platforms have emerged as a promising frontier in antimicrobial research due to their resistance-free mechanisms, high controllability, and precise targeting capability. This study presents a multifunctional nanoscale system, Fe₃O₄@polydopamine -Vancomycin @DC 2.4 cell membrane (FPVM), designed for the enrichment, recognition, and synergistic eradication of S. aureus. The system features an Fe 3 O 4 core coated with polydopamine, which enhances both photothermal performance and biocompatibility. Vancomycin is subsequently conjugated to the surface to enable specific recognition and bactericidal activity. Finally, the nanoparticles are encapsulated with stimulated dendritic cell (DC) membranes, further reinforcing the targeting ability toward S. aureus. Under 808 nm near-infrared irradiation (1.2 W cm -2 ), the FPVM platform (400 µg mL -1 ) reduced the survival rate of S. aureus to below 5% within 9 h and disrupted over 90% of pre-formed biofilms, demonstrating high photothermal conversion efficiency. In summary, the FPVM system integrates enhanced targeting and antibacterial functions, offering a versatile blueprint for constructing next-generation antimicrobial platforms.
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INFLAMMATION
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2026
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IF 5.4
Ren Niansheng,Li Ruixi,Tao Qiang,Hong Shengjie,Wang Jicai,Zha Jiandong,Wang Shikai,Zhang Guangquan
Chronic pancreatitis (CP) is a chronic disease characterized by pancreatic fibrosis driven by pancreatic stellate cell activation and M2 polarization of macrophages. Nicotinamide n-methyltransferase (NNMT) is a methylase critically involved in fibrosis. Galectin-3 (LGALS3), a member of the galectin family, drives M2 macrophage polarization. This study explores the roles of NNMT and LGALS3 in CP. CP was induced in C57BL/6 mice via repeated intraperitoneal injections of 50 µg/kg cerulein. NNMT was upregulated in pancreatic tissues of CP mice, especially in mouse pancreatic stellate cells (mPSCs). Functional inhibition of NNMT in mPSCs, via lentiviral short-hairpin RNA-mediated knockdown or treatment with NNMT inhibitor, suppressed mPSC activation, proliferation, and migration. Moreover, conditioned medium from mPSCs with NNMT inhibition reduced M2 polarization of bone marrow-derived macrophages (BMDMs). In vivo, intraperitoneal administration of 20 mg/kg NNMT inhibitor for 28 days alleviated pancreatic collagen deposition and macrophage M2 polarization, resulting in reduced pancreatic fibrosis. RNA sequencing and bioinformatics analysis identified LGALS3 as a potential downstream target of NNMT. NNMT inhibition downregulated LGALS3 expression in mPSCs, and chromatin immunoprecipitation - quantitative polymerase chain reaction (ChIP-qPCR) confirmed that this suppression was associated with increased trimethylation of lysine 27 on histone H3 (H3K27me3) enrichment at the LGALS3 promoter. Lentivirus-mediated LGALS3 overexpression reversed the inhibitory effect of NNMT knockdown on BMDM M2 polarization. In conclusion, inhibition of NNMT alleviates mPSC activation and suppresses mPSC-induced macrophage M2 polarization via H3K27me3-mediated repression of LGALS3 transcription, with the ultimate effect of mitigating cerulein-induced pancreatic fibrosis.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
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IF 4.6
Erqing Zhao,Jiaming Li,Yudi Guo
Nasicon-type Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) is a potential electrolyte for lithium-ion batteries due to its appropriate conductivity and good air stability. Herein, LATP was co-doped with Ga and Si to improve its ionic conductivity. The Li 1.325 Al 0.29 Ga 0.01 Ti 1.7 Si 0.025 P 2.975 O 12 (LAGTSP025) electrolyte exhibits an ionic conductivity of 8.92 × 10 −4 S/cm at 30 °C, which is mainly ascribed to its enlarged crystal lattice and high densification. This electrolyte material was incorporated into poly(ethylene oxide) (PEO) polymer to form a polymer-based PEO-LITFSI-LAGTSP025 solid composite electrolyte (SCE). The optimized SCE shows a high ionic conductivity of 5.33 × 10 −4 S/cm and excellent interfacial stability at 60 °C. Consequently, a Li/SCE/Li symmetric battery can stably cycle for 1600 cycles at a current density of 0.1 mA/cm 2 . Moreover, an LFP/SCE/Li all-solid-state lithium-ion battery (ASSLIB) maintains a discharge capacity of 143.56 mAh/g and exhibits 95.21% capacity retention after 300 cycles at 0.5C. This work demonstrates PEO-LITFSI-7.5LAGTSP025 SCE is a potential solid electrolyte for ASSLIBs.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Xiaojuan Liu,Zhifeng Li,Yiming Wang,Jiayi Wu,Chengzhou Li,Chunxiang Wang,Youming Yang
Na3V2(PO4)3 (NVP) cathodes suffer from intrinsically low electronic conductivity and sluggish, nonuniform two-phase conversion, which together limit their rate capability, cycle life, and low-temperature performance. A pulsed-laser strategy is developed to simultaneously generate hollow NVP spheres and achieve in situ anchors 3–4 nm carbon quantum dots (CQDs) onto NVP, yielding a hollow/CQD architecture (NVP-L). The hollow morphology shortens Na+ diffusion paths and buffers transformation-induced strain, while uniformly distributed CQDs form an internal conductive network that enhances local electronic transport and homogenizes interfacial reaction environments. Temperature-dependent GITT and Arrhenius analyses reveal a pronounced reduction of the effective activation energy from 0.51 eV for pristine NVP to 0.07 eV for NVP-L, accompanied by a several-fold increase in the Na+ chemical diffusion coefficient. Consequently, NVP-L delivers a high specific discharge capacity of 105.1 mAh g–1 at 20 C and retains 87.1% of its capacity after 3000 cycles and maintains 89.7 mAh g–1 after 500 cycles at −20 °C and 1 C. A full cell paired with a Na3Ti2(PO4)3 anode achieves an energy density of 148.5 Wh kg–1 and retains 91.6% and 88.7% of its capacity after 200 cycles at 1 and 5 C, respectively. This low-energy, scalable pulsed-laser approach provides a practical route to concurrently tailor morphology and interfaces, lower phase-conversion barriers, and realize fast, durable NASICON-type sodium-ion cathodes.
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PubMed
高影响因子
MOLECULES
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2025
·Vol. 30
·期 12
·2478
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IF 4.6
Shiluo Chen,Jinxin Wang,Yuteng Cao,Kangcai Wang,Haijun Yang,Tianlin Liu
Energetic metal–organic frameworks (E-MOFs) have recently emerged as a promising strategy to address the long-standing challenge of reconciling energy and sensitivity in energetic materials. Nitrogen-rich compounds, with their abundant nitrogen atoms and superior enthalpy of formation, are particularly beneficial for forming multiple coordination bonds while simultaneously elevating the energy content. This makes them ideal ligand molecules for constructing E-MOFs. In this work, we report the synthesis and structural design of a novel series of E-MOFs, constructed from the nitrogen-rich energetic ligand BNTA and a range of alkali metals (Na–Rb, compounds2–5). The research indicates that the synthesized E-MOFs exhibit high thermal stability and low sensitivity. Specifically, Compound3displays a high decomposition temperature of 285 °C, with impact sensitivity and friction sensitivity values exceeding 40 J and 360 N, respectively. Moreover, Compound3also exhibits excellent computational detonation performance. Significantly, this study demonstrates how the aromatic character, coordination chemistry, and intermolecular interactions work synergistically to enhance the stability and safety of E-MOFs, thereby establishing fundamental criteria for engineering the next generation of energetic frameworks.
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ANIMAL REPRODUCTION SCIENCE
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2025
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IF 3.3
Xi Huang,Zhangshan Gao,Peichao Gao,Helong Ji,Laizhi Xu,Dengfei Feng,Wentao Fan,Suquan Song
Stress is a well-established disruptor of reproductive function in poultry. Gamma-aminobutyric acid (GABA), a notable postbiotic derived from Lactobacillus plantarum ( L. plantarum ), has attracted increasing attention as a dietary supplement. While existing research predominantly focuses on GABA applications in broilers and other species, its effects on laying hens remain underexplored. This study investigated whether GABA and L. plantarum 1-2-3 supplementation mitigated corticosterone (CORT)-induced chronic stress in laying hens. Results demonstrated that both GABA and L. plantarum 1-2-3 effectively mitigated CORT-induced declines in laying performance and ovarian damage. They reduced ovarian oxidative stress, inflammation, and atretic follicles by enhancing antioxidant capacity and normalizing expression of inflammatory factors ( IL18 , LITAF , IL6 , IL1B) , and apoptosis-related factors ( BCL2 , BAX , CASP9 , CASP3 ). Furthermore, GABA and L. plantarum 1-2-3 markedly increased the serum reproductive hormone levels, as well as the transcription level of ovarian steroidogenic genes ( LHCGR, FSHR, StAR, CYP11A1 ), while modulated ovarian cholesterol metabolism via PPARα-mediated pathways. These findings elucidate the mechanisms by which GABA and L. plantarum 1-2-3 alleviate stress in laying hens, providing a theoretical and practical basis for their use as functional feed additives in stress-exposed flocks.
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高影响因子
Frontiers in Microbiology
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2025
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IF 4.5
Lihua Zhao,Lei Jin,Yunhe Fu,Bin Yang
Background: Indole-3-propionic acid (IPA) is a tryptophan metabolite produced by intestinal bacteria, which has functions such as penetrating tissue barriers and reducing tissue inflammatory reactions. In the present study, the therapeutic effect of IPA on Staphylococcus aureus (S. aureus)-induced mastitis was investigated.Methods: A mouse model of mastitis was established using breast injection of S. aureus. Except for the control group, all other mice were given oral administration of IPA. Hematoxylin eosin (H&E) staining was used to detect pathological changes in mouse mammary tissue. ELISA was used to detect TNF-α and IL-1β levels. Western blot was used to detect protein expression.Results: As the results demonstrated, IPA treatment obviously attenuated S. aureus-induced mammary pathological injury, myeloperoxidase (MPO) activity, malondialdehyde (MDA) content, TNF-α, and IL-1β levels. Meanwhile, IPA treatment could restore blood-milk barrier, as confirmed by up-regulating the expression of ZO-1 and occludin. In vitro, IPA could inhibit TNF-α and IL-1β production and the activation of NF-κB and NLRP3 induced by S. aureus. Furthermore, IPA could increase the expression of aryl hydrocarbon receptor (AhR). In addition, the inhibition of IPA on S. aureus-induced inflammation was reversed by AhR inhibitor.Conclusion: In conclusion, the results suggested that IPA inhibited S. aureus-induced mastitis through inhibition inflammation and restoring blood-milk barrier by activating AhR.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.5
Haozhen Liu,Shiyu Du,Paipai Zhang,Jiawei Zhao,Yanna Chen,Donghai An
A high-performance ultraviolet (UV) nonlinear optical (NLO) material requires three essential characteristics: a short UV absorption edge, a strong secondharmonic generation (SHG) response, and favorable NLO coefficients. In this study, a novel rare-earth borate compound with the formula K 7 MgY 2 (B 5 O 10 ) 3 was successfully synthesized using a high-temperature solution method combined with chemical cosubstitution. The crystal adopts a non-centrosymmetric (NCS) structure (space group R32) and exhibits an SHG intensity 1.3 times that of potassium dihydrogen phosphate (KDP) under 1064 nm laser irradiation. Its UV cutoff edge is determined to be 290 nm, demonstrating exceptional potential for UV optical applications. Combined experimental and theoretical analyses reveal that the synergistic interplay between polarizable [B 5 O 10 ] groups and heterovalent K + /Mg 2+ /Y 3+ substitution underpins its superior NLO performance.
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Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·5
·
IF 2.7
Lee Serim,Kim Moonsu,Shin Seong-Ah,Moon Sun Young,Choi Seyeon,Kim Minji,Lee Jun Hyuck,Youn Ui Joung,Lee Chang Sup
An allergy is an exaggerated immune response to an otherwise harmless substance. These reactions are triggered largely by mast cell activation and the subsequent release of inflammatory mediators. Although current allergy therapies effectively relieve symptoms, they are generally accompanied by side effects, highlighting the need for safer alternatives. In this study, we investigated the anti-allergic effect of ethyl-2-oxo-2H-chromene-3-carboxylate (EtCC), a coumarin derivative. Rat basophilic leukemia (RBL-2H3) cells and a passive cutaneous anaphylaxis (PCA) model were used for in vitro and in vivo evaluations, respectively. In RBL-2H3 cells sensitized with dinitrophenyl (DNP)-specific-immunoglobulin (Ig) E and stimulated with DNP-human serum albumin (HSA), EtCC inhibited histamine and beta-hexosaminidase release, and downregulated mRNA expression of interleukin (IL)-4, IL-13, and TNF-α. EtCC also suppressed phosphorylation of MAPK, AKT, and NF-kB. In vivo, EtCC attenuated ear edema and Evans blue extravasation in a PCA model. These findings demonstrate that EtCC effectively suppresses mast-cell-mediated allergic responses, suggesting its potential as a novel allergy treatment.
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Green Energy & Environment
·
2026
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IF 14.6
Lijun Xiong,Dandan Zhu,Chenglong Qiu,Weihong Zeng,Mingshi Xu,Shanshan Wang,Yong Yang
The photocatalytic reduction of carbon dioxide (CO 2 ) into high-value C 2+ hydrocarbons represents a sustainable pathway to alleviate energy shortages and reduce atmospheric CO 2 levels. In this study, a unique tandem photocatalyst (CoTi-CN), is constructed by integrating bimetallic CoTi-MOF with metal-free half-metallic C(CN) 3 . This composite demonstrates markedly enhanced activity and selectivity in the photocatalytic CO 2 reduction to ethylene (C 2 H 4 ), achieving a C 2 H 4 selectivity of 36.8% and a generation yield of 31.3 μmol g −1 over 5 h. Density functional theory (DFT) calculations combined with in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) analysis reveal that C(CN) 3 acts as an efficient CO 2 to CO converter, while CoTi-MOF favors the adsorption and C-C coupling of *CO intermediates. The spatially decoupled CO generation and C-C coupling processes lead to optimized intermediate coverage and reduced energy barriers, resulting in superior selectivity toward multi-carbon products. This work opens new horizons for the design of tandem photocatalysts that combine half-metallic catalysts with bimetallic MOFs, achieving a significant enhancement in the activity and selectivity of photocatalytic C 2 H 4 production.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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2026
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IF 5.3
Wen Xu,Yujing Zhang,Qianqian Xu,Haibo Zhao,Liya Cui,Chao Wang
Tubulin, the fundamental component of microtubules, remains a critical target in anticancer therapy. The development of small-molecule tubulin polymerization inhibitors continues to drive the discovery of novel chemotherapeutic agents. Through systematic analysis of known tubulin inhibitors and in silico binding pocket models, a focused series of 6-aryl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridine derivatives was rationally designed and synthesized. Compound 8o exhibited superior antiproliferative potency, with IC₅。 values of 0.050-0.078 µM against HeLa, HCT116, and MCF-7 cancer cell lines. Mechanistic investigations confirmed that 8o effectively inhibits tubulin polymerization, disrupts the microtubule cytoskeleton, induces G₂/M phase arrest, and triggers apoptosis. Preliminary physicochemical assessment indicated that 8o adheres to Lipinski’s rule of five, supporting favorable drug-likeness. Collectively, these findings identify 8o as a potent, drug-like colchicine-site tubulin inhibitor with compelling anticancer efficacy, meriting further investigation as a promising lead compound.
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JOURNAL OF LUMINESCENCE
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2019
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IF 2.961
Run Wang,Yue Zhang,Fu-Xing Yu,Yajie Dong,Ya-Lan Jia,Xing-Juan Ma,Qiang Xu,Yanhong Deng,Zu-Hong Xiong,Chun-Hong Gao
An efficient perovkite light-emitting diode (PeLED) is fabricated by incorporating 1,3,5-tri (m-pyrid-3-yl-phenyl)benzene (TmPyPB) between the emitting layer (EML) and the electron transporting layer (ETL), where TmPyPB plays an indispensable blocking effect on both excitons and holes. It shows a maximum current efficiency of 9.37 cd/A, and the corresponding external quantum efficiency (EQE) of 2.42% with a saturated green color Commission International de I'Eclairage (CIE1993) coordinated of (0.1279, 0.7951) under a driving voltage of 6 V. Meanwhile, the operational lifetime of the TmPyPB-based PeLED is improved to about 2.6-fold to that of the one with only the traditional ETL of aluminum 8-hydroxyquinolinate (Alq 3 ). The enhancements of electroluminescence (EL) performance are mainly attributed to better confinement of both the holes and the excitons in the EML, and more balanced carrier transportation in the TmPyPB-based PeLED. This work offers a feasible strategy to develop high performance optoelectronic devices.
研究领域:
材料科学
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光电子学
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纳米技术
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半导体器件
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功能材料
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