MOLECULAR PSYCHIATRY
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2026
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IF 10.4
Huang Miaoqi,Ye Han,Xu Yong,Xie Jiaoyan,Wang Xinyu,Luo Yan,Liu Peng,Ma Xuanyue,Zhang Shiqing,Jiang Bin,Ye Wen-Cai,Peng Yinghui,Shi Lei
Perturbed protein synthesis plays a crucial role in the pathogenesis of autism spectrum disorder (ASD), but the altered translational pattern and underlying mechanism remain poorly understood. Here, we identified an exaggeration of global protein synthesis in the cerebral cortex of offspring mice following prenatal exposure of valproic acid (VPA), a well-established ASD model. Integrative analysis of polyribosome-based translatome and proteome data revealed remarkable upregulation of ribosomal and mitochondrial genes in VPA-exposed cortex at both translational and protein levels, but not transcriptional levels. Further analysis pinpoints that overactivation of the translation initiation factor eIF4E causes the aberrant translatome and mitochondrial impairments in VPA-exposed cortex. Pharmacological inhibition of eIF4E phosphorylation during juvenile displayed persistent effectiveness in mitigating ASD-like social deficits and stereotyped behavior in VPA mice until adulthood. Collectively, these findings demonstrate that eIF4E overactivation leads to imbalanced protein synthesis that favors translation of ribosomal and mitochondrial genes, causing core ASD-like behaviors.
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Nature Communications
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2026
·
IF 18.1
Mao Congyang,Jin Wanyu,Dou Limeng,Guo Tong,Huang Jin,Wang Yi,Liu Xiangmei,Wu Shuilin,Qiao Wei,Xiang Yiming,Zhu Yizhou,Wu Jun,Yeung Kelvin Wai Kwok
The pandemic-scale progression of type 2 diabetes mellitus (T2DM) necessitates innovative interventions targeting the pathogenic triad of insulin resistance, dysregulation of lipid metabolism, and gut microbiome dysbiosis. Here, we report a synthetically bioengineered probiotic consortium (REcN-F/Ca) developed through directed metabolic adaptations of Escherichia coli Nissle 1917 (EcN) under iterative hydrogen peroxide selection, subsequently functionalized with fructooligosaccharide-calcium carbonate composites. REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability. In high-fat diet-induced obese male mice, REcN-F/Ca restores gut microbiota diversity, enriches butyrogenic taxa (Lachnospiraceae and Blautia ), and rescues short-chain fatty acids depletion. Transcriptomic profiling reveals PPAR signaling activation, driving lipid metabolism and suppressing adipose inflammation. These effects translate to systemic metabolic improvements with attenuated weight gain (−25.4%), restored glucose homeostasis, and reduced insulin resistance (HOMA-IR: −73.2%) in the obesity and T2DM murine model. Our findings establish REcN-F/Ca as a synthetically engineered probiotic that simultaneously corrects intestinal ecological perturbations and reverses host metabolic dysfunction, proposing a paradigm for metabolic syndrome management.
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Nature Sustainability
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2026
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IF 32.1
Wu Shuxing,Huang Chuxiong,Shen Wenbin,Long Xianhao,Ye Zhihuan,Qiu Juncheng,Xie Liangxin,Zhou Wenbo,Zhang Shanqing,Wei Xiujuan,Lin Zhan
The substantial growth in the market for lithium-ion batteries has created a huge challenge for their end-of-life management and demands sustainable solutions. Direct recycling is a promising choice due to its superior energy efficiency and environmental benefits, particularly the advantage in preserving the original chemistry and structure of the target materials. However, binders hold the active electrode materials and the current collectors tightly together, and their separation usually involves energy-intensive thermal treatment and environmentally hazardous chemicals. Here we present a water-soluble binder by crosslinking natural sericin protein with sulfuric acid through supramolecular interactions. The as-fabricated binder demonstrates comparable electrochemical performance with the most common polyvinylidene fluoride formulation, when applied to a typical LiNi 1/3 Co 1/3 Mn 1/3 O 2 (NCM111) cathode. A 1.3-Ah pouch cell retained 85.0% of its initial capacity after 500 cycles. Equally importantly, after being soaked in water at 50 °C for less than 1 min, the NCM111 and graphite can be completely detached from the current collectors for recycling. By integrating the circular economy into the battery design, this work paves the way for the development of next-generation battery chemistries with enhanced sustainability.
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Nature Communications
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2026
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IF 18.1
Chen Bin,Ding Miaomiao,Feng Ye,Gao Chao,Rong Jinghui,Tan Haixin,Tian Hao,Wilson Daniela A.,Zhou Yecheng,Tu Yingfeng,Peng Fei
Anxiety and mood disorders, notably major depressive disorder characterized by suppressed neuronal excitability, involve disruption of endogenous molecular polarity homeostasis. Conventional monoamine antidepressants, constrained by delayed therapeutic onset and high risk of drug resistance, neglect and fail to address this pathological feature. Here, we report IC@His-ICG, a near-infrared-responsive photochemical nanomotor that enables polarity switching. Leveraging photochemically driven polarity change, the wireless nanomotors achieved ion-tolerant propulsion in physiological media and phototactic migration to predefined hippocampal targets. Spatiotemporal polarity tuning induced instantaneous calcium oscillations and hippocampal excitation transmission, restoring monoamine homeostasis and combating anxiety and depression in rodents. This polarity-based neuromodulation operates independently of ligand-receptor mechanisms, linking nanoscale polarity dynamics to neurochemical homeostasis and behavioral outcomes in a depressive mouse model. The noninvasive, precision nanomachine strategy differs from traditional intervention frameworks, offering a precise modulation approach for neural disorders.
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ACTA PHARMACOLOGICA SINICA
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2026
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IF 10.4
Chen Chuan-jun,Guo Ding-wen,Yuan Qing-yun,Zhuo You-qiong,Yang Shi-fen,Xu Hao-min,Wang You-rong,Guan Xiao-hui,Deng Ke-yu,Xin Hong-bo
Macrophage migration inhibitory factor (MIF) is a cytokine that possesses multiple enzymatic activities, such as keto-enol tautomerase and thiol-oxidoreductase. We previously found that lack of MIF tautomerase activity significantly alleviated high fat diet (HFD)-induced obesity in mice. In this study, we investigated the regulatory mechanisms of MIF tautomerase in obesity. HFD-induced obese mouse model was established. Adipogenic differentiation was induced in mouse preadipocyte cell line 3T3-L1 and mouse adipose-derived mesenchymal stem cells (ADSCs) in vitro. We showed that MIF tautomerase inhibitors ISO-1 or 4-IPP dose-dependently promoted lipid degradation and mitochondrial thermogenesis by enhancing basal oxygen consumption rate and proton leak, accompanied by increased expression of browning markers (UCP1, PGC-1α, DIO2, CD137) in 3T3-L1 cells under adipogenic induction conditions. In HFD-induced obese mice, administration of 4-IPP (5, 10 mg/kg, i.p.) every 2 days for 12 weeks significantly ameliorated HFD-induced obesity, improved insulin sensitivity, and enhanced energy expenditure. In white adipocytes, 4-IPP (1, 5, 10 μM) dose-dependently promoted CD137 expression, and restored CD137-mediated activation of the PI3K/AKT signaling to improve lipid metabolism. CD137 deficiency abrogated the browning effect of 4-IPP in white adipocytes in vitro. CD137 −/− mice exhibited increased susceptibility to HFD-induced obesity and almost abolished the anti-obesity effects of 4-IPP. Simulation of the protein interaction revealed a direct interaction between MIF and CD137: MIF competitively bound to CD137 on white adipocytes with the endogenous ligand of CD137, which was further confirmed by co-immunoprecipitation. Furthermore, 4-IPP and recombinant CD137 protein inhibited the tautomerase activity of MIF in vitro. In conclusion, MIF promotes obesity by binding CD137 through its tautomerase domain, suppressing CD137-mediated the activation of the PI3K/AKT signaling. MIF tautomerase inhibitors disrupt this interaction, restore CD137 function, and enhance adipocyte browning, offering a promising therapeutic strategy for obesity management.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 5
·402
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IF 3.2
Li Jing,Su Yuchang,Wang Jionghui,Zhang Jing,Zhu Yinyin
As lithium-ion batteries and electronic devices proliferate rapidly, recycling spent batteries and developing advanced electromagnetic microwave absorbers have become increasingly crucial. Upcycling spent graphite anodes into high-performance microwave-absorbing materials provides a value-added pathway for graphite resource reutilization while mitigating electromagnetic pollution. In this study, spent graphite anode waste was directly upcycled to construct PSG@Co (Pre-treated Spent Graphite @ Cobalt) composites via a liquid-phase impregnation followed by a carbothermal reduction process. The cobalt loading and morphology of PSG@Co composites were readily tuned by adjusting the concentration of the cobalt precursor solution, thereby further altering microwave absorption performance. Benefiting from the retained bulk graphitic structure and abundant defective sites of the pre-treated spent graphite, the composites exhibited excellent conductive loss and defect polarization. Moreover, cobalt incorporation significantly improved interfacial polarization, magnetic loss, and impedance matching. Under an optimal cobalt precursor concentration of 0.34 M, the PSG@Co-2 composite delivered remarkable microwave absorption performance, achieving minimum reflection loss of − 63.12 dB at 11.20 GHz and a maximum effective absorption bandwidth of 5.68 GHz at a thickness of only 1.65 mm. The study offers a practical and value-added approach to transforming spent graphite anode waste into high-performance microwave-absorbing materials.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Yang Fang,Lei Sichao,Ma Renyi,Zhang Wen,Luo Minhui,Xie Chenyang
To develop a novel intelligent packaging material capable of real-time food freshness monitoring and preservation, this study prepared a pH-responsive bioactive film (KCNB) by incorporating blueberry anthocyanins (BA) and nano‑zinc oxide (NanoZnO) into a konjac glucomannan/chitosan (KGM/CS) matrix. The resulting KCNB film was structurally characterized and functionally evaluated and results confirmed the successful dispersion of NanoZnO and BA within the matrix. The film exhibited excellent UV‑blocking capacity, significantly enhanced antioxidant activity (DPPH radical scavenging rate increased to 77.57%), and effective antibacterial efficacy against E. coli and S. aureus , which collectively help prevent light‑induced deterioration, chemical oxidation, and microbial spoilage. Crucially, the film displayed a reversible color transition from red to green across the pH range of 2–12, providing a basis for its function as a visual freshness indicator. When applied to chicken breast preservation, the KCNB film, through the synergistic action of these multiple functions, effectively slowed down spoilage, maintained a lower total volatile basic nitrogen (TVB‑N) level, and thereby extended the shelf life by approximately 4 days compared with the control group. This study demonstrates that the developed multifunctional film holds high potential for application in intelligent bioactive packaging of meat products.
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Nature Communications
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2026
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IF 18.1
Jiang Jinhui,Pan Yiwen,Zhao Jingyi,Zhang Siwei,Ma Fulong,Zhang Zicong,Liu Mengli,Qiu Zijie,Zhao Zheng,Sun Jianwei,Kwok Ryan T. K.,Xiong Yu,Lam Jacky W. Y.,Han Wei,Tang Ben Zhong
Organic circularly polarized room-temperature phosphorescence (CPRTP) materials represent an emerging research frontier with broad application prospects. However, achieving efficient and controllable CPRTP remains challenging due to inefficient chirality transfer and the limited ability to regulate chiral environments. Here, we develop a strategy involving self-assembled chiral homopolypeptides to realize manipulable CPRTP. Chiral homopolypeptides functionalized with achiral phosphorescent terminals are first designed, which self-assemble into vesicles exhibiting weak CPRTP. Remarkably, dispersing these vesicles into a poly(vinyl alcohol) matrix induces structural reorganization, leading to inversion and significant amplification of CPRTP. Experimental and computational studies reveal the critical role of matrix-assistance in chirality propagation, inversion, and amplification. Moreover, multicolor afterglow films with tunable emissions are readily achieved by varying the terminal phosphor. This work not only establishes a universal platform for constructing tunable CPRTP materials through homopolypeptide self-assembly but also provides deep mechanistic insights into supramolecular chirality manipulation.
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JOURNAL OF PLANT GROWTH REGULATION
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2026
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IF 4.2
Zahedi Seyed Morteza,Fahadi Hoveizeh Narjes,Mohammadi Zeinab,Gholami Rahmatollah,Padervand Mohsen,Dawi Elmuez A.,Anik Touhidur Rahman,Abdelrahman Mostafa
Nanostructures are increasingly used to mitigate various abiotic stresses in recent years. This study investigated the effects of zinc oxide nanostructures, titanium oxide nanostructures (TiO 2 nanostructures) and zeolite (Zeo)-supported ZnTiO 3 nanostructures on ‘Zard’ fig ( Ficus carica L.) seedlings in alleviating the adverse effects of salinity stress. Fig plants were treated with 10 mg L -1 ZnO nanostructures, 15 mg L -1 TiO 2 nanostructures, and 15 mg L -1 Zeo-supported ZnTiO 3 nanostructures under normal conditions and 75 mM NaCl stress. Salinity stress increased Na⁺ levels by 134%, hydrogen peroxide (H 2 O 2 ) concentrations by 45%, and electrolyte leakage percentage (EL%) by 45%, while significantly reducing root growth parameters. In contrast, treatment with Zeo-supported ZnTiO 3 nanostructures significantly increased root fresh weight by 53% and dry weight by 48%, improved the chlorophyll index; soil plant analysis development values by 12%, boosted superoxide dismutase activity by 25% and glutathione peroxidase activity approximately ~ 2.8-fold, while reducing EL% and H₂O₂ concentrations by 22% each, thereby contributing to the enhanced salinity tolerance in salt-stressed fig plants compared with nanostructure-untreated plants. Although ZnO nanostructures and TiO 2 nanostructures also improved some root system architecture (RSA) parameters under salinity stress, the Zeo-supported ZnTiO 3 nanostructures were more effective. The results indicate that the enhanced efficacy composite Zeo-supported ZnTiO₃ nanostructure is more effective than individual treatments in enhancing salinity tolerance in fig seedlings by modulating key physiological, biochemical, and RSA traits. Combined ZnTiO 3 nanostructures with zeolite substrate showed significantly greater effect in improving salt stress tolerance than the separate application of ZnO or TiO 2 nanoparticles, indicating enhanced efficacy benefits in their combined use. Therefore, future studies should focus on scaling up their application under saline field conditions, assessing long-term environmental safety, and exploring their integration with precision agriculture technologies to further improve sustainable fig production under salinity stress.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4
Chen Shuai-Jun,Huang Biao,Song Li-Xin,Wang Zha,Du Ping-Fan,Xiong Jie,Zhu Hai-Lin,Guo Yu-Hai
Solid polymer electrolytes (SPEs) are considered promising candidates for all-solid-state lithium metal batteries because of their easy preparation and good compatibility with lithium metal. However, their applications are restricted by their low ionic conductivity and poor mechanical properties. In this study, a composite solid polymer electrolyte composed of poly(ethylene oxide) (PEO), poly(vinylidene fluoride- co -hexafluoropropylene) (PVDF-HFP), plasticizer succinonitrile (SN), and polytetrafluoroethylene (PTFE) fibrous porous membranes was prepared. The PTFE fibrous membrane significantly enhanced the mechanical strength of the electrolyte as a supporting framework. SN reduced the crystalline regions of PEO and facilitated rapid lithium-ion transport. PVDF-HFP promoted lithium salt dissolution and improved the electrochemical stability of the electrolyte. Accordingly, the optimized PTFE/PEO/PVDF-HFP/SN polymer electrolyte exhibited a tensile strength of 3.31 MPa at 352% elongation and demonstrated an ionic conductivity of 7.6×10 −4 S·cm −1 at 60 °C. Lithium symmetric cells maintained stable cycling for over 2500 h at 0.15 mA·cm −2 , and Li//LiFePO 4 full cells showed a high capacity retention of 91.6% after 300 cycles at 0.5 C, with coulombic efficiency consistently exceeding 99.9% throughout cycling.
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Scientific Reports
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2026
·Vol. 16
·期 1
·4677
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IF 3.9
Cao Yingjian,Wang Quan,Yao Yingkang,Zhang Jiabao,Wang Fengqi,Liu Zhiyu,Lu Kaiyan,Yang Yaoyong,Li Rui,Xu Xiaomeng
To improve the performance of bulk emulsion explosives, a coal powder water slurry (CPWS) was prepared and introduced to partially replace ammonium nitrate. The microstructure, particle size distribution, and thermal decomposition behavior of emulsified matrices with different CPWS contents were investigated using optical microscopy, laser particle size analysis, and thermogravimetry. The Kissinger method was applied to calculate activation energy, while detonation velocity and brisance were measured. Results show that both viscosity and explosive performance first increased and then decreased with rising CPWS content. The 6% CPWS formulation exhibited the highest detonation velocity (4103.88 m·s − 1 ) and brisance (11.51 cm), along with the lowest activation energy (118.67 kJ·mol − 1 ). In contrast, 12% CPWS led to the highest activation energy (172.46 kJ·mol − 1 ). Overall, the 6% CPWS composition provided the best balance of viscosity, explosive power, and thermal behavior, demonstrating its potential for practical application.
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NATURE MATERIALS
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2026
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IF 38.5
Chen Ruoyang,Zhang Yue-Yu,Huang Xing,Wang Liping,Zhang Lei,Song Chao,Dai Lixiong,Zhang Min,Wang Jun,Jian Yong,Xu Weiyuan,Dong Hui,Peng Bingquan,He Shuqiang,Liang Shanshan,Dai Fangfang,Fan Qihui,Ye Fangfu,Zhang Xin,Zhang Feng,Fang Haiping
Hydrogels do not have observable responses to external magnetic fields as they are conventionally thought to be diamagnetic. These materials require additives for magnetic control, limiting biomedical applications due to potential side effects. Here we show that calcium cations can induce strong paramagnetism of hydrogels rich in groups containing carbon–oxygen double bonds, including alginate, carboxymethyl chitosan, polyacrylamide and N -isopropyl acrylamide. Both experiments and computations reveal that the ubiquitous presence of net magnetic moments, the key to paramagnetism, is induced by the unexpected coupling of a single calcium cation and one carbonyl group under large calcium cation excess conditions. The paramagnetic phenomenon is also observed in the endogenous biomolecule sodium hyaluronate with calcium cations. We further demonstrate the applications of the strongly paramagnetic alginate-calcium hydrogel as a contrast agent in magnetic resonance imaging and a carrier in magnetic drug delivery. Our findings provide insights into the origin of magnetism and advance magnetism-related biomedical innovations.
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危险品化学品经营许可证（带存储）