Nano-Micro Letters
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2026
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IF 38.5
Wenjing Zhang,Xiaoci Liang,Sixing Chen,Xiuquan Ma,Chen Chen,Songjia Han,Chuan Liu
High-density organic electrochemical transistor (OECT) arrays are essential for neuromorphic computing and bioelectronic interfaces, but progress has been limited by the low resolution of electrolyte patterning. Although conventional photolithography offers high feature resolution, it involves a fundamental trade-off among spatial resolution, ionic capacitance, and stability in the electrolyte. Here we report an ion compensation-assisted photolithography (ICAP) strategy that yields electrolyte micro-patterns combining high precision, high capacitance and high stability. A molecularly engineered electrolyte forms, under UV exposure, a physicochemical dual cross-linked network with strong solvent resistance and hydrophobicity, which suppresses swelling during both aqueous development and the subsequent ion-compensation step, preserving pattern fidelity. Ion compensation then restores and enhances the mobile-ion content, increasing areal capacitance. The resulting electrolytes achieve a record 2 μm resolution, 15.6 μF cm −2 capacitance, and strong thermal stability from − 50 to 200 °C. Integrated into OECTs, the ICAP-patterned electrolytes suppress crosstalk by 97.6% and boost on/off ratios by 325%, reducing parasitic coupling by more than 40 times compared to unpatterned arrays. The method is compatible with p -type and n -type organic semiconductors and inorganic oxides, providing a versatile route to scalable neuromorphic circuits and advanced bioelectronics.
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Nature Communications
·
2026
·Vol. 17
·期 1
·1785
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IF 18.1
Zeng Silue,Chen Jingqin,Ren Yaguang,Gu Jianyou,Zhang Junfeng,Liu Liangjian,Xu Zhiqiang,Chen Rui,Tang Chuanyu,Xue Qiang,Wen Sai,Hu Haoyu,Liu Zheng,Ren Ning,Fang Chihua,Liu Chengbo
An acidic tumor microenvironment (TME), a hallmark of cancer progression, promotes tumor growth, invasion, and metastasis. Detecting and targeting tumor acidity have emerged as key frontiers in early cancer diagnosis and treatment. However, current approaches lack sensitive and specific methods to visualize and quantify tumor acidity in vivo across different stages of tumor development. Here we show that ATP6V0C, a subunit of the V-ATPase responsible for proton transmembrane transport, is a critical mediator of TME acidification. High ATP6V0C expression correlates with hepatocellular carcinoma (HCC) progression and metastasis. To enable real-time assessment of tumor acidity, we develop a pH-responsive ratiometric photoacoustic sensor (PPS) that dynamically monitors TME acidity throughout HCC initiation, progression, and metastasis. Using PPS-assisted photoacoustic molecular imaging, we visualize the spatiotemporal evolution of TME acidity from early tumor foci to solid tumors. PPS exhibits enhanced photothermal effects under acidic conditions, and its combination with the proton pump inhibitor esomeprazole synergistically suppresses tumor growth. Overall, PPS-assisted photoacoustic molecular imaging provides a sensitive and specific approach to characterize tumor initiation and progression, supporting its potential application in early diagnosis and therapeutic strategies that target the acidic TME.
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Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Yang Yong,Gu Huan,Zhou Zhenyi,Kong Xiaoguang,Fang Xiaolong,Zhao Guomin,Zhang Jieyu,Xiong Ye,Yu Hongwei
The development of inorganic adhesives can effectively break away from fossil dependence and formaldehyde emissions issues of traditional synthetic resin adhesives. However, achieving both high mechanical strength and good water resistance in magnesium oxychloride cement (MOC) remains challenging. Herein, we present an efficient biomimetic mineralization approach to fabricate a high-strength and water-resistant MOC-based adhesive. Specifically, polyamide polyamine compound (PPC) served as an organic template, facilitating the formation of densely interwoven phase 5 crystals within its polymer network. Sodium citrate (SC) regulated the formation of phase 5 hydration products via Mg 2+ chelation. The synergistic interaction between PPC and SC promoted the development of a compact organic-inorganic hybrid structure within the MOC adhesive, thereby enhancing its mechanical properties, bonding performance, and water resistance. The findings indicated that the MOC-SC-PPC adhesive exhibited significantly enhanced properties. Among the formulations, the MOC-SC-PPC/0.8 adhesive exhibited the highest compressive strength of 36.19 MPa after 7 days of curing, while the MOC-SC-PPC/0.2 adhesive achieved the highest softening coefficient of 0.86, indicating substantially improved water resistance. Moreover, the modified adhesive exhibited a prolonged setting time (from 108 min to 269 min), which is beneficial for practical construction applications. The MOC-SC-PPC/0.6 adhesive exhibited significantly improved wet bonding strength (0.85 MPa vs. 0.61 MPa) compared to the pure MOC adhesive, indicating enhanced water resistance and interfacial bonding performance. This study provides a novel approach for fabricating a formaldehyde-free adhesive via a biomimetic mineralization strategy, which enhances the adhesive’s applicability in humid environments and exerts a positive effect on sustainable resource utilization.
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FOOD SCIENCE AND BIOTECHNOLOGY
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2026
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IF 3.9
Li Na,Mei Jun,Xie Jing
This research evaluated the effects of three specific spoilage organisms (SSOs)- Shewanella baltica , Pseudomonas brenneri and Pseudomonas psychrophila - on quality deterioration and myofibrillar proteins (MPs) degradation in chilled large yellow croaker fillets. The SSOs were found to expedite the conversion of umami/sweet amino acids to biogenic amines (BAs), reduced water holding capacity and textural deterioration. This altered taste activity value (TAV) of representative amino acids and increased the equivalent umami concentration (EUC). SSOs exacerbated MP conformational changes from ordered rigid to disordered flexible structures, enhancing protein solubility and tyrosine content. Findings from SDS-PAGE and TEM indicated significant degradation of myosin, actin, and tropomyosin, and disruption of sarcomere structure. Correlations between quality traits and MPs stability were established. Spoilage impact ranked: Shewanella baltica > Pseudomonas brenneri > Pseudomonas psychrophila . This study highlights the importance of preventing SSOs colonization in delaying quality deterioration and provides comprehensive insights into MPs degradation in SSO-induced spoilage.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wang Qin,Zhao Yun,Mao Yuanhu,Zhang Xiaobo,Huang Lei,Tang Lei,Chen Yi,Gong Zipeng,Peng Jianqing
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease marked by relentless deterioration of pulmonary function. Clinically, oral pharmacotherapy for IPF is hampered by two major limitations: inefficient drug delivery to the lung parenchyma and systemic exposure leading to unavoidable off-target side effects. In this study, we developed an inhalable tanshinone IIA (TA) formulation based on lipid nanocrystals to address these challenges. Leveraging the high drug loading capacity and structural stability of lipid nanocrystals, this platform overcomes the intrinsic hydrophobicity of TA, thereby markedly improving its aqueous dispersibility, aerosolization performance, and regional deposition in the deep lung. In vitro, TA lipid nanocrystals significantly enhanced cellular uptake in both pulmonary epithelial cells and lung fibroblasts. In vivo, they achieved substantially high and sustained pulmonary drug exposure. In a bleomycin-induced mouse model of IPF, inhaled TA lipid nanocrystals attenuated histopathological fibrosis, preserved lung function, and suppressed chronic inflammation via modulating the PI3K-Akt signaling pathway and the coagulation-fibrinolysis system. Collectively, this study establishes TA as a promising inhaled therapeutic agent for IPF and introduces lipid nanocrystals as a versatile, scalable, and clinically translatable platform for targeted pulmonary delivery in fibrotic and other chronic respiratory diseases. Graphical Inhalable TA lipid nanocrystals for IPF treatments
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Cai Shanchen,Zheng Wenfu,Lin Ting,Zhang Siyuan,He Lanye,Zu Mali,Wang Le
Rapid closure is crucial for effective wound healing. However, current wound dressings often fall short in this aspect. Herein, we present a light-responsive wound dressing (A@MC) composed of a heat-curable methyl cellulose (MC) hydrogel and aminophenylboronic acid (ABA)-modified gold nanoclusters (AGNCs). The A@MC is injectable and can conform, connect, and adhere to wounds of irregular shapes before gelation. Upon near-infrared (NIR) light irradiation, the photothermal effect of the AGNCs triggers an instant gelation and contraction of the dressing and simultaneously a sharp shrinkage of the wound. It achieves a shrinkage rate up to 46% within 5 min for bacteria-infected wound in mice. Moreover, the contraction of A@MC can achieve a rapid release (16%, 5 min) of the AGNCs, which can bind to bacteria through ABA-lipopolysaccharide (LPS) interaction, displaying a targeted antibacterial therapy. The A@MC realizes an accelerated healing (complete healing within 14 days) of multidrug-resistant Pseudomonas aeruginosa ( P.a )-infected wounds. Graphical abstract
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Food Analytical Methods
·
2026
·Vol. 19
·期 10
·303
·
IF 3
Tu Xiaodong,Yao Mingcai,Dong Liang
A chloramphenicol (CAP) electrochemical sensor based on zinc tungstate and maghemite nanocomposites (ZnWO 4 /γ-Fe 2 O 3 ) is proposed. First, ZnWO 4 and γ-Fe 2 O 3 nanomaterials were synthesized using a hydrothermal synthesis method, then compositely modified onto glassy carbon electrodes to construct electrochemical sensors for measuring CAP. Under optimal conditions, the ZnWO 4 /γ-Fe 2 O 3 -modified electrode exhibits a stronger reduction peak current for CAP detection than the single-component electrode and demonstrates better electrocatalytic activity. The results demonstrate that ZnWO 4 /γ-Fe 2 O 3 /GCE exhibits a linear detection range of 8–1000 μM and a detection limit of 1.04 μM, demonstrating good selectivity in the presence of different interferers, as well as outstanding stability and reproducibility. ZnWO 4 /γ-Fe 2 O 3 /GCE was used to detect of CAP in milk samples, yielding satisfactory results.
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MOLECULAR NEUROBIOLOGY
·
2026
·Vol. 63
·期 1
·772
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IF 5.5
Tian Xiaofeng,Liu Qing,Zhang Jiacheng,Du Huijiao,Wei Zhaoran,Sun Linjie,Gao Jiamin,Zhao Ruiting,Wang Lei,Zhang Yizhou
In recent years, the association between abnormal cholesterol metabolism and Parkinson’s disease (PD) has attracted considerable attention, but the specific mechanism remains controversial. First, we used Mendelian Randomization (MR) analysis to clarify the relationship between cholesterol and PD. Subsequently, scRNA-seq and RNA-seq were used to identify the crucial role of astrocyte 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in this process. Moreover, we verified its downstream target genes by RNA-seq, in vivo and in vitro experiments. The upstream transcriptional regulator of HMGCR was identified by database and validated by luciferase reporter and siRNA knockdown assays. The results of the MR analysis showed that low cholesterol levels may increase the risk of PD. This phenomenon was also observed in the PD mouse model. The scRNA-seq and RNA-seq results showed that astrocyte HMGCR played an important role in PD. Increasing astrocytic HMGCR alleviated cholesterol level and PD-related phenotypes. Mechanistically, astrocytic HMGCR-mediated cholesterol alleviated PD phenotypes by inhibiting Nuclear Factor Kappa-B (NF-κB) neuroinflammation. Furthermore, knocking down Forkhead Box O1 (FOXO1) restored HMGCR expression and cholesterol levels, subsequently inhibiting NF-κB activation. Our research indicated that the cholesterol synthesis disorder in astrocytes driven by HMGCR can exacerbate the pathogenesis of PD by promoting neuroinflammation. Targeting HMGCR in astrocytes will be a potential therapeutic approach.
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Cell Death & Disease
·
2026
·Vol. 17
·期 1
·198
·
IF 12.2
Guo Chipeng,Luo Siweier,Luo Jigang,Lu Siyao,You Xiaomei,Cao Junlin,Du Yufei,Lv Haoran,Liang Hanzhi,Wang Le,Wang Liangchun,Liu Tao,Zhou Yiming
Ultraviolet B (UVB) is a well-recognized trigger of cutaneous lupus erythematosus (CLE), yet its molecular basis remains largely undefined. Here, using single-cell transcriptomics and a lupus-prone mouse model, we identify keratinocyte-derived macrophage migration inhibitory factor (MIF) as a key amplifier of cutaneous inflammation through a self-sustaining feedback loop. Single-cell RNA sequencing reveals elevated MIF expression specifically within pathogenic, interferon-high keratinocyte subclusters associated with CLE, which is further validated across major CLE subtypes in clinical skin samples. In vitro, UVB irradiation dose-dependently induces the release of MIF from keratinocytes, which in turn promotes inflammatory signaling and matrix remodeling in both keratinocytes and fibroblasts. Mechanistically, we demonstrate that UVB irradiation activates the ribotoxic stress response (RSR), leading to the p38-C/EBPβ-mediated transcriptional upregulation of NLRP3 and GSDMD cleavage in keratinocytes. The ensuing GSDMD-dependent pyroptosis facilitates the release of MIF, primarily through GSDMD pores rather than vesicular secretion, which in turn amplifies the p38-C/EBPβ signaling pathway. Therapeutic disruption of this loop either by gene silencing via AAVs or pharmacological inhibition via microneedles, markedly attenuates epidermal hyperplasia and cytokine imbalance in lupus-prone mice. These findings uncover a previously unrecognized MIF-p38-GSDMD inflammatory loop contributes to the UVB-induced cutaneous lupus, offering both mechanistic insights and translational opportunities for CLE.
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CHEMICAL PAPERS
·
2026
·
IF 2.7
Wu Yanlin,Qin Pixian,Li Yuan,Dong Wenbo,Monfort Olivier,Zeng Yilan
In this study, trace chlorogenic acid (CGA) was introduced as a natural reductant and ligand to facilitate the activation of Fe(III) in a sulfate radical-based advanced oxidation process (SR-AOP), enabling effective Fenton-like degradation of ofloxacin (OFL) under mild conditions. The CGA/Fe(III)/PMS system exhibited excellent performance in the degradation of ofloxacin (OFL) at near-neutral pH. The presence of CGA effectively promoted Fe(III)/Fe(II) cycling via dual redox and chelation effects, thereby enhancing PMS activation. Reactive oxygen species (ROS) analysis suggested that sulfate radicals (SO 4 ·− ) were the dominant contributors to OFL degrdation, while other reactive species played minor roles. The system maintained high activity in the presence of common coexisting anions in water (e.g., Cl − , and SO 4 2− ), whereas HCO 3 − and HPO 4 2− significantly suppressed degradation. These findings demonstrated the promising potential of CGA as an environmentally compatible additive for Fe(III)-based AOPs, providing useful mechanistic insight for mitigating antibiotic contamination in aquatic environments. Graphical abstract
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Surface Science and Technology
·
2026
·Vol. 4
·期 1
·46
·
IF 7
Wang Zian,Wang Yanan,Luo Rifang,Wang Yunbing
Surface-induced thrombosis restricts the clinical safety of blood-contacting devices. Although surface heparinization is a widely commercialized strategy for enhancing hemocompatibility, current methods (e.g., covalent grafting, Layer-by-Layer assembly) suffer from complex procedures or insufficient stability. Herein, we introduce a facile, one-step strategy to construct robust anticoagulant coatings driven by a salt-concentration gradient. By utilizing 4 mol/L NaCl to screen electrostatic interactions between polyethyleneimine (PEI) and heparin, a homogeneous precursor slurry was prepared. During a simple immersion-withdrawal process, rapid salt diffusion at the interface triggers immediate liquid–liquid phase separation, inducing the dense coacervation of polyelectrolyte complexes onto substrates. The resulting coating exhibits exceptional stability via physical entanglement, retaining 73% of heparin after 16 days of physiological incubation. Furthermore, the coating demonstrated a negligible hemolysis rate (0.32%), suppressed platelet adhesion by 98%, and reduced ex vivo thrombus formation by 90%. This scalable assembly paradigm offers a highly effective solution for cardiovascular implant functionalization.
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Nature Communications
·
2026
·
IF 18.1
Wang Siyuan,Kong Fanpeng,Bao Zhengyang,Zhao Xiaozhi,Zhang Lei,Song Zhongxin,Li Junjie,Du Lei,Xu Yongjun,Zhao Bo,Yin Geping,Sun Xueliang
Uniform ionomer distribution and controlled sulfonate adsorption are critical for low-Pt-loading proton exchange membrane fuel-cell membrane electrode assemblies (MEAs), especially at high current density. In conventional Pt/C catalysts, differences between Pt and carbon surfaces promote sulfonate adsorption on Pt and ionomer aggregation on carbon, thereby limiting proton and oxygen transport. Here we show that a single Co atom dipole layer covering Pt/C (SCDC-Pt) regulates the catalyst-ionomer interface through electrostatic attraction between positively charged Co sites and sulfonate groups. The resulting MEA delivers a peak power density of 1.4 W cm −2 and only 26 mV loss at 0.8 A cm −2 after 30,000 square-wave cycles, compared with 0.86 W cm −2 and 75 mV loss for commercial Pt/C under identical conditions. Operando characterization and simulations indicate that surface dipoles promote a more uniform ionomer distribution, suppress sulfonate poisoning of Pt, and stabilize the Pt structure. Electrochemical diagnostics show lower apparent sulfonate coverage ( ~ 8%) and local O 2 transport resistance (38.6 S m −1 ) than those of commercial Pt/C ( ~ 20% and 48.1 S m −1 ).
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