RSC Advances
·
2014
·Vol. 5
·期 1
·628-634
·
IF 3.708
Mingming Liu,Wei Yao,Cun Li,Zhenyu Wu,Liang Li
Strongly luminescent copper and indium co-doped CdS quantum dots (CuIn-doped CdS QDs) were synthesized from copper iodide, indium acetate, cadmium oleate, and 1-dodecanethiol as starting compounds in octadecene solvent. We demonstrated that when co-doping with In, Cu ions can homogeneously dope into CdS QDs and exist in the +1 state. The as-prepared doped QDs exhibited photoluminescence (PL) in the range of 590–800 nm, with a maximum fluorescence quantum yield (QY) of 40%. They also exhibited tunable large Stokes shifts from 100 nm to 300 nm via tuning dopant concentrations of Cu and In. Such an extremely large Stokes shift dramatically decreased the self-reabsorption of QDs. Furthermore, the CuIn-doped CdS QDs exhibited excellent thermal stability and lost only approximately 20% of their emission QY when the temperature was increased from 20 °C to 150 °C. These features make these QDs suitable as emitters for application in lighting.
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Biomedical Physics & Engineering Express
·
2015
·Vol. 1
·期 4
·045009
·
IF 0
Qiaoying Wang,Dan Wang,Danyang Li,Jian Lu,Qingrong Wei
Ovarian cancer has been the leading cause of death worldwide in gynecologic malignancy mainly due to the lack of ultrasensitive diagnosis approaches at its early stage and high cytotoxicity of anticancer drugs to normal cells. In an attempt to overcome the problems, a co-delivery system of folic acid (FA) modified nanoparticles were developed for early diagnosis and to maximize the therapeutic outcome. In the present study, we formulated a diblock copolymer of methoxy poly (ethylene glycol)-b-poly (-caprolactone)(mPEG-b-PCL) polymer micelles, and FA was further conjugated to endow micelles with active targeted capacity. Then paclitaxel (PTX) and superparamagnetic iron oxide (SPIO) were encapsulated in the core of micelles. The in vitro tumor cell targeting capability of FA-NP/SPIO/PTX and NP/ SPIO/PTX nanoparticles was assessed by confocal laser scanning microscopy (CLSM) with human ovarian cancer (SKOV3 cells) which overexpresses FA receptor. Quantitative analysis showed the amount of intracellular Fe in cells incubated with FA-NP/SPIO/PTX nanoparticles was about 13-fold higher than with NP/SPIO/PTX nanoparticles. The imaging contrast capability of FA-NP/SPIO/PTX nanoparticles as a sensitive MRI probe was evaluated by a 3 T clinical MR imaging scanner. The T2 -weighted imaging of cells incubated with targeting nanoparticles was found to have more sensitive imaging enhancement effect on the SKOV3 cells than non-targeting nanoparticles. Furthermore, the antitumor efficiency of targeting nanoparticles was approximately 5-fold higher than that of their counterparts, which further affirmed the feasibility of attaining the higher therapeutic efficacy of antitumor drugs while minimizing damage to healthy cells. The targeting nanoparticles exhibited the biphasic release characteristic in vitro. The results indicated that folate-modified nanoparticles could achieve high targeting specificity, high efficiency of delivery drug and excellent imaging enhancement. Therefore, the targeting nanoplatform has good prospects in non-invasively detecting early ovarian tumors, maximizing the therapeutic efficiency and real-time monitoring of therapeutic response, which can make it possible to lengthen patients' survival and ultimately achieve the goal of individualized medicine for ovarian cancer in the near future.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2014
·
IF 6.007
Moa Z. Granlund,Kjell Jansson,Marita Nilsson,Jazaer Dawody,Lars J. Pettersson
The objective of this paper was to study the influence three promoters (Co, La, Mn) had on the catalytic activity of Rh-based catalysts for autothermal reforming of diesel. The catalysts were supported on CeO 2 -ZrO 2 and the loading was 1 wt.% Rh and 6 wt.% promoter. The catalytic activity was evaluated in a monolith bench scale reactor with Swedish Environmental diesel, MK1. The process parameters employed at the ATR experiments were; O 2 /C ∼ 0.45, H 2 O/C ∼ 2.5 and GHSV ∼ 50,000 h −1 , meanwhile the reactor temperature was ramped from 700 °C to 950 °C. The catalysts were compared based on their fuel conversion, H 2 yield and the selectivity of different short-chain hydrocarbons. The results showed that all three catalysts had both high fuel conversion and H 2 yield in the optimal ATR operation temperatures. The H 2 yield and fuel conversion were increasing in the order Rh/Mn, Rh/La, Rh/Co. To get further insight in the difference between the materials the fresh and aged catalytic materials were characterized. The characterization methods used were H 2 -temperature programmed reduction (H 2 -TPR), powder X-ray diffraction (XRD), and BET surface measurements. The BET surface measurements showed that promotion with La gave improved thermal stability of the material. The XRD showed a high dispersion of all metals except Co, which was present as crystals in the size range of the particles of the support.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 34
·期 1
·104-110
·
IF 1.835
Liu Bo,Liu Dong-tao,Li Shi-hui,Sun Guang-ping,Cui Dong-mei
β -Iminophosphonamide ligated lanthanum bis(benzyl) complex (NPN Dipp )La(CH 2 Ph-4-Me) 2 (THF) (NPN Dipp = Ph 2 P(NC 6 H 3
i Pr 2 -2,6) 2 ), upon activation of AlEt 3 and [Ph 3 C][B(C 6 F 5 ) 4 ], exhibited high catalytic activity and high trans -1,4 stereoselectivity for the polymerization of bio-sourced β -myrcene (MY). Based on which, a series of novel trans -1,4 regulated elastomers could be generated by random/block copolymerization of MY and isoprene (IP).
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CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Lei Miao,Jiwen Hu,Mangeng Lu,Yuanyuan Tu,Xin Chen,Yinwen Li,Shudong Lin,Fei Li,Shengyu Hu
A ternary system thermoresponsive hydrogel, poly( N -isopropylacrylamide- co -hydroxyethyl methylacrylate polycaprolactone)/hydroxypropyl cellulose (or P(NIPAAm- co -HEMAPCL)/HPC), was prepared via “alkynyl/azide” click chemistry between the azide modified graft copolymer P(NIPAAm- co -HEMAPCL-N 3 ) and the alkynyl modified HPC (or alkynyl-HPC). The structures of P(NIPAAm- co -HEMAPCL-N 3 ) and alkynyl-HPC were characterized by 1 H NMR, SEC and FT-IR, and the results demonstrated that the mole ratio of the alkynyl and azide functional groups, and the feed ratios of HPC, PCL, and PNIPAAm could be easily adjusted. The incorporation of PCL and HPC dramatically enhanced the compression modulus of the P(NIPAAm- co -HEMAPCL)/HPC hydrogel, which ranged from 500 to 1000 g/cm 2 . Due to the immiscibility of HPC and PCL, a heterogeneous and semicontinuous structure was observed via SEM. The incorporation of HPC accelerated the water absorption rate and enhanced the hydrogel's ability to shed water. The swelling–deswelling and compressive properties could also be adjusted by changing the feeding ratio. The hydrogel exhibited reversible swelling–deswelling behavior after three “swelling–deswelling” cycles.
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PubMed
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Materials
·
2015
·Vol. 8
·期 3
·1009-1026
·
IF 2.651
Juan Wang,Dongsong Li,Tianyi Li,Jianxun Ding,Jianguo Liu,Baosheng Li,Xuesi Chen
Surface coating is the simplest surface modification. However, bioactive molecules can not spread well on the commonly used polylactone-type skeletons; thus, the surface coatings of biomolecules are typically unstable due to the weak interaction between the polymer and the bioactive molecules. In this study, a special type of poly(lactide-co-glycolide) (PLGA)-based scaffold with a loosened skeleton was fabricated by phase separation, which allowed gelatin molecules to more readily diffuse throughout the structure. In this application, gelatin modified both the internal substrate and external surface. After cross-linking with glutaraldehyde, the surface layer gelatin was tightly bound to the diffused gelatin, thereby preventing the surface layer gelatin coating from falling off within 14 days. After gelatin modification, PLGA scaffold demonstrated enhanced hydrophilicity and improved mechanical properties (i.e., increased compression strength and elastic modulus) in dry and wet states. Furthermore, a sustained release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) was achieved in the coated scaffold. The coated scaffold also supported thein vitroattachment, proliferation, and osteogenesis of rabbit bone mesenchymal stem cells (BMSCs), indicating the bioactivity of rhBMP-2. These results collectively demonstrate that the cross-linked-gelatin-coated porous PLGA scaffold incorporating bioactive molecules is a promising candidate for bone tissue regeneration.Keywords:biomaterials;bone tissue engineering;gelatin;surface coating;recombinant human bone morphogenic protein-2
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MATERIALS LETTERS
·
2015
·
IF 2.489
Zhang Leilei,Li Hejun,Li Kezhi,Liu Shoujie,Zhang Yulei,Yao Pei,Zhang Wenqi,Chen Guanzheng
A multi-layer coating composed of SiC inner-layer and Mg and F co-substituted hydroxyapatite/chitosan hybrid out-layer for carbon fibers has been synthesized using a combination method of chemical vapor deposition , electrochemical deposition and ion exchange method. The morphology, microstructure and in-vitro bioactivity of the multi-layer coating are analyzed. The results show that the SiC inner-layer exhibits a squamous shape. Mg and F co-substituted hydroxyapatite/chitosan hybrid out-layer covers the SiC inner-layer coated carbon fiber entirely and uniformly with a flat structure. The multi-layer coating could induce the precipitation of particle-shaped apatite crystals with Ca/P molar ratios of 1.34–1.51 on its surface in simulated body fluid. The multi-layer SiC/Mg and F co-substituted hydroxyapatite/chitosan coated carbon fibers should have potential application for tissue engineering.
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SYNTHETIC METALS
·
2015
·
IF 2.252
Xiucui Ji,Qiang Xu,Ting Zhou,Xiaotong Wang,Hui Xu,Xue Yao,Wei Lan,Yong Kong
Poly(aniline- co - m -aminophenol)(PANMA)/graphene/NiO nanocomposite was synthesized and applied as a supercapacitor electrode for the first time. Graphene/NiO nanocomposite was first synthesized via a hydrothermal synthesis method from Ni(NO 3 ) 2 ·6H 2 O, urea, and graphite oxide. NiO nanoparticles were distributed uniformly on both sides of the graphene. Then, PANMA was deposited in situ on the surface of the graphene/NiO nanocomposite via the copolymerization of aniline and m -aminophenol. The obtained nanocomposite has a similar porous morphology with that of PANMA. Experimental results indicate that the synergistic contributions from PANMA, graphene and NiO enable the composite electrode with substantially improved energy storage performance metrics. The nanocomposite shows a high specific capacitance of 562 F g −1 at a current density of 0.5 A g −1 , a good rate capability even at high current densities and a better long-term cycling stability.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2015
·
IF 7.435
Xuning Li,Jiayi Liu,Alexandre I. Rykov,Hongxian Han,Changzi Jin,Xin Liu,Junhu Wang
Two kinds of Fe–Co Prussian blue analogues (Fe–Co PBAs) with different iron valence state, Fe 3 [Co(CN) 6 ] 2 ·12H 2 O and Fe[Co(CN) 6 ]·2H 2 O, were developed as the photo-Fenton catalysts for in-depth investigation of the heterogeneous Fenton reaction mechanism. These two catalysts showed exceptionally high efficiencies for the degradation of Rhodamine B. The efficient redox cycling of iron species in the Fe–Co PBAs photo-Fenton process was deeply explored by Mössbauer spectroscopy. The excellent photo-Fenton activities of these Fe–Co PBAs were ascribed to the existence of highly dispersed water coordinated iron sites and abundant vacancies in the metal-organic-frameworks. Singlet oxygen was identified by radical scavenger experiments and electron paramagnetic resonance spectroscopy, which plays a key role in the photo-Fenton process. Based on these comprehensive experimental results, a novel radical reaction mechanism was proposed. This work not only opens up a new avenue for the application of Fe–Co PBAs, but also gives a deeper insight into the mechanisms of heterogeneous Fenton reactions.
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Food and Bioprocess Technology
·
2014
·Vol. 7
·期 11
·3121-3135
·
IF 3.126
Tian Ye,Fu Nan,Wu Winston Duo,Zhu Danhua,Huang Jinjian,Yun Shuo,Chen Xiao Dong
Dairy industries often spray lecithin, a food-grade surfactant, to spray-dried whole milk powders while fluidisation to produce instant powders. Though adding surfactant to milk feed was often reported to improve the wettability of dried powders, this approach was not favourably used. The present study investigated the effects of surfactant addition into high solids milk feed before drying on the wettability of whole milk particles. Adding either 0.1 wt.% Tween 80 or 0.1 wt.% lecithin to un-concentrated whole milk led to a significant wettability improvement of spray-dried powders. At higher feed solids levels of 23 and 33 wt.%, the wetting process of pure milk powders was comparatively rapid, but the surfactant-added powders showed similar wettability to the pure milk powders. The development of powder wettability as drying progressed was investigated using single droplet-drying technique for 32 and 43 wt.% whole milk in the presence and absence with surfactants. The technique captured an advanced shell formation during drying of higher solids milk. The wettability of surface shells formed by surfactant-added milk was similar to those formed by pure milk throughout drying, from initial shell formation to final drying stage. By contrast, coating surfactants on the outer layer of particles being dried could substantially improve wettability. The rapid shell formation and the slow material diffusion owing to the high medium viscosity were considered the main factors limiting the migration of surfactant molecules towards droplet surface during drying.
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Biomicrofluidics
·
2013
·Vol. 7
·期 4
·
IF 3.385
Liu Zhou,Shum Ho Cheung
In this work, we demonstrate a robust and reliable approach to fabricate multi-compartment particles for cell co-culture studies. By taking advantage of the laminar flow within our microfluidic nozzle, multiple parallel streams of liquids flow towards the nozzle without significant mixing. Afterwards, the multiple parallel streams merge into a single stream, which is sprayed into air, forming monodisperse droplets under an electric field with a high field strength. The resultant multi-compartment droplets are subsequently cross-linked in a calcium chloride solution to form calcium alginate micro-particles with multiple compartments. Each compartment of the particles can be used for encapsulating different types of cells or biological cell factors. These hydrogel particles with cross-linked alginate chains show similarity in the physical and mechanical environment as the extracellular matrix of biological cells. Thus, the multi-compartment particles provide a promising platform for cell studies and co-culture of different cells. In our study, cells are encapsulated in the multi-compartment particles and the viability of cells is quantified using a fluorescence microscope after the cells are stained for a live/dead assay. The high cell viability after encapsulation indicates the cytocompatibility and feasibility of our technique. Our multi-compartment particles have great potential as a platform for studying cell-cell interactions as well as interactions of cells with extracellular factors.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2015
·
IF 2.133
Na Zhang,Lei Shi,Tingting Yu,Tianduo Li,Wei Hua,Cong Lin
Pure STW-type germanosilicate (denoted as GeSi-STW), Cu- and Co-containing STW-zeotype (denoted as Cu-STW and Co-STW) materials were synthesized by the hydrothermal method in the presence of an organic structure-directing agent (OSDA), N , N -diethylethylenediamine (DEEDA). The effects of the reaction mixture ratio and the incorporation of transition metals M ( M =Cu and Co) on the synthesis of the pure product was investigated. The synthesized samples were characterized by powder and single-crystal X-ray diffraction (XRD), scanning electron microscopy (SEM), inductively coupled plasma analysis (ICP), thermogravimetric and differential scanning calorimetry (TG–DSC) analysis and UV–vis diffuse reflectance spectra (DRS). The results reveal that the crystallization time, the concentration of H 2 O in the reaction mixture and the addition of HF all have an important impact on the synthesis of pure STW-type zeolite . GeSi-STW is stable up to 800 °C, and has much higher thermal stability than SU-32 (stable to 400 °C). Co and Cu have been introduced for the first time into STW-zeotype materials.
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危险品化学品经营许可证（带存储）