ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Hui Li,Xinyang Peng,Wanning Xi,Tao Jiang,Ziyang Zhao,Xiaoxuan Yu,Wang Liu,Baiheng Wu,Yan Ge,Zhenhui Qi,Junqiu Liu
The explosive growth of information and its widespread availability underscores the need for robust encryption and anticounterfeiting measures. In this study, CdS quantum dots are engineered (QDs) to manifest multiple visual responses to a single trigger through strategic ligand design. The surface engineering method allows QDs to transition from yellow to black upon photoexcitation-induced electron transfer from Cd(II) to Cd(0). Surface ligands desorption under hole injection, leading to an increase in QDs size and resulting in a redshift in photoluminescence. This photoexcitation-induced redox reaction reveals unprecedented photochromism and photoluminescence phenomena, establishing a foundation for advanced information protection measures. Utilizing these QDs, excellent writing performance under UV irradiation is achieved in solid-state substrates, while a dual-mode encryption system is realized in gel matrices, opening up new avenues for information encryption as well as cumulative and interactive information protection. Furthermore, the redox reaction of CdS QDs is employed as ink for 3D printing, enabling for the creation of digitally programmable materials with distinct temporally evolving appearances by controlling the oxygen content in the ink to regulate the rate of photochromism. This advancement also sheds light on the progress in 3D printing technology.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Shining Niu,Pu Qiu,Jialan Meng,Cheng Tao,Mei Wen,Nuo Yu,Zhigang Chen
Reactive chemical bonds are associated with the generation of therapeutic radicals and gases under internal-external stimuli, which are highly attractive for cancer treatments. However, designing multifunctional nanostructures that incorporate multiple chemical bonds remains a significant challenge. Herein, novel core–shell nanobombs integrating azo ( N N ) and tetrasulfide bonds ( S S S S ) have been constructed with sensitive ignition by both near-infrared (NIR) laser and tumor microenvironments (TME) for treating colorectal tumors. The nanobombs (GNR/AIPH@MON@PVP, GAMP) were prepared by the in-situ growth of tetrasulfide-contained mesoporous organosilica nanoshell (MON) on gold nanorods (GNR) as the photothermal initiator, the load of azo compound (AIPH) as the radical producer and polymer modification. Upon NIR irradiation, the GNR core exhibits stable and high photothermal effects because of the passivation of the MON shell, leading to the thermal ablation of cancer cells. Simultaneously, the local hyperthermia ignites AIPH to release alkyl radicals to cause extensive oxidative stress without oxygen dependence. Moreover, the MON shell can be gradually decomposed in a reduced environment and release therapeutic H 2 S gas because of the cleavage of S S S S bonds by the glutathione (GSH) overexpressed in TME, causing mitochondrial injury. Owing to multifunctional functions, the GAMP significantly inhibits the growth rate of tumors upon NIR irradiation and achieves the highest efficacy among treatments. Therefore, this study presents activatable nanoagents containing multiple chemical bonds and provides insights into developing comprehensive antitumor strategies.
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PubMed
高影响因子
Materials Today
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2024
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IF 21.1
Yao Yang,Xiaotong Liang,Qimanguli Saiding,Jiachan Lin,Jinyuan Li,Wenyan Wang,Ping Huang,Li Huang,Wenfeng Zeng,Jinhai Huang,Hongzhong Chen,Wei Tao,Xiaowei Zeng
Photodynamic therapy (PDT) can enhance immune checkpoint blockade (ICB) antitumor immunity. However, PDT can significantly exacerbate the hypoxic tumor microenvironment and stimulate tumor neovascularization, promoting tumor invasion and metastasis. Camptothecin can inhibit angiogenesis by down-regulating hypoxia-inducible factor 1α (HIF-1α). Therefore, this study proposed to combine camptothecin with PDT for the first time to alleviate the disadvantage of PDT, and play its dual role of chemotherapy and antiangiogenesis. Here, a light-activated nanocarrier crosslinked the anti-PD-L1, photosensitizer, and camptothecin prodrug mildly with a thioketal bond for checkpoint blockade immunoregulation was designed. Firstly, photosensitizer-induced PDT and immunogenic cell death effect significantly increase T cell infiltration (33.3 % CD8 + increase), enhancing ICB antitumor immunity. Secondly, the antiangiogenic effect of camptothecin was beneficial for alleviating hypoxic tumor microenvironment exacerbated by PDT (HIF-1α expression decreased in tumor cells). Thirdly, light-activated release facilitates tumor accumulation (3.22 times) and controlled drug release. Thus, the immune checkpoint blockade combined with PDT and an antiangiogenic therapy of camptothecin creates a positive feedback co-delivery platform that exemplifies cascaded synergistic tumor therapy by checkpoint blockade immunoregulation. Besides, it also introduces a new strategy for combining small molecule drugs with macromolecules like proteins to treat various diseases.
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ANALYTICAL CHEMISTRY
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2024
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IF 6.7
Hongji Li,Dandan Wang,Dan Zhang,Juan Zhou,Weiting Yang,Zhongmin Su,Wei Sun,Changming Li
Microcystin-LR (MC-LR) is a severe threat to human and animal health; thus, monitoring it in the environment is essential, especially in water quality protections. Herein, in this work, we synthesize PVDF/CNT/Ag molecular imprinted membranes (PCA-MIMs) via an innovative combination of surface-enhanced Raman spectroscopy (SERS) detection, membrane separation, and molecular-imprinted technique toward the analysis of MC-LR in water. In particular, a light-initiated imprint is employed to protect the chemical structure of the MC-LR molecules. Furthermore, in order to ensure the detection sensitivity, the SERS substrates are combined with the membrane via the assistance of magnetism. The effect of synthesis conditions on the SERS sensitivity was investigated in detail. It is demonstrated from the characteristic results that the PCA-MIMs present high sensitivity to the MC-LR molecules with excellent selectivity against the interfere molecules. Results clearly show that the as-prepared PCA-MIMs hold great potential applications to detect trace MC-LR for the protection of water quality.
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OPTICAL MATERIALS
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2024
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IF 3.8
Jianpu Lin,Shengjie Zhang,Lingfeng Du,Baiquan Zhang,Xiongtu Zhou,Yongai Zhang,Chaoxing Wu
The wavelength tunable and environmentally friendly InP quantum dots are considered one of the most powerful alternatives to cadmium-based quantum dots, and the luminescent devices prepared with them also show great potential. There is still room for improvement in the synthesis methods and device applications of InP based quantum dots. In this work, we report one pot synthesis route for InP/ZnSe/ZnSeS/ZnS green QDs based on tris(dimethylamino)phosphine (DMP) phosphorus by using the strategy of multi shell coating and gradient heating to reduce surface defects of quantum dots. The shell structure, dosage, and growth temperature have all been taken into account in order to explore better performance of InP QDs. The synthesized green quantum dots have 86 % PLQY and a full width at half maximum of 36 nm. In addition, the synthesized green InP quantum dots are applied in AC QLED devices. The experimental results show that the luminescence intensity is affected by the driving voltage and frequency, which is similar to the working mode of non-carrier-injected emitting devices. And there is a matching value between the voltage and frequency.
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ACS Applied Nano Materials
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2024
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IF 5.3
Xin Li,Qi-Wen Ma,Guangning Yu,Ji Shi,Hai-Yang Chang,Rong-Rong Zheng,Hengxue Xiang,Cheng Wang
All-inorganic halide perovskite (CsPbX3) nanocrystals (NCs) have garnered significant attention due to their excellent photoelectric properties. However, their practical application has been limited by stability issues. This study presents a strategy combining physical confinement through a carrier matrix and chemical bond coupling to enhance the stability of CsPbX3 NCs significantly under UV irradiation, polar solvents, and thermal conditions. Specifically, CsPbBr3 NCs exhibited near-complete fluorescence quenching within 300 min when treated with water and ethanol. In contrast, CsPbBr3/DMSNs-NH2 nanocomposites retained 86.9% and 75.4% of their initial photoluminescence intensity after 7 days. This enhanced stability is attributed to the multilevel pore architecture of DMSNs-NH2, which effectively prevents direct interaction with water and oxygen. Furthermore, bright white light-emitting diode (LED) devices were successfully fabricated using these nanocomposites, achieving a color temperature of 6045 K and a color gamut covering 133.5% of NTSC and 99% of Rec.2020 standards. This work demonstrates a promising pathway for the development of stable, high-performance perovskite-based optoelectronic devices.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Xinghao Liu,Nan Li,Xugui Lv,Jingjing Wang,Qingyu Ma,Zheng Xie
Two-dimensional (2D) materials consist of either a single layer or just a few layers of atoms or molecular layers, and their exceptional optoelectronic properties including high carrier mobility, wide spectral absorption range, and optical response from the number of layers. Graphene quantum dots (GQDs) as a small-sized 2D material exhibited unique physical and chemical properties at the quantum scale. In this study, he N, S-doped GQDs (named as Y-GQDs) were synthesized through straightforward solvothermal process using 2,2'-dithiobenzoic acid and o-phenylenediamine as the precursors. The distribution of the prepared GQDs sample was uniform, with height varying between 0.6 and 0.8 nm. The excellent optical properties of Y-GQDs were attributed to the high crystalline graphene structure and rich functional groups including -C-SO 3 -C-, -C-SO 4 -C-, C-N, etc . The optimal excitation and emission wavelengths of Y-GQDs were 380 nm and 535 nm, respectively. Additionally, the multi-color and tunable luminescence characteristics could be achieved by excitation wavelength, solvent, and concentration. Gratifyingly, the N, S-doped GQDs were successfully used to build white light emitting devices via a sol-gel process. The color rendering index reached 83.7 with color temperature of 5306 K, and the GQDs exhibited good optical stability under different driving currents and UV light. This study underscored the significant potential of GQDs in creating promising phosphors for superior lighting applications.
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Materials Today Bio
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2024
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IF 8.7
Xinxin Zhan,Jianglong Yan,Dong Xiang,Hao Tang,Lulu Cao,Yufeng Zheng,Hong Lin,Dandan Xia
Polyetheretherketone (PEEK) is considered as a promising dental implant material owing to its excellent physicochemical and mechanical properties. However, its wide range of applications is limited by its biologically inert nature. In this study, a near-infrared (NIR) light responsive bioactive coating with gold nanoparticles (AuNPs) and metronidazole adhered to the PEEK surface via dopamine polymerization. Compared to pure PEEK, the hydrophilicity of the treated PEEK surface was significantly improved. In addition, under NIR light, the surface coating exhibited photothermal conversion effect, and gold nanoparticles and the antibiotic can be released from the coating. This improved the antibacterial properties of PEEK materials. Moreover, the coating was more conducive to the early adhesion of bone mesenchymal stem cells. The results of in vitro and in vivo osteogenic activity studies showed that the developed coating promoted osseointegration of PEEK implants, and NIR light irradiation further improved the antibacterial ability and osteogenic activity of PEEK implants. Through RNA sequencing, the potential underlying mechanism of promoting bone formation of the AuNPs coating combined metronidazole was interpreted. In summary, the developed coating is a potential surface treatment strategy that endows PEEK with enhanced osseointegration and antibacterial properties.
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PubMed
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yu Zhang,Chunhua Ren,Huayang Liu,Jingyi Duan,Mengyao Wang,Ziao Zhou,Jinyou Duan,Huaimin Wang,Xiaoli Zhang
Antibiotic-resistant bacterial infections are increasing at an alarming rate, posing a significant threat to global health and highlighting the urgent need for innovative therapeutic strategies. Herein, we developed a near-infrared (NIR) photoactivatable amphiphilic precursor molecule of peptide-vancomycin conjugate (PFTV), which could in situ self-assemble into a nanogermicidal agent on bacterial surfaces upon exposure to NIR light. This approach aimed to effectively treat infections caused by vancomycin-resistant Enterococcus (VRE). Our findings indicated that the in situ self-assembly of PFTV triggered by NIR light demonstrated superior antiplanktonic activity compared to free vancomycin, with the minimum inhibitory concentration reduced by two orders of magnitude. Additionally, this strategy enhanced PFTV penetration and removal of VRE biofilms, achieving a bacterial killing efficiency of 99%. Mechanistic studies revealed that the combination of PFTV and NIR light treatment eradicated antibiotic-resistant bacteria via two main actions: membrane perturbation and disruption of cellular homeostasis. Furthermore, the in situ self-assembly of PFTV upon NIR light irradiation demonstrated significant therapeutic efficacy in treating VRE-induced infections and accelerating wound healing in vivo by mitigating inflammation responses and promoting neovascularization. This work has reported an on-demand activated strategy to facilitate peptide-antibiotic conjugate in situ self-assembly into a multivalent nanoantibacterial agent, which could provide novel paradigm for targeted drug delivery and combating multidrug-resistant pathogens.
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高影响因子
Materials Today Bio
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2025
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IF 10.2
Li Miao,Xue Lu,Yaoyao Wei,Jie Zhou,Yuanyuan Liu,Yang Zhang,Changle Meng,Mingyang Li,Hua Zhang,Wen Chen,Han Zhang
In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around the wound, resulting in impaired proliferation of dermal and epidermal cells and impaired skin regeneration in diabetic wounds. To solve the above problems, this study designed a near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel is composed of two-dimensional nanomaterials (2D NMs) MXene as the core, modified by polymer, further loaded with epidermal growth factor (EGF), and has antibacterial, antioxidant, photothermal properties. Meanwhile, EGF/PDA-MXene Gel can be used as a drug repository, alleviating the problem of short half-life, and realizing the sustained release of EGF. The NIR photothermal property induces protein denaturation leading to the death of pathogenic bacteria, avoiding the common clinical problem of antibiotic resistance. In addition, EGF/PDA-MXene Gel promotes diabetic chronic wound healing by promoting epidermal regeneration, collagen deposition, angiogenesis, and several other mechanisms. Therefore, the Gel preparation strategies that combine bioactive molecules with 2D NMs, which maintains the activity of EGF while exploiting the antimicrobial advantages of 2D NMs photothermally, provide a new and promising therapeutic approach for accelerating the repair of chronic infected wounds.
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Journal of Environmental Sciences
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2024
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IF 5.9
Songlin Cai,Ciyuan Huang,Linji Yang,Yuchen Wang,Lingxiao Li,Shangfei Yao,Ke Sun,Caiyun Wang,Guanhui Tan,Tao Yang,Shengjie Wang,Bingsuo Zou,Tao Liu
The widespread use of personal care products poses significant risks to both ecosystems and human health. The construction of photocatalysts with the advantages of enhanced visible light absorption, efficient charge separation and high stability is important for the degradation of persistent environmental pollutants. Herein, we have prepared two D-A heterojunction organic semiconductor photocatalysts: PV-BDTC1:IDTCN/Biochar and PV-BDTC2:IDTCN/Biochar by a simple design method that can be widely applied. Under visible light irradiation, PV-BDTC2:IDTCN/Biochar showed better removal ability for indomethacin, with reaction rate constants 14.7 and 5.1 times higher than those of PV-BDTC2:IDTCN and Biochar, respectively. This is attributed to the construction of a heterojunction between the donor and the acceptor, which expands the light absorption range and promotes the separation of photogenerated carriers, thereby giving the material the ability to produce a large number of reactive oxygen species during the photocatalytic reaction. In addition, Biochar well ensures the stability of D-A heterojunction films under long-term operating conditions. This work highlight the potential of natural biomaterials in constructing effective D-A heterojunction organic photocatalysts/adsorbents for combatting water pollution.
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Surfaces and Interfaces
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2024
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IF 5.7
Xiuhua Yan,Wenxuan Chen,Wen Xiao,Guiyun Yu,Haijun Hou,Chao Liu
The development of green, thorough and high-efficiency photocatalysts for tetracycline hydrochloride (TCH) degradation is a hot spot in environmental and energy fields. In this work, the H + -restacked H 4 Nb 6 O 17 nanotubes (RHNT) were incorporated with BiOCl plates to successfully construct RHNT/BiOCl (RTB) composites with the 1D/2D heterostructure, which was beneficial to the charge carrier separation. The introduction of oxygen vacancies in RTB composites could promote the effective separation of charge carriers and the generation of reactive active species. The performance of the as-synthesized samples was evaluated by TCH photodegradation under simulated solar light. Compared to RHNT and BiOCl, the RTB composites, with an optimal sample of RTB-7, showed the enhanced photocatalytic activity for TCH degradation. The characterization results revealed that the enhanced TCH photodegradation activity for RTB composites was due to the synergistic effect of heterojunction formation and oxygen vacancies. During TCH photodegradation for RTB-7, the active radical species were determined by the radical trapping experiments and EPR spectra. The possible TCH photodegradation pathways and mechanism over RTB-7 were explored based on the characterization results. This work offers an effective approach for the rational design and construction of 1D/2D heterostructured photocatalysts with a high efficiency.
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