JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-17
·
IF 10.6
He Mingping,Fang Ming,Fan Limin,Maimaitijiang Alimujiang
Background Diabetic atherosclerosis is one of the main causes of morbidity and mortality worldwide, but its therapeutic options are limited. Liraglutide (LIR), a synthetic analog of GLP-1 approved as an anti-obesity drug by the FDA, has been reported as a promising drug for diabetic atherosclerosis. However, the main problem with LIR is its use that requires regular parenteral injections, which necessitates the improvement of drug delivery for increased efficiency and minimization of injection numbers. Results The objective of our present study was to prepare and characterize nanoparticles (BSA@LIR-PMF) for targeted drug delivery using LIR-encapsulated platelet membrane fragments (PMF) coated bovine serum albumin (BSA). We used various methods to characterize the prepared nanoparticles and evaluated their efficiency on diabetes-induced atherosclerosis in vitro and in vivo. The results showed that the nanoparticles were spherical and had good stability and uniform size with intact membrane protein structure. The loading and encapsulation rates (LR and ER) of BSA@LIR-PMF were respectively 7.96% and 85.56%, while the cumulative release rate was around 77.06% after 24 h. Besides, we also examined the impact of BSA@LIR-PMF on the proliferation, migration, phagocytosis, reactive oxygen species (ROS) levels, oxidative phosphorylation, glycolysis, lactate and ATP levels, and lipid deposition in the aortas. The results indicated that BSA@LIR-PMF could effectively inhibit ox-LDL-stimulated abnormal cell proliferation and migration, reduce the level of ROS and lactate concentration, and enhance the level of ATP, thereby improving oxidative phosphorylation in ox-LDL-treated cells. Conclusion BSA@LIR-PMF significantly inhibited diabetes-induced atherosclerosis. It was anticipated that the BSA@LIR-PMF nanoparticles might be used for treating diabetes-associated cardiovascular complications.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 30
·1-12
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IF 2.8
Liu Wei,Zhang Weichao,Shen Fenglei
In this paper, 3-glycidyl ether oxypropyltrimethoxysilane (KH560) was incorporated into the reaction product of polyether amine (2-APPG) and polyethylene glycol diglycidyl ether (PEDGE) to create an organic-inorganic hybrid polymer. The hybrid polymer underwent the catalytic hydrolysis of a hydrochloric acid-ethanol solution and was then swelled in the liquid electrolyte containing lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) to form the novel hybrid polymer electrolyte (GPE). The TGA results indicate that the samples underwent a 4% mass loss within the temperature range of 25 °C to 280 °C. The electrochemical test results show that the conductivity of the GPE reaches 1.57 × 10 −3 S/cm at room temperature, and the lithium-ion transference number (t + ) reaches 0.22. In addition, electrochromic devices prepared with APK-1 as the electrolyte exhibit good light density change (∆ (OD) = 0.134), coloring efficiency of 153.3 cm 2 /C, and stability with 400 stable cycles within the voltage range of -2.5 V to 2.5 V. The above tests demonstrate the enormous potential of the proposed GPEs in the application of electrochromic devices.
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ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Zhang Chen-chun,Li Yuan,Jiang Chang-you,Le Qiu-min,Liu Xing,Ma Lan,Wang Fei-fei
The O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is a critical post-translational modification that couples the external stimuli to intracellular signal transduction networks. However, the critical protein targets of O-GlcNAcylation in oxidative stress-induced apoptosis remain to be elucidated. Here, we show that treatment with H 2 O 2 inhibited O-GlcNAcylation, impaired cell viability, increased the cleaved caspase 3 and accelerated apoptosis of neuroblastoma N2a cells. The O-GlcNAc transferase (OGT) inhibitor OSMI-1 or the O-GlcNAcase (OGA) inhibitor Thiamet-G enhanced or inhibited H 2 O 2 -induced apoptosis, respectively. The total and phosphorylated protein levels, as well as the promoter activities of signal transducer and activator of transcription factor 3 (STAT3) and Forkhead box protein O 1 (FOXO1) were suppressed by OSMI-1. In contrast, overexpressing OGT or treating with Thiamet-G increased the total protein levels of STAT3 and FOXO1. Overexpression of STAT3 or FOXO1 abolished OSMI-1-induced apoptosis. Whereas the anti-apoptotic effect of OGT and Thiamet-G in H 2 O 2 -treated cells was abolished by either downregulating the expression or activity of endogenous STAT3 or FOXO1. These results suggest that STAT3 or FOXO1 are the potential targets of O-GlcNAcylation involved in the H 2 O 2 -induced apoptosis of N2a cells.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Qi Jia-Xin,Gong Jing-Wen,Zhang Cheng-Rong,Peng Zhi-Hai,Cai Yuan-Jun,Liu Xin,Liu Jin-Lan,Chen Xiao-Juan,Liang Ru-Ping,Qiu Jian-Ding
Piezoelectric catalysis possesses the potential to convert ocean wave energy into and holds broad prospects for extracting uranium from seawater. Herein, the Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized through in situ growth of covalent organic frameworks (COFs) on the surface of ZnO and used for efficient uranium extraction. The designed COFs shell enables ZnO with stability, abundant active sites and high-speed electron transport channels. Meanwhile, the interface electric field established in the heterojunctions stimulates electron transfer from COFs to ZnO, which break the edge shielding effect of the ZnO’s metallic state. Additionally, the polarization of ZnO is enhanced by heterogeneous engineering, which ensures the excellent piezocatalytic performance. As a result, ZnO@COF achieves an ultra-high efficiency of 7.56 mg g −1 d −1 for uranium extraction from natural seawater driven by waves. In this work, we open an avenue for developing efficient catalysts for uranium extraction from seawater.
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Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1-18
·
IF 7.5
Tan Yanzhen,Li Hong,Cao Guojie,Xin Jialin,Yan Dongxu,Liu Yingying,Li Panpan,Zhang Yuxi,Shi Lei,Zhang Bing,Yi Wei,Sun Yang
Background In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.Methods Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitro and in vivo. The role of matrix metalloproteinase-9 (MMP9) in CTRP9 cleavage was examined, and the effects of different CTRP9 domains on cardiac fibrosis and cardiac fibroblast (CF) activation were investigated.Results gCTRP9 exerted better protective effects than fCTRP9 against MI, demonstrating superior anti-apoptotic and anti-fibrotic properties. fCTRP9 was cleaved by MMP9, resulting in gCTRP9 and nCTRP9. MMP9 overexpression enhanced the cardioprotective effects of fCTRP9, while nCTRP9 supplementation aggravated cardiac fibrosis in MI mice. Mechanistically, nCTRP9 activated CFs via an increase in Rap1 expression and MEK 1/2 and ERK1/2 phosphorylation.Conclusion sDifferent domains of CTRP9 have distinct cardioprotective effects. gCTRP9 shows beneficial effects, while nCTRP9 promotes cardiac fibrosis. These findings highlight the importance of CTRP9 in cardiac function regulation and suggest prospective therapeutic options for MI treatment.
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CELLULOSE
·
2024
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IF 4.9
Gan Peng,Zhang Kai,Li Jinze,Xu Qixi,Yang Guihua,Zhang Yunlai,Dong Xinchuang,Wang Baobin,Zhang Lei,Chen Jiachuan
This study focuses on using agricultural straw—specifically sugarcane bagasse—as the raw material and employs single-factor optimization and response surface modeling strategies to develop a low-temperature NACO pulping process. A mathematical prediction model was constructed to explore the leaching patterns of chemical components in sugarcane bagasse, reveal the reaction mechanism of selective lignin removal through the new oxygen-alkali synergistic approach, and elucidate the green pulping mechanism of the low-temperature NACO method. The research findings indicate that at a temperature as low as 114.3 °C and a Na 2 CO 3 / NaOH mass ratio of 1.86, the paper pulp exhibits optimal performance, with a freeness yield of 52.83%, a viscosity of 675.77 ml/g, a whiteness of 40.95% ISO, and a kappa number of 19.85. At this condition, only 43.96% of the silicon element enters the black liquor. Response surface variance analysis shows that the studied variables have statistically significant effects on different response levels, with all correlation coefficients (R 2 ) greater than 0.93, indicating that the model has good predictive capability for the low-temperature NACO pulping process. Finally, the paper produced from the pulp under the optimal conditions exhibits excellent physical properties, with a tear index of 4.9 kPa·m 2 ·g⁻ 1 , burst index of 3.8 mN·m 2 ·g⁻ 1 , tensile index of 70.9 N·m·g⁻ 1 , and ring crush index of 11.6 N·m·g⁻ 1 , which are 1.9, 1.8, 1.6, and 2.3 times, respectively, compared to the performance of paper made by traditional oxygen-alkali chemical pulping methods.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 9
·1-11
·
IF 5.3
Lu Juan,Guo Yanjia,Shan Xiangyu,Song Yujia,Li Ruidan,Tian Li,Li Xuwen
A solid-state electrochemiluminescence (ECL) sensor was fabricated by immobilizing luminol, a classical luminescent reagent, on a Zn-Co-ZIF carbon fiber-modified electrode for the rapid and sensitive detection of procymidone (PCM) in vegetable samples. The sensor was created by sequentially modifying the glassy carbon electrode with Zn-Co-ZIF carbon fiber (Zn-Co-ZIF CNFs), Pt@Au NPs, and luminol. Zn-Co-ZIF CNFs, prepared through electrospinning and high-temperature pyrolysis, possessed a large specific surface area and porosity, making it suitable as carrier and electron transfer accelerator in the system. Pt@Au NPs demonstrated excellent catalytic activity, effectively enhancing the generation of active substances. The ECL signal was significantly amplified by the combination of Zn-Co-ZIF CNFs and Pt@Au NPs, which can subsequently be diminished by procymidone. The ECL intensity decreased proportionally with the addition of procymidone, displaying a linear relationship within the concentration range 1.0 × 10 –13 to 1.0 × 10 –6 mol L −1 (R 2 = 0.993). The sensor exhibited a detection limit of 3.3 × 10 –14 mol L −1 (S/N = 3) and demonstrated outstanding reproducibility and stability, making it well-suited for the detection of procymidone in vegetable samples. Graphical Abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 10
·1-11
·
IF 5.3
Lu Juan,Li Chao,Guo Yanjia,Feng Yongjia,Song Yujia,Li Ruidan,Tian Li,Wang Jing
Loofah sponge-like carbon nanofibers (LF-Co,N/CNFs) were utilized as a carrier for Ru(bpy) 3 2+ , and then combined with CdS to create a novel solid-state electrochemiluminescence sensor capable of detecting trace amounts of fenpropathrin. LF-Co,N/CNFs, obtained through the high-temperature pyrolysis of ZIF-67 coaxial electrospinning fibers, were characterized by a loofah-like morphology and exhibited a significant specific surface area and porosity. Apart from serving as a carrier, LF-Co,N/CNFs also functioned as a luminescence accelerator, enhancing the system's luminescence efficiency by facilitating electron transmission and reducing the transmission distance. The inclusion of CdS in the luminescence reaction, in conjunction with Ru(bpy) 3 2+ , further boosted the sensor's luminescence signal. The resulting sensor demonstrated a satisfactory signal, with fenpropathrin causing significant quenching of the ECL signal. Under optimized conditions, a linear relationship between the signal quench value and fenpropathrin concentration in the range 1 × 10 –12 to 1 × 10 –6 M was observed, with a detection limit of 3.3 × 10 –13 M (S/N = 3). This developed sensor is characterized by its simplicity, sensitivity, and successful application in detecting fenpropathrin in real samples. The study not only presents a straightforward detection platform for fenpropathrin but also introduces new avenues for the rapid determination of various food contaminants, thereby expanding the utility of carbon fibers in electrochemiluminescence sensors. Graphical Abstract
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JOURNAL OF SOLUTION CHEMISTRY
·
2025
·
IF 1.3
Wang Mingya,Pan Hongxia,Liu Yongzheng,Shi Junli,Shen Fanfan,Cao Duanlin,Zhao Linxiu
1,3-Dinitropyrazole serves as a crucial intermediate in pharmaceutical synthesis and is also recognized as a high-energy density material. Its purity can affect the yield, safety, and stability of the product. Recrystallization is a pivotal step in its purification. This study investigates the solubility of 1,3-dinitropyrazole in twelve solvents, offering guidance for the selection of appropriate solvents. The solubility of 1,3-dinitropyrazole in a selection of twelve solvents, including water, methanol, ethanol, acetonitrile, hexane, cyclohexane, dichloromethane, dichloroethane, benzene, toluene, ethyl acetate, and acetone, was measured by the gravimetric technique across a temperature spectrum from 278.15 to 318.15 K at atmospheric pressure. Under ambient conditions at 298.15 K, the order of solubility was as follows: acetonitrile (48.201 × 10 –2 ) > acetone (45.012 × 10 –2 ) > dichloromethane (37.019 × 10 –2 ) > ethyl acetate (36.088 × 10 –2 ) > dichloroethane (33.244 × 10 –2 ) > benzene (19.563 × 10 –2 ) > methylbenzene (15.221 × 10 –2 ) > methanol (5.531 × 10 –2 ) > ethyl alcohol (3.078 × 10 –2 ) > cyclohexane (0.060 × 10 –2 ) > hexane (0.053 × 10 –2 ) > water (0.051 × 10 –2 ). Additionally, the solubility in these 12 pure solvents increases as the temperature rises. The efficacy of four established thermodynamic models, including the Apelblat equation, Jouyban–Acree model, van’t Hoff model, and λ h model, was evaluated via R 2 , ARD and RMSD criteria. Notably, the Apelblat equation and Jouyban–Acree models demonstrated exceptional accuracy, with the Jouyban–Acree model emerging as the optimal choice for predicting the solubility of 1,3-dinitropyrazole. Meanwhile, the application of Hansen solubility parameters in predicting and analyzing solubility also has its limitations. The data pertaining to the solid–liquid equilibrium of 1,3-dinitropyrazole across a range of solvents are indispensable for the initial assessment of its utility in industrial contexts.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 21
·9250-9264
·
IF 3.5
Liu Lvfei,Zhang Yao,Gu Yunjie,Qu Jiangwen,Wang Naiguang,Ge Shuaichen,Li Jingsha
The sluggish oxygen reduction reaction (ORR) has been one of the most majority bottlenecks of fuel cells and metal-air batteries. It is extremely desirable but challenging to explore low cost, highly active, stable catalysts toward ORR to replace commercial Pt/C catalysts. Herein, a novel hybrid system consisting of trace copper and bi-nonmetallic (N/S) modified the commercial ketjenblack (KB) carbon (Cu–NS–C) has been successfully fabricated by a pyrolysis of Cu–MOF/KB and thiourea to transform crystalline Cu/Cu 2 O nanoparticles into copper sulfide nanoparticles and the subsequent acid leaching. The optimized Cu–NS–C delivers a half-wave potential of 0.81 V versus RHE and a limiting-current density of 5.0 mA cm −2 , which is next to those of commercial 20 wt% Pt/C catalyst. Furthermore, this catalyst demonstrates much better durability and methanol tolerance than Pt/C catalyst.
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Cell Communication and Signaling
·
2024
·Vol. 22
·期 1
·1-21
·
IF 8.2
Wu Chengyan,Hu Li,Liu Bing,Zeng Xingyue,Ma Haixiang,Cao Yongkai,Li Huijun,Zhang Xiaohan
Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists. The binding of β-arrestin to the cytoplasmic cavity of the phosphorylated receptor, which competes with the G protein, has been widely accepted as an extensive model for explaining GPCRs desensitization. However, studies on various GPCRs, including dopamine D 2 -like receptors (D 2 R, D 3 R, D 4 R), have suggested the existence of other desensitization mechanisms. The present study employed D 2 R/D 3 R variants with different desensitization properties and utilized loss-of-function approaches to uncover the mechanisms underlying GPCRs homologous desensitization, focusing on the signaling cascade that regulates the ubiquitination of AKT. Results AKT undergoes K8/14 ubiquitination by TRAF6, which occurs in the nucleus and promotes its membrane recruitment, phosphorylation and activation under receptor desensitization conditions. The nuclear entry of TRAF6 relies on the presence of the importin complex. Src regulates the nuclear entry of TRAF6 by mediating the interaction between TRAF6 and importin β1. Ubiquitinated AKT translocates to the plasma membrane where it associates with Mdm2 to phosphorylate it at the S166 and S186 residues. Thereafter, phosphorylated Mdm2 is recruited to the nucleus, resulting in the deubiquitination of β-Arr2. The deubiquitinated β-Arr2 then forms a complex with Gβγ, which serves as a biomarker for GPCRs desensitization. Like in D 3 R, ubiquitination of AKT is also involved in the desensitization of β 2 adrenoceptors. Conclusion Our study proposed that the property of a receptor that causes a change in the subcellular localization of TRAF6 from the cytoplasm to the nucleus to mediate AKT ubiquitination could initiate the desensitization of GPCRs.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Liu Xianhu,Zhang Wenrui,Zhang Xin,Zhou Zhengui,Wang Chunfeng,Pan Yamin,Hu Bin,Liu Chuntai,Pan Caofeng,Shen Changyu
The rational use and conversion of energy are the primary means for achieving the goal of carbon neutrality. MXenes can be used for photothermal conversion, but their opaque appearance limits wider applications. Herein, we successfully develop visible-light transparent and UV-absorbing polymer composite film by solution blending the MXene with polyethylene and then vacuum pressing. The resulting film could be quickly heated to 65 °C under 400 mW cm −2 light irradiation and maintained over 85% visible-light transmittance as well as low haze (<12%). The findings of the indoor heat insulation test demonstrate that the temperature of the glass house model covered by this film was 6-7 °C lower than that of the uncovered model, revealing the potential of transparent film in energy-saving applications. In order to mimic the energy-saving condition of the building in various climates, a typical building model with this film as the outer layer of the window was created using the EnergyPlus building energy consumption software. According to predictions, they could reduce yearly refrigeration energy used by 31-61 MJ m −2 , and 3%-12% of the total energy used for refrigeration in such structures. This work imply that the film has wide potential for use as transparent devices in energy-related applications.
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