Biomedical Materials
·
2023
·Vol. 18
·期 2
·025003
·
IF 4
Shumin Hu,Qiuli Cheng,Yulu Shang,Zhihao Wang,Rui Zhu,Leitao Zhang,Wenlan Wu,Shouren Zhang,Junbo Li
The response sensitivity of surface material plays an important role in adjustable nano-bio interaction in vivo. In this present, a zwitterionic polymer (polyzwitterion) containing quaternary ammonium cation and sulfonamide anion poly(4-((4-(3-(methacryloyloxy)propoxy)phenyl) sulfonamido)-N, N, N-trimethyl-4-oxobutan-1-aminium chloride) (PMPTSA) was synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization (RAFT) polymerization to explore the pH responsive behavior in tumors. The PMPTSA-coated gold nanoparticles (PMPTSA-@-Au NPs) showed zwitterionic nature such as antifouling ability, low cellular uptake and prolonged circulation time similar with common hydrophilic polymers, including polyethylene glycol (PEG), poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate) functional gold nanoparticles in physiological environment (pH 7.4). A high sensitivity and reversible positive charge conversion of P(MPTSA)-@-Au NPs at tumor slight acidic microenvironment (∼pH 6.8) leaded to an enhanced cellular internalization than that at pH 7.4 and increased tumor accumulation compared with PEG, polycarboxybetaines and polymer sulphobetaine (PSB) functional gold nanoparticles. The highly pH responsive PMPTSA will provide the promising application in cancer nanomedicine.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 7
·3524-3534
·
IF 11.9
Xiaofang Ma,He Xiao,Yang Gao,Man Zhao,Li Zhang,Junming Zhang,Jianfeng Jia,Haishun Wu
Design of efficient and stable hydrogen evolution reaction (HER) electrocatalysts for mass production of hydrogen via electrochemical water splitting is a challenging but urgent task. In this work, a highly dispersed Ru NP catalyst (Ru/HMCs-500) is built using a porous carbon sphere orifice embedded Ru nanoparticle (NP) method and shown to have extremely good HER stability and activity throughout the whole pH range. An ammonia concentration is applied to control the pore size of hollow mesoporous carbon spheres (HMCs) to confine Ru NPs. Noticeably, the mass activities of obtained Ru/HMCs-500 at −50 mV are 1.3 times, 7.0 times, and 3.8 times higher than that of Pt/C in acidic, basic, and neutral solutions, respectively. The characterization results reveal that Ru NPs with an embedded structure are restricted by pores. The high dispersion and anchoring effect ensure the long-term catalytic stability and activity of the catalyst. Metal–support strong interaction (SMSI) optimizes the electronic structure of Ru NPs, which greatly improves their intrinsic activity and reduces the activation energy of the HER. This work enlightens us on how to accurately construct the embedded structure of metal-based materials for enhancing the electrocatalytic HER performance in pH-universal solution.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jieru Guo,Ge Song,Minghua Zhou
Iron-based catalysts usually have a narrow pH application range and are easy to agglomerate and inactivate in the heterogeneous electro-Fenton (Hetero-EF) process. In this work, FeN-carbon nanotubes (FeN-CNTs) catalysts with highly dispersed FeNx sites and tubular structures were synthesized. This FeN-CNTs/Hetero-EF process extended the pH application range to 3–11 with low metal leaching (0.4 mg/L at pH 3) and negligible homogeneous contribution. Compared with nitrogen-doped carbon (N-C, prepared with the same procedure but without FeCl 3 ⋅6H 2 O precursor), its pseudo-first order reaction rate constant was increased by 4.4 times, suggesting that the uniformly dispersed active site FeNx played a key role in the catalytic activation of H 2 O 2 and the efficient degradation of carbamazepine (CBZ). Effective CBZ removal (10 mg/L) could be achieved at low current density (1.25 mA/cm 2 ) and catalyst dosage (50 mg/L) in FeN-CNTs/Hetero-EF. The capture experiments and EPR tests confirmed the existence of various active species such as • OH and 1 O 2 , among which • OH played a dominant role in the degradation of CBZ. FeN-CNTs significantly improves the removal of pollutants under a wide pH range, showing broad application prospects.
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Yang-xiao-xiao Shi,Jia-qi Cui,Feng Zhang,Ke-wei Li,Jun Jiang,Ren-kou Xu
Hexavalent chromium (Cr(VI)) is a toxic heavy metal and its mobility and bioaccessibility in soils are influenced by soil properties. In this study, the soil pH and organic carbon contents of Ultisol , Alfisol , and Inceptisol were adjusted before they were polluted with 230 mg kg −1 Cr(VI). Alkaline digestion, sequential extraction, and an in vitro experiment were conducted to study the valence state, species, and bioaccessibility of Cr in the soils. The results showed that a high soil pH was not favorable for reduction of Cr(VI); therefore the Cr(VI) and exchangeable Cr contents were positively related to soil pH. Soil organic carbon promoted the reduction of Cr(VI). Almost all Cr(VI) was reduced to Cr(III) when the soil organic carbon content reached 10 g kg −1 . Chromium bioaccessibility in simulated gastric and intestinal phase solutions was influenced by Cr(VI) and Cr(III) adsorption/desorption, dissolution/precipitation, and redox reactions. Chromium bioaccessibility differences between the gastric and intestinal phases were associated with the Cr(VI)/Cr(III) ratio. Acidic conditions and a high organic carbon content promoted the conversion of Cr(VI) to Cr(III). When soil pH was increased from 4.01 to 5.85, Cr(VI) in Alfisol without the addition of humic acid increased from 96.38 to 174.78 mg kg −1 , the exchangeable Cr proportion increased from 9.7% to 22.6%, and Cr bioaccessibility increased from 41.29% to 49.14% in the gastric phase and from 41.32% to 48.24% in the intestinal phase. When the organic carbon content increased from 3.95 to 9.28 g kg −1 in Alfisol, Cr(VI) content decreased from 167.66 to 20.52 mg kg −1 , which led to a decrease in Cr bioaccessibility from 49.15% to 13.8% in the gastric phase and from 45.85% to 7.67% in the intestinal phase. Therefore, acidic conditions and increasing soil organic carbon levels can reduce the health risk posed by Cr in soils.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2023
·
IF 6
Shiqi Hu,Xinglian Xu,Wangang Zhang,Chunbao Li,Guanghong Zhou
The activity of cathepsin B in Jinhua ham was affected by various processing parameters, which were investigated and quantified using a multi-layer artificial neural network (ANN). The key factors that influence ham quality are processing temperature, pH, and sodium chloride content. The study discussed the univariate analysis and multivariate interactions between two or three factors. The established ANN model was used for further investigation, and the actual enzyme activity of cathepsin B was characterized. The results showed that high temperature (greater than 60 °C) and an alkaline environment or the addition of Na + cation significantly reduced the enzyme activity ( p < 0.05). The optimal conditions for protease activity were found to be at 40 °C and pH 6.0. The enzyme was found to be unstable at a temperature of 20 °C or pH 6.5–7.0 in the presence of NaCl, indicating significant interactions between temperature, pH value and NaCl content ( p < 0.01). Furthermore, the ANN model showed good match between true and predicted values. The correlation coefficient was 0.98468, and the model provided supplementary information about the effect of NaCl on cathepsin B activity within 0.4M–0.6M. The findings could be useful in Jinhua ham production and the study of the structure-activity relationship of cathepsin B.
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2023
·
IF 6
Yiting Chen,Liyuan Li,Xue Zhao,Xianming Zeng,Xinglian Xu
Improvement of pale, soft, and exudative (PSE)-like chicken breast protein is urgently needed, to reduce the economic losses induced by its downgraded processing quality. The pH-shifting treatment increases the emulsifying properties of the myofibrillar protein (MP) of PSE-like meat, but the emulsion stability under various environmental conditions has yet to be explored. The creaming index under 60 and 80 °C decreased from 20.1% to 28.9%–16.1% and 26.7%, respective, indicating a higher stability against heating. pH-shifting significantly increased the stability of the emulsion, particularly at pH 7.0 and 7.5. Also, the pH-shifted emulsion could more effectively resist instability brought by freeze-thaw cycles. However, at lower salt concentrations, the stability of the pH-shifted emulsion was poor. Throughout the 48-h storage period at 4 °C, the pH-shifted group reached stability faster than the control, and the turbiscan index values were stabilized at 1.8 and 4.7, respectively. Overall, pH-shifting could improve the emulsion stability of PSE-like MP against heating, pH altering, salt content changing, freezing-thawing, and storage.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2023
·
IF 4.3
Rui Wang,Simin He,Wanjing Liu,Hebing Pei,Nijuan Liu,Ruibin Guo,Zunli Mo
Carbon quantum dots are widely used in the field of analysis and detection due to their excellent optical properties. At present, many studies have focused on the preparation of multi-color fluorescent quantum dots by simple methods. Inspired by this, carbon quantum dots with green (G-CQDs) and yellow fluorescence (YN-CQDs) emission were prepared by hydrothermal method using PTCDA and urea as precursors. After characterizing their morphology, structure, and optical properties, fluorescent probes for different purposes were constructed according to their different fluorescence characteristics. Since green G-CQDs are sensitive to acidic environments, pH detection kits are developed. In addition, G-CQDs can also efficiently detect Asp. YN-CQDs are used to detect metal ions and can specifically detect Fe 3+ . Both of them were applied to the detection of actual samples, showing high efficiency and reliability. It provides a new idea for the multi-purpose detection of carbon quantum dot fluorescent probes.
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2023
·
IF 5.2
Xianghui Kong,Weiqi Xu,Kaixin Zhang,Guijie Chen,Xiaoxiong Zeng
Theaflavins (TFs) and theasinensins (TSs) are the key components formed from the enzymatic oxidation of tea catechins , contributing significantly to the biological activities and taste of black and Oolong teas. In this study, we aimed to reveal the catechin conversion and the enzymatic synthesis of TFs and TSs under reaction temperatures and pH values using polyphenol oxidase (PPO) from potato tuber ( Solanum tuberosum L.). The results indicated that different temperatures, pH values and durations had significant effects on the conversion of catechins and the formation of TFs and TSs. During the reaction, the most of catechin substrates was consumed at 60–90 min after reaction initiation, and large amounts of the products TFs (0.04–0.41 mg/mL) and TSs (0.51–1.52 mg/mL) were obtained. The content of TSs was significantly higher and the maximum content of TSs was more than three times that of TFs. Reaction at a lower temperature (20 °C) is suitable for producing dimers, especially for TFs. Higher pH value resulted in higher catechin consumption and higher TSs content, while the maximum of TFs was obtained at pH 5.0. The present results provided a theoretical basis and practical guidance for the targeted processing of tea catechin dimers in vitro .
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yukun Wang,Zhiyu Jin,Zijun Zhang,Changkai Zhou,Zhe Sun,Feng Yan
With the requirements for food safety and quality, there has been increasing attention on intelligent food packaging, especially pH-responsive intelligent packaging. However, the toxicity of indicators and the vulnerability of composite films to leakage tend to change the composition of food and endanger human health. In this study, 2-allyoxy-1-hydroxy-anthraquinone (AhAQ), a pH-responsive plant dye that was modified from alizarin (AI), was grafted onto the pH-responsive intelligent film (AhAQF) via click polymerization. The obtained AhAQF film shows color change in response to ammonia vapor and exhibits adequate reversibility after treatment with volatile acetic acid. The obtained AhAQF exhibits zero leakage, owing to the covalent immobilization of AhAQ. Thus, the prepared pH-responsive films are non-toxic and antibacterial and show promising application prospects in visual food intelligent packaging and gas-sensitive labels.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Tianyu Zhang,Xiaoli Yan,Guangda Zhou,Kui Wang,Jingtao Zhang,Hua Zhang,Junjie Guo
Optimizing platinum-based catalysts for hydrogen generation via water electrolysis in pH-universal electrolytes is significant, and modulating the electronic structure is a viable strategy. Herein, platinum-iron (Pt–Fe) alloys with varying composition supported on carbon onions (CNOs) were successfully synthesized: Pt x Fe y @CNOs (x, y = 0.6, 0.4; 0.5, 0.5; 0.4, 0.6). Beneficial from the precisely modulated crystal plane spacing and electronic structure by tuning the Pt/Fe composition, in general pH electrolytes, Pt x Fe y @CNOs display outstanding hydrogen evolution reaction (HER) activity. The as-prepared Pt 0.5 Fe 0.5 @CNOs shows low overpotentials (η 10 ) of 11, 30, and 19 mV at −10 mA cm −2 in 0.5 M H 2 SO 4 , 1.0 M phosphate-buffered saline (PBS), and 1.0 M KOH electrolyte, respectively. Compared to commercial Pt/C, it displays enduring stability up to 24 h. Density functional theory (DFT) calculations indicate that Pt 0.5 Fe 0.5 @CNOs displays the lowest H* Gibbs free energy (ΔG H* ) and water dissociation energy values, due to the suitable proton adsorption and H 2 O dissociation processes offered by its electronic structure. Moreover, it is proven that the support with better wettability has a positive effect on HER performance of the catalyst. The optimal electronic structure and improved wettability provide novel insight into developing a Pt-based HER pH-universal catalyst.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2023
·Vol. 23
·期 14
·6277
·
IF 3.9
Ya Wang,Yuanhua Wei,Siqi Li,Guang Hu
Benefiting from the advantages like large surface area, flexible constitution, and diverse structure, metal-organic frameworks (MOFs) have been one of the most ideal candidates for nanozymes. In this study, a nitro-functionalized MOF, namely NO2-MIL-53(Cu), was synthesized. Multi-enzyme mimetic activities were discovered on this MOF, including peroxidase-like, oxidase-like, and laccase-like activity. Compared to the non-functional counterpart (MIL-53(Cu)), NO2-MIL-53(Cu) displayed superior enzyme mimetic activities, indicating a positive role of the nitro group in the MOF. Subsequently, the effects of reaction conditions on enzyme mimetic activities were investigated. Remarkably, NO2-MIL-53(Cu) exhibited excellent peroxidase-like activity even at neutral pH. Based on this finding, a simple colorimetric sensing platform was developed for the detection of H2O2and glucose, respectively. The detection liner range for H2O2is 1–800 μM with a detection limit of 0.69 μM. The detection liner range for glucose is linear range 0.5–300 μM with a detection limit of 2.6 μM. Therefore, this work not only provides an applicable colorimetric platform for glucose detection in a physiological environment, but also offers guidance for the rational design of efficient nanozymes with multi-enzyme mimetic activities.Keywords:nanozyme;metal-organic frameworks;multi-enzyme mimetics;glucose;colorimetric sensor
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Huishan Rao,Fei Chen,Lianzhu Lin,Mouming Zhao
Flavonoids have a variety of bioactivities, but their poor solubility, low bioavailability, and weak stability limit their application as functional factors in food systems. Soy extracts (SE) mainly composed of soy proteins and soluble polysaccharides at mass ratios of 4.1–5.8: 1 and possessing good bioactivity and nutritional property might be candidate functional encapsulation carriers to improve defects of flavonoids and enhance overall nutritional quality . In this study, galangin (Gal), a poorly water-soluble flavonoid, was used as an example to evaluate the application potential of SE in flavonoid delivery system. Gal-loaded SE nanoparticles (Gal-loaded SE NPs) with high Gal solubility, encapsulation efficiency and bioaccessibility were successfully constructed by pH-driven method. The solubilizing effect of SE on Gal largely depended on the concentrations of SE and Gal. Combining the encapsulation efficiency and retention rate, the optimal conditions were identified as SE concentration of 40 mg/mL, binding time of 5 min, and Gal to SE mass ratio of 1%. Gal-loaded SE NPs showed good storage, thermal, redissolution, and sodium ions stabilities. Based on Fourier transform infrared spectroscopy , X-ray diffraction, and transmission electron microscope analysis , the proteins in SE might undergo a typical de-folding and re-folding process during pH-shifting and mainly combine with Gal by hydrophobic interaction to form Gal-loaded SE NPs with spherical shape (particle diameter <100 nm). This study broadened the application of SE in flavonoid delivery system and provided new ideas for the design and development of new plant-based health food ingredients with multiple functional factors and high nutritional quality.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）