DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 32
·10630-10634
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IF 4.029
Mei-Yan Gao,Shumei Chen,Lan-Xia Hu,Lei Zhang,Jian Zhang
Four titanium-oxo-clusters with cyclohex-3-ene-1-carboxylate (Cec) ligands, Ti6(μ2-O)2(μ3-O)2(Cec)4(OiPr)12 (PTC-91; HOiPr = isopropanol), Ti6(μ3-O)6(Cec)6(OiPr)6 (PTC-92 and PTC-93) and H2[Ti18(μ2-O)11(μ3-O)14(Cec)20(OiPr)4] (PTC-94), have been solvothermally synthesized under different conditions, respectively. These clusters with the same Cec ligand show totally different structures, and they are stable in water and other common solvents. The Ti6 clusters with different conformations are presented in PTC-91, PTC-92 and PTC-93, while PTC-94 is an unusual Ti18 cluster. The photocatalytic studies reveal that PTC-91 and PTC-94 have good H2 evolution ability.
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2024
·
IF 3.8
Feng-Xia Qu,Xiao Guo,Xiao-Jun Liu,Shu-Wen Zhang,Yue Xin,Jing-Yuan Li,Rong Wang,Chen-Ji Xu,Hai-Ying Li,Chang-Hong Lu
Myocardial infarction (MI) is the primary source of death in cardiovascular diseases. Myricitrin (MYR) is a phenolic compound known for its antioxidant properties. This study aimed to investigate the impact of MYR alone or combined with exercise on a rat model of MI and its underlying mechanism. Sprague-Dawley rats were randomized into 5 groups: sham-operated (Sham), MI-sedentary (MI-Sed), MI-exercise (MI-Ex), MI-sedentary + MYR (MI-Sed-MYR) and MI-exercise + MYR (MI-Ex-MYR). MI was induced through ligation of left anterior descending coronary artery. The treatment with exercise or MYR (30 mg/kg/d) gavage began one week after surgery, either individually or in combination. After 8 weeks, the rats were assessed for cardiac function. Myocardial injuries were estimated using triphenyltetrazolium chloride, sirius red and Masson staining. Changes in reactive oxygen species (ROS) levels, mitochondrial membrane potential (ΔΨm), apoptosis and Nrf2/HO-1 pathway were analyzed by ROS kit, JC-1 kit, TUNEL assay, western blot and immunohistochemistry. Both MYR and exercise treatments improved cardiac function, reduced infarct size, suppressed collagen deposition, and decreased myocardial fibrosis. Additionally, both MYR and exercise treatments lowered ROS production induced by MI, restored ΔΨm, and attenuated oxidative stress and apoptosis in cardiomyocytes. Importantly, the combination of MYR and exercise showed greater efficacy compared to individual treatments. Mechanistically, the combined intervention activated the Nrf2/HO-1 signaling pathway. These findings suggest that the synergistic effect of MYR and exercise may offer a promising therapeutic approach for alleviating MI.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 3.7
Pei Li,Bianfang Shi,Junyao Shen,Ran Cui,Wenze Guo,Ling Zhao,Zhenhao Xi
The amino-functionalization of TS-1 zeolite followed by immobilization of phosphotungstic acid (HPW) was presented to prepare a strong solid acid catalyst for the synthesis of bio-based tributyl citrate from the esterification of citric acid and n -butanol. γ-Aminopropyltriethoxysilane (APTES) was first grafted on the TS-1 zeolite via the condensation reactions with surface hydroxyl groups, and subsequently the HPW was immobilized via the reaction between the amino groups and the protons from HPW forming strong ionic bonding. The Keggin structure of HPW and MFI topology of TS-1 zeolite were well maintained after the modifications. The amino-functionalization generated abundant uniformly distributed active sites on TS-1 for HPW immobilization, which promoted the dispersity, abundance, as well as the stability of the acid sites. The tetrahedrally coordinated framework titanium and non-framework titania behaved as weak Lewis acid sites, and the protons from the immobilized HPW acted as the moderate or strong Brønsted acid sites. An optimized TBC yield of 96.2%(mol) with a conversion of -COOH of 98.1%(mol) was achieved at 150 °C for 6 h over the HPW immobilized on amino-functionalized TS-1. The catalyst exhibited good stability after four consecutive reaction runs, where the activity levelled off at still a relatively high level after somewhat deactivation possibly caused by the leaching of a small portion of weakly anchored APTES or HPW.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Qi Chen,Yue Zhou,Xudong Zhu,Lei Xu,Ge Bai,Yaru Zhou,Nannan Zhang,Hongwen Liu,Yani Pan,Yu Liu,Lishan Wang,Xueni Fu,Jingjing Wei,Lina Zhou,Lu Xu,Yuxiang Sun,Zhangding Wang,Shanshan Shen,Yun Zhu,Lei Wang
Tumor-associated neutrophils (TANs), particularly the N2 phenotype, contribute to T cell exhaustion in cholangiocarcinoma (CCA), leading to low response rates to PD-1 inhibitor therapy. To address this issue, cancer-associated fibroblast (CAF)-derived extracellular vesicles loaded with ruxolitinib (CEVs@Ru) are developed to selectively target and reprogram N2 TANs, thereby modulating the immunosuppressive tumor microenvironment (TME). The combination of CEVs@Ru with anti-PD-1 antibody therapy significantly enhanced antitumor efficacy, reducing tumor weight by 89.86% and normalizing liver weight, without significant adverse effects. This approach improved the local concentration of ruxolitinib, increased CD8+ T cell infiltration, and reduced regulatory T cells, indicating a remodeled TME conducive to effective antitumor immunity. The findings provide a promising strategy for enhancing PD-1 inhibitor efficacy and improving patient outcomes in CCA and potentially other solid tumors.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Shaozhen Huang,Tianbao Li,Zhangdi Xie,Kun Li,Yuejiao Chen,Lin Mei,Gui-Chao Kuang,Zhibin Wu,Yu Zhang,Lin Gu,Libao Chen
Dendrite-free lithium anodes are crucial for developing practical high-energy-density batteries (>400 Wh/kg) with extended cycle life, but conventional interface design lack self-adaptive adjustment against dendrite growth during Li plating. Herein, we obtain a dendrite-free ultrathin Li@FcCHO anode by engineering a stress-responsive nano-interface on lithium strips via a mechanochemical reaction between ferrocene carboxaldehyde (FcCHO) and metallic Li. As proved by in situ Kelvin probe force microscopy and scanning electrochemical microscopy tests, the Li@FcCHO anode shows local potential response to the Li plating stress. Furthermore, density functional theory calculations show that the local surface potential change originates from stress-induced redistribution of anion-pair coordination. The stress-potential coupled interface layers induce uniform and dendrite-free Li deposition beneath the interface by suppressing dendritic Li from capturing Li + with the extra electric field. As a result, the Li@FcCHO anode exhibits ultralong cycling life over 5000 h under high areal capacity conditions, whilst a practical 452 Wh/kg pouch cell (9 Ah) based on the Li@FcCHO anode can survive over 470 cycles with capacity retention of 85.20%. This work pioneers a stress-potential coupled interface design to advance practical ultrathin Li anodes for next-generation high-energy-density batteries.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yong Chen,Xiaoxiao Zhu,Xinping Wang,Yunpeng Su
A facial and cost-effective protocol preparing multi-hollow silicalite-1 (S-1) zeolite was proposed. That is, treating the parent zeolite with tetrapropylammonium hydroxide (TPAOH) solution at low temperature for a period prior to recrystallization. In this protocol, the geometric structure of the product could be highly controlled from hollow to sponge-like multi-hollow configuration, by modulating the period. It was demonstrated that the key role of this step performed before the recrystallization is to create some deep gullies on the parent zeolite that are necessary for constructing the desired multi-hollow structure. This strategy was also succeeded for fast confining single- or bi-metal nanoparticles in much high dispersion within the multi-hollow S-1 without any protective agent addition. It was proved that this protocol is very effective for dispersing Pt within the sponge-like S-1, even for preparing the Pt@S-1 composite with the Pt content as high as 1.67 wt.%. As a specialty of the protocol, it is that, the protocol always gives desired open mesopores to the product material. The Pt@S-1 and PtSn@S-1 exhibited much higher activity for CO oxidation and propane dehydrogenation than the corresponding conventional catalysts.
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RSC Advances
·
2019
·Vol. 9
·期 71
·41591-41602
·
IF 3.049
Yu Qiao,Qian Han,Dong Li,Hongji Li,Bing Wei,Guangbo Che,Wei Jiang,Weisheng Guan
A novel Ag/metal–organic framework/graphitic carbon nitride (Ag/HKUST-1/g-C3N4, AHC) photocatalyst was prepared via an in situ growth strategy and photo-deposition technique for environmental remediation. The as-obtained samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), N2 adsorption–desorption isotherm measurement, UV-vis diffuse reflection spectroscopy (UV-vis DRS), and photoluminescence (PL) spectroscopy. The results indicated that the hybrids have large surface area, mesoporous structure and enhanced visible-light absorption. The as-prepared hybrid samples exhibited considerable improvement in photocatalytic activity and stability for rhodamine B (RhB) degradation under visible light irradiation (λ > 420 nm). In addition, they also have good adsorption properties. Compared to the pure g-C3N4 and Ag/g-C3N4, the 5% AHC photocatalyst showed superior photocatalytic activity. Moreover, 5% AHC exhibits good photocatalytic activity even after four cycles. Additionally, the active species trapping and electron spin resonance (ESR) experiments indicated that h+ and ·OH were the main active species.
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Journal of Energy Storage
·
2024
·
IF 8.9
Xueting Yang,Haoyu Deng,Jie Xu,Dezhan Ye,Xiancai Jiang,Yazhou Chen,Ke Sun,Zengjin Liu
1,3-dioxolane (DOL) shows low interfacial impedance and high Coulombic efficiency, thus its polymer electrolytes have attracted extensive attention. In order to initiate DOL polymerization, catalyst amount of LiPF 6 is usually used rather than as the main lithium salt . Totally replacement of LiTFSI with low cost of LiPF 6 could bring the heat explosion and high viscosity when mixing DOL with 0.9 M LiPF 6 electrolyte (carbonate ester solvent). Here, based on the Lewis acid-base interaction, a new type of Lewis base, pyridine, is added to control the explosive polymerization of 1,3-dioxolane in LiPF 6 electrolyte. Through tuning the pyridine content, the gelling process and electrochemical properties could be controlled. It is demonstrated that the optimized monomer conversion and electrochemical window are up to 85.2 % and 4.6 V; meanwhile, the optimized conductivity and transfer number are 0.99 × 10 −3 S/cm (25 °C) and 0.68, respectively. The stable interface between PDOL and lithium metal anode could be proved by the stable over-potential (50mv, 700 h) at current density of 0.5 mA cm −2 . After 500 cycles at 2C, the assembled Li/PDOL@py 0.125 /LiFePO 4 battery delivers 115 mAh/g and 90 % capacity retention, with high average Coulombic efficiency of 99.83 %. The present results demonstrate the heat suppression role of pyridine toward mixing DOL with 0.9 M LiPF 6 electrolyte, which solves the heat and viscosity problems for PDOL based gelling polymer electrolytes .
研究领域:
电化学
·
高分子化学
·
能源材料
·
锂离子电池
·
界面化学
·
功能材料
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2021
·
IF 3.927
Nengyuan Zeng,Chenwei Wang,Chong Luo,Hongdong Zhao,Yuling Liu,Wantang Wang,Tengda Ma
This article proposed an improvement plan for the slurry to reduce the dishing caused during copper chemical mechanical polishing (CMP) of the interconnect structure. According to the difference in the pressure between the concave and convex parts of the copper film in the high-hardness polishing pad, polishing slurries were designed with a distinct difference in the polishing removal rate under high and low platen pressures to improve their planarization efficiency. 2 wt% GLY (glycine) and 1 wt% H 2 O 2 can provide a chemical dissolution effect, adding 0.1% TAZ (1,2,4-triazole) to slow down the corrosion mainly for the recession, by adjusting the slurry pH to 7. The polishing results showed that the slurry had a high copper removal rate (6772 Å/min) at high pressure (3.0 psi) and a much lower removal rate (3273 Å/min) at low pressure (1.2 psi). The pattern wafer polished with this slurry obtained relatively low dishing. The other comparison groups showed slight differences in copper removal rate at high and low pressure and a deeper dishing of the polished pattern wafer. In this paper, based on the analysis of static dissolution experiments, electrochemical experiments, and XPS experiments of copper films in different slurries, the chemical reaction mechanism of copper films in the solution system of GLY and H 2 O 2 was studied at different pH values. In addition, the inhibition mechanism of TAZ on the copper surface at different slurry pH values was proposed, including the properties of the TAZ molecule adsorption film on the copper surface, the uniformity of the surface coverage, and the thickness of the passivation layer . The results can reflect the polishing results to a certain extent despite some deviations, but it can also be used as a more reasonable argument to explain the optimization scheme of the slurry proposed in this article.
研究领域:
材料科学
·
微电子制造
·
表面化学
·
半导体工艺
·
腐蚀与防护
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Biomedical Materials
·
2024
·Vol. 19
·期 3
·035011
·
IF 3.9
Piaoyi Chen,Qinglin Xiao,Zhaoxiong Guo,Wei Liang,Ou Liu,Liteng Lin,Yugang Huang,Kangshun Zhu,Guodong Ye
Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe3O4@Poly (diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100–300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe3O4 enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.
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RSC Advances
·
2019
·Vol. 9
·期 15
·8315-8325
·
IF 3.049
Zhiping Qi,Wenlai Guo,Shuang Zheng,Chuan Fu,Yue Ma,Su Pan,Qinyi Liu,Xiaoyu Yang
The mammalian central nervous system has a limited ability for self-repair under injury conditions. The treatment of nerve injuries has been revolutionised with the development of tissue engineering techniques. However, the lack of bioactivity has severely restricted the application of biodegradable implants for neurogenesis. Therefore, surface modification of biomaterials is crucial to improve their bioactivity and promote endogenous repair mechanisms for nerve regeneration. Insulin-like growth factor 1 (IGF-1) is a growth factor for neuroprotection and neurogenesis. In this study, IGF-1 was successfully immobilised on graphene oxide (GO)-incorporated poly(lactic-co-glycolic acid) (PLGA) biodegradable electrospun nanofibres. For the in vitro investigation, neural stem cells (NSCs) were cultured on different nanofibres to observe various cellular activities. GO enhanced NSC survival under H2O2 pre-treatment and neuronal differentiation to some extent. More importantly, the immobilisation of IGF-1 onto the PLGA/GO nanofibres resulted in significantly increased NSC survival, proliferation, and differentiation. Findings from this study revealed that using PLGA/GO electrospun nanofibres to immobilise IGF-1 has excellent potential for the enhancement of the neuroprotective and neurogenic effects of nerve implants.
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Frontiers in Pharmacology
·
2026
·
IF 5.4
Fang Wang,Yan Qing Liu,Jun Nan Wei,Xiao Fen Wang,Feng Qin Li,Xiu Jia Tian,Dan Li,Yu Xuan Gao,Xin Zhi Guo,Xue Yan Li,Ping Luo
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder characterized by intrahepatic lipid accumulation, oxidative stress, and inflammatory responses, underscoring the urgent need for effective therapeutic strategies. D-limonene, a cyclic monoterpenoid primarily derived from citrus fruits, possesses well-documented antioxidant, anti-fibrotic, and wound-healing properties. However, its therapeutic potential in MASLD remains largely unexplored. Methods To evaluate the therapeutic efficacy of D-limonene, a rat model of MASLD was established using a high-fat diet (HFD). An integrated approach combining metabolomics, transcriptomics, and network analysis was employed to identify key signaling pathways and molecular targets. The expression levels of candidate targets were validated by RT-qPCR and Western blotting. Molecular docking simulations were performed to predict the binding affinity between D-limonene and the target proteins. Furthermore, a cellular thermal shift assay (CETSA) was conducted to confirm direct binding and protein stabilization. In parallel, cellular experiments using BRL-3A and HepG2 cells were carried out to assess the effect of D-limonene on lipid accumulation. Results D-limonene treatment significantly ameliorated liver injury, reduced excessive lipid deposition, attenuated inflammation, and suppressed oxidative stress in HFD-induced rats. Integrated multi-omics and network analyses identified the PPAR signaling pathway as the core pathway mediating the regulatory effects of D-limonene on lipid metabolism, with PPARγ and SCD-1 pinpointed as key downstream targets. RT-qPCR and Western blot analyses confirmed that D-limonene significantly downregulated the expression of both PPARγ and SCD-1. Molecular docking simulations revealed stable binding of D-limonene to PPARγ and SCD-1. Importantly, CETSA further demonstrated that D-limonene directly binds to and stabilizes these two proteins. Consistently, cellular assays showed that D-limonene significantly reduced lipid accumulation in BRL-3A and HepG2 cells by inhibiting the PPARγ/SCD-1 axis. Conclusion Collectively, these findings suggest that D-limonene alleviates HFD-induced MASLD, and its protective effects may be mediated, at least in part, through inhibition of the PPARγ/SCD-1 axis. This study provides preliminary evidence supporting the potential development of D-limonene as a targeted therapeutic agent for MASLD. Further studies are warranted to validate these findings and elucidate additional underlying mechanisms.
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