RSC Advances
·
2022
·Vol. 12
·期 48
·31186-31191
·
IF 4.036
Dandan Jiang,Minghao Zheng,Xiaoyang Yan,Bin Huang,Hui Huang,Tianhao Gong,Kunming Liu,Jinbiao Liu
Herein, we report a highly selective fluorescent probe for the detection of Cu(II). The detection mechanism relies on the Cu(II)-catalyzed oxidative hydroxylation of 2-(aminocarbonyl)phenylboronic acid into salicylamide, thus recovering the excited-state intramolecular proton transfer (ESIPT) effect and inducing more than 35-fold fluorescence enhancement. The simple structure and readily available fluorescent probe give a novel method for quantitatively detecting Cu(II) in the linear range of 0–22 μM, with a limit of detection down to 68 nM, and exhibiting high selectivity for Cu(II) over 16 other metal ions.
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高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 153
·期 9
·2813-2823
·
IF 2.936
Yang Jian,Li Xuemei,Zhang Jia,Tian Junying,Yao Xiaolan,Liu Hailong,Xia Chungu,Huang Zhiwei
Valuable 5-amino-1-pentanol (5-AP) was efficiently synthesized from biomass-derived dihydropyran over hydroxylapatite nanorod supported Ni catalysts (Ni-HAP), by coupling the in situ generation of 5-hydroxypentanal (5-HP, via the ring-opening tautomerization of 2-hydroxytetrahydropyran (2-HTHP)) and its subsequent reductive amination. The Ni-HAP catalyst with 10 wt% Ni loading exhibited the highest 5-AP yield than the other Ni-HAP catalysts with different Ni loadings and several commercial hydrogenation catalysts, including Ru/C, Pt/C and Pd/C, as well as Raney Ni. High Ni particles dispersion, high reducibility and acidic intensity were found to account for the superior catalytic performance of 10Ni-HAP. The effect of reaction parameters on the catalytic performance was investigated, and an excellent 5-AP yield of 92% was achieved under mild reaction conditions of 80 °C and 2 MPa H 2 . The stability of the Ni-HAP catalyst was studied using a continuous flow reactor, and the sintering of Ni nanoparticles was considered as the major reason for the decline in hydrogenation activity. Graphical Abstract The Ni-HAP catalyst exhibited high catalytic performance to synthesis 5-AP due to the high Ni particles dispersion, reducibility and acidic intensity.
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JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Xingxing Zhao,Yudong Ding,Lijiao Ma,Xun Zhu,Hong Wang,Qiang Liao
Porous liquids (PLs) with porosity and fluidity have shown great potential in gas separation. In this work, a type-III PLs were synthesized by mixing 2-Methylimidazole zinc salt (ZIF-8) nanoparticles as the main units and 1-Ethyl-3-methylimidazolium Bis(trifluoro-methanesulfonyl)-imide ([EMlm][NTf 2 ]) as the solvent. Molecular dynamics simulation evidenced the permanent, vacant, rigid pores of PLs. The prepared PLs were characterized, and their CO 2 uptake performances were obtained using a CO 2 static absorption system. ZIF-8 could significantly increase the CO 2 absorption capacity of the porous liquid, and when the mass fraction of ZIF-8 inside PLs was 10 wt%, the CO 2 absorption capacity increased by 143 %. Then, the CO 2 absorption characteristics of porous liquids were studied in different conditions, including temperature, pressure, and concentration of the ZIF-8. The CO 2 adsorption heat calculated by the Clausius–Clapeyron relation is −6.5 kJ/mol. The absorption rate of PLs was studied using the damping film theory. The CO 2 uptake capacity of the PLs decreased with temperature but increased with pressure and CO 2 concentration. Subsequently, the absorption-adsorption model was established to predict the CO 2 uptake capacity of PLs. The theoretical values agree with the experimental values, indicating that the developed absorption-adsorption model can predict the CO 2 uptake properties of PLs. Finally, analysis of the CO 2 cyclic performance of the PLs showed the PLs could be regenerated under negative pressure, and the CO 2 uptake capacity remained stable after five cycles, indicating the [EMIm][NTf 2 ]/ZIF-8 PLs could be applied in CO 2 capture.
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MOLECULAR PHARMACEUTICS
·
2019
·
IF 4.396
Jiaoyang Tao,Weidong Fei,Hongxia Tang,Chaoqun Li,Chaofeng Mu,Hongyue Zheng,Fanzhu Li,Zhihong Zhu
The poor capability of drugs to permeate through the blood–brain barrier (BBB) and further release inside glioma greatly limits the curative effects of glioma chemotherapies. In this study, we prepared angiopep-2-conjugated liposome-silica hybrid nanovehicles for targeted delivery and increased the permeation of arsenic trioxide (ATO) in glioma. Polyacrylic acid (PAA) was grafted on mesoporous silica nanoparticles (MSN) for pH-sensitive release and supporting the lipid membrane. The prepared “core–shell” nanovehicles (ANG-LP-PAA-MSN) were characterized with uniform size, high drug loading efficiency (8.19 ± 0.51%), and superior pH-sensitive release feature. From the experiments, the enhanced targeted delivery of ATO by ANG-LP-PAA-MSN (ANG-LP-PAA-MSN@ATO) was evidenced by the improvement of transport, enhanced cellular uptake, and apoptosis in vitro. In addition, the pharmacokinetic study was creatively carried out through the blood–glioma synchronous microdialysis and revealed that the half-life (t1/2) of blood and glioma tissue in the ANG-LP-PAA-MSN@ATO treatment group was extended by 1.65 and 2.34 times compared with the ATO solution group (ATO-Sol). The targeting efficiency of ANG-LP-PAA-MSN@ATO (24.96%) was dramatically stronger than that of the ATO-Sol (5.94%). Importantly, ANG-LP-PAA-MSN@ATO had a higher accumulation (4.6 ± 2.6% ID per g) in tumor tissues and showed a better therapeutic efficacy in intracranial C6 glioma bearing rats. Taken together, the blood–glioma synchronous microdialysis was successful used for the pharmacokinetic study and real-time monitoring of drug concentrations in blood and glioma; ANG-LP-PAA-MSN could be a promising targeted drug delivery system for glioma therapy.
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BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Qingqing Zhang,Zetao Chen,Zhenghan Shi,Yaru Li,Zijian An,Xin Li,Jianzhen Shan,Yanli Lu,Qingjun Liu
Photoelectrochemical analysis has been widely used in the field of biosensing due to its high sensitivity and strong anti-interference ability. Herein, a portable and versatile smartphone-based photoelectrochemical biosensing platform was developed for the rapid and on-site biomedical analysis. In the system, light excitation and photocurrent measurements were accomplished by a miniaturized and integrated circuit board. Smartphone with a specifically designed application was utilized to wirelessly control the system via Bluetooth. For photoelectrochemical sensor, graphitic carbon nitride (g-C 3 N 4 ) and gold nanoparticles loaded on indium tin oxide electrodes were utilized as photoactive materials and signal amplification elements, respectively. The gold nanoparticles were also used to immobilized matrix metalloproteinase-2 (MMP-2) specific cleavage peptide that modified with bovine serum albumin (BSA) on the terminal. In the presence of MMP-2, the peptide was specifically hydrolyzed and cleaved. Thus, parts of the peptide chain and BSA were detached from the electrode resulting in the decrease of steric hindrance and the increase of photoelectrochemical currents. The photocurrents changed linearly with the logarithm of MMP-2 concentrations ranging from 1 pg/mL to 100 ng/mL in both buffer and artificial serum with correlation coefficient of 0.9943 and 0.9698. The limit of detections were as low as 0.48 pg/mL in buffer and 0.55 pg/mL in artifical serum. It indicated that the biosensor has good linearity and high sensitivity, which also verified the effectiveness of the portable instrument. This system provides a pioneering solution for the development of miniaturized and portable photoelectrochemical analysis instruments used for the field monitoring of different analytes .
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INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Dan-Na Song,Wen-Yan Li,Hong-Yun Wang,Jing Zhang,Dao-Jun Zhang,Jun-Jie Wang,Ji-Min Du,Ren-Chun Zhang,Yong-Lin An
Cluster-based framework metal iodides have diverse structures and excellent luminescence properties, and show promising applications in sensing and solid-state lighting. However, the design and synthesis of these materials remain great challenges because excess I– ions introduced into the synthesis systems decrease the condensation degree of M–I units. In this work, a new strategy is developed to control the condensation behavior of Ag–I units, and a new silver-rich cluster-based framework iodide [DabcoAg8I6(SPh)2]n (1) (Dabco = 1,4-diazabicyclo [2.2.2] octane) has been synthesized under solvothermal conditions in the presence of silver thiophenolate (AgSPh)n. Compound 1 features a three-dimensional (3-D) cluster-based framework with a pillared layer structure composed of cationic [Ag8I6]2+ clusters bridged by SPh– and Dabco, and displays low-temperature dual emission and luminescence thermochromism.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2017
·
IF 4.519
Chun-Li Xia,Ning Wang,Qian-Liang Guo,Zhen-Quan Liu,Jia-Qiang Wu,Shi-Liang Huang,Tian-Miao Ou,Jia-Heng Tan,Hong-Gen Wang,Ding Li,Zhi-Shu Huang
A series of 2-arylethenyl- N -methylquinolinium derivatives were designed and synthesized based on our previous research of 2-arylethenylquinoline analogues as multifunctional agents for the treatment of Alzheimer's disease (AD) (Eur. J. Med. Chem. 2015, 89, 349–361). The results of in vitro biological activity evaluation, including β-amyloid (Aβ) aggregation inhibition, cholinesterase inhibition, and antioxidant activity , showed that introduction of N -methyl in quinoline ring significantly improved the anti-AD potential of compounds. The optimal compound, compound a12 , dramatically attenuated the cell death of glutamate-induced HT22 cells by preventing the generation of ROS and increasing the level of GSH. Most importantly, intragastric administration of a12 •HAc was well tolerated at doses up to 2000 mg/kg and could traverse blood-brain barrier.
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2022
·
IF 3.461
Ting Xu,Jie-Ru Meng,Wanqing Cheng,Jia-Zheng Liu,Junyan Chu,Qian Zhang,Nannan Ma,Li-Ping Bai,Yong Guo
Honokiol, isolated from a traditional Chinese medicine (TCM) Magnolia officinalis , is a biphenolic compound with several biological activities. To improve and broaden its biological activity, herein, two series of honokiol thioethers bearing 1,3,4-oxadiazole moieties were prepared and assessed for their α -glucosidase and SARS-CoV-2 entry inhibitory activities. Among all the honokiol thioethers, compound 7l exhibited the strongest α -glucosidase inhibitory effect with an IC 50 value of 18.9 ± 2.3 µM, which was superior to the reference drug acarbose (IC 50 = 24.4 ± 0.3 µM). Some interesting results of structure–activity relationships (SARs) have also been discussed. Enzyme kinetic study demonstrated that 7l was a noncompetitive α -glucosidase inhibitor, which was further supported by the results of molecular docking. Moreover, honokiol thioethers 7e , 9a , 9e , and 9r exhibited potent antiviral activity against SARS-CoV-2 pseudovirus entering into HEK-293 T-ACE2 h . Especially 9a displayed the strongest inhibitory activity against SARS-CoV-2 pseudovirus entry with an IC 50 value of 16.96 ± 2.45 μM, which was lower than the positive control Evans blue (21.98 ± 1.98 μM). Biolayer interferometry (BLI) binding and docking studies suggested that 9a and 9r may effectively block the binding of SARS-CoV-2 to the host ACE2 receptor through dual recognition of SARS-CoV-2 spike RBD and human ACE2. Additionally, the potent honokiol thioethers 7l , 9a , and 9r displayed relatively no cytotoxicity to normal cells (LO2). These findings will provide a theoretical basis for the discovery of honokiol derivatives as potential both α -glucosidase and SARS-CoV-2 entry inhibitors.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2017
·
IF 3.012
Qinglin Sheng,Duo Liu,Jianbin Zheng
In this paper, a sensitive novel non-enzymatic nitrite electrochemical sensor based on Pt nanoparticles loaded Ni(OH) 2 /Multi-Walled Carbon Nanotubes nanocomposites (Pt/Ni(OH) 2 /MWCNTs) was described. The composition and morphology of the Pt/Ni(OH) 2 /MWCNTs were characterized by transmission electron microscope and investigated energy dispersive X-ray spectra respectively. Results showed that the Pt nanoparticles could be anchored on the surface of the Ni(OH) 2 /MWCNTs uniformly through a simple reduction process. The electrochemical investigation of the sensor revealed that the Pt/Ni(OH) 2 /MWCNTs exhibited remarkable electrocatalytic performance toward nitrite oxidation , with a sensitivity of 145 μA mM − 1 cm − 2 and a low detection limit of 0.13 mM. Moreover, the obtained Pt/Ni(OH) 2 /MWCNTs modified GCE with excellent reproducibility and selectivity also allows for practical application. It is expected that the combination of noble metal with Ni(OH) 2 /MWCNTs could be expanded to enhance the catalytic performances of nanocomposites and used for the construction of high-sensitive electrochemical sensors.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Mengyuan Liu,Jing Li,Jiali Li,Bingsheng Zhou,Paul K.S. Lam,Chenyan Hu,Lianguo Chen
The application of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) as an antifouling biocide causes high toxicity to non-target marine organisms. To examine the developmental cardiotoxicity and mechanisms of DCOIT, we concurrently performed sub-chronic exposure and life-cycle exposure experiments using marine medaka embryos. After sub-chronic exposure to DCOIT at 1, 3, 10, and 33 μg/L, cardiac defects were caused by upregulation of cardiac gene transcriptions, decreasing heart size, and accelerating heartbeat. Hyperthyroidism in medaka larvae was identified as the cause of developmental cardiotoxicity of DCOIT sub-chronic exposure. In addition, parental life-cycle exposure to 1, 3, and 10 μg/L DCOIT led to transgenerational impairment of cardiogenesis in offspring medaka. A crossbreeding strategy discriminated a concentration-dependent mechanism of transgenerational cardiotoxicity. At 1 μg/L, the DCOIT-exposed female parent transferred a significantly higher amount of triiodothyronine (T3) hormone to offspring, corresponding to an accelerated heart rate. However, DCOIT at higher exposure concentrations modified the methylome imprinting in larval offspring, which was associated with cardiac dysfunction. Overall, the findings provide novel insights into the developmental cardiotoxicity of DCOIT. The high risks of DCOIT—even at environmentally realistic concentrations—raise concerns about its applicability as an antifoulant in a marine environment.
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高影响因子
TALANTA
·
2023
·
IF 6.1
Mingming Chen,Bihang Su,Huiying Wu,Yawen Dai,Tianwen Chen,Fengfu Fu,Zhenyu Lin,Yongqiang Dong
T-2 toxin is one of the naturally dangerous food contaminants, which is harmful to people and animals. Because of its strong toxicity and wide distribution, it is vital to develop a rapid and effective method for the detection of T-2 toxin. Herein, an excellent hydrogel surface-enhanced Raman scattering (SERS) chip is constructed for developing a novel SERS sensor to detect T-2 toxin using a portable Raman spectrometer. The SERS chip is prepared by in-situ Ca 2+ -mediated assembly of silver nanoparticles (AgNPs) in PVA solution, followed by a physical crosslinking possess. The assembled AgNPs produces a strong localized surface plasmon resonance (LSPR) at around 532 nm, which enables the high activity of SERS chip under the irradiation of 532 nm laser. Additionally, the unique structure of hydrogel makes the obtained chip show excellent reliability and anti-interference ability in detection. As a result, the developed SERS sensor shows many obvious advantageous including free of complex sample pretreatment (only a simple extraction), fast response (5 min), low limit of detection (0.41 ppb), wide detection range (1–10000 ppb), good recoveries (90.26–101.81 %) and relative standard deviations (2.8–6.7 %). Therefore, this SERS sensor provides a promising choice for rapid scanning and sensitive detection of trace T-2 toxin in complex matrices.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Cai-Fang Liu,Xiao-Yan Ran,Cheng Liu,Yu-lan Zhu,Yan-Rui Lu,Yu-Ping Yang,Bang-Jin Wang,Jun-Hui Zhang,Sheng-Ming Xie,Li-Ming Yuan:
Chiral metal–organic frameworks, an emerging type of chiral porous materials, possess many outstanding characteristics such as high surface area, tunable pore sizes, and good chemical stability. Herein, we prepared a chiral [Zn 2 (D-Cam) 2 (4,4′-bpy)] n @SiO 2 core–shell composite on the SiO 2 -NH 2 microspheres by an in-situ growth method. The prepared [Zn 2 (D-Cam) 2 (4,4′-bpy)] n @SiO 2 -packed column exhibited high-resolution separation of racemic compounds and positional isomers at a low column backpressure (9–12 bar). Twelve pairs of enantiomers including alcohols, amines, epoxides, ketones, and esters were well resolved with sharp peak shapes on the [Zn 2 (D-Cam) 2 (4,4́-bpy)] n @SiO 2 chromatographic column. Compared the separation performance of [Zn 2 (D-Cam) 2 (4,4́-bpy)] n @SiO 2 -packed column and two chromatographic columns (commercial Chiralpak AD-H column and as-prepared SiO 2 -NH 2 column), the [Zn 2 (D-Cam) 2 (4,4′-bpy)] n -packed column and the commercial Chiralpak AD-H column have a good complementarity in chiral separation, and it also offered better separation performance compared to the SiO 2 -NH 2 column for separating positional isomers. The effects of column temperature and analyte mass on the HPLC separation were investigated. Additionally, the [Zn 2 (D-Cam) 2 (4,4́-bpy)] n @SiO 2 packed column has good repeatability and stability for HPLC separation of enantiomers and positional isomers. The relatvive standard deviations (RSDs) for repeated separations of 2,2,2-trifluoro-1-(9-anthryl)ethanol and o , m , p -bromoaniline were less than 0.8 % and 1.2 % for the retention time and peak area, respectively. After continuous use for one month, the RSDs for the retention time and peak area of them were in the range of 1.1–1.3 % and 1.5–1.8 % (inter-day and intra-day, n = 5), respectively. This work also indicates that the chiral MOFs@SiO 2 composites are promising for HPLC separation.
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