CATALYSIS LETTERS
·
2025
·Vol. 155
·期 8
·1-11
·
IF 2.4
Zhang Lan,Zou Zhipeng,Li Na,Tan Cong,Hao Baofei,Ma Huizhong
The residual antibiotics in the water environment pose a great threat to the ecological environment and human life safety. However, an effective and environmentally friendly method for degrading antibiotics is still lacking. Herein, a novel Bi 2 WO 6 catalyst with optimized morphology and abundant crystal defects was designed to remove tetracycline. The experimental results showed that the generation of grain boundaries and dislocations were induced through the epitaxial growth method, which endowed Bi 2 WO 6 with rapid separation and transfer of photoinduced electrons. Moreover, the specific surface area and light adsorption capacity of optimized catalyst (0.5Bi-Bi) were significantly improved. As a result, 0.5Bi-Bi exhibited the excellent photocatalytic performance, which degraded 90.78% of TC within 40 min under visible light illumination. Meanwhile, the synthesized 0.5Bi–Bi catalyst has robust photocatalytic stability and sustainability. The capture experiment proved that ⋅O 2 − was the prime active substance, and a possible mechanism of photodegradation of TC was proposed. Graphical
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POLYMER BULLETIN
·
2025
·
IF 4
Alassod Abeer,Alkhateeb Weaam,Alghoraibi Ibrahim,Alsabbagh Bassel,Hasan Aus Ali,Almenweer Ibrahim,alkutani M. H. D. abdalkabir,Amer Maysaa,Hlal Alaa,Dagher Wael
In this work, nanocomposite membrane-induced nanoparticles (cobalt–iron) have been successfully fabricated. The morphology observations revealed that the average fiber diameters gradually decreased. The presence of nanoparticles (iron–cobalt) was validated by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis, indicating the successful modification. Parameters such as PH, contact time, sorbent mass, and temperature were examined to study their effect on adsorption behavior. The hydrophobicity of the composite membrane was measured using the water contact angle (WCA) test. The results showed that the WCA of obtained samples improved, where the highest WCA was around 146.45°, proving that the fabricated nanofibers were hydrophobic. The higher wicking height for PAN@Fe2 and PAN@Co2 was revealed to be (67 mm,61 mm) and (55 mm,50 mm) for soybean and motor oils. A modified new composite was successfully applied to absorb oils with a significant sorption capacity for different common oils and organic solvents. Besides, it exhibited good reusability and repeatability. All samples obeyed the pseudo-second model with a coefficient value R 2 > 0.999. The isotherm adsorption for obtained nanocomposite samples was well-fitted with the Langmuir model with a maximum reach in the range of 51.02 g/g–149.25 g/g for n-hexane and motor oil, respectively. Furthermore, the thermodynamic study revealed that the adsorption process was spontaneous and exothermic. This work is environmentally friendly, economical, and practical. It can produce superhydrophobic nanocomposite membranes on a large-scale production, which holds great potential in oil–water adsorption applications.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2025
·
IF 3
Nie Saiyu,Zhang Peng,Zhang Qian,Ding Caifeng
The contamination of marine environments with antibiotics, such as kanamycin, poses a significant ecological threat due to its potential harmful effects on marine organisms. Conventional methods for detecting kanamycin, including high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assays (ELISA), face challenges in terms of cost, complexity, and long detection times. This research aims to address these limitations by developing a novel, highly sensitive biosensing platform for kanamycin detection based on a DNAzyme-driven cascade reaction coupled with nanoparticle technology. The method utilizes aptamers for specific kanamycin recognition, which activates DNAzyme-1, triggering a downstream DNA walker system. This cascade reaction amplifies fluorescence signals, significantly enhancing sensitivity. The optimized platform demonstrated a wide detection range (0.05–3 nmol/L) and a low detection limit of 0.0327 nmol/L. This system showed excellent specificity for kanamycin, even in the presence of other antibiotics, and was successfully applied to detecting kanamycin in seawater samples with high recovery rates (94%–102.9%). This DNAzyme-based biosensor offers a promising approach for rapid, cost-effective, and high-sensitivity monitoring of antibiotic contamination in aquatic environments, with potential applications in environmental monitoring and ecological protection.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 7
·1-12
·
IF 2.4
Wang Li,Song YingJie,Guo Yi,Chen Guobing,Zhang Hua,Liang Changhai
Cyanoacetamides(CAAM) are key precursors for the synthesis of agrochemicals and bioactive organic compounds. The activity of nitrile hydrolase (NHase) on nitrile substrates was greatly improved in our previous studies by optimizing the ribosome binding site and α/β subunit expression balance. However, during the NHase-catalyzed hydration of malononitrile, this increased catalytic activity greatly facilitated the further conversion of the intermediate cyanoacetamide to the by-product malonamide, thus preventing the enrichment of cyanoacetamide. To solve this problem, we designed a mutant library of NHase by substrate channel modification based on the strategy of semi-rational design. Among them, the βM40A mutant showed 7.68% higher regioselectivity than wild-type NHase. Structural and mechanistic analyses showed that the mutant (1) remodeled the substrate binding pocket, (2) narrowed the substrate channel, and (3) increased the metal ion-carbonitrile distance by 1.1 Å. Our results suggest that the enzyme’s regioselectivity for the product can be controlled by rational design of key amino acids in the NHase substrate channel, which provides an effective strategy for enrichment of the monocyanamide product. Graphical
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TRANSITION METAL CHEMISTRY
·
2025
·
IF 1.7
Huang Na-Jing,Li Guo-Hua,Xu Long-Jun,Wang Xiao-Yi
Using a one-step co-reduction method, AgCu bimetallic nanoparticles have been successfully loaded onto few-layer boron nitride nanosheets (BNNSs), which possess high thermal conductivity. The structure and morphology of both the support and the catalyst were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HRTEM). Furthermore, the influence of near-infrared laser irradiation on the catalytic performance of the catalyst was investigated. The study found that the Ag 1 Cu 1 /BNNSs nanocomposite exhibited significant catalytic activity in the reduction of 4-nitrophenol (4-NP). This nanocomposite had an activation energy of only 42.9 kJ/mol and maintained high catalytic activity even after six cycles. Additionally, it was found that near-infrared laser irradiation further enhanced the catalytic activity of the composite material. This enhancement was primarily attributed to the photothermal effect of Ag nanoparticles. Moreover, the BNNSs possess high thermal conductivity. They transferred the photothermal energy generated by the Ag nanoparticles to the external environment, thereby further enhancing the local thermal effect of the catalyst. This work provided a foundation for advancing near-infrared or solar photothermal-enhanced bimetallic nanocomposite catalytic systems.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-18
·
IF 12.6
Zhang Yifan,Zhou Ziyi,Liu Na,Wang Jing,Guo Qingxia,You Yong,Mao Kaiping,Wang Yuanfei,Zhang Weina,Wu Tong
Excessive scarring can impede the normal skin movement, resulting in decreased body flexibility and functional abnormalities. These issues, in turn, impact patients’ daily lives and comfort. To prevent the pathological healing of infected wounds, this study developed a composite hydrogel microneedle that possesses stable mechanical properties and favorable biocompatibility. The microneedles, composed of gelatin methacryloyl hydrogels, were integrated with curcumin-loaded PLGA microparticles to promote wound healing and allow the controlled release of curcumin within a suitable timeframe, thereby minimizing the formation of hypertrophic scars. Zinc oxide nanoparticles were integrated into the base layer of the microneedle, forming a physical barrier and exhibiting significant antibacterial activity against both Staphylococcus aureus and Escherichia coli . Due to the unique structural and functional design, we demonstrated that this class of microneedles could accelerate the healing of infected wounds and downregulate the expression of α-SMA and collagen I in scar fibroblasts, thereby showing potential to inhibit scar formation. In vivo investigations further validated the effective repair of infected wounds in rat skin and demonstrated the inhibition of pathological scars using hypertrophic scar models in rabbit ears. Altogether, these materials exhibit promising potential to provide a new option for preventing pathological scarring in the treatment of infected wounds.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2025
·
IF 3.2
Alhalili Zahrah,Shariq Mohammad,Al-Qasmi Noha,Alqahtani Zahrah,Madkhali O.,Alathlawi Hussain J.,Ali Syed Kashif,Sharma Mukul,Hasan K. F.,Elhelali Thoraya M.
This study used a sol-gel method to prepare BiFeO 3 (BFO) and strontium-doped bismuth ferrite Bi 1-x Sr x FeO 3 (x = 0, 0.01, 0.03, 0.05 and 0.09) (Sr-doped BFO) photocatalysts. The microstructural analysis of the Sr-doped BFO photocatalysts revealed a rhombohedral perovskite structure in the samples. The optical study shows that doping with Sr ions reduced the energy band gap of the photocatalyst from 2.12 eV to 1.97 eV. Moreover, the calculated saturation magnetization (Ms) value was increased after doping with Sr ions, and for Sr (x = 0.05), the doped BFO sample exhibits the highest magnetization value of 0.481 emu/g. It was revealed that the Sr (x = 0.05) doped BFO photocatalyst exhibits 91.2% degradation of methylene blue (MB) dye under visible light radiation. In this study, the formation of trap levels due to the Sr ions, as well as the formation of superoxide anions ( \({O}_{2}^{-}\) ) and OH° radicals played a significant role in the degradation of MB. Graphical
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IONICS
·
2025
·
IF 2.6
Gao Chenxiang,Zhang Hengpu,Hu Xiangpan,Ma Xiaoyan
Solid polymer electrolytes (SPEs) are flexible and safer, but inferior ionic conductivity, electrode/electrolyte interface and mechanical strength limit their use for lithium-ion batteries. Herein, we design and prepare a high ionic conductivity, low internal resistance, stable SPE by in situ polymerization of vinylene carbonate and 1-vinyl-3-pentyl cyano imidazole (trifluoromethanesulfonyl) imide in the mesoporous silica-modified polypropylene separators. Mesoporous silica modified polypropylene separators could efficiently adsorb polymer precursor before in-suit polymerization and inhibit lithium dendrite growth during cycling, improving the mechanical strength of SPEs. The poly ionic liquid with many polar groups could effectively promote the dissociation of lithium salts, while its crosslinked network provides Li + transport channels to facilitate the migration of Li + . Meanwhile, in situ polymerization leads to robust electrode/electrolyte interfaces, which reduce the internal resistance and improve the stability of batteries. The optimized SPE (KCE) has a room temperature ionic conductivity of 8.04 × 10 −4 S cm −1 and an electrochemical window of 4.5 V. Assembled Li//KCE//Li cell could run stably at a current density of 0.1 mA cm −2 for 1000 h. Furthermore, the capacity retention rate of LFP//KCE//Li battery after 500 cycles can maintain over 90% and NCM811//KCE//Li battery shows a capacity retention rate of 86.5% after 100 cycles. The LFP//KCE//Li soft pack battery can light an LED bulb and has an open circuit voltage of 2.95 V, showing great potential in the flexibility field. This work provides a workable strategy for improving the performance of solid polymer electrolytes.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 6
·1-12
·
IF 2.8
Wu Yaowei,Jiang Zuming,Wang Yuhao,Jiang Xiancai,Hou Jian,Wei Bei
Polyacrylamide (PAM) serves as an effective thickening agent for oil recovery. However, its viscosity loss during underground transport significantly reduces oil recovery efficiency in reservoir applications. To solve this problem, polyurethane was selected for microencapsulation of PAM through a simple emulsion polymerization method in this work. It is worth mentioning that non-toxic and renewable D-sorbitol was used as a chain extender in the synthesis of polyurethane microcapsules instead of the commonly used diols or diamines obtained from non-renewable petroleum resources, which has not been reported in previous reports. Mechanical stirring was used to simulate the state of polymer subjected to shear during stratigraphic transport. The releasing performance of the microcapsules was characterized by measuring the change of viscosity with time. Meanwhile, we optimized the ratio of D-sorbitol to achieve the longest release time. Experiments showed that D-sorbitol was feasible as a chain extender for the preparation of microcapsules of polyurethane, and the microcapsules prepared at a concentration of 8% D-sorbitol solution had the longest slow-release time of 75 h at 25 °C and 500 rpm. We also prepared samples with BDO as a chain extender for comparison, and the experiments showed that SO8 has a longer slow-release time and can better meet the demand. The prepared microcapsules SO8 exhibited excellent shear resistance and heat resistance, which was attributed to the rigidity and high cross-linking density brought about by D-sorbitol as a hard chain segment of polyurethane. These PAM-containing microcapsules had a promising application in enhancing oil recovery.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Cheng Yi,Li Jiaxin,Lei Ying,Xu Chuanlan,Li Jianying,Si Yujun,Chen Jinlong,Wang Honghui,Han Wenjing
Carbon-supported bimetallic sites show great potential in the field of oxygen reduction electrocatalysis, yet multi-scale structural engineering of carbon supports plays an important role in modulating the catalytic activity. Herein, we ingeniously synthesized an interconnected multi-dimensional porous carbon matrixs supported FeNi bimetallic catalyst (denoted by FeNi-NC/CNT) through pyrolyzing ZIF-8 precursors mixed with polystyrene (PS) microspheres as a pore-forming agent and carbon nanotubes. The optimized FeNi-NC/CNT catalyst exhibited exceptional bifunctional catalytic activity with high half-wave potential E 1/2 = 0.87 V in the oxygen reduction reaction (ORR) process and high activity in the oxygen evolution reaction (OER) with E j=10 = 1.60 V, leading to an ultralow potential difference (730 mV) that is much lower than that of control sample (843 mV) without PS perforation. In practical application, the FeNi-NC/CNT based zinc-air battery achieved a peak power density of 148.6 mW cm −2 and a steady operation time exceeding 150 h, with a low potential difference of only 950 mV. The enhanced bifunctional catalytic activity can be attributed to multi-dimensional frameworks composed of hierarchical porous carbons and conductive CNTs, provide adequate exposure to active sites and mass/electron transfer pathway, and the tuned interaction of FeNi that contributes to equilibrating the intrinsic ORR/OER bifunctional catalytic activity. Graphical abstract
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MOLECULAR MEDICINE
·
2025
·Vol. 31
·期 1
·1-23
·
IF 6.4
Wang Qiuhong,Wei Dong,Li Chunman,Yang Xiawei,Su Kun,Wang Tao,Zou Renchao,Wang Lianmin,Cun Dongyun,Tang Bo,Wu Tao
Section
Background
Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in the regulation of m6A. However, the therapeutic potential of METTL3 in pancreatic cancer is unclear.
Section
Methods
By means of functional gain and loss experiments, the relationship between METTL3 and gemcitabine resistance as well as ferroptosis was explored. The target genes of METTL3 were screened, and the influence of O-GlcNAcylation on the stability and ubiquitination modification of METTL3 was dissected.
Section
Results
We found that METTL3 is highly expressed in pancreatic cancer and regulates ferroptosis and gemcitabine resistance by promoting the degradation of HMGB1 in an m6A-YTHDF2-dependent manner. O-GlcNAcylation modulates the METTL3’s stability. The interaction between the deubiquitinase EIF3H and METTL3 is influenced by O-GlcNAcylation.
Section
Conclusion
METTL3 affects pancreatic cancer progression by promoting degradation of HMGB1. The O-GlcNAcylation of METTL3 not only stabilizes METTL3 but also augments EIF3H-mediated deubiquitination. These findings uncover potential mechanisms underlying gemcitabine resistance in pancreatic cancer and offer potential therapeutic strategies for the treatment of this disease.
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高影响因子
BIOLOGICAL RESEARCH
·
2025
·Vol. 58
·期 1
·1-14
·
IF 4.6
Liu Huihui,Sun Nianyi,Liu Zhenxing,Li Jinze,Zhang Xianqin
Section
Background
Neurodevelopmental disorders manifest in early childhood and are characterized by cognitive deficits, intellectual disabilities, motor disorders, and social dysfunction. Mutations in BCAS3 gene are associated with syndromic neurodevelopmental disorders in humans, while the detailed pathological mechanism is still unknown.
Section
Methods
CRISPR/Cas9 technology was used to generate a bcas3 knockout zebrafish model. To investigate the effects of bcas3 on development, morphological evaluations were conducted. Locomotor behaviors, including performance in the light-dark test, novel tank test, mirror test, shoaling test, and social test, were assessed through video tracing and quantitative analysis of movement parameters. Transcriptome sequencing analysis was used to identify dysregulated pathways associated with development process. Additionally, Acridine Orange staining was employed to evaluate apoptosis. Western blot and real-time RT-PCR were used to analyze the expression levels of genes.
Section
Results
Bcas3 knockout zebrafish exhibited early larval phenotypes resembling clinical features of patients with BCAS3 mutations, including global delayed development at early embryonic development, microcephaly and reduced body length. Behavior analysis revealed abnormal motor dysfunction, such as social impairment, increased anxiety and heightened aggression. Notably, human BCAS3 rescued the developmental defects and motor disorders in bcas3 knockout larvae. Transcriptomic analysis identified substantial downregulation of genes related to embryonic development and startle response, brain development and neuron migration in bcas3 knockout zebrafish, such as rpl10 , cyfip2 , erbb3b , eya4a , nr2f1b , prkg1b and ackr3b . Additionally, increased apoptosis was observed in bcas3 knockout zebrafish, which was further confirmed by Acridine Orange staining and a decreased Bcl2/Bax ratio in western blot analysis. The increased apoptosis observed in the brain of bcas3 knockout larvae could contribute to the developmental and locomotor deficits.
Section
Conclusion
The bcas3 knockout zebrafish model recapitulates the clinical features observed in patients with BCAS3 mutations. Our results suggest that increased apoptosis may underlie the developmental deficits and motor disorders in these patients. The bcas3 knockout zebrafish model provides a valuable tool to identify dysregulated molecular targets for therapeutic intervention during the early stages of disease progression.
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