JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Shaoyong Weike,Jiang Shouchuan,Wang Yingqian,Li Wei,Wang Zilong,Yang Yixiao,Du Juan,Liu Zhongjie
Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and intestinal endocrine imbalance. No approved pharmacotherapies effectively treat MASH largely because of the difficulty in reversing fibrosis and restoring extracellular matrix homeostasis. Managing intestinal barrier dysfunction and GLP1 secretion has emerged as a promising therapeutic strategy against the progression of metabolic-associated fatty liver (MAFL) to MASH. This study presents MSN@HTL, fabricated using trehalose and temsirolimus on mesoporous silica nanoparticles (MSNs) and encapsulated with sodium alginate using an electrostatic spraying system. After oral administration, MSN@HTL protects against intestinal barrier injury and GLP1 secretion, consequently inhibiting the progression of MAFL. MSN@HTL stimulated intestinal stem cell self-renewal, proliferation, and GLP1 secretion. Mechanistically, MSN@HTL induces lysosomal autophagy to recycle disrupted mitochondria, increasing mitochondrial fusion and energy metabolism, elevating cAMP concentration, and inducing PKA phosphorylation-mediated intestinal barrier revision and GLP1 secretion, thereby impairing MAFL-to-MASH progression. Given its availability and functionality, our study demonstrates the potential of MSN@HTL as a pharmaceutical agent for managing MAFL-to-MASH progression via the mitochondria/cAMP/PKA signaling pathway in humans. Graphical
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Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Cui Ruopeng,Li Yi,Zhang Xuefei,Duan Zewen,Chen Weihao,Chen Jiangyun,Li Jiaming,Che Renchao,Wan Chunlei
Schottky contacts at (semi)metal/semiconductor heterointerfaces, known for their prominent spatial charge separation effect, have attracted increasing interest for microwave absorber (MAM) applications, but the inappropriate and non-uniform barrier heights between existing polycrystalline semiconducting and (semi)metallic components present a major challenge for achieving high-permittivity dielectric matching, a critical prerequisite for ultrathin high-performance MAMs. Here, we report an amorphization-mediated strategy to tailor Schottky contacts via an innovative intercalation-coprecipitation-annealing process. This yields amorphous TiO 2 (a-TiO 2 ) with isotropic nanostructures and a unified work function, interfacing intimately with large-area reduced graphene oxide (rGO) basal planes. Critically, amorphization suppresses the Schottky barrier height to < 0.2 eV via elevated oxygen vacancies, and eliminates barrier dispersion induced by crystallographic orientations. The resultant rGO/a-TiO 2 heterointerfaces enable high-permittivity dielectric matching, achieving controlled dielectric loss (tan δ e ) at enhanced permittivity ( ε ’), thereby overcoming impedance mismatch via curbing the difference between permittivity and permeability of the material effectively. When integrated with flaky carbonyl iron (FCI) to provide magnetic/dielectric synergy, the rGO/a-TiO 2 /FCI (RTF) nanocomposite can achieve first-class absorption (-79.51 dB) at ultrathin thicknesses (< 1.5 mm). This work demonstrates how amorphization engineering precisely modulates the magnitude and uniformity of Schottky barrier, opening pathways for ultrathin high-performance MAMs and other functional applications.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Wu Zhou-Liang,Li Ling-Rui,Zhou Yu,Yang Di,Liao Shuang-Quan,Mei Jun-Fei,Ding Ai-Wu,Luo Ming-Chao
The reprocessing and recycling of vulcanized rubbers remain challenging because conventional vulcanization networks are irreversible. Here, we designed a modified sulfur crosslinker via inverse vulcanization to regulate the exchange kinetics of vulcanization networks, thereby governing the mechanical recovery behavior of reprocessed rubbers. Copolymers of sulfur and thioctic acid (CSTA), synthesized via inverse vulcanization, were employed to crosslink butadiene-styrene rubber. After vulcanization, thioctic acid (TA) introduces dynamic disulfide bonds into the conventional vulcanization networks, enabling thermally activated network rearrangement while preserving the overall crosslinked structure. Kinetic analysis revealed that increasing the TA content accelerated network exchange and significantly lowered the apparent activation energy for network rearrangements. Correspondingly, the recovery of the mechanical properties after reprocessing improved with increasing TA content. These results establish a clear correlation between vulcanization network exchange kinetics and macroscopic mechanical performance, providing a kinetic basis for the design of reprocessable vulcanization networks and offering a promising route toward recyclable high-performance rubber materials.
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Nature Communications
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2026
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IF 18.1
Chen Haojie,Gao Rui-Ting,Wang Lei,Wu Limin
Photoelectrochemical bipolar systems enable bias-free H 2 O 2 synthesis by integrating light harvesting, water oxidation and oxygen reduction. However, poor selectivity due to competing 4e - pathways, slow charge transfer, and inferior stability severely limit their practical application. Herein, we present a bias-free photoelectrochemical bipolar system for H 2 O 2 production, which integrates a Zn-TiO 2 /BVO/WO 3 photoanode for the 2e - water oxidation reaction and a Ru:CuO/Nb-CBO photocathode for the 2e - oxygen reduction reaction. The photoanode suppresses *OOH intermediates to favor H 2 O 2 formation, achieving a Faradaic efficiency (FE) of 90.2% at 0.6 V RHE . The photocathode stabilizes *OOH intermediates and delivers an FE of 91.9% under the same conditions while maintaining performance for over 50 h. Practical testing under natural sunlight with 36 cm 2 electrodes achieves an FE of 163.37% and a yield of 11.44 mmol L −1 . In situ generated H 2 O 2 achieves over 99% bacterial inactivation within 60 min. This work provides an adaptive platform for solar-driven H 2 O 2 synthesis and energy conversion.
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Nature Communications
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2026
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IF 18.1
Bai Jin,Li Jie,Yang Chen,Lv Weipeng,Jin Yi,Zhang Xuxin,Gao Lei
Flexible implantable neural electrodes have been studied extensively due to their chronic single-unit recording capability over weeks or months. However, high-density stable recording of the same neuronal ensembles over years-long periods remains challenging. Here we address this challenge by developing umbrella-type stretchable electrode arrays, which are anchored to surrounding brain tissue, forming a seamless neuroelectronic interface. We show that the umbrella-type stretchable electrode arrays create a neuroelectronic interface with reduced probe drift and gliosis that can stably track the same neuronal ensembles in head-fixed mice over 80 weeks (approximately 1.5 years). We also demonstrate that orientation-selective neuronal populations in the mouse primary visual cortex can be consistently recorded over 20 weeks. The umbrella-type stretchable electrode arrays with long-term recording capabilities hold significant promise for both fundamental neuroscience research and clinical brain-machine interface systems.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Li Yuyan,Lan Jue,Ran Lingshan,Xie Yulu,Yu Jinmei,Yang Yunxin,Tan Xiaofeng,Qu Xiaodong,Wei Hongxia,Luo Jun,Huang Xiaoyu,Qiu Rongmin
Dental caries, a chronic disease resulting from bacterial demineralization of dental hard tissues, poses a significant global health challenge. Remineralization therapy presents a promising strategy to arrest caries progression and restore tissue integrity. However, simultaneously achieving stable, efficient remineralization and effectively combating plaque biofilm formation remains a critical hurdle. Inspired by the hierarchical “brick-and-mortar” architecture of nacre and the adhesive functionality of mussel foot proteins (Mfps), a novel nanoarchitectonic system was developed via a layer-by-layer biomimetic assembly. This multifunctional system comprises amorphous calcium phosphate (ACP) as a mineral ion reservoir, tannic acid (TA) as a bridging and crystallization-regulating layer mimicking the catechol chemistry of Mfps, and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) as a functional antibacterial outer layer. This bioinspired design yields a stable platform capable of sustained release of calcium and phosphate ions for remineralization while providing long-lasting antibacterial activity against cariogenic biofilms. The system not only forms a durable protective barrier on the enamel surface but also facilitates effective biomimetic remineralization of early carious lesions. This nature-inspired strategy provides a comprehensive and clinically translational approach for hard tissue regeneration and synergistic caries management. Graphical
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PubMed
高影响因子
MICROCHIMICA ACTA
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2026
·Vol. 193
·期 9
·646
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IF 5.4
Li Chunli,Zeng Linyun,Hong Ziyi,Xie Wenjia,Luo Tongxi,Pan Jialiang,Zhang Xinguo
Unique orange-emissive carbon dots (O-CDs) are synthesised via a solvothermal method by safranin T and 2,2’-dithiodibenzoic acid in ethanol. O-CDs show a maximum emission peak at 595 nm and a quantum yield of 81.63% when dissolved in dichloromethane. O-CDs are able to be fabricated into fluorescent hydrogels, powders and films exhibiting excellent fluorescence performance. The linear relationship is observed in the concentration range of 0-200 µM with R 2 of 0.9973, and the limit of detection is 0.19 µM. Meanwhile, this method is effectively utilized to analyze real food samples, such as egg yolk and milk, with recoveries ranging from 99.21% to 101.8%. Sensing mechanism is found to be the inner filter effect and dynamic quenching. Furthermore, O-CDs exhibit low toxicity and nice biocompatibility, facilitating the applications in bioimaging of B16F10-2 cells as well as zebrafish, and enabling VB12 detection in live cells. Therefore, the novel O-CDs developed present broad application prospects including food safety, biosensing, bioimaging and fluorescent films. Graphical
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Nature Communications
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2026
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IF 18.1
Wang Wei,Qiao Wang,Chen Zhuo,Chen Jialei,Chen Shan,Zhao Zhuang,Liao Xuelong,Song Wenge,Huang Rong,Lu Tiantian,Li Youzeng,Liu Haonan,Sun Jiacheng,Xu Xing,Yan Zhenhua,Zhao Qing,Liu Zhongfan,Chen Jun,Wang Huan
Low-temperature Li||CF x batteries undergo performance degradation due to the insulating nature of CF x and sluggish Li + kinetics. Herein, we present a dual-modification strategy integrating porous positive electrode architecture design with customized electrode-electrolyte interphase engineering to overcome these limitations. Our approach features: (i) plasma-enhanced chemical vapor deposition-constructed mesoporous CF x with conformal carbon coating, and (ii) electrolyte-mediated in situ formation of a sulfur-rich inorganic interphase layer on CF x surface. The engineered porous framework establishes efficient Li + diffusion channels, while the electrolyte-derived interphase significantly enhances Li + transport and desolvation kinetics. Moreover, the carbon coating substantially improves electronic conductivity and suppresses LiF stacking. The optimized Li||CF x system delivers capacities of 428.4 mAh g −1 at −50 °C and 2 A g −1 , and 333.4 mAh g −1 at −70 °C and 0.1 A g −1 . Practical 5 Ah pouch cells deliver competitive specific energies of 470 and 332 Wh kg −1 at −50 and −70 °C under 0.01 A g −1 , respectively.
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JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 9
·221
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IF 3.5
Li Rongye,Zhu Congying,Song Xiaoping,Zhang Xiaodong,Hamdi Marwa,Chen Jiahong
Recent advances in polymeric nanocarriers have highlighted the potential of amphiphilic block copolymers for the simultaneous delivery of chemotherapeutic agents with different physicochemical properties. In this study, asymmetric poly(ethylene glycol)-b-polylactide-b-poly(ethylene glycol) (PEG- b -PLA- b -PEG) triblock copolymers were synthesized via ring-opening polymerization, end-group functionalization, and click coupling, and subsequently evaluated as biodegradable nanocarriers for the co-delivery of paclitaxel (PTX) and cisplatin (CDDP). The copolymers were characterized by 1 H nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). Self-assembly in aqueous media yielded spherical micelles with uniform size distributions, as confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The micelles exhibited efficient encapsulation of PTX and CDDP with high drug-loading capacities and encapsulation efficiencies. Hydrolytic degradation studies conducted at 37 °C for 45 days revealed progressive cleavage of the ester bond, reduction in molecular weight, and gradual disintegration of the micellar structure. In vitro release studies of single- and dual-drug-loaded micelles demonstrated sustained release of both drugs over time. Analysis of the release data using the Korsmeyer–Peppas model provided insight into the release behavior and suggested contributions from both diffusion and polymer degradation processes. The biocompatibility of the unloaded triblock copolymer micelles was assessed through cytocompatibility, hemocompatibility, and zebrafish embryo assays, which indicated low intrinsic toxicity and minimal hemolytic activity. Collectively, these results demonstrate that PEG- b -PLA- b -PEG triblock copolymer micelles can be recognized as biodegradable carriers capable of dual-drug encapsulation and sustained release, providing a useful platform for further investigation of combination drug delivery systems. Graphical abstract Asymmetric PEG- b -PLA- b -PEG triblock copolymers were synthesized and self-assembled into uniform micelles capable of co-encapsulating Paclitaxel and Cisplatin. The micellar architecture provided controlled degradation and synchronized dual-drug release over 45 days. The combination of tunable structure, sustained release, and excellent biocompatibility highlights these triblock copolymer micelles as efficient nanocarriers for combinational cancer therapy
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·634
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IF 5.4
Li Ce,Zeng Yutong,Wei Keyi,Li Xinyan,Wang Yan
Three exosome fluorescence-labeling workflows based on azide-functionalized cholesterol anchoring and copper-free click chemistry were systematically optimized and comparatively evaluated. A549 cell-derived exosomes were used as the primary model. By varying the sequence of azide introduction and fluorescent click reaction, one-step, two-step, and three-step protocols were compared. Under the tested conditions, the two-step protocol provided the most favorable overall balance among exosome recovery, fluorescence intensity normalized to exosome particle concentration, dye consumption, reaction volume, and operational simplicity. After labeling, the exosomes retained their typical morphology, particle size distribution, while the representative exosome-associated proteins CD63, CD81, and TSG101 remained detectable. The fluorescence intensity of the labeled exosomes showed a strong linear correlation with particle concentration, supporting its potential for rapid quantitative analysis. Cellular uptake experiments confirmed the feasibility of the labeled exosomes for in vitro imaging, and fluorescence remained detectable during the 24-h in vivo observation period. Overall, this study identifies an optimized two-step workflow for exosome fluorescence labeling and provides a practical approach for exosome visualization and tracking under the evaluated experimental conditions. Graphical abstract
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Nature Metabolism
·
2026
·Vol. 8
·期 8
·1713-1729
·
IF 27.5
Deng Jiangming,Meng Wen,Yang Yuanqin,Xiao Ting,Jin Zhangliu,Wang Jing,Li Qing-xin,Xie Lingxiang,Hu Jingyi,Song Rong,Hu Yibo,Chu Yi,Li Qing,Jin Ping,Wang Zheng,Wu Irene XY,Liu Feng,Xiao Yang
The gut constantly interacts with both pathogens and dietary signals, but how it balances immune and metabolic responses remains unclear. Here we show that intestinal cGAS, a key DNA sensor, acts as a regulator linking gut immunity to whole-body metabolism. We show that cGAS signalling is activated in the intestines of humans and male mice with obesity, leading to increased type I interferon production and heightened immune activity in intestinal cells. Strikingly, deleting cGAS specifically in intestinal epithelial cells enhances energy expenditure, protects against diet-induced obesity and improves metabolic health. These effects depend on the gut microbiota, particularly Lactobacillus murinus and its metabolite indole-3-acetic acid (IAA), which promotes adipose thermogenesis. Our findings position intestinal cGAS as a key driver of obesity through gut-to-fat signalling and suggest that targeting the intestinal cGAS–microbiota IAA axis could offer promising strategies to combat obesity and related metabolic diseases.
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高影响因子
Science China-Materials
·
2026
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IF 7.7
He Jiaman,Kang Liwen,Zeng Weigang,Shi Wanxin,Ling Qidan,Lin Zhenghuan
Organic-inorganic hybrid metal halides (OIMHs) based on Cu(I) ions show broad application prospects in the field of stimulus-responsive luminescent materials based on their rich structural diversity and highly adjustable electronic state. However, achieving sensitive and broad-temperature-range thermal responses for OIMHs remains a significant challenge, despite the growing interest in smart luminescence materials. In this study, 4-morpholinopiperidine (4-MP) and CuI are used to synthesize a zero-dimensional warm white-light emitting OIMH, namely MPC-W ((C 9 H 20 N 2 O) 4 (Cu 2 I 4 )(Cu 2 I 6 )(H 2 PO 2 ) 2 ), which features hybrid structures of [Cu 2 I 4 ] 2− and [Cu 2 I 6 ] 4− . Owing to the coexistence of three luminescent mechanisms-organic cluster luminescence (CL), self-trapped exciton (STE) emission of [Cu 2 I 6 ] 4− , and cluster-centered (CC) state luminescence of [Cu 2 I 4 ] 2− , MPC-W exhibits temperature and excitation wavelength-dependent dynamic luminescence. When the temperature is increased from 77 to 297 K, the luminescence color of MPC-W can be continuously tuned from blue to cyan, green, yellow-green, and white. In the range of 217–463 K, MPC-W displays an abnormal luminescence enhancement phenomenon with increasing temperature. Additionally, upon chemical stimulus, MPC-W can reversibly transform into a blue-light emitting crystal named MPC-B ((C 9 H 20 N 2 O)Cu 2 I 4 ), and a yellow-light emitting crystal named MPC-Y ((C 9 H 18 N 2 O) 7 Cu 8 I 8 ). These unique dynamic luminescent properties endow MPC-W with great application potential in temperature sensing, optical anti-counterfeiting, and password locks. The work provides a new insight for the development of novel wide temperature-responsive multifunctional intelligent luminescent materials.
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