CHEMOSPHERE
·
2021
·
IF 7.086
Sheng Deng,Shuxuan Wu,Xu Han,Fu Xia,Xiangjian Xu,Liangjing Zhang,Yonghai Jiang,Yuhui Liu,Yu Yang
Mercury (Hg 2+ ) contamination in water is associated with potential toxicity to human health and ecosystems. Many research studies have been ongoing to develop new materials for the remediation of Hg 2+ pollution in water. In this study, a novel thiol- and amino-containing fibrous adsorbent was prepared by grafting 2-amino-5-mercapto-1,3,4-thiadiazol (AMTD) onto PAN fiber through a microwave-assisted method. The synthesized functional fiber was characterized by FTIR, SEM, and elemental analysis. Adsorption tests depicted that for mercury uptake, PAN MW -AMTD fiber exhibited enhanced adsorption capacity compared with other fibrous adsorbents and selective adsorption feature under the interference of other metal ions , including Pb 2+ , Cu 2+ , Cd 2+ , and Zn 2+ . The influence of pH on the adsorption process was investigated and the effect of temperature revealed that the adsorption sorption process was endothermic and the adsorption performance of PAN MW -AMTD was elevated with the increase of temperature. Kinetic studies of PAN MW -AMTD fiber followed the pseudo-second-order and the adsorption isotherm of Hg 2+ was well fitted by Sips and Langmuir equations, given the maximum adsorption amount of 332.9 mg/g. XPS results suggested that a synergetic coordination effect of sulfur and nitrogen in functional fiber with mercury took responsibility for the adsorption mechanism in the uptake process. In addition, the prepared PAN MW -AMTD fiber could easily be regenerated with 0.1 M HCl for five times without significant reduction of mercury removal efficiency. Thus, this study will facilitate the research on novel functional material for the removal of mercury from water.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Armin Rezayan,Ke Wang,Renfeng Nie,Tianliang Lu,Jianshe Wang,Yongsheng Zhang,Chunbao Charles Xu
Catalytic transformation of carbohydrates to bio-chemicals such as 5-Hydroxymethylfurfural (HMF) has become a hot research topic, but development of cost-effective/efficient catalysts and processes remains a challenge for industrial application. In this study, efficient bifunctional Sn/KIT-1/C catalysts with controllable acid sites were synthesized and applied for glucose-to-HMF conversion. Strong Lewis acid sites were introduced into the framework of disordered mesoporous silica by liquid-phase grafting of tin chloride, and Bronsted acid sites were generated by inserting carbon into the mesopores, followed by controlled oxidation of the carbon. Characterizations revealed that optimizing the amount of carbon source, and carbonization and oxidation temperature provided a proper amount and strength of acidity that could significantly catalyze glucose dehydration reaction to HMF with suppressed byproducts formation. The best catalyst Sn/KIT-1/C(75–400-300) demonstrated superior catalytic performance at 175 °C for 2 h under THF/H 2 O biphasic system, obtaining 78.4 ± 2.1% and 82.9 ± 2.4% HMF yield and selectivity, respectively. The high activity may be attributed to catalyst high surface area/porosity, and the presence of well-balanced amounts and strength of Lewis/Bronsted acid sites. The catalyst could maintain its excellent catalytic activity for five consecutive runs, suggesting the high physical–chemical stability of the catalyst. The results obtained in this work demonstrated that bifunctional metal-supported silica–carbon composites can be a promising catalyst for simple/complex carbohydrates conversion to HMF/bio-based chemicals.
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 62
·39221-39227
·
IF 3.108
Songyan Jia,Xinjun He,Zhanwei Xu
Converting saccharides into 5-hydroxymethylfurfural (5-HMF) has attracted more and more research interest under the background of global energy shortage. A lot of effort has been devoted to the conversion of fructose and glucose. However, other underused sugars receive very limited attention, although some of them have considerable reserves in nature as well. In this work, mannose, a major component from hemicellulose, was effectively converted into 5-HMF under mild conditions. AlCl3·6H2O exhibited superior activity among the tested catalysts, achieving a maximum 5-HMF yield of 60% in a dimethyl sulfoxide (DMSO)/water mixed solvent at 130 °C within 45 min. Adding an appropriate amount of water in DMSO could suppress some side reactions while preserving the reactivity of mannose dehydration. Mannose showed a comparable reactivity to fructose in the employed catalytic system. The studied system was also effective in the conversion of di/trisaccharides such as cellobiose and melezitose into 5-HMF. A number of control experiments with different catalysts and additives were conducted to elucidate the preliminary mechanism.
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高影响因子
BIOORGANIC CHEMISTRY
·
2020
·
IF 4.831
Shiyang Zhou,Gangliang Huang
In this study, a series of novel 7 H -benzo [ c ] [1,3] dioxolo [4, 5- f ] chromen-7-one derivatives were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as inhibitors of tumor. These target compounds have the novel chemical structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong of anti-tumor activity. Such as the target compound 4n to MCF-7 was IC 50 = 0.35 ± 0.01 μM, to A-549 was IC 50 = 0.37 ± 0.01 μM, to Hela was IC 50 = 0.56 ± 0.02 μM, to MDC-803 was IC 50 = 0.53 ± 0.02 μM and COLO-205 was IC 50 = 0.50 ± 0.02 μM in vitro . At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound 4n had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound 4n could be used as a candidate drug for further research and development, in order to be used as early as application in the clinical treatment of tumors.
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PubMed
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Qi Sun,Limei Yang,Songtao Huang,Zheng Xu,Yan Li,Wei Wang
Synergistic solvent extraction of nickel by 2-hydroxy-5-nonylacetophenone oxime (Mextral 84H, denoted as HL) mixed with organic acids (denoted as HA) containing neodecanoic acid (Versatic 10) and bis(2-ethylhexyl) phosphoric acid (P204) diluted in aliphatics was comparatively studied. The synergistic effects on nickel with Mextral 84H/Versatic 10 and Mextral 84H/P204 systems were investigated by extraction pH isotherm and equimolar method. The nickel-organic extractants species structure and stoichiometry were determined by slope analysis, Fourier transform infrared (FT-IR) spectrometry and ultraviolet and visible (UV-Vis) spectrometry. The results showed that synergistic effects on nickel with a negligible shift of 0.06 pH units in the Mextral 84H/Versatic 10 system and a significant shift of 0.79 pH units in the Mextral 84H/P204 system were observed compared with single Mextral 84H system. Versatic 10 has little effect on the nickel extraction. The square-planar complex with a formation of Ni L 2 in the Mextral 84H/Versatic 10 system was proposed, the same as that in the single Mextral 84H system. P204 participates in the reaction between nickel and Mextral 84H, probably forming an octahedral complex with a formation of Ni ( H 2 A 2 L 2 ) . The synergistic effect could result from this formation of more stable and hydrophobic nickel adducts, which promote the distribution ratio of nickel.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Chenxia Yang,Ying Meng,Xintong Wang,Xin Li,Tong Yu,Weiming Liao,Wenjun Xie,Qianchen Jiang,Han Wang,Cheng Shi,Wenxuan Jiao,Xiling Bian,Fang Hu,Xiaowei Wang,Yani Liu,Liangren Zhang,KeWei Wang,Qi Sun
Enhancing α7 nAChR function serves as a therapeutic strategy for cognitive disorders. Here, we report the synthesis and evaluation of 2-arylamino-thiazole-5-carboxylic acid amide derivatives 6–9 that as positive allosteric modulators (PAMs) activate human α7 nAChR current expressed in Xenopus ooctyes. Among the 4-amino derivatives, a representative atypical type I PAM 6p exhibits potent activation of α7 current with an EC50 of 1.3 μM and the maximum activation effect on the current over 48-fold in the presence of acetylcholine (100 μM). The structure–activity relationship (SAR) analysis reveals that the 4-amino group is crucial for the allosteric activation of α7 currents by compound 6p as the substitution of 4-methyl group results in its conversion to compound 7b (EC50 = 2.1 μM; max effect: 58-fold) characterized as a typical type I PAM. Furthermore, both 6p and 7b are able to rescue auditory gating deficits in mouse schizophrenia-like model of acoustic startle prepulse inhibition.
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PubMed
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Hai-Long Yang,Zhao-Hui Li,Pei-Pei Liu,Xiao-Wen Sun,Zhong-Hui Wang,Hong Yao,You-Ming Zhang,Tai-Bao Wei,Qi Lin
The booming of host–guest assembly-based supramolecular chemistry provides abundant ways to construct functional systems and materials. Attracted by the important application prospect of white light emission and aggregation-induced emission (AIE) materials, herein, we report an efficient way for fabricating metal-free white light-emitting AIE materials through the supramolecular assembly of simple organic compounds: methoxyl pillar[5]arene (MP5) and tri-(pyridine-4-ylamido)benzene (TAP). By host–guest assembly, MP5 and TAP formed a supramolecular polymer (MP5-T); meanwhile, the MP5-T xerogel powder emitted white light at CIE coordinates (0.29 and 0.29). The supramolecular assembly and white light-emitting mechanisms were carefully investigated by experiments as well as quantum chemical calculations including density functional theory (DFT), reduced density gradient, electrostatic surface potential, independent gradient model, and frontier molecular orbital (highest-occupied molecular orbital–lowest-unoccupied molecular orbital) analyses. Interestingly, according to the experiments and calculations, the supramolecular assembly is critical in the white light-emitting phenomenon. Moreover, in this work, the quantum chemical calculations could not only support experimental phenomena but also provide deep understanding and visualized presentation of the assembly and emission mechanism. In addition, the obtained MP5-T solid powder could serve as a novel and easy means to make material for white light-emitting devices.
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高影响因子
FUEL
·
2024
·
IF 6.7
Zhonghai Liu,Kaili Wang,Yayun Pang,Chenglei Xiao,Xiaoping Wu,Jinliang Song,Tiejun Wang
One-pot dehydration-oligomerization of biomass-derived alcohols provides a promising strategy for the production of renewable jet fuels, but it is still a great challenge. In this study, the hierarchically porous plate-like HZSM-5 catalysts were constructed to catalyze dehydration-oligomerization of higher alcohols derived from upgrading of fermentation ethanol. It was observed that the P40(0.2) catalyst showed the best performance with the C 8 -C 16 products selectivity of 66.4%. Systematic investigations revealed that the outstanding performance of P40(0.2) originated mainly from the synergistic effect of the finely tuned acidity and the hierarchical porous plate-like structure. Notably, the good activity of P40(0.2) on dehydration-oligomerization of the actual oil phase from ethanol upgrading confirmed the great potential of practical applications for the synthesis of jet fuels from biomass-derived alcohols.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Bei Zhang,Zhong-Kai Zou,Jian-Fan Cai,Wen-Ming Tan,Jun-Wei Chen,Wei-En Li,Jing-Nan Liang,Wei-Pei Wu,Gang Wang,Xiao-Hong Ruan,Pei-Liang Zhao
Phosphodiesterase 5 (PDE5) is a cGMP-specific hydrolytic enzyme and widely distributed in versatile tissues. PDE5 has been identified as a valid therapeutic target for treating erectile dysfunction and pulmonary arterial hypertension (PAH). Herein, a hit-to-lead structural optimizations were performed on the PDE1 inhibitor 10c, leading to compound 14b possessing great potency against PDE5A (IC50 = 3 nM) with high selectivity over PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11 by more than 1125-fold, and remarkable safety properties. Furthermore, oral administration of 14b (5.0 mg/kg) exerted much better pharmacodynamics effects on both mPAP (mean pulmonary artery pressure) and RVHI (index of right ventricle hypertrophy) than sildenafil citrate (10.0 mg/kg) in a monocrotaline-induced PAH rat model. Overall, these results proposed a novel highly selective PDE5 inhibitor 14b which could serve as a potential candidate for treatment of PAH.
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高影响因子
Journal of Cleaner Production
·
2024
·
IF 9.7
Shanshan Shao,Yu Cao,Jiaxin Jiang,Xiaohua Li,Yongbo Yu
In this study, metal-loaded HZSM-5 was prepared with metal ion extracted from the cathode materials of spent lithium batteries (lithium iron phosphate, LFP; lithium nickel-cobalt manganate, NCM) with citric acid for the improved production of light aromatic hydrocarbons by catalytic pyrolysis of rape straw. Because of the dealuminization effect of citric acid on HZSM-5, mesopores were introduced, and the diffusion and conversion of pyrolysis gas over acid sites were improved. After metal loading with acid-leaching solution, the amount of weak and total acids in metal-loaded HZSM-5 increased a lot, which was conducive to the dehydration, deoxygenation, decarbonylation and aromatization of pyrolysis, and the production of monocyclic aromatic hydrocarbons (MAHs). With 0.1 mol/L citric acid for LFP and NCM treatment, the metal-loaded catalyst showed a higher yield of benzene, toluene and xylene (BTX) of 11.10 wt% during catalytic pyrolysis of rape straw. Compared with 0.1-NCM-H5, a higher yield of MAHs was obtained over 0.1-LFP-H5 with a more favorable pore structure and higher amounts of weak and total acid sites. In general, the high-valued utilization of agricultural wastes and spent lithium batteries was realized in this study to produce clean energy.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2020
·
IF 5.006
Feng Lin,Yulong Ma,Yonggang Sun,Xiuqin Men,Yingbo Zhu,Tingting Gao,Kanghe Zhao
Strategies for catalytic lignin depolymerization to yield ethylbenzene chemicals are green, sustainable and environmentally friendly methods. In this study, a series of Ni-CeO 2 /H-ZSM-5 catalysts were prepared via the precipitation method, which catalytically degraded the β-O-4 chemical bonding structure to yield ethylbenzene chemicals. The 2-(2-methoxy-phenoxy)-1-phenylethanol substance (β-O-4) was selected as a typical lignin model compound for the investigation of the intrinsic depolymerization mechanism and the catalytic performance. The results demonstrated that the introduced CeO 2 active phase can effectively promote the catalytic conversion of the β-O-4 chemical bonding structure to ethylbenzene chemicals. Physicochemical data demonstrate that the reaction pathways and hydrogenation selectivity were effectively regulated and controlled by the tuning of the dehydration and hydrogenolysis processes via the introduction of CeO 2 , which realized the selective adjustment of the redox properties and the surface valence states of active species in the catalytic process due to its excellent oxygen transfer performance.
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高影响因子
JOM
·
2024
·Vol. 76
·期 5
·2478-2490
·
IF 2.1
Wang Chengwang,Zhang Ruihan,Li Xingshi,Huang Yaoguo,Chen Linlin
The article presents the synthesis and application of a novel collector, 5-methyl butylxanthate-1,2,4-triazole-3-thione (MBuXTT), for chalcopyrite flotation separation from pyrite. Various interfaces and surface characterization analysis methods were employed to study the flotation separation mechanism. The micro-flotation and contact angle experiments demonstrated a significant enhancement in the surface hydrophobicity of chalcopyrite following treatment with MBuXTT. Within the pH range investigated, MBuXTT effectively enriched chalcopyrite while separating it from pyrite. Compared to the traditional collector sodium butyl xanthate, MBuXTT exhibited superior selectivity and collecting ability towards chalcopyrite. Adsorption of MBuXTT on the chalcopyrite surface was found to be an endothermic-spontaneous chemisorption process. ζ -Potential analyses and UV spectra confirmed specific adsorption of MBuXTT on chalcopyrite rather than pyrite surfaces. Additionally, FTIR, XPS, and DFT calculations were conducted to explore the adsorption mechanism on the chalcopyrite surface, and the results indicated that MBuXTT-Cu complexes can be covered on the chalcopyrite surface with formation of Cu(I)-S and Cu(I)-N bonds along with release of H + and oxidation product formation involving S–S bonds.
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高影响因子
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