RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Li Zhen,Guo Guizhang,Yu Zhou,Ma Zengyue,Yu Libo
In the pursuit of highly efficient hydrogen production through photoelectrochemical water splitting, expanding the utilization of the visible spectrum and extending the lifetime of photogenerated electrons are crucial challenges for improving the efficiency. To address these challenges, we prepared CdS sensitized TiO 2 photoanodes using a one-step hydrothermal method, employing thioglycolic acid (TGA) and mercaptopropionic acid (MPA) as linkers. The successful synthesis of CdS QDs and the CdS/TiO 2 photoanode was confirmed through various characterization techniques, including transmission electron microscopy (TEM), X-ray diffraction, and scanning electron microscopy. Performance evaluations revealed that the TGA-decorated CdS/TiO 2 photoanode exhibited superior photocurrent density and stability compared to the MPA-modified counterpart. Notably, its applied bias photo-to-current conversion efficiency was 1.7 times greater than that of the MPA-modified CdS/TiO 2 photoanode. Furthermore, UV–visible absorption spectrum analysis demonstrated that the incorporation of CdS QDs significantly broadened the spectral response of the TiO 2 photoanode, extending it from the ultraviolet to the visible range. This enhancement is crucial for improving light harvesting capabilities. Additionally, our analysis of electron lifetime indicated that the shorter molecular chains of TGA effectively minimize the transfer distance for photogenerated electrons from the CdS QDs to the TiO 2 , resulting in improved electron lifetimes and, consequently, enhanced photocurrent density.
✓ 已验证
产品关联
DOI
高影响因子
Biology Direct
·
2025
·Vol. 20
·期 1
·1-15
·
IF 4.9
Wei Xiaoyong,Zou Long,Huang Yanqing,Qiu Chuan,Cheng Guang,Chen Ye,Rao Jun
Background Hepatocellular carcinoma (HCC) is among the deadliest cancers globally. Yes-Associated Protein (YAP), a Hippo pathway effector, crucially regulates cell proliferation and apoptosis. Recent research has implicated YAP’s role in HCC progression, but the mechanisms are unclear. This study aims to clarify YAP’s function in HCC, emphasizing its regulation of key pathways and targets. Results Gene knockout and overexpression models were established in nude mice and cell lines of HCC cells to investigate YAP’s impact on tumorigenesis. Additionally, functional assays and molecular biology techniques were employed to identify YAP’s regulatory networks. The study demonstrates that LDHA-regulated lactate production promotes YAP activation and malignant phenotypes in HCC. Overexpression of LDHA in HepG2 and Huh7 cells increased lactate levels and activated the YAP pathway, enhancing cell proliferation, migration, and invasion. Lactate treatment also promoted these malignant phenotypes by inhibiting YAP phosphorylation at Ser127. In a xenograft model, lactate accelerated tumor growth through YAP activation. YAP lactylation at K102 antagonized its Ser127 phosphorylation, further promoting malignant progression. Conclusions This study highlights the significance of YAP in HCC pathogenesis, providing insights into potential therapeutic targets for HCC management. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Wang Haoji,Liu Tongchao,Chen Hongyi,Mei Yu,Gao Jinqiang,Ni Lianshan,Hong Ningyun,Huang Jiangnan,Hu Xinyu,Deng Wentao,Zou Guoqiang,Hou Hongshuai,Silvester Debbie S.,Banks Craig E.,Ji Xiaobo,Amine Khalil
Transition-metal (TM) layered oxides have emerged as the primary cathode choice for sodium-ion batteries (SIBs) due to their high energy density and sustainable chemistry using non-critical elements. However, their anisotropic lattice strain and stress accumulation during (de)sodiation lead to severe structural degradation, yet an intrinsic strain-depressant approach remains elusive. Herein, we propose entropy regulation with zero Li/Co usage to mitigate harmful lattice displacements and enhance the electrochemical performance of sodium layered cathodes. Our findings demonstrate that high entropy design effectively inhibits TMO 6 octahedra distortions upon cycling, as evidenced by hard X-ray absorption spectroscopy, greatly reducing near-surface structural deconstruction and interface side reactions. Furthermore, multicationic interactions driven by configurational entropy thermodynamically mitigate the formation of oxygen defects and strengthen ligand-to-metal coordination. The complementarity inherent in charge compensation within complex systems is unveiled and the restrained lattice parameters deviations without interior volume residuals are successfully achieved. As a result, the multicationic cathode exhibits improved cycling stability and Na + diffusion kinetics in both half and full cells. The cathode chemistries outlined here broaden the prospects for lattice engineering to alleviate bulk fatigue and open up the possibility to develop an economically viable layered oxides with long durability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Tang Linghui,Huang Yufeng,Wang Yue,Zhao Hongbin
The development of a selective, sensitive, and effective electrochemical sensor for the simultaneous analysis of multiple drugs presents a significant and urgent challenge. In this work, an electrochemical sensor capable of separating and detecting paracetamol (PAR) and diclofenac sodium hydrochloride (DIC) was constructed through the synthesis of a carbon nanotube (CNT)-doped hydrogel. Because of the hydrophilic functional groups on CNTs, they can be uniformly dispersed in organic precursor solution to form a homogeneous conductive hydrogel. The structure and morphology of the CNT-doped hydrogel was studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The operating conditions of the sensor were optimized, including the hydrogel volume, electrolyte pH, electrochemical deposition potential, and deposition time. Under optimal working conditions, the linear ranges for PAR and DIC detection were 10–80 μM and 10–80 μM, with detection limits of 3.5 and 3.6 μM, respectively. In addition, the hydrogel sensor demonstrated good reproducibility, long-term stability, excellent flexibility in bending and twisting, and favorable mechanical properties, with a maximum strain rate of 478% and tensile strength of 0.102 MPa. This research provides a new flexible material for drug separation sensors, and opens up a new research platform for hydrogels.
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 7
·1-15
·
IF 2.4
Yang Ji-Feng,You Deng,Zheng Li-Ying,Zhang Jin-Yang,Deng Lin,Luo Shen-Lian
Chloramphenicol (CAP), a broad-spectrum antibiotic extensively utilized in ocular and bacterial infection therapies, enters aquatic ecosystems predominantly through anthropogenic discharge pathways such as hospital effluents and wastewater systems, thereby posing substantial ecological and public health hazards. This investigation explores a sulfate radical-based advanced oxidation processes (SR-AOPs) leveraging FeSe 2 -activated PMS for effective CAP degradation. Experimental data reveal that FeSe 2 exhibits exceptional catalytic performance in PMS activation, attaining 83.9% CAP degradation efficiency under the optimum condition. Systematic parametric analysis identified pronounced operational dependencies on pH, catalyst dosage, and PMS concentration. Radical scavenging assays confirmed SO 4 ·− as the dominant reactive species, superseding HO· in degradation efficacy. The catalyst maintained superior recyclability across three successive cycles, exhibiting negligible metal leaching, a phenomenon likely attributed to synergistic Fe 2+ /Se 2− redox cycling mechanisms. DFT simulations coupled with LC-MS/MS analytical data pinpointed the C2 position as the principal reactive site, with degradation pathways encompassing hydroxylation, nitro-group reduction, and aromatic ring cleavage, culminating in complete CAP mineralization to CO 2 . ECOSAR predictive modeling indicated a significant reduction in ecotoxicological risks among transformation products relative to the parent compound. This study not only validates the FeSe 2 /PMS system as an sustainable solution for antibiotic-laden wastewater treatment but also elucidates mechanistic insights critical for metal selenide-driven SR-AOPs. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Science-Materials in Engineering
·
2025
·Vol. 20
·期 1
·1-10
·
IF 0
Wang Ruoxi,Sun Rongke,Ren Yanmei,Ma Yanqing,Ma Lei
There is still limited research on the influence of polymer content in inorganic/organic materials on thermoelectric properties. In this study, we systematically investigated the influence of the content of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) in the Ag 2 Se nanowires/PEDOT:PSS (Ag 2 Se NWs/PEDOT:PSS) composite films on the thermoelectric properties. When the content of PEDOT:PSS is 1.54 wt%, the composite film achieved the highest power factor (PF) of ~ 2074.0 µW m −1 K −2 at room temperature. The maximum output power ( P max ) of the single-leg thermoelectric device based on the composite film is approximately 49.42 nW, and the maximum power density (PD max ) is 4.28 W m −2 at a temperature difference of 25 K. Furthermore, the film exhibits superior flexibility with 94.3% of the original performance retention after 2000 bending cycles around a rod with a diameter of 5 mm. This work provides valuable guidance for the design and fabrication of high-performance flexible inorganic/organic composite thermoelectric materials.
✓ 已验证
产品关联
DOI
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Zhang Nan,Hu Yang,Zhang Zhuang,Wu Chao,Zhu Jiamin,Zhang Yuqing,Shen Wei,Wu Shanshan,Xi Shibo,An Li,Xi Pinxian,Yan Chun-Hua
Transition metal sulfides (TMSs) are promising catalysts for water oxidation due to their unique electronic properties, but their application is limited by structural instability during the oxygen evolution reaction (OER). The specific mechanisms by which crystallinity variations in TMSs influence their structural evolution and catalytic performance remain poorly understood. Here, we investigate the structural evolution of CoS 2 catalysts with varying crystallinities and their effect on the OER. In-situ characterization and density functional theory (DFT) calculations reveal that lower crystallinity enables rapid equilibrium among surface sulfur-oxygen exchange, metal site activation, and oxygen intermediate evolution, enhancing the transformation of bulk phase into small amounts of sulfur-stabilized oxyhydroxide and improving OER performance. Conversely, moderate crystallinity leads to self-corrosion and progressive structure collapse from the exterior inward, resulting in deactivation. This work highlights the potential of crystallinity control in optimizing the electronic states and catalytic behavior of water oxidation catalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Liu Lu,Zhang Anlin,Sun Huapeng,Lei Yanhua,Deng Bin
To address the insufficient color performance in contemporary solid-state lighting, a novel series of orange-red-emitting KSr 6 ScSi 4 O 16 :Sm 3+ (KSSSO: Sm 3+ ) phosphors was synthesized employing conventional solid-state synthesis. Comprehensive characterization encompassing phase analysis, luminescence properties, and thermal behavior was performed on the temperature-optimized material. Under 402 nm excitation, the Sm 3+ -activated phosphors exhibit four distinct emission bands centered at 562 nm, 599 nm, 645 nm, and 708 nm, corresponding to the characteristic 4 G 5/2 → 6 H 5/2 , 4 G 5/2 → 6 H 7/2 , 4 G 5/2 → 6 H 9/2 , and 4 G 5/2 → 6 H 11/2 transitions of Sm 3+ ions, respectively. Notably, the 599 nm emission ( 4 G 5/2 → 6 H 7/2 transition) dominates the luminescence spectrum, resulting in an orange-red emission color for the phosphor. The ideal Sm 3+ concentration was determined to be 2 mol%, exceeding this level induces concentration quenching primarily via dipole-dipole interactions. All synthesized samples demonstrate exceptional color purity exceeding 98%. The phosphor exhibits the remarkable property of very low thermal quenching, demonstrating exceptional thermal stability with a retention intensity of 99.58% even at an elevated temperature of 420 K. A phosphor-converted white light-emitting diode (pc-WLED) was fabricated via a tri-color blending approach, demonstrating an ideal correlated color temperature (CCT) of 5638 K and an excellent color rendering index ( R a = 92.8). These outstanding photometric properties confirm the exceptional suitability of the phosphor for high-performance WLEDs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Wei Siyi,Xu Yanqing,Long Qian,Xie Haotian,Wu Wenqi,Chen Xueke,Lin Yan,Cui Hanfeng F.
Cysteine (Cys) plays a critical role in both physiological and food domains, with abnormal levels being closely linked to various diseases. Therefore, the development of highly selective and sensitive detection methods is essential. In this study, a “On-off” fluorescent probe, TPA-DNBS, based on a triphenylamine (TPA) derivative, was designed. Compared to traditional probes, TPA-OH offers greater rigidity, stronger conjugation, and a larger Stokes shift, demonstrating superior signal-to-noise ratio and detection stability in complex biological and environmental samples. The probe exhibits specific response to Cys via a photo-induced electron transfer (PET) mechanism: in the presence of Cys, the DNBS quencher group is cleaved, leading to a significant increase in fluorescence. The probe shows excellent detection performance, with a linear range from 1 × 10⁻³ M to 1 × 10⁻⁹ M and a detection limit as low as 1.05 nM, along with good selectivity, interference resistance, stability, and reproducibility. In practical sample analysis, the recovery rates of spiked Cys in milk and mineral water were 99.7%–106.6% and 102.1%–103.3%, respectively, with relative standard deviations below 2.5%. These results indicate the broad applicability of the probe in complex samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICAL RESEARCH
·
2025
·Vol. 30
·期 1
·1-22
·
IF 3.4
Liang Liang,Wang Junyan,Shang Wei,Taib Haslina,Liszen Tang,Ghani Zuryati Ab
Background This study evaluated the effects of hydroxyapatite microtubes and chitosan composite scaffold (HMTs–CHS) on bone regeneration in rat calvarial critical-size defects (CSDs). Methods HMTs–CHS composites were fabricated through hydrothermal synthesis and atmospheric pressure sintering. The scaffolds were analyzed using SEM, XRD, and FTIR to verify their structural and chemical characteristics. In vitro studies assessed cell proliferation, cytotoxicity, and osteogenic differentiation using bone marrow mesenchymal stem cells (BMSCs). For in vivo evaluation, 24 rats with 8-mm critical-size calvarial defects were divided into three groups: blank, CHS, and HMTs–CHS. Bone regeneration was evaluated at 30 and 60 days using micro-CT and histological analysis. Results The HMTs–CHS scaffold exhibited a well-organized honeycomb-like structure with optimal pore size distribution (100–160 μm). The scaffold significantly enhanced BMSC proliferation and osteogenic differentiation, with increased EdU-positive cells, elevated ALP activity, and enhanced matrix mineralization. Osteogenic markers (RUNX2, COL1, OPN, OCN, BSP) were significantly upregulated in the HMTs–CHS group at both gene and protein levels. In vivo, the HMTs–CHS group showed superior bone regeneration with higher bone volume fraction (BV/TV: 14.07 ± 0.84% at 60 days, representing a − 44% relative improvement over the CHS group at 9.74 ± 1.36%) and better trabecular architecture ( p < 0.05). Histological examination confirmed enhanced bone formation and maturation. Conclusions The HMTs–CHS composite significantly improved bone regeneration in CSDs compared to CHS alone or no treatment. These findings suggest HMTs–CHS could be a promising biomaterial for treating cranial bone defects, offering an alternative to traditional bone grafts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Si Mengyao,Han Guo,Liu Tianwen,Wang Xiaoying
Aberrant overexpression of c-Myc protein (c-Myc) serves as a critical biomarker for aggressive lymphomas, yet its trace-level quantification remains challenging due to insufficient sensitivity in conventional assays. Here, we present an electrochemical immunosensor leveraging homogeneous gold–palladium (AuPd) nanohybrids for dual amplification, achieving both simplified fabrication and enhanced analytical performance. A chitosan–graphene oxide–AuPd nanorod composite (CS-GO-AuPd) was engineered as an electrode modifier, offering high conductivity, biocompatibility, and abundant antibody immobilization sites. Prussian blue-doped AuPd nanoparticles (PB-AuPd@Ab 2 ) were simultaneously designed as catalytic signal probes, synergistically amplifying responses through electron mediation and nanozyme activity. This homogeneous material strategy eliminated heterogeneous nanomaterial interfaces, streamlining sensor assembly while ensuring signal reproducibility. The sandwich-type immunocomplex formation triggered a PB-derived differential pulse voltammetry signal proportional to c-Myc concentration, yielding a 0.5 pg mL −1 –1 ng mL −1 linear range, with a detection limit of 0.25 pg mL −1 . Comparative validation against clinical methods confirmed robust accuracy, highlighting the platform’s potential for dynamic monitoring of lymphoma progression and therapy response. This work establishes a paradigm for unifying material homogeneity with dual-amplification mechanisms in biosensing, extensible to diverse low-abundance biomarkers. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Dong Anrui,Lin Gaoxin,Li Zhiheng,Wu Wen,Cao Xing,Li Wenlong,Wang Linqin,Zhao Yilong,Chen Dexin,Sun Licheng
The mechanical stability of the catalytic electrodes used for hydrogen evolution reactions (HER) is crucial for their industrial applications in anion exchange membrane water electrolysis (AEM-WE). This study develops a corrosion strategy to construct a self-supported electrocatalyst (Int-Ni/MoO 2 ) with high mechanical stability by anchoring the Ni/MoO 2 catalytic layer with a dense interlayer of MoO 2 nanoparticles. The Int-Ni/MoO 2 exhibits a strengthened homostructural interface between the interlayer and catalytic layer, preventing the detachment of the catalyst during ultrasonic treatment. The blade-shaped catalytic layer reduces bubble shock and potential fluctuations at high current densities up to −6000 mA cm −2 . As a result, the Int-Ni/MoO 2 electrode exhibits a low overpotential of 73.2 ± 14.2 mV and long-term stability for 6000 h at −1000 mA cm −2 in a 1 M KOH solution. The Int-Ni/MoO 2 assembled AEM-WE device demonstrates long-term stability at 1000 mA cm −2 for 1000 h with a very low degradation rate of 3.96 µV h −1 .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）